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The respiratory system in humans responsible for the exchange of gases, primarily
oxygen and carbon dioxide, between the body and the external environment. It facilitates the
intake of oxygen for cellular respiration and the removal of carbon dioxide, a waste product
generated by metabolic processes. It can be divided into two regions, upper respiratory tract,
The upper respiratory tract includes the mouth, nose, nasal cavity, pharynx
1. Mouth. The mouth is the external opening through which air can enter the respiratory
2. Nose and Nasal Cavity. The nose is the only external visible composed of nose,
cartilage, and fatty tissues. The external openings of nose are called nostrils and the inner
hollow spaces are called nasal cavities, which are partitioned by means of nasal septum.
Anterior parts of nasal cavities near the nostrils are called vestibules which contain hair. Both
3. Pharynx. Pharynx is a cone-shaped passageway leading from the oral and nasal
cavities to the esophagus and larynx. It is a part of both digestive and respiratory system. It is
4. Nasopharynx. The nasopharynx is the upper part of the pharynx (throat) located
behind the nasal cavity. It is a passageway for air and connects the nose to the oropharynx.
5. Adenoid (Pharyngeal Tonsil). The adenoid, also known as the pharyngeal tonsil, is a
particularly in children.
6. Oropharynx. The oropharynx is the middle part of the pharynx located behind the
mouth. It serves as a common pathway for both air and food and plays a role in the early
the nasal and oral cavities to the larynx and esophagus. It plays a role in both breathing and
8. Larynx (Voice Box). The larynx is an enlargement in the airway at the top of trachea
and below the pharynx. The larynx is composed primarily of muscles and cartilages. On of
the cartilage is epiglottis. Inside the larynx there two vocal cords which are responsible for
vocalization.
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9. Epiglottis. The epiglottis is a flap-like structure in the larynx that prevents food and
liquids from entering the trachea during swallowing. It helps direct materials toward the
These components collectively make up the upper respiratory tract, playing crucial
roles in filtering, conditioning, and directing air before it reaches the lower respiratory tract.
The upper respiratory tract also serves as a barrier against potentially harmful particles and
microorganisms, contributing to the overall health and functionality of the respiratory system.
It includes trachea, bronchi and bronchioles, alveolar ducts and alveoli, and lungs.
that connects the larynx to the bronchi. It allows the passage of air into and out of the lungs.
2. Bronchi. The bronchi are two large tubes that branch off from the trachea, leading to
each lung. They further divide into smaller bronchioles within the lungs.
3. Bronchioles. Bronchioles are smaller airways branching from the bronchi. They
continue to divide and become progressively smaller, ultimately leading to the alveoli.
4. Alveolar Ducts and Alveoli. Alveolar ducts are tiny passageways that connect
bronchioles to alveoli. Alveoli are microscopic air sacs located at the end of bronchioles
within the lungs. They are the primary sites for gas exchange, where oxygen is taken up by
the blood and carbon dioxide is released. There are 700 million alveoli in each lung, the wall
5. Lungs. Lungs are paired, spongy organs responsible for respiration. Each lung is
conical in shape, with its base resting on the diaphragm. The right lung has three lobes, while
the left lung has two lobes. They contain bronchi, bronchioles, and alveoli. The right and left
lungs are separated medially by the heart and mediastinum, which is the area between the
lungs.
6. Pleura. The pleura is a double-layered membrane surrounding the lungs and lining
the chest cavity. It consists of the visceral pleura (attached to the lungs) and the parietal
pleura (lining the chest wall). The pleural cavity between them contains a small amount of
fluid, reducing friction during breathing movements and facilitating lung expansion and
contraction.
These components collectively make up the lower respiratory tract, where the main
function is the exchange of gases between the air and the bloodstream. The trachea, bronchi,
and bronchioles conduct air into the lungs, while the alveoli provide a vast surface area for
efficient gas exchange. The entire lower respiratory system is essential for the oxygenation of
blood and the removal of carbon dioxide, supporting the overall respiratory function and
The Heart
The heart is a fibromuscular organ that, by contracting and relaxing, pumps blood
The heart is, essentially, the center of a rapid-transit system that carries oxygen to body
cells and removes carbon dioxide and other wastes from cells.
Under healthy conditions, the cardiovascular, respiratory, and digestive systems are
integrated: The digestive system produces nutrients, and the respiratory system furnishes
oxygen, both of which circulate through the blood to various parts of the body.
Location in the Mediastinum. The heart is situated in the mediastinum, the central
providing protection and reducing friction during heartbeats. The outer layer is the fibrous
Anatomy of the Heart. The heart is divided into four chambers: two atria (upper
Right Atrium. Receives deoxygenated blood from the body via the superior and
Left Atrium. Receives oxygenated blood from the lungs via the pulmonary veins.
Right Ventricle. Pumps deoxygenated blood to the lungs via the pulmonary artery.
Left Ventricle. Pumps oxygenated blood to the rest of the body via the aorta.
Epicardium. Outer layer, the thin serous membrane comprising of the smooth outer
Myocardium. Thick, muscular layer made up of cardiac muscle cells, responsible for
pumping blood. The myocardium of the left ventricle is thicker than that of the right due to its
Endocardium. Smooth inner lining, providing a surface for blood flow and
preventing clotting. The heart valves are formed by a fold of endocardium, making a double
Right Atrium and Ventricle. Walls are thinner as they pump blood to the nearby
Left Atrium and Ventricle. Walls are thicker, especially the left ventricle, as it
Heart Valves
Tricuspid Valve (Right Side). Between the right atrium and ventricle.
Mitral (Bicuspid) Valve (Left Side). Between the left atrium and ventricle.
Pulmonary Semilunar Valve. Guards the entrance to the pulmonary artery from the
right ventricle.
Aortic Semilunar Valve. Guards the entrance to the aorta from the left ventricle.
Arteries
Carry oxygenated blood away from the heart. The largest artery is the aorta, carrying
oxygenated blood from the heart to the body, which branches into smaller arteries. Arteries
branch into arterioles and then into capillaries. All arteries carry oxygenated blood apart from
Veins
Transport deoxygenated blood back to the heart. The superior and inferior vena cava
are large veins that return blood to the right atrium. The superior vena cava returns
deoxygenated blood from the upper body to the heart, while the inferior vena cava returns
blood from the lower body. All veins except the pulmonary vein carry oxygenated blood and
Capillaries
Microscopic vessels connecting arteries and veins. Facilitate the exchange of oxygen,
Blood
Red Blood Cells (RBCs). Contain hemoglobin and transport oxygen from the lungs
to the tissues.
White Blood Cells (WBCs). Part of the immune system, defend against infections.
Vascular Pathway
from the body enters the right atrium of the heart through the superior and inferior vena
cava. From there, it flows through the tricuspid valve into the right ventricle, which
contracts to pump the deoxygenated blood through the pulmonary valve into the pulmonary
artery. This artery carries the blood to the lungs, where it undergoes oxygenation. The newly
oxygenated blood returns to the heart through the pulmonary veins, entering the left atrium.
Systemic Circulation. In systemic circulation, the left atrium propels the oxygenated
blood through the mitral valve (Bicuspid) into the left ventricle. The left ventricle contracts,
pumping the oxygenated blood through the aortic valve into the aorta, which then distributes
it to the rest of the body. As the oxygen is utilized by tissues, deoxygenated blood returns to
the heart via the superior and inferior vena cava, restarting the circulation process. This
continuous cycle ensures the efficient exchange of oxygen and nutrients throughout the body,
Involves the autonomic nervous system and hormones (e.g., adrenaline) to regulate
Coronary Circulation
Blood vessels (coronary arteries and veins) supplying the heart muscle with oxygen
and nutrients.
that oxygen and nutrients reach cells and tissues while removing waste products. This
coordinated effort supports the body's metabolic processes and overall homeostasis.