Epoetin Alpha

1.
Epoetin Alpha (EPO; Erythropoietin)
2.

Eprex

3. ,

Injection solution; Prefilled Syringe

6000, 4000 3000 U/ml; 1

ml

4.

Erythropoietic drug; Hematopoietic drug;

Antianemics

5.

Anemia
,


,
,
Zidovudine,

Anemia

6.

IV SC
50-100 U/kg 1-3

( hemoglobin
2
g/dl )

25 U/kg
4

hemoglobin
2

g/dl
50 U/kg
3
1 1
-

200 U/kg 1-3

maintainance dose
Dialysis : 75 U/kg 3

Nondialysis : 75-150 U/kg

3
-

hemoglobin

10-12
g/dl

IV infusion

7.

erythropoietin

(tissue oxygenation)

Erythropoietin endogeneous
glycoprotein hormone

Eprex purified glycoprotein

biological activity
immunological reactivity
human erythropoietin

Eprex

(Erythropoiesis)

close precursors of
nature erythrocites late erythroid
progenitor cells

8.

C;

9.

Human
albumin /

10.

ischemic vascular disease,

hemoglobin serum
electrolytes

hemoglobin

2 g/dl
hemoglobin

potassium


hyperkalemia

dialysis prescription

11.

28.6%

Thrombosis vascular access

sites 13.0%

Flu-like symptoms,


7.6 %
12.

, >10%

13.

2-8

Single-use vials; 1ml

2

Multiple dose vials; 2 ml

1

14.

IV Half life
4
7-8

SC Half life
28

15.

1 Prefilled Syringes = 1,921 (

VAT 7%)

16.

ED ()

17.

1)

(National Drug Committee).

.. 2547. :
; 2547.
2)

Lacy CF, Armstrong LL, Gddman MP,

Lance LL. Drug information handbook.
th

11 ed. Ohio: Lexi-Comp; 2007-8.

3)

MIMs annual Full Prescribing

Information. 14 Edition (3) 2005.

th

4)

http://www.thomsonhc.com

5)

Eprex
Prefilled Syrings 6000 U/ml
- , 2551.