MULTIPLE CHOICE QUESTION

1.Essential pentosuria is due to defect in:

A. HMP Pathway
B. Glycolysis
C. Gluconeogenesis
D. Uronic acid pathway
Ans: (D) Uronic acid pathway
2.Glucose-6-phosphatase is not present in.
A. Liver and kidneys
B. Kidneys and muscles
C. Kidneys and adipose tissue
D. Muscles and adipose tissue
Ans:(D) Muscles and adipose tissue
3. Glucose-6-phosphatase is absent or
deficient in
A. Von Gierke’s disease
B. Pompe’s disease
C. Cori’s disease
D. McArdle’s disease
Ans: (A) Von Gierke’s disease
4.The enzymes involved in Phosphorylation
of glucose to glucose 6- phosphate are
A. Hexokinase
B. Glucokinase
C. Phosphofructokinase
D. Both (A) and (B)
Ans:(D) Both (A) and (B)
5. An allosteric enzyme responsible for
controlling the rate of T.C.A cycle is
A. Malate dehydrogenase
B. Isocitrate dehydrogenase
C. Fumarase
D. Aconitase
Ans:(B) Isocitrate dehydrogenase
6. The glycolysis is regulated by
(A) Hexokinase
(B) Phosphofructokinase
(C) Pyruvate kinase
(D) All of these
Ans:(D) All of these
7. Which of the following enzyme is not
involved in HMP shunt?
(A) Glyceraldehyde-3-p dehydrogenase
(B) Glucose-6-p-dehydrogenase
(C) Transketolase
(D) Phosphogluconate dehydrogenase
Ans: (A) Glyceraldehyde-3-p dehydrogenase
8. Invert sugar is
(A) Lactose
(B) Mannose
(C) Fructose
(D) Hydrolytic product of sucrose
Ans:(D) Hydrolytic product of sucrose
9.Before pyruvic acid enters the TCA cycle it
must be converted to
(A) Acetyl CoA
(B) Lactate
(C) α-ketoglutarate
(D) Citrate
Ans: (A) Acetyl CoA
10.Transketolase activity is affected in
(A) Biotin deficiency
(B) Pyridoxine deficiency
(C) PABA deficiency
(D) Thiamine deficiency
Ans: (B) Pyridoxine deficiency
11.Phrynoderma is a deficiency of
(A) Essential fatty acids
(B) Proteins
(C) Amino acids
(D) None of these
Ans:(A)Essential fatty acids
12.Kwashiorkar is characterized by
(A) Night blindness
(B) Edema
(C) Easy fracturability
(D) Xerophthalmia
Ans:(B) Edema
13.Ketone bodies are synthesized from fatty
acid oxidation products by which of the
following organs?
(A) Liver
(B) Skeletal muscles
(C) Kidney
(D) Brain
Ans:(A) Liver

14.During each cycle of β-oxidation of fatty

acid, all the following compounds are
generated except
(A) NADH
(B) H2O
(C) FAD
(D) Acyl CoA
Ans:(B) H2O
15.In short bowel syndrome, fat cannot be properly absorbed, so
long chain fatty acids are mobilized from adipose tissueto generate
energy for cell survival. The initiating substrate for fatty acid
oxidation is which of the following
.
A. Long chain fatty acid
B. Fatty acyl carnitine
C. Fatty acyl CoA
D. Beta -hydroxy acyl COA
Ans:(C) Fatty acyl CoA
16.Bile acid synthesized in liver is/are:
A. Cholic acid
B. Chenodeoxycholic acid
C. Both (a) and (b)
D. None
Ans:(C) Both (a) and (b)
17.Vitamins are
(A) Accessory food factors
(B) Generally synthesized in the body
(C) Produced in endocrine glands
(D) Proteins in nature
Ans:(A) Accessory food factors

18. Vitamin A or retinal is a

(A) Steroid
(B) Polyisoprenoid compound containing acyclohexenyl ring
(C) Benzoquinone derivative
(D) 6-Hydroxychromane
Ans:(B) Polyisoprenoid compound containing acyclohexenyl ring
19. β-Carotene, precursor of vitamin A, is
oxidatively cleaved by
(A) β-Carotene dioxygenase
(B) Oxygenase
(C) Hydroxylase
(D) Transferase
Ans:(A) β-Carotene dioxygenase
20. Vitamin K regulates the synthesis of blood
clotting factors.
(A) VII
(B) IX
(C) X
(D) All of these
Ans:(D) All of these
21. The colour of cyanomethmoglobin is
(A) Pale yellow
(B) Pink
(C) Brown
(D) Bright red
Ans:(D)Bright red
22.Thiamine is
(A) Water-soluble vitamin
(B) Fat soluble vitamin
(C) Purine base
(D) Pyrimidine base
Ans:(A) Water-soluble vitamin
23.The egg injury factor in raw egg white is
(A) Biotin
(B) Avidin
(C) Albumin
(D) Calcium salts
Ans:(B) Avidin
24.Pantothenic acid acts on:
A. NADP
B. NADPH
C. FAD
D. COA
Ans: (D) COA
25.A 32 year old women present with extreme fatigue and vague
neurologic complaints.On examination, it is found that she has
decreased positional and vibrational sense, and her complete blood
count reveals megabolastic anemia.She realtes a histroy of gastric
resection 4 years ago for severe stomach ulcers. Which vitamin
deficiency does this represent ?
A. Vitamin C
B. Vitamin D
C. Vitamin K
D. Vitamin B12
Ans:(D)Vitamin B12
26.Rice-polishings contain whcih of the
following Vitamin?
(A) Riboflavin
(B) Niacin
(C) Thiamine
(D) Vitamin
Ans: (C)Thiamine
27.Active form of vitamin D is:
A. Cholecalciferol
B. 1,25-(OH)2 Cholecalciferol
C. 24,25-(OH)2 Cholecalciferol
D. 25-(OH) Cholecalciferol
 Ans: (B)1,25-(OH)2 Cholecalciferol
28.Normal range of serum urea is
(A) 0.6–1.5 mg/dl
(B) 9–11 mg/dl
(C) 20–45 mg/dl
(D) 60–100 mg/dl
Ans:(C)20–45 mg/dl
29. Normal range of serum creatinine is
(A) 0.6–1.5 mg/dl
(B) 9–11 mg/dl
(C) 20–45 mg/dl
(D) 60–100 mg/dl
Ans:(A) 0.6–1.5 mg/dl
30. Standard urea clearance is
(A) 54 ml/min
(B) 75 ml/min
(C) 110 ml/min
(D) 130 ml/min
Ans:(A)54 ml/min
31.The 4 rate limiting enzymes of
gluconeogenesis are
(A) Glucokinase, Pyruvate carboxylae
phosphoenol pyruvate carboxykinase and
glucose-6-phosphatase
(B) Pyruvate carboxylase, phosphoenol pyruvate
carboxykinase, fructose1,6 diphosphatase
and glucose-6-phosphatase
(C) Pyruvate kinase, pyruvate carboxylase,
phosphoenol pyruvate carboxykinase and
glucose-6-phosphatase
(D) Phospho fructokinase, pyruvate carboxylase,
phosphoenol pyruvate carboxykinase and
fructose 1, 6 diphosphatase

Ans: (B) Pyruvate carboxylase, phosphoenol pyruvate

carboxykinase, fructose1,6 diphosphatase
and glucose-6-phosphatase
32.After a 72 hour fast the substance likely to involved in the
formation of energy would be :
A. Muscle glycogen
 B. Liver glycogen
C. Amino acid
D. Acetoacetate
Ans:(D) Acetoacetate
33.Glucose 6 phosphate is an initial substrate for all the
following , except
:
A. Glycolysis
B. HMP shunt
C. Glycogenesis
D. Neoglucogenesis
Ans:(D) Neoglucogenesis
34. Glycoaminoglycans:
A. Are the carbohydrate portion of the glycoprotein
B. Contain large segment of a repeating unit,typically consisting
of a hexosamine and a uronic acid
C. Always contain sulphate
D. Exist only in two forms
Ans:(B) Contain large segment of a repeating unit,typically
consisting of a hexosamine and a uronic acid
35.When blood glucose rises, which of the following hepatic
enzyme activity falls?
A. Adenylate cyclase
B. protein kinase
C. 6-phosphofructo-2 kinase (PFK-2)
D. Fructose-1,6 bisphosphatase
Ans:(C) 6-phosphofructo-2 kinase (PFK-2)

36. The reaction ; Succinyl COA + acetoacetate and acetoacetyl COA

+ Succinate ,occure in all of the following , except.
A. Brain
B. Striated muscle
C. Liver
D. Cardiac muscle
Ans ; (C) Liver
37. Acetyl-COA acts as a substrate for all the enzymes, expect:
 A. HMG-COA synthetase
B. Malic enzyme
C. Malonyl COA synthetase
D. Fatty acid synthetase
Ans (B) Malic enzyme
38 .Rate –limiting enzyme of cholesterol synthesis is
A. HMG –COA reductase
B. HMG-COA lyase
C. HMG COA synthase
D. 7alpha hydroxylase
Ans (A) HMG-COA reductase
39. Refsum disease is due to deficiency of which of the following
enzyme ?
A. Malonate dehydrogenase
B. Thiophorase
C. Succinate thiokinase
D. Phytanic acid alpha oxidase
Ans (D) Phytanic acid alpha oxidase
40. Total and net number of ATP produced after complete beta
oxidation of palmitic acid are:
A. 106 and 102
B. 108 and 106
C. 100 and 98
D. 116 and 114
Ans : (B) 108 and 106
41. Nicotinamide is derived from:
A. Histidine
B. Methionine
 C. Tryptophan
D. Phenylalanine
Ans: (C) Tryptophan
42.. Which vitamin deficiency can result in nonclassical
homocystinuria?
A. Vit.B1
B. Vit.B2
C. Vit.B5
D. Vit.B12
Ans :( D) vit.B12
43..Guanidium group is associated with:
A. Tyrosine
B. Arginine
C. Histidine
D. Lysine
Ans : (B) Arginine
44..Myoglobin:
A. Contains four heme per molecule
B. Shows the Bohr effect
C. Has an O2 dissociation curve that is unaffected by wide range of
pH
D. None of the above
Ans: (C) Has an O2 dissociation curve that is unaffected by wide range
of pH
45. Porphyria cutanea tarda is the most common of the porphyrias
and results form a deficiency
Of:
A. Porphobilinogen deaminase
B. Uroporphyrinogen III cosynthase
 C. Ferrochelatase
D. Uroporphyrinogen decarboxylase
Ans:(D) Uroporphyrinogen decarboxylase
46.. A 4day old infant develops severe jaundice and is transferred to
the neonatal intensive care unit for aggressive phototherapy. He is
found to have a complete loss of UDP –glucuronyltransferase activity .
The loss of this enzyme activity leads to which of the following
disorder?
A. Crigler-Najjar syndrome
B. Gilbert syndrome
C. Dubin Johnson syndrome
D. Hereditary orotic aciduria
Ans:( A) Crigler-Najjar syndrome
47..How many molecules of 2,3-BPG bind to single haemoglobin?
A. 3
B. 1
C. 2
D. 4
Ans:( B) 1
48..Which of the following is not a heme protein?
A. Myoglobin
B. Cytochrome
C. Catalase
D. Albumin
Ans: (D) Albumin
49..Ferrous of heme is bound to:
A. Proximal histidine
B. Distal histidine
C. Tyrosine of alpha chain
 D. None of the above
Ans; (A) None of the above
50. A 10 year old boy presented with abdominal pain, muscle
weakness and fatigue. On investigation, serum lead levels were found
increased in blood .Activity of which of the following enzymes in the
liver is increased?
A. ALA synthase
B. Ferrochelatase
C. PGB deaminase
D. Heme oxygenasde
Ans: (A) ALA synthase