Scribd Logo
Upload

Welcome to Scribd!

  • Metabolisme Purin Dan Pirimidin 2014

    Uploaded by

    arumingtyas pawestri
    99 views24 pages
    Human tissues can synthesize purines and pyrimidines from intermediates. Ingested nucleic acids and nucleotides are broken down into mononucleotides that can be absorbed or further broken down into purine and pyrimidine bases like uric acid. Purine nucleotides are essential components of nucleic acids and are involved in energy transformation, phosphorylation reactions, and acting as intracellular messengers. They can come from the diet, degradation of endogenous nucleotides, or de novo synthesis.

    Original Description:

    metabolisme purin pirimidin

    Original Title

    Metabolisme Purin Dan Pirimidin 2014(1)

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Human tissues can synthesize purines and pyrimidines from intermediates. Ingested nucleic acids and nucleotides are broken down into mononucleotides that can be absorbed or further broken down into purine and pyrimidine bases like uric acid. Purine nucleotides are essential components of nucleic acids and are involved in energy transformation, phosphorylation reactions, and acting as intracellular messengers. They can come from the diet, degradation of endogenous nucleotides, or de novo synthesis.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    99 views24 pages

    Metabolisme Purin Dan Pirimidin 2014

    Uploaded by

    arumingtyas pawestri
    Human tissues can synthesize purines and pyrimidines from intermediates. Ingested nucleic acids and nucleotides are broken down into mononucleotides that can be absorbed or further broken down into purine and pyrimidine bases like uric acid. Purine nucleotides are essential components of nucleic acids and are involved in energy transformation, phosphorylation reactions, and acting as intracellular messengers. They can come from the diet, degradation of endogenous nucleotides, or de novo synthesis.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 24

    METABOLISME PURIN DAN

    PIRIMIDIN
    METABOLISME PURIN DAN PIRIMIDIN

    NUKLEOPROTEIN

    ASAM NUKLEAT

    MONONUKLEOTIDA

    MONONUKLEOSIDA

    PURIN PIRIMIDIN CO2 DAN H2O


    ASAM URAT
    BLOK-BLOK PEMBANGUN DNA

    DNA merupakan struktur yang


    dibangun oleh KH (pentosa),
    fosfat dan suatu basa dalam
    bentuk polimer dan
    berkombinasi membentuk helix
    ganda.

    Gugus pembangun DNA adalah


    “5-carbon sugar deoxyribose”
    yang saling dihubungkan oleh
    ikatan fosfodiester sehingga
    terbentuk dua untai ganda
    dengan tulang punggungnya
    dibentuk dari ikatan KH-fosfat
    pada bagian luar helix.
    • Nucleotides — The monomer units or
    building blocks of nucleic acids — serve
    multiple additional functions.

    • They form a part of many coenzymes and


    serve as donors of phosphoryl groups (eg, ATP
    or GTP), of sugars (eg, UDP- or GDP-sugars),
    or of lipid (eg, CDP-acylglycerol)
    • Human tissues can synthesize purines and pyrimidines from
    amphibolic intermediates.
    • Ingested nucleic acids and nucleotides, which therefore are
    dietarily nonessential, are degraded in the intestinal tract to
    mononucleotides, which may be absorbed or converted to
    purine and pyrimidine bases.
    • The purine bases are then oxidized to uric acid, which may be
    absorbed and excreted in the urine.
    • While little or no dietary purine or pyrimidine is incorporated
    into tissue nucleic acids, injected compounds are
    incorporated.
    • The incorporation of injected [3H] thymidine into newly
    synthesized DNA thus is used to measure the rate of DNA
    synthesis.
    • Purine nucleotides are essential components
    of nucleic acids: they are intimately involved
    in energy trans- formation, phosphorylation
    reactions and act as intracellular messengers.
    • There are three sources of purines in humans:
    the diet, degradation of endogenous
    nucleotides and de novo synthesis
    ASAM NUKLEAT DAN DERIVAT NUKLEOTIDA
    NUKLEOSIDA DAN NUKLEOTIDA
    5-Phospho- -D-ribosyl-1-pyrophosphate
    (PRPP)
    Biosintesis Purin
    BIOSINTESIS PURIN
    INOSIN MONOFOSFAT

    • Daur diawali dgn


    perubahan PRPP 
    IMP
    • IMP = Inosine
    monofosfat mrpkn
    bentuk nukleotida
    purin yang pertama
    dibentuk dlm daur ini

    • Sebagai basa adalah


    hypoxanthin
    DAUR DARI IMP → AMP DAN GMP
    Metabolisme de novo nukleotida pirimidine
    DEGRADASI PURIN
    DEGRADASI PURIN

    Vertebrata terestrial  urea  ureotelic


    Burung & reptil  asam urat  uricotelic
    Binatang di air  ammonia ammonotelic
    DEGRADASI PIRIMIDIN
    Overview of purine
    synthesis. Details of
    the first two reactions
    and sources of the
    atoms of the purine ring
    in inosine 5′-
    monophosphate (IMP)
    are shown. PRPP, 5′-
    phosphoribosyl-1-
    pyrophosphate; Gln,
    glutamine; Gly, glycine;
    Asp, aspartate; THF,
    tetrahydrofolate.
    Regulation of
    purine synthesis by
    the nucleotides and
    the intermediate,
    5′-phosphoribosyl-1-
    pyrophosphate
    (PRPP). Both
    feedback and feed-
    forward mechanisms
    are utilized in this
    intricate scheme.
    IMP, inosine
    monophosphate.
    hypoxanthine-guanine phosphoribosyl transferase (HCPRT), and for
    adenine by adenine phosphoribosyl transferase (APRT).

    You might also like