Insight Into the Asian Market

Asia Customer
Total Solution
Coverage Orientated

Major
Active
Healthcare
Response
Research
Rate
Agencies

100,000+
Rich
Verified Localization
Experience
Panelists
 Our Story
2005 Holden and Dajiashuo Consumer Community founded, started to provide Asia online consumer
market research services to global customers.
2011 Established the FIRST Doctor Panel Community in China, start to provide online Healthcare
market research services to global clients.
2012 Established Nanjing branch.
2014 Built partnership overall Asia, including Hong Kong, Taiwan Japan, Korea, India, and SEA, started
to provide Healthcare market research services to global clients.
2015 Built in-house recruiting team, moderation team, started to provide full service for Healthcare
Qualitative research to global research agencies.
2017 Established Japan branch.
2020 Established USA branch.
2022 Started strategy partnership with SeedPlanning (Japan)
2023 Established APPA (Asian Physician Panel Alliance) with SeedPlanning (Japan), the Owl (Taiwan)
Your Teaminto
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Holden Team

John Xu Kenneth Lee Jeffrey Kelsch

Founder, CEO Partner, COO Partner, Overseas
Business Operation

Eva Glenn Foley Baldwin,

VP, Research & Director of Business Research Director
Client Delivery Development (USA)

Nicole Gaku SASAKI Angela Alex

Ada Coco
Operation Director Senior executive officer of Research Director of Research Director of
Sales Director Panel Manager
SeedPlanning (APPA-Japan) APPA-Taiwan APPA-Hong Kong
Your Team On the Ground in ASIA

APPA

Seamless Access to: China Japan Taiwan Hongkong

2023-02-28

China-based healthcare fieldwork and research agency, Holden Healthcare,

announced today that they have established a global strategic partnership
alliance named “APPA” (Asia Physician Panel Alliance), in an effort to
enhance physician panel access throughout markets in the Asia-Pacific
region, inclusive of traditionally difficult to access markets.

APPA brings a group of highly passionate and professional Asian healthcare

research companies together. We empower and develop companies to
realize their potential and help them excel.

Find more info at www.appa360.com

Holden’s
Services
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Market

All types of research tools

Quant survey

In-depth Interview Quick Mini survey

Tele-depth Interview Our Patient Record Form

Research
Tools

Web-assisted TDI Online Bulletin Board

Focus group
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Total solution for any stage of research process

Project Management

Facility
Survey Programming

Simultaneous Translation
Transcript
Recruitment Reporting
Moderation

Analysis
Material Translation
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Procedure of Quantitative projects

• After receiving the B, Online

q’ire from client, our • Sampling target HCPs D, Data and Report
questionnaire from panel and invite
local experts will programming delivery
check the translation them for survey.
and questions, make • All survey URLs are user
• Our experienced ID / password protected. • Raw data can be
sure it’s appropriate
programmer delivered to client at
for the market.
implements Excel or SPSS format
questionnaire online, • Researcher analysis
A, Questionnaire if needed. C, Data collection / data and deliver the
localization fieldwork final report.
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Procedure of Qualitative projects

• After receiving the • Holden PM contacts

screener from client, with the recruited
our local experts will respondents by •Holden arrange
check if it’s appropriate B, Recruitment phone, double D, Schedule the F2F or F, Delivery
for the market. check if they meet web/Tele
& 1st Screening
the screening interview,
• Set up the screener on • After client •According to
criteria. provide on-site
system, prepare the • Approach target confirming the client’s request,
links and invitation. • Deliver qualify or tech support
HCPs from panel respondents’ list to respondent, we Holden can
will schedule the accordingly. delivery recording,
A, Screener or by referral. client.
• Invite them to the interview time transcript, content
check & set-up C, Screening E, Interview
screening survey. and update it to analysis, or
client. summary report.
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Recruitment Methods

Recruit from online Recruit from

Ask panelists to Offline recruiters
HCP and patient non opted-in
recommend recruit in hospitals
panel database
 Rich
Resource
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Ground in ASIA
Market

Rich HCP & Patient Resources all over Asia

HCP: 15000
HCP: 43596
Patient: 13645
Patient: 60110
HCP: 18284
Patient: 84510
HCP: 60972
Patient: 53000
HCP: 10400
Patient: 2300
HCP: 3700
Patient: 5718
HCP: 4870
Patient: 589

HCP: 1000
Patient: 2000
HCP: 14870
Patient: 57000

HCP: 800
Patient: 1500
HCP: 2070
Patient: 6000

HCP: 3280
Patient: 1290
HCP: 6005
HCP: 2000
Patient: 2000
Patient:1000
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Panel Recruitment channel – HCP

Cooperate with
offline FW
agencies
Cooperate with
Recommended
online HCP
by HCP panelists
communities

Face to face
Online
recruit in
advertisement
hospital
Your Teaminto
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Panel Recruitment channel – Patient

Recommended
by HCPs
Cooperate with
Recommended
online patient
by panelists
communities

Recruit through Online

gen pop panel advertisement
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Panel Quality Control

We take strict validation process, to make sure every HCP/Patient panelist is Real, Reliable, and Available.

Physician
Nurse • Upload license ID
Pharmacist • Upload work ID

Verification code via Technician

email / SMS

• Check CV, match with info in website

Hospital administrator
• Call hospital’s office
ID number & Name
verify

Patient • Upload medical record with diagnosis

• Upload prescription with diagnosis
China Panel Number
·HCP: 43596
·Patient: 60110
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China HCP Panel Number – Title

1090 872 218

2.5% 2% 0.5%

4360
4360 10%
10% ➢ Reference – Universe Size
3924
9% Doctor 2,028,296
Resident doctor 144,009
18746 Attending doctor 348,867
10027 43%
23% Associate Chief doctor 640,942
Chief doctor 894,478
Nurse 3,237,987
Pharmacist 307,570
Resident doctor Attending doctor
Associate chief doctor Chief doctor Laboratorian 362,518
Nurse Pharmacist
* as of the end of 2019
Technician HOD/C-level

* HCP Panel Total Number: 43596

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China HCP Panel Number – Hospital Level & City Tier

➢ Hospital Level
➢ City Tier
5%
6%
19%
4%
4%

43%
50%

21%

4% 38%
6%
Level 3A Level 3B Level 3C Level 2A
Tier 1 (3 cities) Tier 2 (30 cities) Tier 3 & Others
Level 2B Level 2C Level1 Others

* HCP Panel Total Number: 43596

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China Doctors Panel Number – Top 20 Specialties

4850

3538
2986
2564 2545
2357
2085 1959
1796 1739 1651
1399 1298 1247
1218 1095
932 895 724 604
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Reference - Universe size of Doctors in China

Specialty Universe Size Specialty Universe Size

Preventive care medicine 57,789 Psychiatry 38,532
General practice 128,440 Infectious Diseases Medicine 25,688
Internal medicine 1143,116 Oncology 35,316
Surgery 407,797 Emergency medicine 67,431
Pediatric 141,284 Rehabilitation Medicine 35,321
Gyn/Ob 269,724 Anesthesiology 86,697
Ophthalmology 44,954 Pathology 19,266
E.N.T. 44,954 Medical Imaging/Radiology 221,559
Stomatology 183,027 Clinical Laboratory 9,633
Dermatology 28,899 Others 266,513

* as of the end of 2019

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China Patient Panel Number – Common Disease

6707

5207
4386
4128

3212
2703 2699 2506
1996 1985 1928 1876
1360 1270
936 830
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China Patient Panel Number – Non common Disease

856 831
714

416
365 344
312
221
140 123 112 112 109 102 98
56 45 33 23
Japan Panel Number
·HCP: 18284
·Patient: 84510
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Ground in ASIA
Market

Japan HCP Panel Number – Title

860 550 130

5% 3% 1%

➢ Reference Data – Universe Size

Physician 323,700
Nurse 1,218,000
Pharmacist 311,000
Technician 59,759
16744
Laboratorian 14,000
91%
* as of 2021

Physician Technician Pharmacist IT staff

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Japan Doctor Panel Number – Top 20 Specialties

2311

1178
1079
950
812 745 727
651 650 602 573 533 530 491 476 468 423 383 376 304
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Reference - Universe size of Doctors in Japan

Universe Size Specialty Universe Size
Internal Medicine 61,514 Urology 7,685
Respiratory Medicine 6,728 Neurosurgery 7,349
Cardiology 13,026 Orthopedic Surgery 22,520
Gastroenterology 15,432 Plastic Surgery 3,945
Nephrology 5,360 Stomatology/Dentists 104,000
Neurology 5,758 Oncology 1,000
Endocrinology 5,630 Ophthalmology 13,639
Hematology 2,840 E.N.T. 9,598
Dermatology 9,869 Psychiatry 17,375
Allergy 169 Infectious Diseases Medicine 594
Rheumatology 1,831 Pediatrics 18,884
Gyn/Ob 13,673 Medical Imaging/Radiology 7,112
Surgery 13,211 Anesthesiology 10,277
Respirator Surgery 2,075 Emergency Medicine 3,950
Cardiovascular Surgery 3,222 Rehabilitation Medicine 2,903
Breast Surgery 2,173 Clinical Laboratory 631
Anorectal surgery 456 Pathology 2,120
Gastrointestinal Surgery 5,814 Other 23,394
* as of 2021
Taiwan Panel Number
·HCP: 10400
·Patient: 2300
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Taiwan Doctor Panel Number – Top 20 Specialties

1,000 1,000

500 500
450
330 300 300 300
200 200 200 200 200 200 200
150 150 150 150
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Reference - Universe size of Doctors in Taiwan

Specialty Universe Size Specialty Universe Size

GP/Family medicine 3,581 Dermatology 1,211
Internal medicine 16,282 Psychiatry 1,654
Surgery 4,211 Urology 822
Orthopedic Surgery 1,648 Oncology 791
Plastic surgery 516 Anesthesiology 1,209
Pediatrics 3,537 Emergency Medicine 1,876
Gynecology and Obstetrics 2,373 Medical Imaging/Radiology 1,643
Ophthalmology 1,808 Pathology 546
Neurology 1,070 Rehabilitation Medicine 1,209
E.N.T. 2,449 Clinical Laboratory 8,138
Stomatology/Dentists 14,717 Others 5,680

* as of 2018
Hong Kong Panel Number
·HCP: 4870
·Patient: 589
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Hong Kong Doctor Panel Number – Top 20 Specialties

700

280
225
200 200 200
160 150
125
90 90 90 90 90 90 90
50 50 50 50
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Reference - Universe size of Doctors in Hong Kong

Specialty Universe Size Specialty Universe Size

GP/Family medicine 508 Dermatology 115
Internal medicine 1,473 Psychiatry 444
Surgery** 751 Infectious Diseases Medicine 82
Orthopedic Surgery 492 Urology 146
Plastic surgery 71 Oncology 213
Pediatrics 713 Anesthesiology 524
Gynecology and Obstetrics 476 Emergency Medicine 543
Ophthalmology 326 Medical Imaging/Radiology 438
Neurology 144 Pathology 227
E.N.T. 194 Rehabilitation Medicine 25
Stomatology/Dentists 2,751 Others 200

* as of 2022
Experience
Sharing
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Market

Experience
Rare Disease
• Leukemia (AML, ALL, CLL)
Specialties

• Hemophilia A/B
• Willebrand Disease
• MDS
• Spinal muscular atrophy (SMA)
• IBD (UC, CD)
• Hereditary angioedema (HAE)
• Hypoparathyroidism (HypoPT)
• Lupus (SLE, DLE)
• Multiple myeloma (MM)
• Cold Agglutinin Disease (CAD)
Therapeutic areas

• Pulmonary Hypertension (PH)

• Thrombocytopenic purpura (TP)
• Primary biliary cirrhosis (PBC)
• Giant cell tumor oftendon sheath (GCTTS)
• Melanoma
• Pompe Disease
• Fabry Disease
• Leucoderma
• Interstitial Lung Disease (ILD)
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Case sharing - HCP Quant

Case 1- Cardiac medicine study Case 2 - HCV study

Targets: Cardiologists, Interventional cardiologists, ER Targets: Gastroenterology, Infectious disease, Internal
physicians medicine; who treat 10+ HCV patients per month
LOI: 30min LOI: 45min
Sample size: 100n Sample size: 150n
Fieldwork: 10 days Fieldwork: 2 weeks
Markets: China, Japan Markets: China, Taiwan, Korea

Case 3 - Pharmaceutical Branding Study Case 4 - Dentists Study

Targets: GPs, Oncologists, Neurologists, Cardiologists, Targets: Dentists (dental surgeons)
Pharmacists, Healthcare policy influencers
LOI: 15min
LOI: 15min
Sample size: 100n
Sample size: 500n
Fieldwork: 10 days
Fieldwork: 2 weeks
Markets: China, Japan
Markets: China, Taiwan, Japan, Korea, India
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Case sharing - HCP Qual

Case 1 – MM(multiple myeloma) treatment journey Case 2 – NSCLC DSA message testing
Targets: MM treaters (oncologist, hematologist), MM patients Target group: NSCLC treaters (oncologist, respiratory
Methodology: TDI with web specialists)
Sample size: 20n (15 doctors, 5 patients) Methodology: TDI with web
Special request: both doctors and patients have to finish pre-work Sample size: 15n
before interview Markets: China and Japan
Market: China Recruiting time: 10 days
Recruiting time: 3 weeks Interview and deliver: 8 days
Interview and deliver: 4 weeks Delivery: recruiting, moderation, simul-translation,
Service: recruiting, moderation, simul-translation, English English recordings, English transcripts
recordings, English transcripts, content analysis
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Case sharing - Patient Quant

Case 1 – BGM product research Case 2 – MF patient concept testing

Target respondents: Type 1 and Type 2 Diabetes patients who Target respondents: MF(myelofibrosis) patients
use blood glucose monitors
Sample size: 20
Sample size: 200 (40 of T1D, 160 of T2D)
LOI: 20min
LOI: 20min
Market: Taiwan
Market: China
Fieldwork time: 3 weeks
Fieldwork time: 2 weeks

Case 3 – COPD and Asthma Case 4 – Patient Experience Program

Target respondents: COPD patients, Asthma patients, Target respondents: Patients with Multiple Myeloma, Psoriasis,
caregivers of child patients with asthma. Inflammatory Bowel Disease (including UC/Chron's disease), B-
Sample size: 120 (60 per market) cell malignancy
LOI: 20min Sample size: 120 (40 per market)
Market: China, Japan LOI: 20min
Fieldwork time: 3 weeks Market: China, Japan, Korea
Fieldwork time: 3 weeks
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Case sharing - Patient Qual

Case 1 – Chron’s new product testing Case 2 – HIV patient journey research
Research purpose: To get deeper understanding from Research purpose: Getting insights from patients
Chron’s patients for a new biologic product who are infected with HIV and understanding their
Target respondents: Moderate/severe Crohn’s Disease journey from being aware of their illness to diagnosis
patient, who are currently taking/have ever taken and treatment
medicine to control Crohn’s Disease Target respondents: HIV patients
Method: TDI Method: TDI
Market: China, Japan Market: China
LOI: 60min LOI: 60min
Sample size: 10 per market Sample size: 5
Service: recruiting, moderation, transcripts, content Service: recruiting, moderation, transcripts, summary
analysis report
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Case sharing – Purchaser / Payer

Case 1 – New product enter market research
Research purpose: To understand the restrictions for
product X to enter China market, the challenges/barriers,
purchasing process of hospital, reimbursement policy, etc.
Target respondents: Lab director, Purchasing director
Method: TDI
Market: China
LOI: 60min
Sample size: 20 (10 for each target)
Service: recruiting, moderation, transcripts, content
analysis, interview notes
Case 2 – VBP process and policy understanding
Research purpose: By talking to VBP stakeholders
from national and provincial level, to understand the
VBP process and policy in China, help client to
understand how to fit their products in China market
within the VBP environment.
Target respondents: VBP stakeholders (officers work
in Healthcare Security Administration/Health
Commission/Medical Products Administration)
Method: TDI
Market: China
LOI: 60min
Sample size: 5
Service: recruiting, moderation, simul-translation,
transcripts, final report
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THANK YOU

Tel (CHN): +86 21 58306270 E-mail(Jeff): jeffrey.kelsch@holdendata.com Website: www.holdendata.com

Tel (USA): +1 208 809 7117 E-mail(Team): team@holdendata.com