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MLB 203 Lecture Hormones-I
MLB 203 Lecture Hormones-I
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HORMONES I
substances, produced by
endocrine glands, secreted
thyroid
gland
into the blood stream to
adrenal
control metabolic and gland
pancreas
biological activities in target ovary
cells. testis
Thyroid gland
Adrenal gland
glucagon, insulin, oxytocin.
Testis (male)
H H
(Steroid) Hormones H R
DNA Transcription
mRNA
mRNA
Translation
Specific protein
Biochemical
response
Adenylate
CAMP performs its role as a second messenger cyclase
Cytosol
ATP PPi
in eliciting biochemical responses.
Phosphodiesterase R C
AMP 4cAMP
( )
R C
R2C2
R
C C
R
Protein Phosphoprotein
MLB 203 BIOCHEMISTRY II
_____________ Phosphatase
Hormones I
Ultimate
Pi biochemical
9 FACULTY OF APPLIED SCIENCES response
DEPARTMENT OF MEDICAL LABORATORY TECHNOLOGY
Regulation
288
of TG Lipase BIOCHEMISTRY
ATP
Epinephrine
Norepinephrine
Glucagon, Thyroxine Adenylate cyclase
Glucocorticoids Hormone sensitive
TSH, ACTH, GH TG lipase b
(inactive)
Triacylglycerol Diacylglycerol
FFA
Glycerol
Phosphatidylinositol 4,5-bisphosphate in
the plasma membrane is hydrolyzed by a
specific phospholipase C in response to
hormonal signals. Both products of
hydrolysis act as intracellular messengers.
Hypothalamus
Hypothalamus is a specialized
center in the brain that functions as
a master coordinator of hormonal Anterior pituitary
(adenohypophysis)
action.
Pars intermedia
(intermediate lobe)
Posterior pituitary
(neurohypophysis)
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Corticotropin-releasing hormone (CRH): stimulates anterior pituitary to release
adrenocorticotropic hormone (ACTH) which in turn, acts on adrenal cortex to liberate
adrenocorticosteroids. CRH contains 41 amino acids.
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Gonadotropin-releasing hormone (GnRH): a decapeptide. GnRH stimulates anterior
pituitary to release gonadotropins (luteinizing hormone (LH) and follicle stimulating
hormone (FSH).
MLB 203 BIOCHEMISTRY II
13 FACULTY OF APPLIED SCIENCES _____________
DEPARTMENT OF MEDICAL LABORATORY TECHNOLOGY Hormones I
Hypothalamic Hormones (cont.)
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Growth hormone-releasing hormone (GRH): consists of 44 amino acids. GRH
stimulates the release of growth hormone (GH or somatotropin) which promotes growth.
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Growth hormone release-inhibiting hormone or somatostatin (GRIH): contains 14
amino acids. GRIH inhibits the release of growth hormone from the anterior pituitary.
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Prolactin release-inhibiting hormone (PRIH): a dopamine and/or a small peptide that
inhibits the release of prolactin (PRL) from anterior pituitary.
II.Glycoprotein hormones.
III.Pro-opiomelanocortin family.
1. Effects on growth
Thyroid stimulating hormone (TSH)
Follicle stimulating hormone (FSH)
Luteinizing hormone (LH)
Human chorionic gonadotropin (hCG)
Promotes the uptake of iodide from the circulation by thyroid gland.
Organification: conversion of iodide (I-) to active iodide (I+).
Proteolysis of thyroglobulin to release T3 and T4.
Increased synthesis of proteins, nucleic acids and phospholipids in thyroid
gland.
In females: FSH stimulates
follicular growth, enhances the
production of estrogens.
In males: FSH stimulates
testosterone production, required
for spermatogenesis and growth
of seminiferous tubules.
Promotes the conversion of ACTH Overproduction:
cholesterol to pregnenolone in the - causes Cushing’s syndrome:
adrenal cortex.
Hyper-pigmentation
Enhances RNA and protein synthesis
Negative nitrogen balance
and thus promotes adrenocortical
Impaired glucose tolerance
growth.
Hypertension
Increases lipolysis by activating
Edema
lipase of adipose tissue.
Muscle Atrophy
MLB 203 BIOCHEMISTRY II
26 FACULTY OF APPLIED SCIENCES
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DEPARTMENT OF MEDICAL LABORATORY TECHNOLOGY
Hormones I
β Lipotropin Hormone (β-LPH)
Promotes lipolysis.
Increases mobilization of fatty acids.
Serves as a precursor for the formation of beta-
endorphins and enkephalins (natural analgesics).
In some animals, MSH promotes synthesis of skin
pigment - melanin (melanogenesis).
In humans, MSH does not appear to play any role
in melanin synthesis.
Nipple stimulation, vaginal and
Stimulates kidneys to retain water.
uterine distention.
Diabetes insipidus (polyuria) – may
Induces labour. be caused by inadequate levels of
Milk ejection from breast. ADH or a defect in the receptors of
Inhibits synthesis of steroids. target cells.