مادة الصيدالنيات Prepared By: • Takwa Morad Shlaki Drugs • Drug is any chemical substance that affects the functioning of living organisms. • This includes not only humans but also bacteria, fungi, and viruses. • Drugs can be natural (derived from plants or other biological sources) or synthetic (created in laboratories) Medicine • Medicine ( pharmaceutical drug) is a chemical substance typically of known structure, used to treat, cure, prevent, or diagnose a disease or to promote well-being.
• Traditionally drugs were obtained through extraction from medicinal
plants, but more recently also by organic synthesis. • Pharmaceutical drugs may be used for a limited duration, or on a regular basis for chronic disorders. Difference Between a Drug and a Medicine • the purpose of a medicine is benign; it’s a product produced and regulated to impart a positive medical effect on a patient.
• A medicine also tends to have many different components. In addition
to the active ingredient, medicines also contain other substances, called excipients, that assist in the formulation and efficacy of that medicine for the patient. • A drug, in contrast to a medicine, can have a positive or negative effect on a patient.
• For example, heroin is a drug, in that it’s a substance that causes a
specific biological effect. Heroin is not, though, categorized as a substance that “prevents, alleviates or cures a symptom, ailment or disease state”. In that sense, heroin is a not a medicine. • Both drugs and medicines can be poisons, though. This depends on the dose of the drug and/or medicine. “All things are poisons and nothing is without poison, only the dosage makes a thing not poison”. All Medicines are Drugs, whereas not all Drugs are Medicines. Nomenclature of Drugs ● Drug have three different names :
Chemical name : Based on the chemical composition and structure.
Non proprietary(Generic) name : This is usually the abbreviated form of the chemical name ,This name is used and chosen by official bodies. Proprietary (Brand, Company) name : the name given by the company which markets the drug . Sources of Drugs 1. Natural Source : Animal sources. Plants Sources. Mineral/ Earth sources. Microbiological sources. 2. Semi synthetic sources. 3. Synthetic sources. 4. Bio-Synthetic sources. Classification of Drugs ● Drugs are classified based on : 1. Chemical Nature 2. Sources 3. Target Organ/Site of Action 4. Mode of Action 5. Therapeutic Uses 6. Physiological System 7. Physical Effect Dosage Forms ● Definition : Dosage Forms are means by which drug molecules are delivered to sites of action within the body . ● Drug (Active pharmaceutical ingredients, API):chemical compound intended for used in diagnosis , treatment or prevention of diseases. ● Excipients : inactive pharmaceutical ingredients used to technological , biopharmaceutical and stability reasons.
Dosage form = drug(API) + Excipients
Classification of Dosage form ● Basically, there are 4 types of dosage forms :
Solid Dosage Form
Semi-solid Dosage Form Liquid Dosage Form Gaseous Dosage Form Solid Dosage Form ● Solid dosage forms are one type of dosage form, It's solid in nature and contains one or more drugs for therapeutic effects and excipients like binding agents, sweetening agents, coloring agents, etc.
Example of solid dosage form:
Tablets, capsules, granules, sachets, powders, powder for inhalation, etc Semi-solid Dosage Form: ● Semisolid dosage forms are that types of dosage forms that contain both solid and liquid. It is used for therapeutic, protective, or cosmetic functions. It may be applied to the skin, nasal, vaginal, or rectal cavity. Normally used for topical or external application. ● Examples of semi-solid dosage forms: Ointments, pastes, cream, plasters, gels, and rigid foams. Liquid Dosage Form: ● The liquid form of a drug dose for administration or consumption. The route of administration may be oral, intravenous, intramuscular, cutaneous, subcutaneous, etc.
Examples of semi-solid dosage forms: Syrup, mixture, linctuses, elixirs,
parenteral preparations, etc. Gaseous Dosage Form: ● Gaseous dosage forms are gas in nature. In the form of gas, therapeutically active medicaments are present in it. It may be applied for internal as well as external purposes like skin, nose, mouth, etc.
Examples of semi-solid dosage forms: Sprays, vaporizers, Aerosols,
nebulizers, Inhalers, etc. Classification Dosage form ● According to the route of administration, there are : Oral Dosage Form Topical Dosage Form Rectal Dosage Form Parenteral Dosage Form Vaginal Dosage Form Inhaled Dosage Form Ophthalmic Dosage Form Otic Dosage Form Nasal Dosage Form Pharmacology • Pharmacology is the scientific study of how a drug affects a biological system and how the body response to the drug encompasses various aspects, such as: Pharmacology Mechanism of action: How drugs work at the molecular level. Physical and chemical properties: Understanding drug characteristics. Metabolism: How the body processes and breaks down drugs. Therapeutics: Clinical applications of drugs. Toxicity: Potential harm caused by drugs Thank you !