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Getting Ahead of ADHD What Next Generation Science Says About Treatments That Work and How You Can Make Them Work For Your Child Joel T. Nigg
Getting Ahead of ADHD What Next Generation Science Says About Treatments That Work and How You Can Make Them Work For Your Child Joel T. Nigg
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ebook
THE GUILFORD PRESS
Praise for Getting Ahead of ADHD
“As a parent who has read every book on the subject, I tried everything to
help my son with ADHD. I made him feel like a lab rat and wasted time,
energy, and money. If I could turn back time, this one book would sit on my
nightstand. It is so nice to have a vision for a bright future alongside realistic,
meaningful actions we can take right now. Getting Ahead of ADHD gives me
the confidence and tools I need to make wise decisions.”
—Marie B., Oregon
“How can you stay abreast of the rapidly growing research base on ADHD
and its treatment, when even clinical professionals can’t keep up? Simple—
read this book! Dr. Nigg is a foremost clinical scientist with a talent for mak-
ing complex ideas digestible. He explains what is currently known about the
causes of ADHD, and, more important, offers numerous insights and recom-
mendations for how to find the best treatment for your unique child.”
—Russell A. Barkley, PhD, ABPP, ABCN, author of
Taking Charge of ADHD, Third Edition
“Thank you, Dr. Nigg! As a parent of a child with ADHD, I found this book
tremendously valuable as well as enjoyable to read. It condenses the best cur-
rent research into practical advice. For example, we’ve restricted the amount
of added sugar in our family’s diet and see a noticeable reduction in my child’s
irritability. I will definitely recommend this book to other parents who are
looking for expert guidance.”
—Laura S., Michigan
“Dr. Nigg presents a new understanding of ADHD that reveals how both genes
and environment shape the disorder. He reviews the pros and cons of diet,
exercise, and other novel treatments, helping you choose among a wide range
of options for your child. Misinformation about ADHD abounds—this book
separates facts from fiction.”
—Stephen V. Faraone, PhD, Distinguished Professor of Psychiatry
and of Neuroscience and Physiology, State University
of New York Upstate Medical University
The information in this volume is not intended as a substitute for consultation with
healthcare professionals. Each individual’s health concerns should be evaluated by a
qualified professional.
Acknowledgments vii
Introduction 1
Resources 261
References 271
Index 291
v
Acknowledgments
This book is the product of my perception that the latest emerging sci-
entific ideas about ADHD reach parents and families too slowly. I hope
those who have asked me for this type of information will find it useful.
No book is possible without the help of many different people in
direct and indirect ways. Too numerous to name are the colleagues, stu-
dents, and families who over the years have helped me refine my think-
ing and decide on the value of writing a trade book on this topic. I have
tried to credit within the book many of the scientists and clinicians
whose work has increased my understanding, although I am sure I have
overlooked some who deserved mention.
However, a few individuals deserve specific thanks for their help with
this book: Kitty Moore of The Guilford Press was inexhaustibly patient
with multiple ideas and false starts before everything clicked. Christine
Benton was superlative as line editor, advisor, reality check—and offered
a perfect balance of candor and pragmatic encouragement. Both were
exemplary in their professionalism, solution-oriented approach to snags,
and good cheer. Keith Cheng, MD, and Kyle Johnson, MD, offered
invaluable critique and comment on treatments and sleep, respectively.
Katherine Holton, PhD, and Jeanette Johnstone, PhD, assisted in prior
writings on which sections of the nutrition chapter rely.
To everyone, and to those not named who have encouraged and
taught me, thank you, and good health.
vii
GETTING AHEAD OF ADHD
Introduction
ADHD is the most widely studied disorder affecting children. Why then
do parents still have so many questions about it? If you have a child with
this condition or a related one, you’ve already benefited from how research
evidence amassed over several decades has informed diagnosis and treat-
ment. But everywhere you turn you still run into conflicting reports,
controversies, debates, and claims about the latest “breakthrough” treat-
ments or revelations about the “real” cause of this prevalent and chal-
lenging disorder. This is especially true for alternative interventions like
diet or exercise; reliable information on these popular alternatives is
much harder to come by relative to information on standard care via
medicine or counseling.
A big reason for this confusing array of information and misinfor-
mation is that our scientific understanding of ADHD is rapidly chang-
ing. A more complex picture is emerging that offers you an opportunity
to make a big difference in your child’s health and happiness—and that
of your whole family—both now and into the future. This is obviously
great news, as long as you can sort fact from fiction. There’s a lot to sift
through, and it evolves every day.
The goal of this book is to present a clear explanation of what “next-
generation” science tells us about ADHD—particularly a new understanding
of how it is caused and the role of environmental influences. In the following
pages I hope to put to rest some persistent myths and tell you what reli-
able research reveals and what we’re still studying. I’ll help you look at
the controversies and claims with a discerning eye and form a solid idea
of what kind of help is most likely to actually help your child.
1
2 Introduction
What you’ll read in this book is all founded on four major discover-
ies of recent years that are reshaping how we look at ADHD and are
translating into practical new ways to help your child:
what doesn’t and how to identify reliable treatments and qualified pro-
fessionals. In Chapter 9 I’ll help you bring all of this new understanding
together so that you can decide on a course of action that will offer your
child the best outcome, and one that’s not so hard on your family that
the “cure” ends up worse than the “disease.”
Meanwhile, here are some of the main areas of discussion informed
enormously by next-generation science:
from how much money people will earn, to how healthy they will be, to
how long they will live. When self-regulation fails in an extreme way, as
in some kids with ADHD, the results can be disastrous: school failure,
drug addiction, divorce, employment failure, illness, injuries, and earlier
death. Even when ADHD is not quite this severe, it is typically associ-
ated with ongoing struggles in terms of emotional control, conflict with
other people, and difficulty and frustration in school and work settings.
We now know that it is also associated with a range of poorer health
outcomes. In fact, because ADHD is related to so many subsequent
problems, its total public health impact is probably still underappreciated
despite all the publicity it continues to attract.
This is why you are right to want to help your child with ADHD get
better at managing her own emotions, thinking, and behavior. It’s why
learning as much as we can about the problem through reliable and cur-
rent scientific research is so essential.
eries from twin studies showing real genetic influences. But here, too,
the science has moved on. It is now clear that while genetics are clearly
crucial, the traditional genetic model is simplistic enough to mislead us.
Chapter 2 briefly explains the new perspective of epigenetics, which is
closely related to a concept called “gene × environment interaction.”
Epigenetics as I use it in this book means that experiences can create
stable, enduring—yet potentially reversible—changes in gene expres-
sion. These enduring changes in biology help us understand in a new way
the importance of early life and ongoing stress, diet, exercise, and other
influences. Not only can a child’s environment, starting in the womb,
steer development toward ADHD, but new, corrective, or healing experi-
ences can restore healthier levels of gene expression. Much of this book
is devoted to helping you see just where we are on this interesting, and
largely underrecognized, frontier of science as it relates to ADHD.
One of the important strengths of science is that it evolves; it self-
corrects; new knowledge supplants old knowledge. Seventy-five years
ago, most experts did not think genetics was a major contributor to men-
tal illness. A “naive environmentalism” ruled. Between 1960 and 2000
it became clear that we needed to take into account a major role for
genes in ADHD and other mental disorders. But the pendulum swung
too far—for many reasons. A genetic story was appealing; it felt safely
grounded in rock-solid biology and had been successful in explaining
other diseases in the past. (For example, insights from genetics revolu-
tionized our understanding of the causes and treatments for intellectual
disability in the second half of the twentieth century.) And it was easy,
though logically incorrect, to think that because medication seemed to
control ADHD symptoms, the disorder is biologically determined.
But science kept going. We realized through studies over the life span
of individuals that medications didn’t cure ADHD; they only controlled
the symptoms (at least partially). And even that effect often seemed
to “wear off” after a few years. Coincidentally, we also learned that we
weren’t in fact “solving” ADHD with genetics alone. The expected break-
throughs didn’t occur. We began to realize that genes aren’t the entire
story, and that enduring yet potentially modifiable changes in how genes
work are caused by early-life experiences—such as stress or diet—that
change brain and behavior. Development is always the joint interplay of
8 Introduction
genetics and environment. This is the revolution that helped inspire the
ideas in this book.*
Meta-analysis. This means that all the studies on a question are com-
bined in one “super analysis” to answer a question about how effective
something is. A major development in the last few years is that today the
methods of these analyses are widely known and used. For the first time
we have summary data on almost all our questions rather than relying
on isolated studies alone. The reliability of findings from meta-analysis
depends on the size, quality, and number of individual studies being
pooled, but it is still generally much better than insights from one study.
*One scientific dispute is whether the epigenetic approach is in fact revolutionary. It’s
not revolutionary in one sense—epigenetic effects have been known about for decades.
But what is revolutionary is the recognition that a great deal of human disease, par-
ticularly complex problems like psychiatric and behavioral disorders, probably involves
epigenetic mechanisms. The epigenetics of human brain and behavior is still a new and
in many ways revolutionary approach to the field.
Introduction 9
other half get a milk shake that tastes the same but has no food coloring.
In a random assignment, there is no way to explain effects other than
that they are caused by the one variable that was controlled—such as
food coloring in this example. Randomization removes all other possible
causes. The power and magic of experimental random assignment is that
these studies can show that one thing caused another, not just that the
two happened to appear together.
children (and adults) with ADHD as well as the very important varia-
tions that occur in the disorder. It also helps us recognize that many of
the frustrating behaviors associated with ADHD are just as frustrating
to the individuals with ADHD themselves, seeming to occur before they
can get a handle on what is going on. However, in children and adults,
this frustration can get turned outward, toward blaming others for their
own problems. Together, these new perspectives can clear the way for
new hope and new solutions to help children with ADHD.
What Is Self-Regulation?
ment, that “I can see why she has ADHD because she can’t focus on her
homework for more than two minutes without me standing right there to
make her do it. But then she gets so focused on her doll collection that I
can’t get her to break away from it to do something else. And she can
lock on to a video game for hours! So it seems like she can pay attention
when she wants to.” The explanation for this apparent contradiction is
that Jenny cannot optimize her attention. She can’t really control it.
Instead, her attention controls her. She can’t focus on her homework
when she needs to. Her attention is captured by her doll collection or the
video game, and she can’t break away without a struggle. In a way, Jenny
isn’t entirely free, because she can’t put her attention where her ultimate
goals would suggest. (Caution—if the only time attention is a problem is
when a child is doing schoolwork, it’s important to rule out a learning
disability.)
All of self- regulation is connected. Self-regulation applies
Kids who can’t focus their attention also to a child’s thoughts,
frequently cannot get a handle on behav- actions, and emotions,
which is why the typical
ior. This is why classic ADHD looks like
picture of ADHD includes
inattention plus impulsivity (and in young
problems with mental
children hyperactivity, or in older individu-
focus (inattention) and
als extreme restlessness). It’s also why prob- problems controlling
lems getting a handle on emotions com- behavior (impulsivity).
monly plague kids with ADHD as well. Yet
the degree of these different problems varies like a rainbow among kids
with ADHD, with different profiles common.
What Is Impulsivity?
It will be seen that two coolies, by means of these bars, can carry a
great weight—as much as two hundred pounds is carried between
them—and they will cover with this weight twenty to twenty-five miles
a day. Chair-carriers will, with the attendant luggage-carriers, cover
as much as twenty-five miles, but their burdens are less heavy.
CARRIAGE
OF MERCHANDISE
THE MODE OF CARRYING
OIL AND WINE.
This Chengtu Plain, with its 2,500 square miles of country and
4,000,000 population, is perhaps the best cultivated and most fertile
spot in the world. It owes its fertility to the work of two engineers,
who, more than two thousand years ago (250 years B.C.), designed
and carried out the most perfect system of irrigation. They were Li
Ping, the father, and his son, and are familiarly known to-day as the
first and second gentlemen of China. The land bears four crops in
the year. With all this produce and population, the traffic is
enormous, and it is mainly carried on by means of wheelbarrows,
which are so contrived, by placing the wheel in the centre and
platforms at the side and behind it, as to enable one man to wheel
five hundredweight with ease. The narrow roads of the plain are
covered by an almost endless procession of these wheelbarrows,
which are often preceded by one man pulling in addition to the man
behind.
WHEELBARROW TRAFFIC
ON THE
CHENGTU PLAIN
THE WHEELBARROW
OF NORTH CHINA.