Professional Documents
Culture Documents
Sem VI
(1) In medicine:
The use of radio isotopes for diagnosis and therapy of
various diseases is one of major application of isotopes.
They can be used either by oral or intravenous
administration to humans or by performing a test in vitro
on blood or urine. This branch of medicine is called
“Nuclear medicine.”
Reactor radio isotpes:
• Molybdenum-99 (66 h): Used as the 'parent' in a
generator to produce technetium-99m.
• Technetium-99m (6 h): Used in to image the skeleton
and heart muscle in particular, but also for brain,
thyroid, lungs (perfusion and ventilation), liver,
spleen, kidney (structure and filtration rate), gall
bladder, bone marrow, salivary and lacrimal glands,
heart blood pool, infection and numerous specialized
medical studies.
• Cobalt-60 (10.5 mth): Formerly used for external
beam radiotherapy.
• Copper-64 (13 h): Used to study genetic diseases
affecting copper metabolism.
• Iodine-131 (8 d): Widely used in treating thyroid
cancer and in imaging the thyroid; also in diagnosis
of abnormal liver function, renal (kidney) blood flow
and urinary tract obstruction. A strong gamma
emitter, but used for beta therapy.
• Phosphorus-32 (14 d): Used in the treatment of
excess red blood cells. (Beta emitter).
• Potassium-42 (12 h): Used for the determination of
exchangeable potassium in coronary blood flow.
• Sodium-24 (15 h): For studies of electrolytes within
the body
Cyclotron Radioisotopes:
• Carbon-11, Nitrogen-13, Oxygen-15, Fluorine-18:
These are positron emitters used for studying brain
physiology and pathology, in particular for localizing
epileptic focus, and in dementia (Associated with a
decline in memory or other thinking skills severe
enough to reduce a person's ability to perform
everyday activities), psychiatry and neuro
pharmacology studies. They also have a significant
role in cardiology.F-18 in FDG
(Fluorodeoxyglucose) has become very important in
detection of cancers and the monitoring of progress
in their treatment.
• Cobalt-57 (272 d): Used as a marker to estimate
organ size and for in-vitro diagnostic kits.
• Iodine-123 (13 h): Increasingly used for diagnosis of
thyroid function, it is a gamma emitter without the
beta radiation of I-131.
• (2) In agriculture:
Radioisotopes can be used to understand chemical
and biological processes in plants.This is true for two
reasons:
1)radioisotopes are chemically identical with other
isotopes of the same element and will be substituted
in chemical reactions
2)radioactive forms of the element can be easily
detected with a G.M counter or other such device.
Example:
A solution of phosphate, containing radioactive
phosphorus-32, is injected into the root system of a
plant. Since phosphorus-32 behaves identically to
that of phosphorus-31, the more common and non-
radioactive form of the element, it is used by the
plant in the same way. A GM counter is then used to
detect the movement of the radioactive phosphorus-
32 throughout the plant. This information helps
scientists understand the detailed mechanism of how
plants utilized phosphorus to grow and reproduce.
Radiations from certain radioisotopes are used for
killing insects which damage the food grains. Certain
seeds and canned food can be stored for longer
periods by gently exposing them to radiations. Better
yields of milk from cows, and more eggs from hens
have been obtained on the basis of information
gained by mixing radioisotopes with their diet.
Radioisotopes are used for determining the function
of fertilizer in different plants. Radioisotopes are also
used for producing high yielding crop seeds. Thus the
agricultural yield is increased.
Food Irradiation
Food irradiation is a method of treating food in order
to make it safer to eat and have a longer shelf life.
This process is not very different from other
treatments such as pesticide application, canning,
freezing and drying. The end result is that the growth
of disease-causing micro organisms or those that
cause spoilage are slowed or are eliminated
altogether. This makes food safer and also keeps it
fresh longer. Food irradiated by exposing it to the
gamma rays of a radioisotope -- one that is widely
used is cobalt-60. The energy from the gamma ray
passing through the food is enough to destroy many
disease-causing bacteria as well as those that cause
food to spoil, but is not strong enough to change the
quality, flavor or texture of the food. It is important
to keep in mind that the food never comes in contact
with the radioisotope and is never at risk of becoming
radioactive. Irradiation of certain foods also have
additional benefits. Since the energy passing through
the food can disrupt cellular processes.
(this is the mechanism for destroying
microorganisms) it also can halt the cellular
processes that lead to the sprouting or ripening of
foods. Potatoes and onions are irradiated to retard
their sprouting.
(3) In studying reaction mechanism in photo
synthesis:
An example of naturally-occuring biological
oxidation-reduction reactions is the process of
photosynthesis.In this process the energy is taken
From sunlight and via a series of oxidation-
reduction reactions oxygen and sugar are
produced, as well as other compounds
The overall equation for the photosynthetic
process may be expressed as:
6 CO2 + 6H2O --------> C6H12O6 (glucose) + 6 O2
Here a fundamental question arises.
i.e what is the source of separated O2? We can get the
answer using radio active isotope of oxygen(O18).
Use of this isotope has suggested that the liberated
oxygen is not from CO2 but from H2O.the process can
be shown as
6CO2 + 6H2O18 → C6H12O6 + 6O218
Nuclear Reactor:
A nuclear power plant is a thermal power plant in
which heat is produced by a nuclear reactor instead of
combustion of fossil
fuels .Nuclear fission is a self – sustaining chain
reaction as long as released neutrons able to be
captured by more fissionable material. This is the
basis upon which nuclear reactor operate to produce
energy. The fission chain reaction is controlled by
using natural uranium instead of U235, U238 absorbs
neutrons and retards explosive fission. {One type of
reactor uses metal slug containing uranium placed
into a graphite block to form a “pile”. Another type,
known as “breeder” reactor uses ordinary uranium
but makes new fissionable metal Pu239
92U + 0n1 92U 93Np +-1e0 94Pu +
238 239 239 239
-1e
0
Stellar energy .
In 1932 it was proposed that heat of sun and stars is
due to a series of nuclear reaction. For the Sun and
other normal main-sequence stars, the source of
energy lies in the conversion of hydrogen to helium.
The nuclear reaction thought to occur in the Sun is
called the proton-proton cycle. In this fusion reaction,
two protons (1H) collide to form a deuteron (a
nucleus of deuterium, 2H), with the liberation of
a positron (the electron’s positively
charged antimatter counterpart, denoted e+). The main
source of energy in hotter stars is the carbon
cycle (also called the CNO cycle
for carbon, nitrogen, and oxygen), in
which hydrogen is transformed into helium, with
carbon serving as a catalyst. The reactions proceed as
follows: first, a carbon nucleus, 12C, captures
a proton (hydrogen nucleus), 1H, to form a nucleus of
nitrogen, 13N, a gamma-ray photon being emitted in
the process; thus, 12C + 1H → 13N + γ. The light 13N
nucleus is unstable, however. It emits a positron, e+,
which encounters an ordinary electron, e−, and the
two annihilate one another. A neutrino also is
released, and the resulting 13C nucleus is stable.
Eventually the 13C nucleus captures another proton,
forms 14N, and emits another gamma-ray photon.
Again, the positron meets an electron, and the two
annihilate each other while the neutrino escapes.
Eventually the 15N nucleus encounters a fast-moving
proton, 1H, and captures it, but the formation of an
ordinary 16O nucleus by this process occurs only
rarely. The most likely effect of this proton capture is
a breakdown of 15N and a return to the 12C nucleus
Thus, the original 12C nucleus reappears, and the four
protons that have been added permit the formation of
a helium nucleus.
This transformation involves C-H-N cycle.
12
C + 1H → 13N + γ.
13
N → 13C + e+ + ν;
13
C + 1H → 14N + γ
14
N + 1H → 15O + γ;
15
O → 15N + e+ + ν.
15
N + 1H → 12C + 4He + γ.
Overall change may be summarized as follows
41H1 2He + 1e + ϒ
4 0