Excitable

tissue
• Neurons are identified as
excitable cells because
they have the ability to be
electrically excited
resulting in the
generation of action
potentials.
• Other examples of
excitable cells are skeletal,
smooth, and cardiac
muscle cells and
secretory cells of the
pancreas.
 • Neuromuscular
Synaptic Cleft
Junction
Hormonal Excitation
 •Irritability
• Excitability
•Conductivity

Basic properties of •Lability

•Contractibility
excitable tissue •Ability to secretion
Irritability
• Change metabolism under
stimulation (only organic
nature)
 Excitability
•respond to stimuli by development
of excitation in the form of a specific
response and a bioelectrical process.
Can be evaluated by methods of
stimulation and registration of
electrophysiological manifestation
Conductivity
•Propagate excitation. It's measured in m/sec. Conductivity
of skeletal muscles 3 5 m/sec, smooth muscles 0.02 – 0.1
m/sec, nervous tissue 0.5 – 120 m/sec.
• Depending on the type of the nerve fibers
Lability

• A tissue's lability reflects the time

necessary to restore the tissue's work
capacity after an excitation cycle. The
greatest lability is found in the processes of
the nerve cells, the axons, which are capable
of reproducing as many as 500 or 1,000
impulses per sec.
• (from Latin "labilis" meaning unstable)
determines functional mobility of excitable
tissue. This term was introduced in physiology by
Wedensky. He defined lability as a "higher or
lower speed of elementary responses that
accompany physiological activity of the given
specific structure". According to Wedensky a
measure of lability is the largest possible number
of elementary excitation cycles which can be
reproduced by an excitable structure per unit
time in accordance with the frequency of
stimulation. If frequency of stimulation exceeds
the measure of lability, in this tissue will develop
inhibition (protective-restorative function
Contractibility
• Literally defined the term
contract infers that
something has become
smaller, shrunk or shortened.
The addition of the suffix
"ility" implies the quality of
this process. In physiology it
is the ability of muscle fibers
to shorten or change their
tension.
 Ability of
Secretion
• it is the ability for exocytosis,
that means, the release of
biologically active compounds by
the cells
 1-Nervous (Irritability -
Excitability - Conductivity –
Lability)
Different
kinds of 2-Muscular - (Irritability -
Excitability - Contractility -
excitable Conductivity -Lability)

tissue 3-Glandular - (Irritability -

Excitability - Ability to
secretion)
The main parameters of excitable tissue.

• Threshold of excitability
- is the minimum force
of stimulus required to
produce excitation in cell
or tissue.
• If the threshold of
excitability is low, it
means that the
excitability is high
(inversely proportional).
 Latent Period

• Latent period of excitation is a time interval

from the moment of application of a stimulus
to manifestation of the first signs of
excitation. If the latent period is short, it
means that the excitability is high (inversely
proportional).