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Connector: Questions on prior learning linked to Answers:
todays lesson:
Gene: A gene is a section of DNA which
Recall and Retention controls part of a cell's chemistry - particularly
1.What do you already know about DNA? protein production.
Allele: each of two or more alternative forms
of a gene that arise by mutation and are found
Challenge: For each key word draw a diagram to at the same place on a chromosome.
help you remember them
Chromosome: The structure made of DNA that
codes for all the characteristics of an organism.
Nucleotides: The units or molecules of which
DNA or RNA is composed
Polynucleotides: a chain of repeating units of
“nueceotides”.
Learning Outcomes
• Describe how the four bases make up a code
• Explain why the correct folding of a protein is important to its function
• Describe the steps involved in producing a protein inside the cell.
• Discuss possible issues surrounding genome sequencing.
• Explain how the order of bases determines the type of protein made.
AQA spec link:
6.1.5 Students should be able to describe
• DNA as a polymer made from four different nucleotides. Each nucleotide consists of a common sugar and phosphate group with one of four
different bases attached to the sugar.
• DNA contains four bases, A, C, G, and T.
• A sequence of three bases is the code for a particular amino acid. The order of bases controls the order in which amino acids are assembled to
produce a particular protein.
• The long strands of DNA consist of alternating sugar and phosphate sections. Attached to each sugar is one of the four bases.
• The DNA polymer is made up of repeating nucleotide units.
• Students should be able to:
• • recall a simple description of protein synthesis
• • explain simply how the structure of DNA affects the protein made
• • describe how genetic variants may influence phenotype: a) in coding DNA by altering the activity of a protein: and b) in non-coding DNA by
altering how genes are expressed.
• In the complementary strands a C is always linked to a G on the opposite strand and a T to an A.
• Students are not expected to know or understand the structure of mRNA, tRNA, or the detailed structure of amino acids or proteins.
• Students should be able to explain how a change in DNA structure may result in a change in the protein synthesised by a gene.
• Proteins are synthesised on ribosomes, according to a template. Carrier molecules bring specific amino acids to add to the growing protein
chain in the correct order.
• When the protein chain is complete it folds up to form a unique shape. This unique shape enables the proteins to do their job as enzymes,
Bio Only
The section of your
Checklist we are covering
today
Proteins Recall and Rention
Proteins are made of long chains of amino acids. There are 20 different types of
amino acid from which to make proteins.
protein
molecule 1
amino acids
protein
molecule 2
12:20
Changes in proteins
1. What is a mutation?
Random/spontaneous change in the DNA
2. Name some factors which can cause a mutation?
Carcinogens, UV light, Tobacco,
3. How can a mutation lead to a different protein being produced?
If a mutation occurs its changes the gene, it will code for a different
amino acid and then the call makes a different protein.
Challenge – Explain the different types of mutations that can occur
in the body
New Information for Learning Outcome 2
• The genetic code is the sequence of bases that code for each amino acid
• There are 20 amino acids.
• AAATATCTCCCCGCATGGTACTCCTTTTGACGC
12:20
New Information for Learning Outcome 2
12:20
04/15/2021
DNA is a polymer
DNA is a polymer. The monomer units
of DNA are nucleotides, and the polymer is
known as a "polynucleotide."
• thymine, T
• adenine, A
• guanine, G
• cytosine, C
Base pairs
• There are chemical bonds between the two strands in DNA, formed by pairs of
bases. They always pair up in a particular way, called complementary base
pairing:
mRNA
Occurs in the
Translation
cytoplasm
Protein
What is mRNA?
When a polypeptide is required, the triplet code of its gene is
converted into a molecule of messenger RNA (mRNA).
• Messenger RNA (mRNA) leaves nucleus and goes to ribosome (the site of protein
synthesis)
A A T C A A T A G
T T A G A T A T C
A A T C A A T A G
U
U G U C
A
U A
G
G C G
Exposed base attracts complementary RNA.
A A T C A A T A G
RNA
POLYMERASE
U
U G U C
A
U A
G
G C G
A A T C A A T A G
U U
G U C
A
U A
G
G C G
The enzyme RNA polymerase adds one complementary RNA nucleotide to the
existing one.
A A T C A A T A G
U U
G U C
A
U A
G
G C G
A A T C A A T A G
U U A
G U C
U A
G
G C G
A A T C A A T A G
U U A G
U C
U A
G
G C G
Complementary RNA nucleotide is added to the growing chain of
mRNA one by one.
A A T C A A T A G
U U A G U
U A
G
G C G
Complementary RNA nucleotide is added to the growing chain of
mRNA one by one.
A A T C A A T A G
U U A G U U
A
G
G C G
Complementary RNA nucleotide is added to the growing chain of
mRNA one by one.
A A T C A A T A G
U U A G U U A
A
G
G C G
Complementary RNA nucleotide is added to the growing chain of
mRNA one by one.
A A T C A A T A G
U U A G U U A U
G
G C G
Complementary RNA nucleotide is added to the growing chain of
mRNA one by one.
A A T C A A T A G
U U A G U U A U C
G
G C G
Complementary RNA nucleotide is added to the growing chain of
mRNA one by one.
A A T C A A T A G
U U A G U U A U C
G
G C G
Complementary RNA nucleotide is added to the growing chain of
mRNA one by one.
Transcription and codons
During transcription, the mRNA is built up by complementary
base pairing, using the DNA as a template. The DNA’s base
triplets are converted into mRNA codons.
A A T C A A T A G
U U A G U U A U C
mRNA
CYTOLPLASM
Nuclear pore
A A T C A A T A G
CYTOLPLASM
U U A G U U A U C
mRNA
mRNA leaves the nucleus through the nuclear pore.
What is translation?
Once a molecule of mRNA has been transcribed, it moves
out of the nucleus via a nuclear pore.
ribosome
In the cytoplasm, the
mRNA combines with a
ribosome – the cellular
structure on which the
polypeptide chain will
be built in a process
called translation. mRNA
strand
How are the correct amino acids transported to the ribosome,
and how are they linked together in the correct order?
A A U Anti-Codon
CYTOLPLASM
U U A G A U A U C
mRNA
tRNA Aspartic
Acid
tRNA Leucine
C U A
RIBOSOME A A U
U U A G A U A U C
mRNA
tRNA
Ribosome C U A
A A U
U U A G A U A U C
mRNA
Leucine Aspartic
Acid
U A G
A A U C U A
U U A G A U A U C
Threo
nine
Leucine Aspartic
Acid
U A
G
A A U C U A
U U A G A U A U C
A A U C U A U A G
U U A G A U A U C
Leucine
Aspartic Threonine
Acid
A A U C U A U A G
U U A G A U A U C
Amino acid is linked to the previous amino acids with peptide bond.
Leucine
Aspartic Threonine
Acid
A A
U C U A U A G
U U A G A U A U C
A tripetide is formed.
Leucine
Asparti
c
Threon
Acid in e
A
A U
C U A
U A G
U U A G A U A U C
• Due date:
End of Lesson Review
• Quick fire question round. All students to make up 3 questions based on todays lessons
and ask their peers.