Propolis Study Sample Intervention Clinical intervention Time

Author Formulation Design Baseline Outcome follow-up P value

CAL BOP PD CAL BOP PD
Nakao et all Propolis RCT 24 patients Propolis ointments were 3 month P < 0.001
ointment administered to each study significant
group (three times at 1-month
intervals) to a tooth with
periodontal pockets ≥ 5 mm
without local anesthesia.
Salvatori C et Liquid Extract RCT 150 patients - treatment SRP + curretage 3 month P < 0.001
all propolis with - treatment SRP + curretage+ significant
generalized chlorhexidine
chronic treatment SRP + curretage +
periodontitist propolis
El-Shennawi capsules RCT 18 patient - The patients had undergone 1.38 ± 0.24 0.11 ± 1.13 ± 1.93 ± 0.08 ± 1.23 ± 3 month P < 0.001
et all,2016 178mg (made with agressive periodontal therapy (scaling 0.06 0.01 0.39 0.06 0.14 Significant
by periodontitist and root planing).
Arkopharma, - The patients had undergone
Spain), periodontal therapy (scaling
and root planing) with
periodontal surgery or the
use of Propolis.

Seth et all, Liquid Extract RCT 20 patients - subgingival irrigation with 3 month p <0.0001
2022 propolis with chronic 25% propolis extract Significant
periodontitist - subgingival irrigation with
0.2% chlorhexidine
Park et all, Propolis RCT 104 patients 0.0618 0.7272 0.5940 0.7879 3 month p <0.0001
2021 capsule Significant
Mali et all , Honey Bee RCT 20 patients - Irrigation for two weeks with 4 3 month p <0.0001
2018 Propolis with chronic mL 20% propolis Significant
Solution periodontitist hydroalcoholic solution two
times a week.
Ultrasonic scaling and root
planning
Andrade et all. Honey Bee RCT 18 patients 5,75 ± 1,17 5.63 ± 6 months p <0.0001
2017 Propolis with chronic 0.84 Significant
extract periodontitist