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TANNINS
Gallotannins Ellagitannins
Catechin
• Cardiovascular disease, principally heart disease
and stroke, are the leading cause of mortality in
both men and women in all racial and ethnic
groups.
• Antioxidant activity
Scavenge free radicals and reduce oxidative stress.
No. of rats 10 10
6 5
5 4
4 control
mmol /l
mmol/ l
3 control
3 PGT
2 PGT
2
1 1
0 0
1 2 3 4 1 2
A
B
1. Total cholesterol m mol / l
1. Serum triglyceride
2. HDL - Ch
3. VLDL + LDL - Ch
2. Serum lipid peroxide
4. Atherogenic index
Plasma cholesterol, TG and oxidative state of plasma
lipoprotein in mice fed on atherogenic diet with and without
tea extract. (Miura, et al., 2001)
Particular Time Control Tea group
(3.2 mg /d)
No of mice 16 17
Body weight, g 0, wks 25.1 25.9
14 23.4 26.5
Plasma cholesterol, 0, wks 14.6 14.6
m mol/ l 14 83.2 75
Plasma triglyceride, 0 0.89 0.86
m mol /l 14 0.49 0.85
Plasma lipid 0 6.48 8.63
peroxidase, 8 30.3 20.0
µmol MDA /l
Atheromatous area, aortic weights and aortic lipid contents in
mice fed an atherogenic diet with and without tea extract.
(Miura, et al., 2001)
Catechins Mg/ g
(-)Gallocatechingallate (GCg) 16
(-)Epicatechin-gallate (ECg) 5
Caffeine. 4
Varying level of Potency among Catechins.
catalase
160
% intensity of catalase
140
120
expression
100
80 catalase
60
40
20
0
1 2 3
Control BTP GTP
3000
2500
2000
Control
1500
Catechin
1000
500
0
1
Composition of Phenolic Compounds in Muscadine
0.3
0.2
0.1
0
1 2
1 : Muscadine wine
2 : Ethanol (Percival et al.,2002)
• Catechins hypothesized to help protect against
various diseases by contributing, along with
antioxidant vitamins (i.e. Vit. C & E) and enzymes
(i.e. SOD and Catalase)