MULTIBLE CHOICE

QUESTIONS
Questions:
▰ Q1. Which is not a mediator of innate immunity:

a. T cells

b. NK cells

c. B1 cell

d. Neutrophil

2
Questions:
▰ Q2. Primary immune response - the correct statement is:

a. Involves IgG

b. Antibody producing cells- Memory B cell

c. No lag period

d. Slow and sluggish

3
Questions:
▰ Q3. Toll-like receptor is a component of:

a. Innate immunity

b. Acquired immunity

c. Active immunity

d. Passive immunity

4
Questions:
▰ Q4. Acute phase reactant proteins are all, except::

a. Serum amyloid A

b. C-reactive protein

c. Fibrinogen

d. Coagulase

5
Questions:
▰ Q5. Superantigen causes:

a. Enhancement of phagocytosis

b. Polyclonal activation of B cells

c. Antigen presentation by macrophage

d. Activation of complement

6
Questions:
▰ Q6. Which part of the bacteria is most antigenic:

a. Protein

b. Carbohydrate

c. Lipid

d. Nucleic acid

7
Questions:
▰ Q7 Which of the following antigen is T-dependent:

a. Bcaterial capsule

b. Flagella

c. Lipopolysaccharide

d. Exotoxin

8
Questions:
▰ Q8. Diagnostic application of heterophile antigens include all, except:

a. Weil-Felix reaction

b. Paul-Bunnell test

c. Widal test

d. Cold agglutination test

9
Questions:
▰ Q9. C-3 convertase in alternative complement pathway is:

a. C14b2a

b. C3bBb

c. MBL/MASP-C4b2a

d. C3b

10
Questions:
▰ Q10. Endotoxin acts by:

a. Classical pathway

b. Lectin pathway

c. Alternative pathway

d. None

11
Questions:
▰ Q11. Early complement deficiency is a predisposing factor for all, except:

a. Systemic lupus erythematosus (SLE)

b. Disseminated Neisseria infection

c. Glomerulonephritis

d. Pyogenic infections

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Questions:
▰ Q12. T cell area of lymph node is:

a. Cortex

b. Medulla

c. Paracortical area

d. All of the above

13
Questions:
▰ Q13. Cell type which lacks HLA antigen is:

a. Monocyte

b. Thrombocyte

c. Neutrophil

d. RBC

14
Questions:
▰ Q14. Which of the following represents the T cell area of spleen:

a. Periarteriolar lymphoid sheath (PALS)

b. Marginal zone

c. Red pulp

d. All of the above

15
Questions:
▰ Q15. M cells act as the portal of entry of following microbes, except:

a. Salmonella

b. Shigella

c. E. histolytica

d. Poliovirus

16
Questions:
▰ Q16. The phenomenon of receptor editing occurs during: :

a. B cell development

b. T cell development

c. NK cell development

d. Macrophage development

17
Questions:
▰ Q17. Cell-mediated immunity is by virtue of:

a. NK cell

b. Eosinophil

c. Cytotoxic T cells

d. All above

18
Questions:
▰ Q18. Perforins are produced by:

a. Plasma cells

b. Suppressor T cells

c. Cytotoxic T cells

d. Memory helper T cells

19
Questions:
▰ Q19. Professional antigen-presenting cells (APCs) include all, except:

a. Dendritic cells

b. Macrophages

c. Fibroblasts (skin)

d. B cells

20
Questions:
▰ Q20. Type I hypersensitivity is mediated by which of the following
immunoglobulins:

a. IgA

b. IgG

c. IgM

d. IgE
21
Questions:
▰ Q21. Type of hypersensitivity reaction in myasthenia gravis is:

a. Type I

b. Type II

c. Type III

d. Type IV

22
Questions:
▰ Q22. Example of antibody-dependent cellular dysfunction or ADCD:

a. Graves’ disease

b. Hemolytic anemia

c. Pemphigus vulgaris

d. Transfusion reaction

23
Questions:
▰ Q23. Autoimmunity can be caused due to all of the following, except:

a. Pressure of forbidden clones

b. Expression of cryptic antigens

c. Negative selection of T- cells in the thymus

d. Release of sequestered antigens

24
Questions:
▰ Q24. Autoantibodies bind to basement-membrane antigens on kidney
glomeruli and the alveoli. This is the hallmark of:

a. Goodpasture syndrom

b. Myasthenia gravis

c. Graves’ disease

d. Hashimoto’s thyroiditis
25
Questions:
▰ Q25. Anti-citrullinated peptide antibodies (ACPA) are diagnostic for:

a. Systemic lupus erythematosus (SLE)

b. Rheumatoid arthritis

c. Sjögren syndrome

d. Scleroderma

26
Questions:
▰ Q26. Chronic granulomatous disease is due to deficiency of:

a. Tyrosine kinase

b. NADPH oxidase

c. Adenosine deaminase

d. Myeloperoxidase

27
Questions:
▰ Q27. Wiskott–Aldrich syndrome (WAS): All are true, except:

a. Thrombocytopenia

b. Low IgA and IgE

c. Defective response to bacterial polysaccharides

d. Prone to develop non-Hodgkin B-cell lymphomas

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Questions:
▰ Q28 Ataxia telangiectasia all are true, except:

a. Difficulty in maintaining balance while walking

b. Telangiectasia

c. Hyper IgA

d. Profound sinopulmonary infections

29
Questions:
▰ Q29. Chronic granulomatous disease is due to deficiency of:

a. Tyrosine kinase

b. NADPH oxidase

c. Adenosine deaminase

d. Myeloperoxidase

30
Questions:
▰ Q30. Wiskott–Aldrich syndrome (WAS): All are true, except:

a. Thrombocytopenia

b. Low IgA and IgE

c. Defective response to bacterial polysaccharides

d. Prone to develop non-Hodgkin B-cell lymphomas

31