ANTI -HISTAMINIC AGENTS/DRUGS

A drug that reduces or eliminates the effects mediated by the chemical

histamine. True histamine are only the agents that produce a therapeutic effect that is mediated
by negative modulation of histamine receptors. It only refers to H1 receptor antagonist.
 Classification :
1) First Generation :
a) Propylamine :
Chlorpheniramine Phenindamine

b)Ethanolamines :

Diphenhydramine Clemastine

c) Ethylenediamines :

Pyrilamine Tripelennamine
d)Phenothiazines :

Promethazine
Trimeprazine

e)Piperazines :

Cyclizine
Meclizine

f) Heptanes :

Azatadine Cyproheptadine
c

g) Phthalazinone :
 Azelastine

2)Second Generation :
a) Piperazine :

Citrizine Levocitrizine

b) Piperidines :

Loratadine Fexotenadine