ACUTE AND CHRONIC INFLAMATION Neutralizing antibodies

INFLAMATION- body’s alert system

Elie Metchnikoff INFLAMMATION

- Describes phagocytosis  A protective response involving host

- Noble Prize 1908 cells, blood vessels, and proteins
o Eliminate initial course of cell
Paul Erlich
injury
- Who recognized the role of serum o Remove necrotic cells and
factors, mainly antibodies tissue
o Initiate the process repair
Granulocytes
 Also a potential harmful process
Basophils – inflammation o Components of inflammation
that are capable of destroying
Eosinophils – parasitic infection
microbes can alas injury
Neutrophils – bacteria bystander normal tissue

Symptomatic treatment

Agranulocytes “itis” = inflammation

Lymphocyte “function aesa”

 B – “Bursa of Fabricius” CARDINAL SIGNS OF INFLAMMATION

 Plasma Cells
 Heat (calor)
 Produce antibodies
 Redness (rubor)
 IgG – genitalia, chronic
 Swelling (tumor)
infections
 Pain (dolor)
 IgA – “asa labas”
o Celsus, De Medecina
section
o
 IgM – “mauuna”
 Loss of function
“Malaki”, Acute section
o Rudolf Virchow “father of
 5 IgG = 1 IgM
modern pathology”
 IgD – “Di alam” ~to
help~ Vascular Reactivity - involves blood vessels
 IgE – “Ellergy” “Parasitic
infection” Vasoconstriction -blood vessels constrict and get
 T – “Thymus” narrower.
 T-Helper Vasodilation - blood vessels get wider.
 T-Killer
 T-Suppressor Endothelial cells - form a single cell layer that
lines all blood vessels and regulates exchanges
Monocytes between the bloodstream and the surrounding
tissues.
- Engulfing phagocyting
CELLS

 Platelets
 Granulocytes (PMNs, Mast, etc.)
 Lymphocytes
 Fibroblasts

Hemostasis – blood balance

 Primary (only the platelets)

o Constriction of the blood
vessels
 adhesion
o Formation of a temporary
“platelet plug”
 activation
o Activation of the coagulation
 secretion
o Formation of “fibrin plug” or
the final clot
 aggregation
 Secondary (involves coagulation factors)
o Stable clot

Proteins

 Complement, Pentraxins, MBL, Ficolins

 Coagulation
 Kininogens
 Proteoglycans