TATALAKSANA

FARMAKOLOGI
 TREATMENT

GOALS OF THERAPY:

 Control disease manifestation

 Allow patient to have a good quality of life without major exacerbations
 Prevent serious organ damage that adversely affects function or lifespan
 Prevent adverse effects of the drugs used

PHARMACOTHERAPY

Corticosteroids Immunosuppressants NSAIDs Sunscreen

 TREATMENT

CORTICOSTEROIDS

Oral corticosteroids
 Patients w/ mild SLE do not normally require use of systemic corticosteroids
but there are patients who has low quality of life if not given low-dose
corticosteroids
 Lowest possible dose should be used for maintenance therapy
 High-dose corticosteroids are necessary for refractory manifestations of SLE
& for severe organ systems’ manifestations especially CNS, renal &
hematologic manifestations
 Decreases inflammation by suppression of the immune system

Topical corticosteroids
 Helpful for discoid lesions especially on the scalp
 Use a less potent steroid on the face because it is more prone to atrophy
 TREATMENT

CORTICOSTEROIDS

Parenteral corticosteroids
 Pulse therapy with IV corticosteroids in combination with
immunosuppressive therapy is recommended for Class III and IV SLE patients
with confirmed glomerulonephritis
 TREATMENT

IMMUNOSUPPRESSANTS

These agents act as immunosuppressive, cytotoxic & anti-inflammatory agents

 In the treatment of severe CNS & severe glomerulonephritis,

thrombocytopenia & hemolytic anemia, high dose glucocorticoids &
immunosuppressantS are used

 Concomitant use with corticosteroids allows lower doses of

immunosuppressants

1. Azathioprine
2. Belimumab
3. Cyclophosphamide
4. IV Immune Globulin (IVIg)
5. Methotraxate
 TREATMENT

NSAIDS

 These drugs provide symptomatic relief of fever, arthritis & mild serositis

 Inhibit inflammatory reactions & pain by decreasing prostaglandin synthesis

 SLE patients have a high incidence of NSAID-induced hepatotoxicity

SUNSCREEN

Patients with SLE should apply sunscreen with at least an SPF of 15 to prevent
dermal or systemic disease flares upon exposure to ultraviolet light
FA RM A K OLOGIS
Terapi didasarkan p a d a o rgan d a n b eratnya manifestasi

Serositi Hematologi Neulorogi

s • OAINS s • Simptomatik
• Kortikosteroid
• Kortikosteroid • Kortikosteroid
• Immunosupressiv
• Immunosupressiv • Immunosuppresiv
e
e e
Artritis Renal Ras
• OAINS h • Kortikosteroid topikal
• Kortikosteroid
• Hydroxychloroquine
• Immunosupressiv • Kortikosteroid
• DMARDS
e sistemik
• Kortikosteroids
• Hydroxychloroquine
• Immunosupressiv
• Methotrexate
e
• Immunosupressive
PENATALAKSANAAN SLE SESUAI KEPARAHAN MANIFESTASINYA