1.

Gastrin Migrating Motor Complex (MMC) - slow

Gastrin (two types G17 and G34) - peptide peristaltic contractions from stomach every
hormone released from stomach G Cells 90 mins
Gastrin Function - stimulates acid secretion and  Keeps the gut clean = less bacteria,
promotes mucosal growth
prevent reflux
 
Gastrin release stimulated by:  
1. Proteins/amino acids Pyloric sphincter stays relaxed for anything to
2. Parasympathetic input/Ach (because of pass into small bowel
gastric stretch) - process mediated by
gastrin releasing peptide 5. Motilin 
  Motilin (22 alpha amino acid) - stimulates
Gastrin release INHIBITED by: MMC
 H+ (negative feedback)  Secreted by M Cells and erythromycin
 Inhibited by feeding
Gastrin and CCK - part of the same family
 Gastrin shares receptors with CCK (CCK-B
receptor)
Parietal Cell Acid Secretion:
2. Somatostatin Gastrin and Ach (from Vagus) stimulate
parietal cells
Somatostatin - 2 forms (peptide hormone) – binds SOMATOSTATIN inhibits parietal cells = stops
to G cells to stop GASTRIN, CCK and secretin
gastrin release
release
 INDIRECT effect - mediated by
Two Types: histamine
1. 28 amino acid form - from D-Cells of
stomach, duodenum and pancreas
 Release stimulated by H+
 Inhibited by acetylcholine
2. 14 amino acid form (not common)

3. Secretin
Secretin (27 amino acids):
 Secreted by S Cells of small intestines in
response to acid
Effect:
 Stimulates bicarbonate secretion by
pancreas and liver
 Inhibits gastric acid production

4. CCK

Cholecystokinin-Pancreaozymin (CCK) - 33 amino

acids (last 5 are identical to GASTRIN)
 Secreted in response to LIPIDS/PEPTIDES
by I cells in small intestines
 CCK A receptors - for CCK
 CCK B receptors - for Gastrin
Effects:
1. Stimulates pancreatic secretion (from
acinar cells)
2. Stimulates gallbladder emptying