BO CO TH NGHIM HU C

H v tn SV: on c Minh MSSV : 60801245 Lp : HC08CHC Nhm : 04 Chiu T.5 GVHD: L V H

Bi 6: Tng hp Aspirin
Ngy TN:

1. Ni dung th nghim: Tng hp aspirin t acid salicilic v anhydrit acetic bng phn ng ester ha vi xc tc H2SO4 . 2. C ch phn ng, phn ng chnh, phn ng ph: a. Phn ng chnh:

b. C ch phn ng:

3. Tnh cht nguyn liu, sn phm: Dng Lng, khng mu Tinh th Lng, khng mu Lng, khng mu Tinh th tan /100g H2O V hn

Tn Anhydrit acetic

m(v) 7ml

Hm lng 95%

d(g/ml) 1,081

Tnc 0 C 16,7

Ts C

139

Acid salicilic H2SO4

5g 0,5ml

100% 98% 1,873

158 10,5 330

0,32g V hn V hn

Etanol

20ml

96%

0,802

-112

78,4

Aspirin

135

0,33g

4. S khi th nghim:

5g acid salicilic 7ml anhydrit acetic 0,5ml H2SO4

un cch thy

- Khuy u - T0C: 50600C - t = 15 pht - Khuy u - Gi nhit phng

Lm ngui 120ml H2O Lc chn khng

20ml Etanol nng

Ha tan

Thm 75ml H2O m

ngui

Lc chn khng

Acetic acetyl salicilic (Aspirin)

5. S lp rp dng c:

1. Phiu 2. Bnh lc chn khng 3. Bnh ht m 4. My ht chn khng

S lc chn khng 6. Tnh ton kt qu l thuyt: S mol acid salicilic: nacid salicilic= m/ M = 5/138 = 0,036 mol S mol Anhydrit acetic: nanhydrit acetic= (dxV)/M = (1,081x7) /102 = 0,074mol T phn ng (1): nAspirin= nacid salicilic= 0,036 mol Khi lng sn phm theo l thuyt:

msp= 0,036 x180 = 6,48g