Autoimmunity :

To :Dear
Rheumatoid Arthritis Vandana
ma’am
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 Overview

01 02 03
Autoimmunity Types of autoimmunity Rheumatoid
arthritis

04 05 06
Symptoms and cure Facts References
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 Autoimmunity
● The immune system could go awry and, instead of reacting
against foreign antigens,
could focus its attack on self-antigens.
● “Horror autotoxicus.”
● Mechanism of self-tolerance normally protect an individual
from potentially self-reactive lymphocytes, there are failures.
Serge I. They result in an inappropriate response of the
metalnikoff immune
system against self-components termed
autoimmunity.
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 What actually happens?
Not all self-reactive lymphocytes are deleted during T-cell and B-
cell maturation. Instead,
normal healthy individuals have been shown to possess mature,
recirculating, self-reactive lymphocytes. Since the presence of these self-
reactive lymphocytes in the periphery does not inevitably result in
autoimmune reactions, their activity must be regulated in normal
individuals through clonal suppression. Breakdown in this regulation can
lead to activation of self-reactive clones of T or B cells, generating humoral
or cell-mediated responses against self-antigens.
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 Types
1) Organ specific
2) Systemic
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- Paul Ehrlich
 Rheumatoid Arthritis

01
Many individuals with rheumatoid arthritis produce a
group of auto-antibodies called rheumatoid factors that
are reactive with determination the Fc region of IgG. The
classic rheumatoid factor is an IgM antibody with that
reactivity. Such auto-antibodies bind to normal circulating
IgG, forming IgM-IgG complexes that are deposited in the
joints. These immune complexes can activate the
complement cascade, resulting in a type III hypersensitive
reaction, which leads to chronic inflammation of the joint.
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Figure
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Did you know?
There’s more to it

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There’s more to it

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Did you know?
There’s more to it

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 Symptoms

The major symptom is chronic

inflammation of the joints,
although the hematologic,
cardiovascular, and respiratory
systems are also frequently
affected.
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 Facts..
In the name of cure we only have presence of immunosuppresent.

Physiotherapy and medication can help slow the disease‘s progression

Self care, therapy and surgery’s are some other options.

It is more common in women of age between 35 and 50 years old but it can start at
any age.

It can effect any joint but is particularly common in your hands and feet.

Joints are swollen painful and stiff in the morning and often becomes deformed after
many years.
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 Some facts

There are more than females are

100
autoimmune diseases.
60% 3x
Chances of heart attack More susceptible than
man

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 Do you have any

Thank questions?
● Don’t ask.
● Just kidding!!

you!
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