Manufacturing Drills 2

1.
The method for the preparation of compressed tablets wherein the granulation is
formed by compacting large masses of the mixture and subsequently crushing and sizing
these pieces into smaller granules.
a. Dry granulation method
b. Wet granulation method
c. Direct compression method
d. All of the above
2. Aside from fluidity, powders for compression must possess…
a. Flowability
b. Adhesiveness
c. Compressibility
d. All of the above
3. Drugs that are available as sustained release dosage froms utilizing ion exchange resins
include:
a. Spansule
b. Ionamine
c. Gradumet
d. All of the above
4. Film coating problems due to internal stress
a. Cracking
b. Lamination
c. Mottling
d. Orange peel or roughness
5. The disintegration medium for plain uncoated tablet is:
a. Simulated gastric fliud TS
b. Simulated intestinal fluid TS
c. Distilled water
d. A and C
6. The most commonly used of determining the particle size of powders and granules
a. Coulter counter
b. Sieve method
c. Microscopy
d. None
7. The following are binders, except
a. Starch
b. Acacia
c. Bentonite
d. Cab-O-sil
8. Content uniformity is used to ensure which of the following qualities in tablet products
a. Disintegration
b. Potency
c. Purity
d. toxicity
9. for rapid disintegration of tablets of compressed tablet, this range of concentration of
starch is recommended:
a. 5%
b. 10-15%
c. 15-20%
d. 20-25%
10. Rule of thumb is used for testing
a. Ampules
b. Hydremic needles
c. Compressed tablets
d. Vials
11. A tablet formulation calls for 2 active ingredients which are chemically incompatible
a. Dry granulation
b. Wet granulation
c. Double layered tablets
d. Spray drying
12. Poorly manufactured tablets may have small pinholes on the surface, this defect is
called:
a. Mottling
b. Picking
c. Capping
d. Compacting
13. I n the preparation of effervescent tablets, the most important ingredients necessary to
give the effervescent effects are:
a. NaHCO3 and Citric Acid
b. Citric Acid and Tartaric Acid
c. Na2CO3 and Tartaric Acid
d. A and C
14. Common binder used in tablets
a. Gelatin solution
b. Lycopodium powder
c. Liquid petrolatum
d. Lactose
15. The theoretical weight of ten (10) tabs is 9.35 grams. Each tablet contains 425mg of the
active ingredients. Using this data, determine the amount of additive needed to prepare
160,000 tablets
a. 51.0 kg
b. 102.5kg
c. 81.6 kg
d. 149.6 kg
16. separation of a tablet into 2 or more distinct layers
a. Mottling
b. Granulation
c. Speculation
d. Lamination
17. Part of a tablet machine which controls the size and shape of the tablet is
a. Punches
b. Hopper
c. Die
d. Cam
18. Formulation methods of achieving sustained drug release include
a. Use of coating
b. Microencapsulation
c. All of these answers
d. Embedding the drug in matrix
19. The method of tablet manufacture for easily compressible or adhesive ingredients is:
a. Dry granulation
b. Direct compression
c. Slugging
d. Wet method
20. One of the following does not apply to uses of colloid mills
a. Homogenize viscous emulsions
b. Granulate
c. Produce finely divided solids
d. Reduce particle size of solids
21. One of the following substances is not used as lubricant in tablet manufacturing
a. Starch
b. Talc
c. Magnesium Stearate
d. Calcium Stearate
22. One of the following is not an advantage of multi-layered tablets
a. Maybe coated tablet
b. 2 incompatible drugs may be kept separated
c. Accurate control of the delayed action part
d. Each layer has a separate color for identity
23. The ability of the tablet to withstand abrasion in packaging and shipping is evaluated by:
a. Content uniformity
b. Dissolution test
c. Hardness
d. Friability
24. This is common lubricant for tablets:
a. Mannitol
b. Acacia
c. Start
d. Magnesium Stearate
25. Which of the following is/are used in tablet formulation to reduce friction during tablet
compression?
1. Calcium Stearate
2. Magnesium Stearate
3. Stearic Acid
a. None of these answers

b. 1 and 3
c. 1 and 2
d. All of the Above
26. Which of the following is/are uses of starch in pharmaceutical formulation
1. LUBRICANT
2. DILUENT
3. DISINTEGRANT
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
27. Which of the following are official sources of Starch USP
1. Zea mays
2. Triticum aestivum
3. Manihot esculanta
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
28. What is the allowable limit of silicon dioxide in gelatin?
a. 2%
b. 1%
c. 0.5%
d. 0.25%
e. 0.15%
29. What is Pharmaceutical Glaze?
a. Denatured alcoholic solution of PVP
b. Denatured alcohol solution in Shellac
c. Hydroalcoholic solution of NaCMC
d. Hydroalcoholic solution of Starch
e. Aqueous solution of Glucose
30. Which if the following is obtained by the incomplete partial hydrolysis of starch and
consists mainly of dextrin, maltose and water?
a. Dextrates
b. Dextrose excipients
c. Liquid glucose
d. Modified starch
e. Sucrose
31. Which of the following can be considered as use/s of Directly Compressible Starch?
1. Binder
2. Diluent
3. Disintegrant
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
32. Lactose is a relatively inexpensive tablet bulking agent. Which of the following types of
drugs or excipients is/are incompatible with lactose?
1. Amine drugs
2. Water-based binding solutions
3. Alcohol-based binding solution
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
33. Maillard Reaction is a documented incompatibility of certain excipients with acetates,
phosphates, and lactates. Which of the following excipients can manifest such reaction?
1. Anhydrous lactose
2. Pregelatinzed starch
3. Spray-dried lactose
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
34. Moisture content of excipients and active drug can affect the properties and production
of compressed tablets. Which of the following excipients has the smallest moisture
content?
a. Dicalcium phosphate
b. Monocalcium phosphate
c. Sorbitol
d. Mannitol
e. Sucrose
35. Sodium starch glycollate and croscarmelose are primarily used in tablet formulation as
a. Lubricants
b. Disintegrants
c. Diluents
d. Binders
e. Glidants
36. Which of the following excipients is expected to possess the greatest adhesive property?
a. Acacia
b. Gelatin
c. Starch
d. Glucose
e. Simple syrup
37. Which of the following excipients can be used for direct compression?
1. Pregelatinized starch
2. Anhydrous lactose
3. Mannitol
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
38. Which of the following is/are sucrose-based tablet diluent-binder?
1. Nutab
2. Avicel
3. Cab-O-sil
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
39. What is the concentration of Starch in Starch paste used as a binder solution?
a. 0.5% - 1%
b. 1-5%
c. 5-10%
d. 10-15%
e. 15-25%
40. Which of the following principles is/are employed in the use of lubricants in tablet
formulation?
1. Higher concentrations of lubricants are employed when active drugs
and other excipients used have bigger particle sizes
2. Lubricants are added together with the rest of the excipients in the
initial step in production
3. Lubricants generally increase the disintegration time and reduce
dissolution rate
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
41. Double compression method of tablet manufacturing is the preferred method in which
of the following condition?
1. When the initial powder blend has a significant quantity of fine
powders
2. When the active ingredients are sensitive to moisture or elevated
temperature
3. When the active ingredients and the excipients are free-flowing
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
42. Which of the following mechanism explain the use of glidants in tablet formulation?
a. Reduce interparticulate tension leading to improved flow of particles
b. Surface active ingredients that reduce friction between the inner die walls and
the tablet
c. Reduce sticking of particles to the wall of the die and the contact surface of the
punches
d. By capillary action, improve uptake of water into the interior of the tablet
e. Increase interparticulate attraction achieved during the process of compression
43. Which of the following precautions are observed during addition of tablet lubricants in
formulations?
1. Add lubricants prior to wetting of powder blends or slugging, as
applicable
2. Add lubricants at concentrations consisting of about 20-25% of the
final tablet weight
3. Mix lubricants with the rest of the granules for about 2-5 minutes
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
44. Sterotex, Magnesium stearate, and the high melting point waxes can be categorized as
1. Water-soluble lubricants
2. Glidants
3. Water-insoluble lubricants
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
45. Talc in tablet formulation is generally used as
1. Glidant
2. Lubricant
3. Anti-adherent
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
46. An internal disintegrant is used in which of the following methods of manufacturing?
1. Wet granulation
2. Dry granulation
3. Direct compression
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
47. What is a “RUNNING POWDER”
a. Powder blend with improved lubrication
b. Combination of a disintegrant and a lubricant
c. Combination of a disintegrant and a binder
d. Powder combination to improve flow
e. Combination of a glidant and a binder
48. What are referred to as “LAKES” in pharmaceutical manufacturing?
a. Binder solution
b. Wetted powder blends in wet granulation
c. Magmas and suspensions
d. Flavors in hydroalcoholic mixtures
e. Dyes adsorbed on aluminum hydroxide
49. Flavors of pharmaceutical oral liquids or chewable tablet are chosen based on the
baseline taste of the active ingredient. Which of the following flavors are recommended
for drugs with a sour baseline taste?
1. Cherry
2. Citrus
3. Strawberry
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above
50. Which of the following is/are advantages of wet granulation method of tablet
manufacturing?
1. Good color distribution
2. Uniform composition of granules during processing, transport and
handling
3. Useful for heat-sensitive material
a. 1 only
b. 1 and 2
c. 3 only
d. 1 and 3
e. All of the above

Manufacturing Drills 2

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Manufacturing Drills 2

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a. None of these answers

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