Professional Documents
Culture Documents
Transport In Humans
BY: DR TAHIR
03337666554
Learning Objectives
• To understand the need for a circulatory
system
• To state the functions of blood
• red blood cells
• white blood cells
• platelets
• plasma
• To list the different ABO blood groups and
all possible combinations for the donor and
recipient in blood transfusions
The Need for a transport
system
In mammals:
Transport system = blood system +
lymphatic system
Features of the
circulatory system
vein 1. Heart
heart
artery
2. Blood
3. Blood
vessels
Blood
• Blood is a tissue
fluid
• An average human
has 5.5 litres of
blood.
• Composition of
blood
(i) Plasma (55%)
(ii) Blood cells (44%)
(iii) Platelets (1%)
Plasma
• Pale yellow liquid
• Composed mainly of water (90%)
• Soluble proteins (fibrinogen, albumin,
globulin, prothrombin, antibodies)
• Excretory products (urea, uric acid and
creatinine, carbon dioxide as bicarbonate
ions)
• Hormones (insulin)
• Food substances (glucose, amino acids, fats
and vitamins)
• Dissolved mineral salts (chlorides, sulphates
and phosphates of calcium, potassium and
sodium, hydrogencarbonates )
Red Blood Cells (Erythrocytes)
•Circular , biconcave ,
flattened disc
•Has no nucleus
•Diameter < 0.01mm
•Elastic --> so it can
squeeze through the
capillaries
• 1 mm3 = 5 million RBCs
Red Blood Cells
• Produced in the bone marrow
• Can live for 3 to 4 months
• Destroyed in the spleen and the liver
• Contain haemoglobin
• Haemoglobin = special protein containing
iron
• Allows RBCs to transport oxygen
effectively
White Blood Cells
(Leucocytes)
• Are colourless
• Do not contain
haemoglobin
• Larger than RBCs
• Fewer in number
• 1mm3= 5000 to
10000
• Irregular in shape
• Contains nucleus
• Can move
• Can change its shape and squeeze through
the walls of the capillaries
• 2 main kinds:-
(i) Lymphocytes
(ii) Phagocytes
§ Functions:-
keep the body healthy by fighting
diseases.
Normal life span is a FEW days.
Lymphocytes
• Produced in bone marrow
and mature in the lymph
nodes
• Has a large, rounded nucleus
• Small amount of non-
granular cytoplasm
• Show limited movements
• Produce antibodies
Production of antibodies
• By lymphocytes
• Attaching to bacteria and rupturing their
surface membrane
• Clumping / agglutinating bacteria together
for phagocytosis
• Neutralising toxins
• Attaching to viruses to prevent binding to
host cell.
Phagocytes
• Produced by the bone
marrow
• Ingest foreign particles
like bacteria
• Lobed nucleus and granular
cytoplasm
• Consists of monocytes and
polymorphs
Blood Platelets
(Thrombocytes)
• Not true cells
• Membrane-bound fragments of
cytoplasm from bone marrow cells
• Helps in clotting of blood
Blood Groups
Red blood cells contain:
• Antigens (surface proteins)
• Antibodies (always present in the blood)
• Antibodies react only with other antigens
Agglutination-clumping of blood
Blood Antigen on RBC Antibody in
group serum
A Antigen A Antibody b
B Antigen A Antibody a
AB Antigen A and B No
Antibodies
O No Antigen Antibodies a
and b
Recipient’s Antibody in Donor’s blood group
Blood recipient’s
group plasma
A B AB O
A a - + + -
B b + - + -
AB - - - - -
O a and + + + +
b
- No agglutination + agglutination
Transport of oxygen
• Oxygen diffuses from lungs to blood
capillaries
• Haemoglobin has great affinity for oxygen,
combine to form oxyhaemoglobin
• Oxygen diffuses in solution into tissue
cells
Functions of Blood
1. Acts as a transport medium carrying
substances from one part of the body
to another.
§ Digested food from the intestines to all
parts of the body
§ Excretory products to the excretory
organs for removal
§ Hormones from glands
§ Heat from respiring body tissues
§ Oxygen from lungs
Exchanges through tissue fluid
Acclimatisation
• At high altitudes, more rbc are
produced
• More oxygen can be transported to
tissue cells
• Long-distance runners train at high
altitudes to increase haemoglobin
Functions of Blood
2. Protects the body against disease-
causing organisms (pathogens)
• Phagocytosis
• Production of antibodies
• Clotting of blood
Phagocytosis
• Phagocytes can ingest and destroy
foreign particles that gain entry into
the blood.
• Process of engulfing and ingesting
foreign particles by the white blood
cells.
A phagocyte engulfing a bacteria
. Clotting of blood to
prevent excessive
loss of blood
• Clot seals the
wound and stops
foreign particles
from entering the
blood stream.
Mechanism of Blood Clotting
blood platelet red blood cell
wall of blood
When blood vessels are damaged, damaged
capillary
tissues and blood platelets release an
enzyme known as thrombokinase.
thrombokinase
thrombokinase
thrombokinase thrombokinase
clot
Prothrombin thrombokinase
Thrombin (active)
2 (inactive) and calcium ions
•Heart
•Blood Vessels
•Lymphatic
The Circulatory System
• Blood flow is called the blood
circulation
• 4 parts:
1. The heart
2. Arteries
3. Veins
4. Capillaries
1
The heart
• The blood is kept circulating throughout
the body by means of a muscular pump, the
heart.
heart
1
The heart
heart • The blood is kept circulating throughout
the body by means of a muscular pump, the
heart.
• When the heart relaxes, it fills up with
blood, and when it contracts, the blood is
squeezed out with great force.
1 The heart
• The blood is kept circulating throughout
the body by means of a muscular pump, the
heart heart.
• When the heart relaxes, it fills up with
blood, and when it contracts, the blood is
squeezed out with great force.
• The blood then circulates through the
blood vessels which direct the blood flow
round the body.
2 Arteries
• The blood vessels that carry blood away
from the heart are called arteries.
heart
artery
blood flowing
from the heart
2 Arteries
• The blood vessels that carry blood away
from the heart are called arteries.
heart • The large artery that leaves the left side of
the heart is the aorta. It branches to form
small arteries.
artery
blood flowing
from the heart
arteries
3 Arterioles
• These arteries branch again to form tiny
vessels called arterioles.
heart
artery
blood flowing
from the heart
arterioles arteries
3 Arterioles
• These arteries branch again to form tiny
vessels called arterioles.
heart • The arterioles divide and ultimately their
branches become very tiny blood vessels
called capillaries.
artery
blood flowing
from the heart
capillaries arteries
arterioles
4 Blood capillaries
• Capillaries are microscopic blood vessels
cut end of capillary showing that are found between the cells of almost
single layer of endothelial cells all the tissues. They have walls made up of
only a single layer of greatly flattened cells
called the endothelium.
artery
blood flowing
a capillary from the heart
network links
arteries and veins
capillaries arteries
venules arterioles
6 Veins
• Venules in turn join to form bigger veins.
Veins carry blood back to the heart.
heart
vein
artery
blood
flowing blood flowing
back to a capillary from the heart
the heart network links
arteries and veins
• Arteries
• Capillaries
• Veins
Arteries
• The blood vessels which carry blood AWAY from the
heart.
• Thick-walled, muscular, elastic
– High pressure
• Aorta > smaller arteries > arterioles > capillaries.
Arteries
• Blood vessels that
carry blood away
from the heart
• Receive blood
directly from the
heart
• Walls are thick,
muscular and elastic
• Thick elastic wall
helps to maintain
high blood pressure
Arteries
• Elasticity permits
stretching and
recoiling of the
artery wall.
• Helps to push the
blood along (pulse)
• Carry mainly
oxygenated blood
Veins
• Blood pressure is low
• Blood flows more slowly
and smoothly
• Veins are not as thick and
muscular as arteries
• Contain less elastic tissue
• Have semi-lunar valves
Veins
Capillaries
• To allow exchange of substance
• Endothelium>> selectively permeable
– Enable some substance to diffuse quickly
• Branch repeatedly
– Large surface area
– Lowers the blood pressure
Capillaries
• Network of microscopic
vessels linking an artery
and a vein.
• One cell thick
• Take nutrients, oxygen and
other useful substances to
the cells and remove waste
products produced by in
these cells.
• Easy for diffusion of
materials
• Blood flows smoothly
• No valves present.
Transfer of Materials
• Tissue liquid
• In the CAPPILARIES
<<<<
• Blood>>> bell-shaped
– Diameter decreased
– Surface area increased
– Rate of blood flow decreased
Differences
Arteries Veins Capillaries
vena
cava left
ventricle
right atrium
right 2
ventricle
aortic arch
3
pulmonary
arch bicuspid right left
valve ventricle ventricle
tricuspid
valve
pulmonary vein
1 1 • Both the atria and the ventricles
are relaxed.
left atrium
• The right atrium receives blood
vena from the venae cavae while the left
cava left atrium receives blood from the
ventricle pulmonary veins.
right atrium
right 2
ventricle
aortic arch
3
pulmonary
arch bicuspid right left
valve ventricle ventricle
tricuspid
valve
pulmonary vein 2 • The atria contract, forcing blood
1
left atrium into the ventricles.
vena left
cava ventricle
right atrium
right
ventricle 2
aortic arch
3
pulmonary
arch bicuspid left
valve ventricle
tricuspid right
valve ventricle
pulmonary vein 3 • After a short pause, the ventricles
1
left atrium contract. This is called ventricular
systole.
vena left
cava ventricle
right atrium
right
ventricle 2
aortic arch
bicuspid
valve
pulmonary right left
arch ventricle ventricle
tricuspid
valve
pulmonary vein 3 • After a short pause, the ventricles
1
left atrium contract. This is called ventricular
systole.
vena left • The increase in blood pressure
cava ventricle forces the bicuspid and tricuspid
right atrium valves to close, preventing
backflow of blood into the atria.
right This produces a loud ‘lub’ sound.
ventricle 2
aortic arch
bicuspid
valve
pulmonary right left
arch ventricle ventricle
tricuspid
valve
pulmonary vein 3 • After a short pause, the ventricles
1
left atrium contract. This is called ventricular
systole.
vena left • The increase in blood pressure
cava ventricle forces the bicuspid and tricuspid
right atrium valves to close, preventing
backflow of blood into the atria.
right This produces a loud ‘lub’ sound.
ventricle 2 • When the pressure in the left
aortic arch ventricle becomes higher than the
pressure in the aorta, the
3 semi-lunar valves in the
pulmonary and aortic arches are
forced open.
bicuspid
valve
pulmonary right left
arch ventricle ventricle
tricuspid
valve
pulmonary vein 3 • After a short pause, the ventricles
1
left atrium contract. This is called ventricular
systole.
vena left • The increase in blood pressure
cava ventricle forces the bicuspid and tricuspid
right atrium valves to close, preventing
backflow of blood into the atria.
right This produces a loud ‘lub’ sound.
ventricle 2 • When the pressure in the left
aortic arch ventricle becomes higher than the
pressure in the aorta, the
3 semi-lunar valves in the
pulmonary and aortic arches are
forced open.
• Blood flows from the left
bicuspid
ventricle into the aortic arch. As
valve
pulmonary right left the ventricles contract, the atria
arch ventricle ventricle relax.
tricuspid
valve
pulmonary vein
1 4 • The ventricles then relax. This is
ventricular diastole.
left atrium
vena
cava left
ventricle
right atrium
right 2
ventricle
aortic arch
3
pulmonary
arch bicuspid right left
valve ventricle ventricle
tricuspid
valve
pulmonary vein
1 4 • The ventricles then relax. This is
ventricular diastole.
left atrium
• The drop in pressure in the
vena ventricles causes the semi-lunar
cava left valves in the two arches to close.
ventricle This produces a soft ‘dub’ sound.
right atrium
This prevents the backflow of
blood into the ventricles.
right 2
ventricle
aortic arch
3
pulmonary
arch bicuspid right left
valve ventricle ventricle
tricuspid
valve
pulmonary vein
1 4 • The ventricles then relax. This is
ventricular diastole.
left atrium
• The drop in pressure in the
vena ventricles causes the semi-lunar
cava left valves in the two arches to close.
ventricle This produces a soft ‘dub’ sound.
right atrium
This prevents the backflow of
blood into the ventricles.
right 2 • The drop in pressure in the
ventricle ventricles also causes the bicuspid
valves to open.
aortic arch
3
pulmonary
arch bicuspid right left
valve ventricle ventricle
tricuspid
valve
pulmonary vein
1 4 • The ventricles then relax. This is
ventricular diastole.
left atrium
• The drop in pressure in the
vena ventricles causes the semi-lunar
cava left valves in the two arches to close.
ventricle This produces a soft ‘dub’ sound.
right atrium
This prevents the backflow of
blood into the ventricles.
right 2 • The drop in pressure in the
ventricle ventricles also causes the bicuspid
valves to open.
aortic arch
• The whole cycle (1-4) then
3
repeats.
pulmonary
arch bicuspid right left
valve ventricle ventricle
tricuspid
valve
Main blood vessels of the
body
• Pulmonary artery
• Aortic arch
• Hepatic artery (liver)
• Renal artery (kidney)
• Pulmonary vein
• Vena cava (anterior and posterior)
• Hepatic vein
• Renal vein
• Hepatic portal vein
The
main
arteries
and
veins
Lymph and the Lymphatic System
Blood
TRANSPORT SYSTEM IN
MAMMALS
consists of
Blood
Consists of:
• Red blood
cells •
White blood cells
• Platelets
•
Plasma
TRANSPORT SYSTEM IN
MAMMALS
consists of
Blood
Consists of:
• Red blood
cells •
White blood cells
• Platelets
•
Circulates from:
Plasma
• Heart to lungs and
back (pulmonary
circulation)
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
Consists of:
• Red blood
cells •
White blood cells
• Platelets
•
Circulates from:
Plasma
• Heart to lungs and
back (pulmonary
circulation)
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
Consists of:
• Red blood
cells •
White blood cells
• Platelets
•
Circulates from:
Plasma
• Heart to lungs and
back (pulmonary
circulation)
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
Arteries
Consists of:
• Red blood
cells •
White blood cells
• Platelets
•
Circulates from:
Plasma
• Heart to lungs and
back (pulmonary
circulation)
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
Arteries
branch into
Consists of:
• Red blood
cells •
White blood cells
• Platelets
•
Circulates
Plasma from:
• Heart to lungs and
back (pulmonary
circulation)
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
Arteries Arterioles
Arteries Arterioles
branch into
Consists of:
• Red blood
cells •
White blood cells
• Platelets
•
Circulates
Plasma from:
• Heart to lungs and
back (pulmonary
circulation)
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood
cells •
White blood cells
• Platelets
•
Circulates
Plasma from:
• Heart to lungs and
back (pulmonary
circulation)
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood Atria
cells •
White blood cells
• Platelets
•
Circulates
Plasma from:
• Heart to lungs and
back (pulmonary
circulation)
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood Atria
cells •
White blood cells
• Platelets
•
Circulates
Plasma from:
• Heart to lungs and
back (pulmonary
circulation)
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood Atria
cells •
White blood cells
• Platelets right
•
Circulates
Plasma from:
• Heart to lungs and
back (pulmonary
circulation)
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood Atria
cells •
White blood cells
• Platelets right
•
Circulates
Plasma from: receives
• Heart to lungs and deoxygenated
back (pulmonary blood from the
circulation) rest of the body
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood Atria
cells •
White blood cells
• Platelets right left
•
Circulates
Plasma from: receives
• Heart to lungs and deoxygenated
back (pulmonary blood from the
circulation) rest of the body
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood Atria
cells •
White blood cells
• Platelets right left
•
Circulates
Plasma from: receives receives
• Heart to lungs and deoxygenated oxygenated
back (pulmonary blood from the blood from
circulation) rest of the body the lungs
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood Atria Ventricles
cells •
White blood cells
• Platelets right left
•
Circulates
Plasma from: receives receives
• Heart to lungs and deoxygenated oxygenated
back (pulmonary blood from the blood from
circulation) rest of the body the lungs
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood Atria Ventricles
cells •
White blood cells
• Platelets right left
•
Circulates
Plasma from: receives receives
• Heart to lungs and deoxygenated oxygenated
back (pulmonary blood from the blood from
circulation) rest of the body the lungs
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood Atria Ventricles
cells •
White blood cells
• Platelets right left right
•
Circulates
Plasma from: receives receives
• Heart to lungs and deoxygenated oxygenated
back (pulmonary blood from the blood from
circulation) rest of the body the lungs
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood Atria Ventricles
cells •
White blood cells
• Platelets right left right
•
Circulates
Plasma from: receives receives pumps
• Heart to lungs and deoxygenated oxygenated deoxygenated
back (pulmonary blood from the blood from blood into the
circulation) rest of the body the lungs lungs
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood Atria Ventricles
cells •
White blood cells
• Platelets right left right left
•
Circulates
Plasma from: receives receives pumps
• Heart to lungs and deoxygenated oxygenated deoxygenated
back (pulmonary blood from the blood from blood into the
circulation) rest of the body the lungs lungs
• Heart to the rest of
the body and back (systemic
circulation)
TRANSPORT SYSTEM IN
MAMMALS
consists of
branch into branch into join up to form join up to form is divided into
chambers
Consists of:
• Red blood Atria Ventricles
cells •
White blood cells
• Platelets right left right left
•
Circulates
Plasma from: receives receives pumps pumps
• Heart to lungs and deoxygenated oxygenated deoxygenated oxygenated
back (pulmonary blood from the blood from blood into the blood to the
circulation) rest of the body the lungs lungs rest of the
• Heart to the rest of body
the body and back (systemic
circulation)