COLLEGE OF NURSING
NAME: FAJARDO, ANDREA LAUREN A.
CLINICAL INSTRUCTOR: ________________________________
Name of Drug, Dosage, Route
and Generic Name and
Classification
Drug Name: Piperacillin /
Tazobactam
Brand Name: Zosyn
Dosage:
Moderate to Severe
Infections
Adult: IV 3.375 g q6h, infused
over 30 min, for 7–10 d
Child: IV <6 mo, 150–300 mg
piperacillin/kg/d divided q6–
8h; 6 mo, 240 mg piperacillin
component/kg/d divided q8h
Nosocomial Pneumonia
Adult: IV 4.5 g q6h, infused
over 30 min, for 7–10 d
Mechanism of Action
Tazobactam broadens the
spectrum of piperacillin and
ceftolozane by making them
effective against organisms that
express beta-lactamase and
would normally degrade them.
This occurs through the
irreversible inhibition of beta-
lactamase enzymes. In addition,
tazobactam may bind covalently
to plasmid-mediated and
chromosome-mediated beta-
lactamase enzymes. Tazobactam
is predominantly effective against
the OHIO-1, SHV-1, and TEM
groups of beta-lactamases, but
may also inhibit other beta-
lactamases.
DATE: ________________________
SCORE: _______________________
Indication/Contraindication
Indication:
- Treatment of skin and skin
structure infections, including
cellulitis and skin abscesses
- treatment of diabetic foot
ulcer
- treatment of surgical incision
site infections
- treatment of necrotizing
infections of the skin, fascia,
and muscle
- treatment of animal bite
wounds
Side Effects/Adverse Effects Key Nursing Responsibilities and Management
Side Effects: - Obtain history of hypersensitivity to penicillins,
cephalosporins, or other drugs prior to administration
More common:
- Monitor patient carefully during the first 30 min after
Diarrhea initiation of the infusion for signs of hypersensitivity
- Report rash, itching, or other signs of
Less Common: hypersensitivity immediately.
-Bladder pain -Report loose stools or diarrhea as these may indicate
pseudomembranous colitis.
-Blurred vision
-Chest pain -Do not breast feed while taking this drug without
consulting physician
-Dizziness, faintness or light
headedness
-fever or sweating
-headache
-problem with vision or hearing
-skin rash

Route: Intravenous
Generic Name: Tazobactam
Classification:
Antiinfective; Beta-Lactam
Antibiotic; Antipseudomonal
Penicillin
COLLEGE OF NURSING
-slow/fast heart beat
- treatment of skin and skin -troubled breathing
structure infections
Rare:
- treatment of skin and skin -Agitation
structure infections ● -bone pain
● -bruising
- treatment of moderate to
severe infections including ● -chills
pelvic inflammatory disease
(PID) and endometritis
● -cold sweats
● -cough
- treatment of pediatric patients
with intraabdominal infections
● -deep or fast breathing with
dizziness
- treatment of adult patients ● -depression
with intraabdominal infections
● -diarrhea, watery and severe,
which may also be bloody
Contraindications:
● -drowsiness
-Critical illness, dialysis, renal
 COLLEGE OF NURSING

failure, renal impairment ● -dry mouth

- Hypokalemia, sodium
● -hives
restriction

- Carbapenem hypersensitivity,● -hostility

cephalosporin hypersensitivity,
penicillin hypersensitivity ● -itching of the vagina or genital
area
- Anticoagulant therapy,
bleeding ● -lethargy

-Sexually transmitted disease

● -muscle pain, cramps, stiffness, or

- Seizure disorder twitching

- Cystic fibrosis ● -nightmares

-Geriatric
Adverse Effects:
-Pregnancy

-Breastfeeding
CNS: Headache, insomnia, fever.

GI: Diarrhea, constipation,

nausea, vomiting,
dyspepsia, pseudomembranous
 COLLEGE OF NURSING

colitis.

Skin: Rash, pruritus,

hypersensitivity reactions

NAME: FAJARDO, ANDREA LAUREN A. DATE: ________________________

CLINICAL INSTRUCTOR: ________________________________ SCORE: _______________________
Name of Drug, Dosage, Route
and Generic Name and Mechanism of Action Indication/Contraindication Side Effects/Adverse Effects Key Nursing Responsibilities and Management
Classification
 COLLEGE OF NURSING

Drug Name: Rebamipide Prostaglandin Increasing Effect:
(Mucosta) Rebamipide increased the
endogenous prostaglandin E2
(PGE2) content in the gastric
Brand Name: mucosa in rats. The drug also
increased PGE2 and PGI2 content
in the gastric juice, as well as the
content of 15-keto-13, 14-PGE2,
Dosage:
a metabolite of PGE2.
Adult dose: 1 100mg tablet
Route: Oral
Indications:
-Treatment of peptic ulcer,
gastroduodenal ulcers, and
gastric disorders.
-Indicated during bleeding,
erosion, redness, and edema (all
signs of gastric mucosal lesions)
that occur in acute gastritis and
acute exacerbation of chronic
gastritis.
Side Effects:
Skin: rash, pruritus, drug eruption
like eczema
Gastrointestinal: constipation,
bloating, diarrhea, nausea,
vomiting, stomach upset,
heartburn, abdominal pain,
belching, taste abnormality
-Monitor the patient’s blood pressure levels after
administering the drug
-Advise the patient to report any discomfort or pain
experienced upon taking or during the drug therapy
- Do not exceed from the prescribed dosage per day by
tracking the amount of drug intake consumption
- Closely monitor the patient’s hematologic levels which
can indicate hepatic dysfunction, thrombocytopenia, and
leukopenia.
- Monitor the patient’s condition for any allergic reaction
such as skin rashes, swelling, difficulty in swallowing or
breathing, chest pain or tightness and hives.

-Treatment of recurrent oral in Others: cold sweat, difficulty

Generic Name: Rebamipide breathing
Behcet’s disease.

Classification: Adverse Effects:

Contraindications:
Gastrointestinal
-Contraindicated in elderly and
Cytoprotectives
children and adult patients with Hepatic: elevated levels of
chronic illness including cancer. alkaline phosphates, GPT, GOT,
and y-GPT, that indicated
impaired hepatic function
-Should not be prescribed to
patients allergic to synthetic
 COLLEGE OF NURSING

formulations, dye and Hematologic: thrombocytopenia,

chemicals. leukopenia

-Breastfeeding