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c Pharmacokinetics MCQs [set-1]
Biopharmaceutics and
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Chapter: Absorption

1. The process by which molecules diffuse from a region of higher

concentration to a region of lower concentration and no external energy is
expended is called

A. Passive diffusion

B. Active transport

C. Pore transport

D. Facilitation diffusion

Answer: A

2. Which law states that 'the rate of diffusion is proportional to both the
surface area and concentration difference and is inversely proportional to
the thickness of the membrane’?

A. Fick's Law

B. Avagadro's Law

C. Hooke's Law

D. Pascal's Law

Answer: A

3. Which of the following is a not mechanism of drug absorption through

GIT

A. Pore transport

B. Active transport

C. Endocytosis

D. Metastasis

Answer: D

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cparticulate material is called
4. The process of engulfing of

A. Pinocytosis
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B. Phagocytosis

C. Convective transport

D. Facilitated diffusion

Answer: B

5. Which of the following process is also called "cell drinking"?

A. Pinocytosis

B. Phagocytosis

C. Convective transport

D. Active tr

Answer: A

6. The absorption of drugs like (quaternary ammonium compounds,

sulphonic acid) are explained by

A. Ion pair transport

B. convective transport

C. active transport

D. Facilitated diffusion

Answer: A

7. Fick's law is used for study of

A. Dissolution rate

B. Disintegration rate

C. Dissociation rate

D. Diffusion rate

Answer: D

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c the skin is known as
8. The delivery of a drug through

A. Sublingual
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B. Transdermal

C. Inhalation

D. Buccal

Answer: B

9. Which route of drug administration shows 100% Bioavailability?

A. Oral

B. Intravenous

C. Rectal

D. Topical

Answer: B

10. If drug administered by Intravenous route appears in feaces, it implies

that the drug

A. Undergo first pass metabolism

B. Undergoes enterohepatic recycling

C. It is not completely absorbed

D. It is not completely metabolized

Answer: B

11. Which of the following is characteristic of the oral route?

A. Absorption depends on GI tract secretion and motor function

B. Fast onset of effect

C. A drug reaches the blood passing the liver

D. The sterilization of medicinal forms is obligatory

Answer: A

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12. When the active transportcsystem become saturated, the rate process
become M
A. Zero order

B. Second order

C. Pseudo first order

D. Pseudo zero order

Answer: A

13. Rate of absorption of drug by passive diffusion is maximum in

A. Small intestine

B. Large intestine

C. Stomach

D. Oesphagus

Answer: A

14. Maximum movement of drug across the membrane occurs by

A. Completely ionised

B. Unionised

C. Partially ionised

D. None of them

Answer: B

15. If drug has pKa value of 3 then at pH value of 7 what would be the
degree of ionisation of the drug?

A. Majority portion would be ionised

B. Majority portion would be unionised

C. Approximately 50% would be ionised and 50% unionised

D. None of the above

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Answer: A
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16. Which of the followingM
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is not the characteristic of the carrier mediated
transport system?

A. Energy dependent

B. Reach equilibrium

C. Metabolically inhibited

D. Structurally specific and saturable

Answer: B

17. Which of the following is alimentary route of administration when

passage of drug through liver is minimized?

A. Oral

B. Transdermal

C. Rectal

D. Intraduodenal

Answer: C

18. ………………is the process of movement of unchanged drug from the

site of administration to the systemic circulation.

A. Absorption

B. Dissolution

C. Distribution

D. Elimination

Answer: A

19. Energy is utilized in ………………… diffusion mechanism.

A. Passive

B. Active

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C. Pore
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D. Cellular c
Answer: B M
20. ……………… involves the engulfment of small molecules or fluid.

A. Endocytosis

B. Pinocytosis

C. Phagocytosis

D. None of the above

Answer: B

21. The concentration of drug in blood or plasma will be comparatively in

the GI tract.

A. High

B. Low

C. Very High

D. Very Low

Answer: A

22. ................mechanism is useful to describe charged or highly ionized

drug molecules.

A. Ion-pair transport

B. Cellular transport

C. Active transport

D. Passive tr

Answer: A

23. To avoid bioavailability issues, the drug must have a minimum aqueous
solubility of

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A. 150%
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B. 10% c
C. 100% M
D. 1%

Answer: D

24. When the solvent molecules are entrapped in the crystalline structure
of the polymorph, it is called as

A. Pseudo-polymorphism

B. Amorphism

C. Crystallinity

D. All of the above

Answer: A

25. The occurrence of food in the GI tract can affect the drug bioavailability
from an oral drug product. The above give statement is?

A. True

B. False

C. Both of the above

D. None of the above

Answer: A

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