Pharmaceutics Exam 2 Example Problems 0.15 grams of compound X in 100ml of octanol is shaken with 10 ml of water.

After equilibrium was achieved, the water layer contained 0.067 grams of compound X. What is the partition co-efficient [K] of compound X?

500ml of a 0.2 M aqueous solution of Drug A [mol wt = 225] is extracted with 100ml of ether. If the partition co-efficient, K1 = 35, how many grams of drug solution remain in water after extraction?

If 30ml [V1] of water containing 15 mg (W) of salicylate is extracted with 30 ml (V2) of chloroform, 2.59 mg (W1) of salicylate remains in the water layer. Assuming water and chloroform are immiscible, what is the distribution or partition co-efficient of salicylate in the chloroform water solvent system?

At 350 C, the vapor pressure of water is 43.4 mmHg. What is the vapor pressure of a 1.00 molal solution of NaCl?

The normal boiling point of benzene is 80.1C. It has a boiling point elevation constant of 2.53C/m. If we make up a 0.500 molal solution of Br2 in benzene, what is the boiling point of the mixture?

What is the freezing point of a solution containing 1.8g of glucose an 1L of water? Kf is 1.86, Mw of glucose is 180

The freezing point of a solution which contains 1.00 G of an unknown compound, A, dissolved in 10.0 G benzene is 2.070C. The freezing point of pure benzene is 5.480C. The molal freezing point depression constant of benzene is 5.120C/molal. What is the Mw of the unknown compound?

Two grams of glucose, Mw 180 is dissolved in 250 ml solution at 250C. What is the osmotic pressure of the solution?

What amount of NaCl is required to adjust the tonicity of a 1L bag containing a 1% w/v morphine sulfate (5 H20) (mol wt = 759, E-value, or NaCl equivalent value = 0.11) so that it is an isotonic solution?

How many milligrams each of NaCl and chloramphenicol are required to prepare 500 ml of a 1% solution of chloramphenicol isotonic with blood?

12.1 grams of a new drug was dissolved in water to make up a 750ml solution. At 250C the osmotic pressure was 0.6 atm. What is the Mw of the solute?

From the table, we see that the plasma conc of Cl- ions is 103 mEq/L. Suppose you want to make 500mL of an aqueous solution of KCl, which has the same concentration of chloride ions. How many milligrams of KCl would you add? The equivalent weight of KCl is the same as its molecular weight, which is 74.5 g/Eq.

Calculate the Milliequivalent weight of aluminum sulfate