Pathogenesis Hiv Slide 2

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Pathogenesis Hiv Slide   
Farina Hashimi
Oct. 26, 2012 • 123 likes • 57,224 views
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 Pathogenesis Hiv Slide

1. PATHOGENESIS of HIV RAJA ZAHIDAH BINTI RAJA ISMAIL
ANIS NABILA BINTI MD NOR FARINA BINTI NOR HASHIMI
MUHAMMAD FATTAH BIN FAZEL
2. PATHOGENESIS of HIV Entering The Information Slide
3. INTRODUCTION BINDING AND FUSION REVERSE
TRANSCRIPTION INTERGRATION TRANSCRIPTION ASSEMBLY
BUDDING
4. INTRODUCTION • Definition of Pathogenesis Pathogenesis:
The development of a disease and the chain of events leading to
that disease.
5. INTRODUCTION Infection is transmitted when the virus
enters the bloodstream or tissues of a person and comes into
contact with a suitable host cell, principally the CD4 T
Lymphocytes HIV infected cells are more infective than a cell
free virus
6. HOW HIV ENTER THE HOST CELL? HIV enter the host cell via
mechanism which are: • Binding and fusion • Reverse
transcription • Integration • Transcription • Assembly • Budding
7. 1) Binding and Fusion HIV begins its life cycle when it binds
to a CD4 receptor and one of two co-receptor on the surface of a
CD4+ T-lymphocyte a.k.a T-helper cell. The virus then fuses
with the host cell A!er fusion, the virus releases RNA, its
genetic material, into host cell
8. Terms : • CD4 receptor is a protein present on the outside of
infection-fighting white blood cell • Function : Helps in T cell
recognition of a foreign antigen. Also the binding site for HIV. •
Co- receptor: In addition for HIV to binding a CD4 receptor to get
into a cell • T-lymphocyte : A type of white blood cell that detects
and fight foreign invaders of the body
9. 2) REVERSE TRANSCRIPTION An HIV enzyme called reverse
transcriptase It converts the single stranded HIV RNA to
double-stranded HIV DNA
10. 3) INTEGRATION The newly formed HIV DNA (doubled-
stranded DNA) enters the host cell’s nucleus, HIV enzyme
called integrase ‘hides’ the HIV DNA within the host cell’s own
DNA The integrated HIV DNA is called provirus Provirus may
remain inactive for several years and producing few or no new
copies of HIV
11. 4) TRANSCRIPTION The host cell receives a signal to
become active. The provirus uses a host enzyme called RNA
polymerase to create copies of the HIV genomic material as
shorter strands of RNA called messenger RNA(Mrna) The mRNA
is used as a blueprint to make long chains of HIV proteins
12. 5) ASSEMBLY An HIV enzyme called protease cuts the long
chains of HIV proteins into smaller individual proteins. The
smaller HIV proteins come together with copies of HIV’s RNA
genetic material. Then a new virus particle is assembled
13. 6) BUDDING The newly assembled virus pushes out (‘buds’)
from the host cell During budding, the new virus steals part of
the cells outer envelope. This envelope acts a covering is
studded with protein/sugar combinations called HIV
glycoproteins.
14. 6) BUDDING These HIV glycoproteins are necessarry for the
virus to bind CD4 and co-receptors the new copies of HIV can
now move on to infect other cells.
15. REFERENCE http://aidsinfo.nih.gov/contentfiles/
HIVLifeCycle_FS_en.pdf http://www.slideworld.org/slidesho
w.aspx/Pathogenesis-of-HIV-ppt- 2847180 Pearson
International Edition, Campbell, Reece Biology Eighth Edition.
16. In matter of style, swim with the current. In matter of
principle, stand like a rock.
Editor's Notes
Types of T-cell Helper (CD4 +

T)CytotoxicMemoryRegulatoryNatural Killer
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Pathogenesis Hiv Slide   

Oct. 26, 2012 • 123 likes • 57,224 views

Laboratory diagnosis of HIV

The human immunodeficiency

Pathology - HIV (AIDS)

HIV epidemiology and

Herpes simplex virus

Microbiology of HIV VIRUSES

More Related Content

HIV infection (AIDS)

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Plasma cell disorders

Plasma cell dyscrasia

Life cycle and pathogenesis hiv

IMWG updates on plasma cell

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 Pathogenesis Hiv Slide

Types of T-cell Helper (CD4 +

Copyright Cookie Preferences English 

Do not sell or share my

© 2023 SlideShare from Scribd  

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