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CHAPTER 9
DEVELOPMENT OF THE NERVOUS SYSTEM: FROM FERTILIZED EGG TO YOU
MULTIPLE CHOICE QUESTIONS
1) The process of the growth of a fertilized egg into a mature nervous system is called
A) neural growth.
B) neuroplasticity.
C) neurodevelopment.
D) psychological development.
E) rewiring.
Answer: C
Diff: 1 Page Ref: 214
Topic: Chapter 9 Introduction
Type: (Factual)
2) The case of Genie emphasizes the role of

A) the brain in behavior.
B) experience in human neural and psychological development.
C) the brain in language.
D) language in learning.
E) neuroplasticity in development.
Answer: B
Topic: Chapter 9 Introduction
Type: (Factual)
3) A zygote divides to form

A) a sperm cell and an ovum.
B) two ova.
C) two zygotes.
D) two daughter cells.
E) two sperm cells.
Answer: D
Topic: 9.1 Phases of Neurodevelopment
Type: (Factual)
4) The first major phase of neurodevelopment is induction of the

A) neural tube.
B) neural grove.
C) growth cones.
D) neural plate.
E) neural growth factors.
Answer: D
Type: (Factual)
Copyright © 2014 Pearson Education, Inc. All rights reserved.

Test Bank for Biopsychology, 9/e
5) The neural plate is a patch of

A) multipolar neurons.
B) ectodermal tissue.
C) mesoderm.
D) endodermal tissue.
E) growth cones.
Answer: B
Type: (Factual)
6) A developing cell that is totipotential

A) is capable of developing into any type of cell in the organism.
B) is totally committed to one cell type for life.
C) cannot divide.
D) is totally developed and will not differentiate.
E) is entirely potent in excitation or inhibition.
Answer: A
Type: (Factual)
7) The very first cells to develop in the embryo are

A) multipolar.
B) bipolar.
C) myelinated.
D) totipotent.
E) mesodermal.
Answer: D
Type: (Factual)
8) Embryonic cells that have the potential for unlimited renewal and have the ability to develop into
different kinds of mature cells if they are transplanted to different sites are often called
A) daughter cells.
B) embryonic stem cells.
C) zygotes.
D) multipolar cells.
E) ectodermal cells.
Answer: B
Type: (Factual)
Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

2
Chapter 9: Development of the Nervous System
9) Many cells of the neural tube have lost their pluripotency and have become
A) totally specified.
B) totipotent.
C) multipotent.
D) mesodermal.
E) neural plates.
Answer: C
Type: (Factual)
Rationale: This must be inferred from information on page 215; it is not explicitly stated.
10) Immature cells that have the potential to develop into many, but not all, classes of mature cells (e.g.,
blood, skin, hair, neurons) are called
A) ependymal.
B) pluripotent.
C) ventricular.
D) multipolar.
E) totipotent.
Answer: B
Type: (Factual)
11) Developing cells that have the potential to develop into neurons of any type but into no other class of
body cells are said to be
A) multipotent.
B) totipotent.
C) multipolar.
D) pluripotent.
E) unipolar.
Answer: A
Type: (Factual)
12) The neural plate develops directly into the

A) neural tube.
B) neural groove.
C) brain.
D) CNS.
E) PNS.
Answer: B
Type: (Factual)

3
13) The neural groove develops into the neural

A) tube.
B) plate.
C) mesoderm.
D) endoderm.
E) cord.
Answer: A
Type: (Factual)
14) At 18 days after conception, this structure becomes visible in the developing embryo; it is the neural
A) mesoderm.
B) tube.
C) plate.
D) floor.
E) crest.
Answer: C
Type: (Factual)
15) By 40 days after conception, three swellings become visible at the anterior end of the human neural
tube. The most anterior of these swellings eventually develops into the
A) brain.
B) midbrain.
C) hindbrain.
D) forebrain.
E) ventricles.
Answer: D
Type: (Factual)
16) By 40 days after conception, swellings are clearly visible at the anterior end of the neural tube. There
are
A) 2.
B) 3.
C) 4.
D) 32.
E) 64.
Answer: B
Type: (Factual)

4
17) After the formation of the neural tube, the number of cells destined to become part of the adult
nervous system
A) actually declines.
B) stays the same until the end of the neural-plate phase.
C) stays the same until the end of the neural-groove phase.
D) increases rapidly.
E) quickly doubles and then declines.
Answer: D
Type: (Factual)
18) Most cell division in the developing neural tube occurs in the
A) hindbrain zone.
B) ventricular zone.
C) ventricles.
D) posterior zone.
E) midbrain.
Answer: B
Type: (Factual)
19) Most neural proliferation in the developing neural tube occurs in the layer that adjacent to
A) the fluid-filled central canal.
B) the cortex.
C) the marginal zone.
D) layer 6.
E) the neural crest.
Answer: A
Type: (Factual)
20) Many new neural tube cells migrate radially

A) along axons of other neurons.
B) along radial glial cells.
C) to the ventricular zone.
D) all of the above
E) both B and C
Answer: B
Type: (Factual)

5
21) In addition to the radial migration of developing neurons, there is considerable __________
migration.
A) rapid
B) tangential
C) intermediate
D) circuitous
E) axonal
Answer: B
Type: (Factual)
22) The pattern of neural migration that is indicated by the arrows in this illustration is
A) radial.
B) tangential.
C) inside out.
D) outside in.
E) posterior.
Answer: A
Type: (Factual)
23) There seem to be two different mechanisms of neural migration: glia-mediated migration and
A) amoeboid migration.
B) somal translocation.
C) pioneer migration.
D) growth cone translocation.
E) neural cresting.
Answer: B
Type: (Factual)
24) Research on the migration of developing neocortical neurons has made one important point:
__________ is everything.
A) Timing
B) Location
C) Genetics
D) Experience
E) Age
Answer: A
Type: (Factual)

6
25) The pattern of migration of future neocortical neurons is referred to as

A) accelerated.
B) insidious.
C) inside out.
D) subventricular.
E) ependymal.
Answer: C
Type: (Factual)
26) During the formation of the neural tube, a few cells break off from the neural tube and form a
structure that lies just dorsal to the tube. This structure is the neural
A) groove.
B) canal.
C) crest.
D) zone.
E) layer.
Answer: C
Type: (Factual)
27) At 24 days after conception, the precursor of the PNS is visible in the developing embryo. This
structure, which is illustrated here at the end of the pointer line, is the neural
A) tube.
B) plate.
C) crest.
A) groove.
E) stem.
Answer: C
Type: (Factual)
28) The neural crest develops into the

A) ventricular system.
B) cortex.
C) peripheral nervous system.
D) circulatory system of the brain.
E) neural tube.
Answer: C
Type: (Factual)

7
29) The neural crest

A) is just anterior to the neural tube.
B) is the bottom of the neural tube.
C) develops into the hindbrain.
D) develops into the PNS.
E) develops into the spinal cord.
Answer: D
Type: (Factual)
30) Cell adhesion molecules are thought to mediate

A) differentiation.
B) aggregation.
C) proliferation.
D) sprouting.
E) cell death.
Answer: B
Type: (Factual)
31) Which of the following are amoebalike in their appearance and movements?
A) growth cones
B) ependymal cells
C) neural cell-adhesion molecules
D) radial glial cells
E) retinal ganglion cells
Answer: A
Type: (Factual)
32) At the tip of each growing axon or dendrite is an amoebalike process called
A) an amoeba cell.
B) a growth cone.
C) a pioneer cell.
D) a blueprint cell.
E) a growth cell.
Answer: B
Type: (Factual)

8
33) Growth cones extend and retract finger-like cytoplasmic extensions as if they were feeling their way.
These extensions are called
A) adhesion digits.
B) growth cone adhesion digits.
C) filopodia.
D) pseudopodia.
E) siphons.
Answer: C
Type: (Factual)
34) Sperry’s experiments on eye-rotation in frogs led to an influential hypothesis that explains how
growth cones find their way to their targets: the
A) radial glial hypothesis.
B) cell-adhesion hypothesis.
C) chemoaffinity hypothesis.
D) growth cone hypothesis
E) CAM hypothesis
Answer: C
Type: (Factual)
35) Frogs, unlike mammals, have retinal ganglion cells that are capable of
A) degeneration.
B) proliferation.
C) color vision.
D) regeneration.
E) aggregation.
Answer: D
Type: (Factual)
36) In frogs, salamanders, and other simple vertebrates, retinal ganglion cells project primarily to the
A) thalamus.
B) tectum.
C) tegmentum.
D) cerebellum.
E) visual cortex.
Answer: B
Type: (Factual)

9
37) In Sperry's classic studies of eye rotation and regeneration of the optic nerves, he assessed the visual
capacities of his subjects by assessing their ability to
A) strike accurately at fly-like stimuli.
B) identify colors.
C) perform a visual discrimination task.
D) detect the presence of dim lights.
E) solve maze problems.
Answer: A
Type: (Factual)
38) Sperry's initial version of the chemoaffinity hypothesis of axon growth has difficulty accounting for
A) the results of Sperry's own eye-rotation regeneration experiments.
B) the ability of axons to grow to their correct targets.
C) the ability of axons to follow exactly the same circuitous route to their target in every member of a
species.
D) all of the above
E) both A and B
Answer: C
Type: (Conceptual)
Rationale: This problem is discussed in the text; A and B are incorrect.
39) The first growth cone of a developing tract to reach the target is called a __________ growth cone.
A) fast
B) pioneer
C) quick
D) early
E) premier
Answer: B
Type: (Factual)
40) Only those growth cones that are not pioneer growth cones can normally find their way to their
targets by
A) chemoaffinity.
B) fasciculation.
C) blueprints.
D) topographic gradients.
E) stopping and asking for directions.
Answer: B
Type: (Factual)

10
41) If an optic nerve of a mature frog is transected and half of the associated retina is destroyed,
A) the axons grow out from the retinal ganglion cells in the remaining half of the retina to their original
targets on the optic tectum.
B) the destroyed retina regenerates and then axons grow out from the complete retina and innervate the
optic tectum in the species-typical fashion.
C) the axons grow out from the retinal ganglion cells in the remaining half of the retina to targets
systematically distributed over the entire optic tectum.
D) half of the optic tectum degenerates.
E) both A and D
Answer: C
Type: (Factual)
Rationale: This point is clearly illustrated in Figure 9.6.
42) In support of the topographic-gradient hypothesis, it has been shown that

A) axons do not grow out from the retinas until the retinas are fully grown, which is why babies have
disproportionately large eyes.
B) axons do not grow out from the retinas until their target structures (e.g., optic tectums) are fully grown.
C) retinas and optic tectums always grow in precise proportion to one another.
D) the synaptic connections originally formed by retinal ganglion cells on the optic tectums gradually
shift as both the eyes and optic tectums grow at different rates during development.
E) both A and B
Answer: D
Type: (Factual)
43) Eyes and optic tectums grow at different rates. As they grow, the synaptic connections that were
originally formed on the tectum by axons of retinal ganglion cells shift so that the retina is always fully
and faithfully mapped on the tectum. This finding supports the
A) chemoaffinity hypothesis.
B) pioneer hypothesis.
C) topographic-gradient hypothesis.
D) all of the above
E) both A and C
Answer: C
Type: (Conceptual)
44) Less is known about synapse formation than axon growth because synapse formation requires
A) fasciculation.
B) coordinated activity in at least two cells.
C) growth cones.
D) guidance molecules.
E) regeneration.
Answer: B

11

Type: (Factual)
45) A recent finding is that synaptogenesis seems to depend on the presence of

A) astrocytes.
B) neurons.
C) growth cones.
D) pioneer cones.
E) guidance molecules.
Answer: A
Type: (Factual)
46) When it comes to synaptogenesis, neurons display a substantial degree of

A) specificity.
B) promiscuity.
C) monogamy.
D) faithfulness.
E) inertia.
Answer: B
Type: (Factual)
47) In vitro, neurons will form synapses

A) only with their correct targets.
B) only with neurons of the same type.
C) with almost any neuron.
D) only with glial cells.
E) only with the correct glial cells.
Answer: C
Type: (Factual)
48) Neuron death

A) starts to occur in humans around the age of 50.
B) is a stage of normal early neural development.
C) is rare in healthy humans until after puberty.
D) is a common, but unfortunate, consequence of accidental exposure to neural gradients.
E) is always followed by regeneration.
Answer: B
Type: (Factual)

12
49) Evidence suggests that many neurons die during development because
A) they are genetically programmed to die.
B) of their inability to compete successfully for their target's life-preserving chemicals.
C) of failures of regeneration.
D) both A and B
E) both B and C
Answer: D
Type: (Factual)
50) Most of the cell death associated with early development of the brain is
A) necrotic.
B) passive.
C) apoptotic.
D) both A and B
E) both B and C
Answer: C
Type: (Factual)
51) Apoptosis is safer than necrosis because apoptosis does not involve
A) neuron death.
B) inflammation.
C) suicide.
D) degeneration.
E) synapse rearrangement.
Answer: B
Type: (Factual)
52) Neurotrophins
A) are life-preserving chemicals for neurons.
B) are supplied to neurons by their synaptic targets.
C) promote neuron death.
D) both A and B
E) both B and C
Answer: D
Type: (Factual)

13
53) Neurotrophins can

A) promote neuron growth.
B) promote neuron survival.
C) function as axon guidance molecules.
D) all of the above
E) both A and B
Answer: D
Type: (Factual)
54) The general effect of synapse rearrangement is to

A) increase the number of different target cells innervated by each neuron.
B) increase the number of synaptic contacts received by each neuron.
C) focus the output of each neuron on fewer postsynaptic cells.
D) increase the ratio of axosomatic synapses to axodendritic synapses.
E) increase the number of synapses.
Answer: C
Type: (Factual)
55) The development of the human brain is unique in that

A) there is no early cell death.
B) there is no early reorganization.
C) it develops so slowly.
D) it develops so quickly.
E) the PNS develops before the CNS.
Answer: C
Topic: 9.2 Postnatal Cerebral Development in Human Infants
Type: (Factual)
56) Between birth and adulthood, the size of the human brain
A) doubles.
B) quadruples.
C) actually declines.
D) stays about the same although the skull grows.
E) increases 10 fold.
Answer: B
Type: (Factual)
57) The last part of the human brain to reach full maturity is the
A) hippocampus.
B) prefrontal cortex.
C) amygdala.
D) occipital cortex.

14
E) hypothalamus.
Answer: B
Type: (Factual)
58) The postnatal growth of the human brain results from

A) synaptogenesis.
B) an increase in the number of neurons.
C) myelination.
D) all of the above
E) both A and C
Answer: E
Type: (Factual)
59) The human brain grows after birth because of

A) synaptogenesis.
B) myelination.
C) increased dendritic branching.
D) all of the above
E) none of the above
Answer: D
Type: (Factual)
60) Synaptic density in the primary visual cortex of infants

A) is maximal by the seventh or eighth postnatal month, and then it declines.
B) almost reaches adult levels by the seventh or eighth prenatal month.
C) follows the same course of development as the myelination of prefrontal cortex.
D) both A and C
E) both B and C
Answer: A
Type: (Factual)
61) The course of human cognitive development is thought to reflect development in the
A) prefrontal cortex.
B) hippocampus.
C) secondary neocortex.
D) posterior parietal cortex.
E) hypothalamus.
Answer: A

15
Type: (Factual)
62) The prefrontal cortex seems to play a role in

A) working memory.
B) planning and carrying out sequences of action.
C) inhibiting responses that are inappropriate in the current situation but not in others.
D) all of the above
E) both A and B
Answer: D
Type: (Factual)
63) Functions of the prefrontal cortex include

A) working memory.
B) planning and carrying out sequences of action.
C) locating objects in space.
D) all of the above
E) both A and B
Answer: E
Type: (Factual)
64) Perseveration is the tendency to

A) form long-term working memories.
B) form permanent short-term memories.
C) continue making formerly correct responses that are currently incorrect.
D) continue making formerly incorrect responses that are currently correct.
E) fasciculate.
Answer: C
Type: (Factual)
65) Perseverative errors are often made by children between the ages of
A) 3 to 5 months.
B) 7 to 12 months.
C) 1 to 2 years.
D) 2 to 4 years.
E) 4 to 8 years.
Answer: B
Type: (Factual)

16
66) It has been suggested that human infants between 7 and 12 months old make perseverative errors
because they do not have a fully developed
A) cortex.
B) prefrontal cortex.
C) hippocampus.
D) visual system.
E) motor system.
Answer: B
Type: (Factual)
67) Experiences that permit information in brain genetic programs to be expressed and maintained are
called
A) instructive experiences.
B) permissive experiences.
C) critical experiences.
D) sensitive experiences.
Answer: B
Topic: 9.3 Effects of Early Experience on Development
Type: (Factual)
68) In comparison to the cortices of rats that had been reared in enriched environments, the cortices of
rats that had been reared by themselves in barren cages
A) were thinner.
B) had less dendritic development.
C) had fewer synapses per neuron.
D) all of the above
Answer: D
Type: (Factual)
69) The disruptive effects of total visual deprivation of the left eye on subsequent vision through the left
eye are greater when the
A) right eye is deprived at the same time.
B) deprivation occurs early in life.
C) right eye is not deprived at the same time.
D) both A and B
E) both B and C
Answer: E

17
Type: (Factual)
70) If just one eye is deprived of input for a few days early in life,
A) the contralateral visual cortex totally degenerates.
B) there is a decrease in the ability of visual cortex to be activated by stimulation of the deprived eye.
C) there is an increase in the ability of visual cortex to be activated by stimulation of the nondeprived eye.
D) both A and B
E) both B and C
Answer: E
Type: (Factual)
71) Early monocular deprivation

A) eliminates ocular dominance columns.
B) decreases the width of ocular dominance columns from the deprived eye.
C) increases the width of ocular dominance columns from the nondeprived eye.
D) causes ocular dominance columns to develop sooner.
E) both B and C
Answer: E
Type: (Factual)
72) How long does one eye have to be deprived of stimulation early in life in order to reduce its ability to
activate visual cortex?
A) a few days
B) a few minutes
C) a few seconds
D) a few years
E) a few months
Answer: A
Type: (Factual)
Rationale: This point was not made explicitly, but the experiments that were described all studied the
effects of a few days of monocular deprivation.
73) In one study, a few days of early monocular deprivation decreased the axonal __________ of lateral
geniculate nucleus neurons that normally conducted signals from the deprived eye.
A) branching
B) regeneration
C) width
D) layers
E) degeneration
Answer: A

18
Type: (Factual)
74) In a classic experiment, Roe and colleagues (1990) caused the developing axons of ferret retinal
ganglion cells of the visual system to synapse in the medial geniculate nuclei of the auditory system. Once
the ferrets matured, their
A) auditory cortex responded to visual stimuli.
B) auditory cortex was laid out retinotopically.
C) auditory cortex had totally degenerated.
D) both A and B
E) both A and C
Answer: D
Type: (Factual)
75) In a classic experiment, Knudsen and Brainard (1991) raised barn owls with vision-displacing prisms
over their eyes. This led to the ontogenetic development of
A) a corresponding shift in the auditory topographic map in the tectum.
B) a discrepancy between where a stimulus was heard to be and where it was seen to be.
C) the degeneration of the tectum.
D) the degeneration of the visual tectum.
E) the degeneration of the auditory cortex.
Answer: A
Type: (Factual)
76) Several studies have shown that early music training increases the size of the
A) auditory cortex that responds to complex musical tones.
B) right hemisphere.
C) auditory cortex that responds to pure tones.
D) brain.
E) auditory cortex.
Answer: A
Type: (Factual)
77) It is now generally acknowledged that adult brains are

A) incapable of substantial reorganization.
B) capable of major changes.
C) not as plastic as developing brains.
D) both B and C
Answer: D
Topic: 9.4 Neuroplasticity in Adults

19
Type: (Factual)
78) The first evidence that new neurons can be created in the brains of adult vertebrates came in the
1980s from the study of
A) the hippocampus.
B) the olfactory bulbs.
C) songbirds.
D) hamsters.
E) the amygdala.
Answer: C
Type: (Factual)
79) In mammals, adult neurogenesis occurs in the

A) hippocampus.
B) olfactory bulb.
C) amygdala.
D) all of the above
E) both A and B
Answer: E
Type: (Factual)
80) Studies have shown that about __________ new neurons are created each hour in the hippocampus of
adult animals?
A) 4
B) 8
C) 50
D) 100
E) 2,000
Answer: E
Type: (Factual)
81) Adult stem cells that ultimately migrate to the olfactory bulbs are created at certain sites in the
A) subventricular zone of the lateral ventricles.
B) ependymal layer.
C) hippocampus.
D) all of the above
E) both A and B
Answer: B
Type: (Factual)

20
82) Adult stem cells that ultimately become hippocampal dentate gyrus neurons are created near the
A) dentate gyrus of the hippocampus.
B) olfactory bulbs.
C) ventricles.
D) ependymal layer.
E) central canal.
Answer: A
Type: (Factual)
83) The function of the neurons created in the adult hippocampus by neurogenesis is
A) to improve long-term memory.
B) to improve episodic memory.
C) to improve implicit memory.
D) to improve short-term memory.
E) currently unknown.
Answer: E
Type: (Factual)
84) Tinnitus in adults

A) is ringing in the ears.
B) leads to degeneration restricted to the contralateral auditory cortex.
C) leads to a reorganization of primary auditory cortex.
D) all of the above
E) both A and C
Answer: E
Type: (Factual)
85) In a classic study, the area of right somatosensory cortex receiving input from the left hand was
found to be bigger in
A) African drummers.
B) tennis players.
C) piano players.
D) accordionists.
E) musicians who fingered stringed instruments with the left hand.
Answer: E
Type: (Factual)

21
86) Autism almost always becomes apparent

A) before the age of 6 months.
B) before the age of 3 years.
C) after the age of 6 years.
D) after the age of 8 years.
E) after the age of 10 years.
Answer: B
Topic: 9.5 Disorders of Neurodevelopment
Type: (Applied)
87) A core symptom of autism is

A) reduced ability to interpret emotions and intentions of others.
B) reduced capacity for social interaction and communication.
C) tremor at rest.
D) all of the above
E) both A and B
Answer: E
Type: (Applied)
88) Many children with autism display

A) seizures.
B) mental retardation.
C) empathetic talkativeness.
D) all of the above
E) both A and B
Answer: E
Type: (Applied)
89) A major feature of the symptoms of autism is their

A) serenity.
B) variability from case to case.
C) homogeneity.
D) consistency.
E) universality.
Answer: B
Type: (Applied)

22
90) About how many individuals with autism display some savant abilities?
A) 1%
B) 10%
C) 50%
D) 70%
E) 90%
Answer: B
Type: (Applied)
91) Which of the following statements is true?

A) About 50% of savants are diagnosed with autism.
B) About 10% of autistic individuals display some savant abilities.
C) About 50% of autistic individuals are savants.
D) both A and B
E) both A and C
Answer: D
Type: (Applied)
92) Evidence suggests that autism

A) has no genetic basis.
B) is caused by a single dominant gene.
C) is caused by a single recessive gene.
D) is caused by two abnormal genes.
E) is caused by several genes and interactions with the environment.
Answer: E
Type: (Applied)
93) The brain damage associated with autism tends to

A) be variable.
B) involve the cerebellum in some cases.
C) involve the frontal cortex in some cases.
D) involve the amygdala in some cases.
E) all of the above
Answer: E
Type: (Applied)

23
94) Both autism and Williams syndrome are associated with

A) mental retardation.
B) talkativeness.
C) emotional insensitivity.
D) severe language problems.
E) empathy.
Answer: A
Type: (Applied)
95) Considering their mental retardation, people with Williams syndrome tend to have remarkably good
A) spatial ability.
B) language ability.
C) mathematical ability.
D) explicit memory.
E) drawing ability.
Answer: B
Type: (Applied)
96) Although they have many cognitive problems, Williams people have good
A) musical abilities.
B) drawing abilities.
C) language abilities.
D) all of the above
E) both A and C
Answer: E
Type: (Applied)
97) Most cases of Williams syndrome are associated with

A) a missing section of chromosome 7.
B) creative and accurate drawing skills.
C) an abnormal gene on chromosome 1.
D) multiple sclerosis.
E) increased levels of elastin.
Answer: A
Type: (Applied)

24
98) Despite general cortical thinning in cases of Williams syndrome, the thickness of the __________
cortex is often normal.
A) orbitofrontal
B) dorsolateral frontal
C) superior temporal
D) posterior parietal
E) both A and B
Answer: C
Type: (Applied)
99) People with Williams syndrome tend to look like

A) leprechauns.
B) their fathers more than their mothers.
C) Williams.
D) their mothers more than their fathers.
E) hippies.
Answer: A
Type: (Applied)
FILL-IN-THE-BLANK QUESTIONS
1) When the lips of the neural __________ fuse, the result is the neural tube.
Answer: groove
Type: Factual
2) Radial migration of developing neurons occurs along __________ glial cells.

Answer: radial
Type: Factual
3) The cortex develops in six waves of radial migration. These waves occur in an __________ pattern.
Answer: inside-out.
Type: Factual
4) The neural __________ is situated just dorsal to the neural tube and develops into the PNS.
Answer: crest

25
Type: Factual
5) Aggregation of neurons is thought to be mediated by __________ molecules.

Answer: cell-adhesion
Type: Factual
6) Pioneer growth cones and their axons lead the growth of subsequent axons along the same route by a
process known as __________.
Answer: fasciculation
Type: Factual
7) The first neurotrophin to be isolated was __________ factor.

Answer: nerve growth
Type: Factual
8) If just one eye is deprived of light for several days early in life, the width of the associated ocular
__________ in layer IV of primary visual cortex become narrower.
Answer: dominance columns
Type: Factual
9) Early experience and the resulting changes in neural activity fine-tune subsequent stages of normal
__________ .
Answer: neurodevelopment
Type: Factual
10) The growth of new neurons in adults is called adult __________.

Answer: neurogenesis
Type: Factual
11) In the 1980s, adult neurogenesis was convincingly documented in __________ before being described
in mammals.
Answer: birds (or songbirds)
Type: Factual
12) In mammals, substantial adult neurogenesis occurs only in the __________ and hippocampuses.
Answer: olfactory bulbs

26

Type: Factual
13) Adult neural stem cells that eventually migrate to the olfactory bulbs are created at certain sites in the
layer of cells lining the lateral cerebral __________.
Answer: ventricles
Type: Factual
14) Enriched environments increase adult neurogenesis in the rat hippocampus. This effect occurs
largely, if not entirely, because rats living in enriched environments tend to get more __________.
Answer: exercise
Type: Factual
15) __________, or ringing in the ears, causes a reorganization of primary auditory cortex.
Answer: Tinnitus
Type: Factual
16) Approximately 80% of children with __________ are male; 50% suffer from mental retardation; and
35% experience seizures.
Answer: autism
Type: Applied
17) Despite being intellectually handicapped, about 10% of autistic individuals display __________
abilities.
Answer: savant
Type: Applied
18) Autism has been linked to abnormalities of the fusiform face area and __________ neurons.
Answer: mirror
Type: Factual
19) In several respects, autism and ___________ are opposites, which is why it may prove useful to
investigate them together.
Answer: Williams syndrome
Type: Applied
20) The __________ and social skills of people with Williams syndrome are remarkable considering

27
their poor intellectual development.

Answer: language (or verbal)
Type: Applied
ESSAY AND OTHER MILTIPLE-MARK QUESTIONS
1) Discuss the developmental progression from totipotency, to pluripotency, to multipotency, to total

specification. Why are embryonic stem cells so interesting to medical researchers?
Answer:
40% for defining totipotency, pluripotency, multipotency, total specification, and embryonic stem cells
40% for describing the increased specification of cells that occurs with embryonic development
20% for explaining the potential of stem cells in the treatment of neurological disorders
Diff: 1 Page Ref: 214-215
Type: (Applied)
2) Describe Sperry's eye-rotation experiments and the important theoretical point that they made.
Answer:
70% for describing the experiments
30% for describing the chemoaffinity hypothesis
Type: (Factual)
3) Discuss the increase in size of the human brain after birth and three kinds of growth that contribute to
it.
Answer:
25% for describing the postnatal growth of the human brain
25% for describing postnatal synaptogenesis
25% for describing postnatal myelination
25% for describing postnatal dendritic branching
Type: (Factual)
4) Discuss the effects of early experience on neurodevelopment, and describe two examples.
Answer:
60% for discussing the effects of experience on development including critically sensitive periods and the
use-it-or-lose-it principle
40% for two examples of the effects of experience on neurodevelopment
Type: (Factual)
5) Describe and discuss the research on adult neurogenesis. Describe both early and current research.
Answer:
20% for explaining the concept of adult neurogenesis
40% for describing the research that led to the recognition of adult neurogenesis

28
40% for describing research that is contributing to our current understanding of adult neurogenesis
Type: (Factual)
6) Describe Williams syndrome and its genetic and neural correlates.

Answer:
50% for describing Williams syndrome
25% for discussing the relevance of chromosome 7 and elastin
25% for describing the associated patterns of cortical thinning
Type: (Applied)

29
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MULTIPLE CHOICE QUESTIONS

2) The case of Genie emphasizes the role of

3) A zygote divides to form

4) The first major phase of neurodevelopment is induction of the

Copyright © 2014 Pearson Education, Inc. All rights reserved.

5) The neural plate is a patch of

6) A developing cell that is totipotential

7) The very first cells to develop in the embryo are

Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

12) The neural plate develops directly into the

Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

13) The neural groove develops into the neural

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20) Many new neural tube cells migrate radially

Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

25) The pattern of migration of future neocortical neurons is referred to as

28) The neural crest develops into the

Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

29) The neural crest

30) Cell adhesion molecules are thought to mediate

Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

42) In support of the topographic-gradient hypothesis, it has been shown that

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Topic: 9.1 Phases of Neurodevelopment

45) A recent finding is that synaptogenesis seems to depend on the presence of

46) When it comes to synaptogenesis, neurons display a substantial degree of

47) In vitro, neurons will form synapses

48) Neuron death

Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

53) Neurotrophins can

54) The general effect of synapse rearrangement is to

55) The development of the human brain is unique in that

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58) The postnatal growth of the human brain results from

59) The human brain grows after birth because of

60) Synaptic density in the primary visual cortex of infants

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62) The prefrontal cortex seems to play a role in

63) Functions of the prefrontal cortex include

64) Perseveration is the tendency to

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Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

71) Early monocular deprivation

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77) It is now generally acknowledged that adult brains are

Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

79) In mammals, adult neurogenesis occurs in the

Copyright © 2014 Pearson Education, Inc. All Rights Reserved.

84) Tinnitus in adults

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86) Autism almost always becomes apparent

87) A core symptom of autism is

88) Many children with autism display

89) A major feature of the symptoms of autism is their

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