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In Drosophila, the genes y, f, and v are all X-linked. y f v females are crossed to wild-type males and the F1 females are test-
crossed. The F2 are distributed as follows:
yfv 3210
yf+ 72
y+v 1024
y++ 678
+fv 690
+f+ 1044
++v 60
+++ 3222
10,000
5-1
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
1.
Which of the following linkage maps correctly shows the order and distance between the y, f, and v genes?
A.
f——35 mu——y——15 mu——v
B.
f——22 mu——y——15 mu——v
C.
y——35 mu——f——22 mu——v
D.
y——22 mu——v——15 mu——f
E.
y——15 mu——v——22 mu——f
Bloom's: 4. Analyze
Learning Objective: 05.03.02 Refine genetic maps based on data from three-point testcrosses.
Section: 05.03
Topic: Mapping: Locating Genes Along a Chromosome
5-2
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
2.
A.
0
B.
0.2
C.
0.4
D.
0.6
E.
0.8
Bloom's: 3. Apply
Learning Objective: 05.03.03 Explain how a genetic map (in map units) is related to actual physical distance (in base pairs of DNA).
Section: 05.03
Topic: Mapping: Locating Genes Along a Chromosome
Females heterozygous for the recessive second chromosome mutations pn, px, and sp are mated to a male homozygous for all
three mutations. The offspring are as follows:
px sp cn 1,461
px sp + 3,497
px + cn 1
px + + 11
+ sp cn 9
+ sp + 0
+ + cn 3,482
+++ 1,539
10,000
5-3
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
3.
What is the genotype of the females that gave rise to these progeny?
A.
px+ sp cn / px sp+ cn+
B.
px+ sp cn+ / px sp+ cn
C.
px+ sp+ cn+ / px sp cn
D.
px sp cn+ / px+ sp+ cn
E.
Insufficient data
Bloom's: 4. Analyze
Learning Objective: 05.03.02 Refine genetic maps based on data from three-point testcrosses.
Section: 05.03
Topic: Mapping: Locating Genes Along a Chromosome
5-4
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
4.
A.
px
B.
sp
C.
cn
D.
Insufficient data
Bloom's: 4. Analyze
Learning Objective: 05.03.02 Refine genetic maps based on data from three-point testcrosses.
Section: 05.03
Topic: Mapping: Locating Genes Along a Chromosome
5-5
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
5.
Which of the following linkage maps correctly shows the order and distance between the px, sp, and cn genes?
A.
sp——0.21 mu——px——30.01 mu——cn
B.
sp——30.01 mu——px——0.21 mu——cn
C.
sp——0.2 mu——px——30 mu——cn
D.
px——0.2 mu——sp——30.2 mu——cn
E.
px——30.2 mu——sp——0.2 mu——cn
Bloom's: 4. Analyze
Learning Objective: 05.03.02 Refine genetic maps based on data from three-point testcrosses.
Section: 05.03
Topic: Mapping: Locating Genes Along a Chromosome
5-6
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
6.
A.
0
B.
0.16
C.
0.33
D.
0.5
E.
0.66
Bloom's: 3. Apply
Learning Objective: 05.03.03 Explain how a genetic map (in map units) is related to actual physical distance (in base pairs of DNA).
Section: 05.03
Topic: Mapping: Locating Genes Along a Chromosome
In peas, tall (T) is dominant to short (t), red flowers (R) is dominant to white flowers (r), and wide leaves (W) is dominant to
narrow leaves (w). A tall, red, wide-leaved plant is crossed to a short, white, narrow-leaved plant and the progeny are as
follows:
5-7
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
7.
A.
Tt Rr Ww
B.
Tt Rr WW
C.
TT RR WW
D.
TT Rr Ww
E.
TT RR Ww
Bloom's: 4. Analyze
Learning Objective: 05.01.02 Differentiate between parental and recombinant gametes.
Section: 05.01
Topic: Gene Linkage and Recombination
5-8
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
8.
A.
T/t
B.
R/r
C.
W/w
D.
All three genes are linked.
Bloom's: 4. Analyze
Learning Objective: 05.03.02 Refine genetic maps based on data from three-point testcrosses.
Section: 05.03
Topic: Mapping: Locating Genes Along a Chromosome
5-9
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
9.
If two or more of the genes are linked, what map distance separates them?
A.
4 mu
B.
12 mu
C.
24 mu
D.
50 mu
E.
None of the genes are linked to each other.
Bloom's: 4. Analyze
Learning Objective: 05.01.03 Conclude from ratios of progeny in a dihybrid cross whether two genes are linked.
Section: 05.01
Topic: Gene Linkage and Recombination
A dihybrid test cross is made between the genes C and D with the following results:
CcDd ccdd
CD 222
Cd 280
cD 280
cd 218
1000
5-10
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
10.
Calculate the 2 value used test the hypothesis that the C and D genes are unlinked.
A.
0
B.
0.0576
C.
10.8
D.
14.4
E.
Cannot be determined
Bloom's: 3. Apply
Learning Objective: 05.04.01 Explain the purpose of the chi-square test.
Section: 05.04
Topic: The Chi-Square Test and Linkage Analysis
5-11
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
11.
A.
1
B.
2
C.
3
D.
4
Bloom's: 3. Apply
Learning Objective: 05.04.01 Explain the purpose of the chi-square test.
Section: 05.04
Topic: The Chi-Square Test and Linkage Analysis
5-12
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
12.
Given this data, which of the following is the most accurate range within which the p value falls, and what can be concluded?
A.
0 < p < 0.01, genes C and D are most likely unlinked.
B.
0 < p < 0.01, genes C and D are most likely linked.
C.
0.01 < p < 0.05, genes C and D are most likely linked.
D.
0.01 < p < 0.05, genes C and D are most likely unlinked.
Bloom's: 4. Analyze
Learning Objective: 05.04.03 Evaluate the significance of experimental data based on the chi-square test.
Section: 05.04
Topic: The Chi-Square Test and Linkage Analysis
5-13
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
13.
If only 100 progeny had been counted and the same proportion observed, how would the p value and the conclusion drawn
about linkage change?
A.
The p value would increase, and the likelihood of linkage increases.
B.
The p value would decrease, and the likelihood of linkage increases.
C.
Neither the p value nor the likelihood of linkage would change.
D.
The p value would decrease, and the likelihood of linkage decreases.
Bloom's: 4. Analyze
Learning Objective: 05.04.03 Evaluate the significance of experimental data based on the chi-square test.
Section: 05.04
Topic: The Chi-Square Test and Linkage Analysis
5-14
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
14.
A. The different alleles of two or more genes that are on a chromosome are inherited in an manner inconsistent with Mendel's
Second law
B. Recombination between homologous chromosomes during meiosis results in different combinations of alleles for
different genes
C. Recombination between sister chromatids during meiosis results in different combinations of alleles for different genes
A.
A only
B.
B only
C.
C only
D.
A and B
E.
A, B, and C
Bloom's: 1. Remember
Learning Objective: 05.01.01 Define linkage with respect to gene loci and chromosomes.
Section: 05.01
Topic: Gene Linkage and Recombination
5-15
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
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