> MECHANISM OF DRUG1 ABSORPTION THROU6 H GIT.

I. Trasallulan / nraalulau ransport

D pasive Transport pocs
) pautve atuson
T) pore hransprt
) lon- pa hauprt.
iy) Faitated oY medfated dHuston.
B) Acfve trausport prous
I)
1)
pfmany
Sesnda
ympart ( to-rauspot)
a) (ounto hansport)
) Anport
Trauspot :
2. Paraalulantnen elllan
through tght Junhn of epithellal
4) ermeatôn
calla.
B) psorpton.
3. Vesiula corp usula Trausport [endoytsts
8) phagouy tosà.
 pausive

TYanuallulan

Transpat
capllaula wh

paxocallula Poraalu an

ErdutSblood vesiula

aolate)
Apüalsds
.
Trawsululaa /ahhaallulan Trausport :
aurss
thu Gl epfthelkim
skps olved
> petmeakin o Hl epthelal al membrane
) Movement aLDss thy enhraellular spau (uhsat)
> petmeatbn ß th daa ar baso laleral membranu

A] pausive Trauupart prous

z) paustve a?tusin
Also called non- oni diuion
The
graduit
wuhochemûal
Fek's Rrst Jauo f alHuson staas that the
du moleules dEtse ftom aregion f hglher
Lonanhahin to u sß loon ¡ncenhraæn unfI
squltbium atahed 4 that thu rat aitusian
gradânt ayass the
membrane.
da DAK ms (Car-c)
dt

A - Surtau area c the absophg membrany

behween membtan
Kmlo th phase
(Car) =DHrnu plasm
h thi knes sf- t membyane (engh).
I pare Tramsport.
Also called convechfe raus prth bulk
4ftratân
The
bran.
oSmot dtun abss the mum

n lom- paai TraWsport : ammonn

Absoptön
[benzalkantum ehlsfde, bengeth¡nlum chloda)
Lompounds undy
aid eohteh ontae
4sulphoni aud lsutanî
all pH condih.
paa
>propanstet
olet auid
a

Gjashotesthal lumen Membran blood

Catont tndogerou,
Antn

Neuh al
paute dkusn
aa i- mediakd Trausport.
Monosacehaldus, am1ßo aulds,vltams
s E:
& iovcved (auy that bnds
> The meehaom uth th solute
moleles
uveMsibly
to be hauspored

ha

absorphen

thot speraes
casu- mediaed rauupart syslem
> # a a
douun the gradirnt (douon ht| haprt)

Nsmbiav Hood

vA B inh(oer

ump
&J Adve Trausport prouuses :

moleuls Hom AtP 5 move bug mdeula'

Exhraallular to inhraullular mleu.

) prmany Aefua hauapart :

> There e ATP nqulenad

Afve aNaport:
No düct quaemauk of ATP.
gmport (io-tranaport).
>(nvolVes moumut o both moluules t he

Nat glose symponrte

Antfport (countn- haupart) :
hvou momt f molules n the opasihe
dfetin
 feLcnday(oupld AcRe Tiau:po
AtRve

ATP. ATP
ATE

AP

An pat )
Symport
a) Paraculan /hkrallulan Trausport behween
funatos
thu 6t1 eplthellal alla
than
oheh ae

the aquous pres.

Insul Canda

pomeattn o$ dug through em poray opengs

> ep?hellal calls
by chedding $ -to
formed
lumen

ulan Trausport lendo yros]

a] vestulan or corpus
thase arealso
auiue hrausporti substanus ulth
but nvsve rauspor S
prouses
Vesfles ôb a ul
 rea pana?bl or the callulan uptoku ß maDmole
nuhfents ke jals sarch ol stubu vetamins
A1D,¬ k. Hao golubu virami tik Bja

4)Phagoyhsa [cel eatthg].

Adborphn uptake oß caot panflaes

Solute.
Numbran blood.

prouws of

VOLUME OF DISTRI BUTION.

ditbues to vaious gans

>A

ohen prous oc dåhibuion i complet ditunt ogs

> hakn of dnug &
and tAws contah vayhg conun
present.
have incanhrahhs of dng
> Ditt tiues
the youme dâbuh§n cannot have hru phytolog
 sulahonsho behoen the
exist a nstant
annout
plasma ( c) 4 he
body ix)
X c

Nd prop tfonallky umstaut (volume)

yotune f daRbuh&n
populandy calted Appanuat
to
hypothehlal vstume
Defhed dhfbuted
oheh a
called appatut votumu beause all pats of
do not have 4qual
squíirad uth duug
body
omunrahôn

Atpasut vst: of Amount

Dibutn plasma doug concanhrahn

wih ea)
ARreut selakonship
beas 00
> Appat vd
dishibuhon.

volume s
ARsibuhin has phyotagal
The real
is Yelaled to badyae,
meanta
 Body tud voune body weght TB
RUNIC

Vasla Hd /6lood b(3) 9 (-s) 15 (4s)

(Plasma) Abs
Exhaullular tutd
(exdu'- plasna)
Yntaulular Huld 54
(exeudag-blood cella)
(00
Toga body Hao (TBw) 2
TISSUE -DRD Gn BINDN
> PLASMA PROTEIN - DRUGt BINDING

Plasma Pntth- Dng bhdngTsu

hvdes
and thus lsHslble and covatuh bond tu
shang
that büd to plasma prtein ooug bod to extravasl ar
have small apparent va +asula have Aarge apparent va
Halt i f plasma prokeh bound Halk sie of estravasu<ar
dug datvey tort
Does not Usult &n toy
bodig sit a süphumunt by oter dnags
DBplaument om gaenaly doeand
posstbls by othen dngs
behween dhg for badng Tür- dng bhdeng
compelRBn non- tompefhve.
to plasma. prote tan
OCeur.
 NICAL SI61 NIFNCANCE OF PROTEIN BINDING.

Absorphon:
Kelts, ohen
(onyentonal
docage to tollouw st ardon absaphon
2 debs thu
thuu mare. then
squttbium
Disiouhoh : does not cnss the B8B,
pantla
prokeih bound
baser, hu glomexulus
th plauntal dug.
daureases the desibutdn o6

Metabolim:
dwease the metaboln of digs
Proteir
enhanws th

unbound fraton get melabold.

ony

Elnhatin :
proBen thding preent enhy dng to meabobg
Oyan to gomsu lus fhaton.

at as vehlde er
hydophobl drags
solutde vit.
sevido, hepasin il
 NDI

proten uñaefvates the dgs beeaus

Onunhathßn canrot be buhd

SLstain sulae.

Dmplex of doug prokeh n blocd at as a resev

the 7ree dng

4 conthusuly auy
E9 Suramh - sodfum prkes bödhg or .anttrypansama)
ahon.

biagnasts :
chlorße atom f chlonquhereplaud uth radfolabelk
Can be bed to visuai - melanamas s ye
 oru aals Vandn *
luu
unitytoxéy b¡nds. Don
bonds
Hyduophcbo |#*
bands Hydogen *
covatent 4
bond] chemal [weak
LRare] Revelbu
proteis, to
proleah Mechanam
ß
bfhaig allulaH Inra
haatlular
bhdbg proleis
prote
complex
phamauodynarmo pharmaokhetts
t
ertnes phamaloglay &hena |
bautve
b to du dng baund protefh As>
metatolyed nelther
nor
calud
omplex phenomnenon
sf The
daug omaton
oc
DRUGis DF
NDING
 Blood
to blood
componeuts
Bood plasma
wlls
prole
D- ree dng
Lver "a plasma Ruy lo cal fsahi
D + Enyms P-D
Dg 'metabolile
bhdng to llver

Metabalks D

ecepta
to renal

Exrekon Ache
Seerehn

Exrehim
 MOLECULAR CONENTRATIoN
DRUGS THAT BIND
ROTEIN, WEIG HT (gz)
uman krum 35-5-o
65/000
Albuma
Such as Imiptami
KË- Ad 0-0 - 0-)
Giyapmokin
44000
docae, quntshe ,et
2,00;000 lo Vayiabu Basl, tophta Jnugs
kpoprokei 31400r000 hlsrpvomu
orfosterone
seolds Jko
s9 00O
o 008 -0-007 yamcobalam?
? hyroxte
Vrams AD,E4 k
O.o1S-0-06
Kg- globutn ,34 000 upe n
phenyto,penhbarbral
|-l6
Hemoglobih phenohla3s