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  • Diclofenac Sodium (Drug Monograph)

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    Muhammad Arsalan
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    Diclofenac sodium/potassium is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, rheumatoid arthritis, osteoarthritis, and other conditions. It works by inhibiting prostaglandin synthesis. Common adverse reactions include gastrointestinal issues like abdominal cramps and indigestion. It should be used cautiously in patients with certain medical conditions and contraindicated in those with NSAID hypersensitivity or porphyria. The adult dose for analgesia is 50 mg 3 times daily and for rheumatoid arthritis is 150-200 mg daily in divided doses.

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    Precise drug information

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    Diclofenac Sodium (Drug Monograph)

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    Diclofenac sodium/potassium is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, rheumatoid arthritis, osteoarthritis, and other conditions. It works by inhibiting prostaglandin synthesis. Common adverse reactions include gastrointestinal issues like abdominal cramps and indigestion. It should be used cautiously in patients with certain medical conditions and contraindicated in those with NSAID hypersensitivity or porphyria. The adult dose for analgesia is 50 mg 3 times daily and for rheumatoid arthritis is 150-200 mg daily in divided doses.

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    Download as DOCX, PDF, TXT or read online from Scribd
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    73 views1 page

    Diclofenac Sodium (Drug Monograph)

    Uploaded by

    Muhammad Arsalan
    Diclofenac sodium/potassium is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, rheumatoid arthritis, osteoarthritis, and other conditions. It works by inhibiting prostaglandin synthesis. Common adverse reactions include gastrointestinal issues like abdominal cramps and indigestion. It should be used cautiously in patients with certain medical conditions and contraindicated in those with NSAID hypersensitivity or porphyria. The adult dose for analgesia is 50 mg 3 times daily and for rheumatoid arthritis is 150-200 mg daily in divided doses.

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    Drug Monograph Diclofenac Sodium/potassium

    Generic name: Diclofenac sodium or diclofenac potassium Brand Names: Cataflam Oral; Voltaren Ophthalmic; Voltaren Oral; Voltaren-XR Oral Pharmacological category: NSAID Indications/ uses: Acute treatment of mild to moderate pain; acute and chronic treatment of rheumatoid arthritis and osteoarthritis; used for juvenile rheumatoid arthritis, gout, dysmenorrhea; ophthalmic solution for postoperative inflammation after cataract extraction Mechanism of action: Inhibits prostaglandin synthesis by decreasing the activity of the enzyme, cyclooxygenase, which results in decreased formation of prostaglandin precursors

    Adverse reactions:
    Common: Rare: Cardiovascular: Angina pectoris, arrhythmias Central nervous system: Dizziness, nervousness Dermatologic: Itching Gastrointestinal: GI ulceration, vomiting Genitourinary: Vaginal bleeding Otic: Tinnitus (perception of sound in ear in absence of external sound) Dermatologic: Rash Gastrointestinal: Abdominal cramps, heartburn, indigestion, nausea

    Warnings/precautions: Use with caution in patients with congestive heart failure, dehydration, hypertension, decreased renal or hepatic function, history of GI disease, or those receiving anticoagulants Contraindications: Known hypersensitivity to diclofenac, any component, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs); porphyria Pregnancy Category: B (no evidence of risk)

    Dose:
    Adult Dose: Analgesia: Starting dose: 50 mg 3 times/day Rheumatoid arthritis: 150-200 mg/day in 2-4 divided doses

    Child Dose: Not recommended


    Reference: Lexicomp

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