Biofarmasi 3 (2): 57-60, Agustus 2005, ISSN: 1693-2242

2005 Jurusan Biologi !I"A #NS Sura$arta

Pengaruh Ekstrak Rimpang Kunyit (Curcuma domestica Val.)
terhadap Peningkatan Kadar SGOT dan SGPT Tikus Putih (Rattus
norvegicus) akibat Pemberian Asetamin!en
Effects of turmeric extract ("ur#uma dmesti#a Val.) on the increase of SGOT
and SGT level in the mice (Rattus nr$egi#us) due to the acetamino!hen
administration
%ARTO&O
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( )*A &+R,AT)
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( -A&. )KASAR)
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( ,)R.A&TO
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1
a$ultas %&'o$t&ran #ni(&rsitas S&)&las !ar&t (#NS) Sura$arta 57126
2
Jurusan Biologi !I"A #ni(&rsitas S&)&las !ar&t Sura$arta (#NS) Sura$arta 57126

%or&s*on'&nsi: Jl+ Ir Suta,i 36A Sura$arta 57126+ -&l+ . a/+: 062-271-664171+ &,ail: 2 ar to n o3$un s 45a 2 oo+ 6o,
7it&ri,a: 17 !&i 2005+ 7is&tu8ui: 15 Juni 2005+
"#stract. -ur,&ri6 (Curcuma domestica 9al.) 6ontains a *&6uliar su)stan6& 6all&' kurkumin t2at )&ars ,&'i6al ,&rit+
-2& r&sults o3 (arious t5*&s o3 stu'5 :it2 kurkumin s2o: t2at it is a)l& to r&stor& 'a,ag&' l&(&r 6&lls; t2&r&3or&, it is
*r&'i6t&' t2at t2& tur,&ri6 &/tra6t also )&ars t2& sa,& a)ilit5+ -2is stu'5 ai,s at 3in'ing out :2&t2&r t2&r& is an &33&6t
o3 t2& tur,&ri6 &/tra6t on t2& in6r&as& o3 S<=- an' S<"- l&(&l in t2& ,i6& 'u& to t2& a6&ta,ino*2&n a',inistration+-2is
is an &/*&ri,&ntal stu'5 :it2 a post-test only controlled group design+ -2& r&s&ar62 us&' :&r& 20 ,al& ,i6& (Rattus
norvegus), Strain >istar, ag&' 0 2 ,ont2s ol', :&ig2&' 150 gra,s+ -2&5 :&r& 'i(i'&' into 4 grou*s, an' &a62 grou*
6onsist&' o3 4 ,i6&+ <rou* 1 :as 6ontrol grou*+ <rou* 2 :as &/*os&' to on&-ti,& a',inistration o3 a6&ta,ino*2&n :it2
t2& to/i6 'osag& o3 1+35 gra,s o(&r &a62 $ilogra, o3 )o'5 :&ig2t+ <rou*s 3 an' 4 :&r& &a62 gi(&n tur,&ri6 &/tra6t :it2
t2& 'osag& o3 5 ,illigra,s an' 10 ,illigra,s o(&r &a62 $ilogra, o3 )o'5 :&ig2t r&s*&6ti(&l5; a3t&r t:o 2ours, t2&5 :&r&
su)8&6t to on&-ti,& a6&ta,ino*2&n a',inistration :it2 t2& 'osag& o3 1+35 gra,s o(&r &a62 $ilogra, o3 )o'5 :&ig2t+
7ata gat2&ring :as t2&n 6on'u6t&' 3ollo:ing 41 2ours o3 t2& lat&st tr&at,&nt )5 ta$ing t2& )loo' sa,*l&s o3 t2& ,i6&
t2roug2 t2&ir sinus orbitalis+ -2& )loo' sa,*l&s 3ro, t2& 4 grou*s :&r& t2&n &/a,in&' 3or t2&ir l&(&l o3 S<=- an' S<"-
:it2 a $in&ti6 ,&t2o'+-2& 'ata :&r& anal5?&' )5 ,&ans o3 AN=9A 3ollo:&' )5 "ost @o6 -&st using -u$&5 t&st 6o,*l&t&'
:it2 2o,og&nous su)s&ts+ -2& r&sults s2o: a signi3i6ant &33&6t o3 t2& tur,&ri6 &/tra6t on t2& in6r&as& o3 t2& S<=- an'
S<"- l&(&l in t2& ,i6& 'u& to t2& a6&ta,ino*2&n a',inistration+
Key 0rds: tur,&ri6, S<=-AS<"-, a6&ta,ino*2&n, ,i6&+
PE&*A%+1+A&
%un5it (Curcuma domestica 9al+) ,&ru*a$an
8&nis t&,u-t&,uan 5ang ,&ngan'ung kurkuminoid,
5ang t&r'iri atas s&n5a:a kurkumin 'an turunann5a
5ang ,&li*uti desmetoksikurkumin 'an bisdesme-
toksikurkumin (Brnita 'an Cos5i'a2, 2000)+
Kurkuminoid ,&ru*a$an )a2an a$ti3 'ala, ri,*ang
$un5it 5ang ,&,*un5ai a$ti(itas )iologis )&r-
s*&$tru, luas, 5ang sala2 satun5a anti2&*atoto$si$
(Su8atno, 1997)+ %un5it t&la2 'i$&nal 'an 'i,an-
3aat$an ol&2 ,as5ara$at s&6ara luas )ai$ 'i *&r-
$otaan ,au*un 'i *&'&saan t&ruta,a 'ala, ru,a2
tangga $ar&na )&r)agai ,a6a, $&gunaann5a+
Bagian 'ari $un5it 5ang t&ruta,a 'i,an3aat$an
a'ala2 ri,*angn5a 5aitu )an5a$ 'i,an3aat$an
untu$ $&*&rluan ra,uan o)at tra'isional, )a2an
*&:arna t&$stil, )u,)u *&n5&'a* ,asa$an,
r&,*a2-r&,*a2, 'an )a2an $os,&ti$+ !an3aat
ri,*ang $un5it s&)agai o)at tra'isional antara lain
untu$ o)at gatal, $&s&,utan, gusi )&ng$a$, lu$a,
s&sa$ na*as, sa$it *&rut, )isul, $u'is, &n6o$, sa$it
$uning, ,&,*&r)ai$i *&n6&rnaan, anti'iar&,
*&na:ar ra6un, 'an s&)again5a (Cu$,ana, 1999)+
7ari *&n&litian s&)&lu,n5a t&la2 'i$&ta2ui
)a2:a &$stra$ t&,ula:a$ (Curcuma xanthorrhiza
Co/)) 'a*at ,&n6&ga2 $&rusa$an 2ati a$ut 5ang
'iin'u$si ol&2 DDl
4
'an as&ta,ino3&n *a'a ,&n6it
(Ein et al+, 1995)+ S&lain itu 8uga t&la2 'i$&ta2ui
&3&$ 2&*ato*rot&$ti3 'ari &$stra$ t&,u *uti2
(Curcuma zedoaria Cos6) a$i)at *&,)&rian
as&ta,ino3&n *a'a ti$us *uti2 8antan (Nurro62,a'
'an !ur:anti, 2000)+
Ag&n 2&*atoto$si$ antara lain as&ta,ino3&n+
"&nggunaan as&ta,ino3&n s&)agai analg&ti$ 'an
anti*ir&ti$ t&la2 'i$&nal ol&2 ,as5ara$at u,u, 'an
)an5a$ 'i8ual )&)as 'i *asaran+ @al ini
,&n5&)a)$an '&ngan ,u'a2n5a ,as5ara$at
,&ng$onsu,sin5a tan*a 2arus ,&ngguna$an r&s&*
'o$t&r 'an *&ng&ta2uan ,as5ara$at ,&ng&nai o)at
ini ,asi2 sangat $urang t&ruta,a t&ntang
to$sisitasn5a )ila 'iguna$an 'ala, 'osis )&rl&)i2an+
A$i)atn5a, o)at t&rs&)ut s&ring 'i$onsu,si 'ala,
'osis )&rl&)i2an sa,*ai ,&n6a*ai 'osis to$si$
s&2ingga ,&n5&)a)$an 2&*atoto$sisitas, 5ang
'itan'ai '&ngan $&nai$an $a'ar Serum lutamic
!xaloacetic "ransaminase (S<=-) 'an Serum
lutamic #yruvic "ransaminase (S<"-), laktat
51
Biofarmasi 3 (2): 57-60, Agustus 2005
dehidrogenase, $a'ar )iliru)in s&ru, s&rta
*&,an8angan ,asa *rotro,)in (>il,ana 'ala,
Nurro62,a' 'an !ur:anti, 2000)+
S&ru, transa,inas& a'ala2 in'i$ator 5ang *&$a
*a'a $&rusa$an s&l-s&l 2ati+ %&nai$an $a'ar
transa,inas& s&ru, 'is&)a)$an ol&2 s&l-s&l 5ang
$a5a a$an transa,inas& ,&ngala,i n&$rosis atau
2an6ur+ Bn?i,-&n?i, t&rs&)ut ,asu$ $& 'ala,
*&r&'aran 'ara2+ %a'arn5a 'ala, 'ara2 ti'a$
2an5a 'is&)a)$an ol&2 $&rusa$an 2ati $ar&na
&n?i,-&n?i, t&rs&)ut t&ruta,a <=- 8uga t&r'a*at
*a'a organ-organ tu)u2 5ang lain+ @al-2al 5ang
'a*at ,&ning$at$an $a'ar S<=- 'an S<"- antara
lain *&n5a$it 8antung, gin8al, trau,a otot 5ang
)&rat, 'an *&n5a$it *a'a saluran *&n6&rnaan
(S*&i62&r 'an S,it2, 1996)+
7&ngan a'an5a $an'ungan s&n5a:a kurkumin
'ala, $un5it, ,a$a *&nulis ingin ,&ng&ta2ui a*a-
$a2 a'a *&ngaru2 &$stra$ ri,*ang $un5it t&r2a'a*
*&ning$atan $a'ar S<=- 'an S<"- ti$us *uti2
(Rattus norvegicus) a$i)at *&,)&rian as&ta,ino3&n+
2A%A& *A& 3ETO*E
$lat dan bahan
Alat 5ang 'iguna$an a'ala2, son'& la,)ung,
ta)ung ,i$ro$a*il&r, ra$ ta)ung r&a$si, ta)ung
r&a$si $&6il, ti,)angan+
Ba2an 5ang 'iguna$an a'ala2, &$stra$ $un5it,
56,25 ,g air, a$ua'&s, Broill&r (BC) I, as&ta,ino3&n
s&'iaan 'ro* 100 ,gA1 ,E+ @&:an u8i a'ala2 20
&$or ti$us *uti2 (Rattus norvegicus) 8antan, strain
>istar '&ngan u,ur 2 )ulan 'an )&rat )a'an 150
gra,+ BC I 'iguna$an s&)agai *a$an s&)an5a$ 15-
20 gr satu $ali s&2ari 'an ,inu,an 5ang 'iguna$an
a'ala2 air )iasa s&)an5a$ 15-30 ,E satu $ali
s&2ari+ 7osis *&,)&rian *a$an ti'a$ 'i)&'a$an
antara $&lo,*o$ $ontrol 'an $&lo,*o$ *&rla$uan+
Rancangan
#enelitian
7ala, *&n&litian ini 'iguna$an ran6angan
*&n&litian s&'&r2ana pot-test only control group
design% '&ngan 4 ,a6a, *&rla$uan s&tia*
*&rla$uan '&ngan 5 ulangan (@a'i, 1995)+
Cara ker&a
%&giatan *&n&litian 'i)agi ,&n8a'i 2 ta2a*an
5aitu ta2a* *&rsia*an *&n&litian 'an ta2a*
*&la$sanaan *&n&litian+ -a2a* *&rsia*an *&n&litian
,&li*uti a'a*tasi 20 ti$us *uti2 8antan, s&la,a 10
2ari 'i la)oratoriu, Bio$i,ia a$ultas %&'o$t&ran
#NS+ "&ng&lo,*o$an 2&:an u8i t&r'iri atas 5 ti$us
$&lo,*o$ $ontrol 'an 5 ti$us untu$ ,asing-,asing
$&lo,*o$ *&rla$uan I, II 'an III+ !asing-,asing
$an'ang )&risi 1 ti$us (Su2ar'8ono, 1993)+
"&ngu$uran )&rat )a'an 2&:an u8i 'ila$u$an
s&)&lu, 'an s&su'a2 *&rla$uan+ "&ngu$uran su2u
'an $&l&,)a)an u'ara 'ila$u$an s&la,a *&n&litian
)&rlangsung+
-a2a* *&rsia*an )&ri$utn5a a'ala2 *&,)uatan
&$stra$ ri,*ang $un5it+ Ci,*ang $un5it 'iti,)ang
s&)&rat 500 gra,, $&,u'ian 'i6u6i, 'itiris$an, lalu
'i$&ring$an '&ngan o(&n 50
o
D s&2ingga 'i'a*at$an
)o)ot $&ring+ Bo)ot $&ring 'iti,)ang lalu 'i)uat
s&r)u$ ('igiling 'an 'ia5a$)+ S&r)u$ $&ring
'iti,)ang 50 ,g $&,u'ian 'i,asu$$an $&rtas
saring 'an 'i,asu$$an labu soxhlet+ S&lan8utn5a
'ila$u$an *ros&s soxhletasi '&ngan *&larut al$o2ol
96F G 500 ,E+ "&,)uatan &$stra$ 'ila$u$an 'i
Balai "&n&litian -ana,an =)at (B"-=)
-a:ang,angu, %arangan5ar+ B$stra$ ri,*ang
$un5it 'i'a*at$an 'ala, )&ntu$ $&ntal (*asta)+
#ntu$ ,&,*&r,u'a2 *&,)&rian *a'a ti$us *uti2,
&$stra$ 'i&n6&r$an '&ngan aHua'&s+
-a2a* *&la$sanaan *&n&litian )&rlangsung
s&la,a 3 2ari, s&)&lu, *&rla$uan 2&:an u8i
'iti,)ang l&)i2 'ulu+ S&t&la2 sia* su)8&$ *&n&litian
'i)agi 'ala, &,*at $&lo,*o$, ,asing-,asing
$&lo,*o$ t&r'iri 5 ti$us (-a)&l 1+)+
Tabel '. "&,)agian $&lo,*o$ 2&:an u8i 'an 'osis 5ang
'i$&na$an+
Kel. *sis
1 $&lo,*o$ $ontrol, 2an5a 'i)&ri ,a$anan BC I 'an
air+
2 $&lo,*o$ *&rla$uan I, 'i)&ri as&ta,ino3&n 'osis
to$si$ *&roral s&)an5a$ 1,35 gra,A$g BB+
3 $&lo,*o$ *&rla$uan II, 'i)&ri &$stra$ $un5it 'osis
tunggal *&roral tia* ti$us s&)an5a$ 5 ,gA$g BB,
*&,)&rian '&ngan son'& la,)ung+ S&t&la2 2 8a,,
'i)&ri as&ta,ino3&n 'osis to$si$ s&)an5a$ 1,35
gra,A$g BB+
4 $&lo,*o$ *&rla$uan III, 'i)&ri &$stra$ $un5it
'osis tunggal *&roral tia* ti$us s&)an5a$ 10
,gA$g BB 'an 2 8a, $&,u'ian 'i)&ri as&ta-
,ino3&n 'osis to$si$ s&)an5a$ 1,35 gra,A$g BB+
S&luru2 2&:an u8i s&la,a *&,)&rian *&rla$uan
'i)&ri ,a$anan BC I 'an air+ B,*at *ulu2 '&la*an
8a, s&t&la2 *&,)&rian as&ta,ino3&n (2ari $&-3
*&n&litian), s&,ua 2&:an u8i ($&lo,*o$ 1, 2, 3, 'an
4) 'ia,)il 'ara2n5a ,&lalui sinus or)italis '&ngan
,&ngguna$an ta)ung ,i$ro$a*il&r s&)an5a$ 1,5 ,E
$&,u'ian 'i*&ri$sa $a'ar S<=- 'an S<"- '&ngan
,&to'& $in&ti$+ "&ngu$uran $a'ar S<=- 'an S<"-
'ila$u$an s&t&la2 41 8a,, s&)a) 2&*atoto$sisitas
,a$si,al t&r8a'i 41 8a, s&t&la2 *&,)&rian
as&ta,ino3&n (Ca62,ania 'ala, Nurro62,a' 'an
!ur:anti, 2000)+
$nalisis data
7ata 5ang 'i*&rol&2 'ianalisis '&ngan u8i Ano(a
'ilan8ut$an #ost 'oc "est ,&ngguna$an analisis
"ukey 'an 'omogeneous Subset (Santoso, 2003)+
%AS)1 *A& PE32A%ASA&
"&n&litian ini ,&ngguna$an as&ta,ino3&n
s&)agai ,o'&l $&rusa$an 2&*ar+ In'i$ator
$&rusa$an 2&*ar 'i'asar$an *a'a *&r)&'aan $a'ar
S<=- 'an S<"- antara $&lo,*o$ 1 'an 2+ @asil
*&ngu$uran S<=- 'an S<"- ti$us *uti2 8antan *a'a
$&lo,*o$ 1 'an 2 s&*&rti t&rli2at *a'a -a)&l 2+
@AC-=N= '$$+ I #engaruh ekstrak "ur#uma dmesti#a terhadap S!" dan S#" 59
%a'ar S<=- rata-rata untu$ $&lo,*o$ 1 s&)&sar
152 #AE+ %&lo,*o$ 2 $a'ar S<=- rata-rata 1091
#AE+ %a'ar S<"- rata-rata untu$ $&lo,*o$ 1
s&)&sar 41 #AE+ %&lo,*o$ 2 $a'ar S<"- rata-rata
311 #AE+ 7ari u8i $nova 'ilan8ut$an '&ngan analisis
"ukey 'i$&ta2ui )a2:a t&r'a*at *&r)&'aan rata-
rata $a'ar S<=- 'an S<"- 5ang )&r,a$na antara
$&lo,*o$ 1 'i)an'ing $&lo,*o$ 2 ( J 0,05)+ @al
ini 'itun8u$$an '&ngan nilai *J0,000 )ai$ untu$
$a'ar S<=- 'an S<"-+ %a'ar S<=- 'an S<"- *a'a
$&lo,*o$ 2 8au2 l&)i2 tinggi 'i)an'ing $&lo,*o$ 1+
@asil t&rs&)ut ,&nun8u$$an )a2:a *&,)&rian
as&ta,ino3&n 'osis 1,35 gra,A$g BB ,a,*u
,&,)&ri$an &3&$ $&rusa$an *a'a 2&*ar ti$us *uti2+
@al ini s&suai '&ngan 2asil *&n&litian 7&2*our et al+
(1999), Nurro62,a' 'an !ur:anti (2000), 'an Ein
et al. (2000)+
"&,)&rian as&ta,ino3&n 'osis tinggi a$an
,&nga$i)at$an *&nurunan *ros&s $on8ugasi '&ngan
asa, glu$uronat 'an asa, sul3at *a'a 2&*ar 5ang
)&ra$i)at *&ning$atan o$si'asi 5ang 'i$atalisis
sito$ro, *-450 s&2ingga t&r8a'i *&ning$atan
*&,)&ntu$an (-acetyl-para-
benzo)uinoneimine
(NA"KI), 'an si,*anan glutathion 2ati ,&n8a'i
)&r$urang+ -&r)&ntu$n5a ,&ta)olit antara NA"KI
'ala, 8u,la2 5ang )an5a$ 'an *&nurunan 8u,la2
glutathion 2ati, a$an )&ra$i)at t&r)&ntu$n5a i$atan
$o(al&n antara ,&ta)olit '&ngan ,a$ro,ol&$ul s&l-
s&l 2ati s&2ingga t&r8a'i n&$rosis atau $&rusa$an
2ati+ @&*atosit 5ang rusa$ ,&l&*as$an 3a$tor-3a$tor
*&nari$ 'an ,&nga$ti(asi ,a$ro3ag 2ati,
,&n5&)a)$an n&$rosis s&l '&ngan ,&l&*as$an
&n?i, *rot&oliti$ lisoso,al 'an o$sig&n r&a$ti3+ S&l-
s&l 2ati 5ang rusa$ a$an ,&l&*as$an &n?i,-&n?i,
5ang ,&nan'ai $&rusa$an t&rs&)ut 'iantaran5a
S<=- 'an S<"- (@usa'2a, 1996)+
Tabel /. %a'ar S<=- 'an S<"- 'ara2 ti$us *uti2 (#AE)
$&lo,*o$ 1, 2, 3, 'an 4, 41 8a, s&t&la2 *&rla$uan
t&ra$2ir+
)&r,a$na ( J 0,05) antara $&lo,*o$ 2 'i)an'ing
$&lo,*o$ 3, 5ang 'itun8u$$an '&ngan nilai * J
0,000+ @asil t&rs&)ut ,&nun8u$$an )a2:a ti$us
*uti2 5ang 'i)&ri$an ri,*ang $un5it s&)&lu,
*&,)&rian as&ta,ino3&n $a'ar rata-rata
S<=-AS<"- 8au2 l&)i2 r&n'a2 'i)an'ing $&lo,*o$
ti$us 5ang tan*a *&,)&rian ri,*ang $un5it+ @al ini
,&nun8u$$an )a2:a ri,*ang $un5it ,a,*u
,&n6&ga2 $&nai$an $a'ar S<=-AS<"- a$i)at
*&,)&rian as&ta,ino3&n 'osis to$si$+ "&ngaru2
ri,*ang $un5it s&)agai 2&*ato*rot&$tor s&,a$in
8&las *a'a $&lo,*o$ 4, 5ang 'i)&ri$an ri,*ang
$un5it '&ngan 'osis 2 $ali 'osis $&lo,*o$ 3 5aitu
10 ,gA$gBB+ @al ini 'a*at 'ili2at *a'a -a)&l 2+
-&r8a'i *&r)&'aan $a'ar rata-rata S<=-AS<"- 5ang
signi3i$an antara $&lo,*o$ 4 'i)an'ing $&lo,*o$ 3,
t&ruta,a untu$ $a'ar S<"-+ %a'ar rata-rata
S<=-AS<"- $&lo,*o$ 4 l&)i2 r&n'a2 'i)an'ing
$&lo,*o$ 3, ,&s$i*un 'i)an'ing $&lo,*o$ 1
($ontrol) $a'ar rata-ratan5a ,asi2 l&)i2 tinggi
t&ta*i 'i)an'ing $&lo,*o$ 2 $a'arn5a ,asi2 8au2
l&)i2 r&n'a2+
@asil analisis t&rs&)ut 'i atas ,&nun8u$$an
)a2:a ri,*ang $un5it ,&,)&ri$an &3&$
2&*ato*rot&$tor *a'a 2&:an u8i+ @asil analisis
statisti$ ini ti'a$ 8au2 )&r)&'a '&ngan 2asil
*&n&litian Ein et al+ (1995)+ 7ari *&n&litian t&rs&)ut
t&la2 'i$&ta2ui )a2:a &$stra$ t&,ula:a$ (Curcuma
xanthorrhiza Co/)) 'a*at ,&n6&ga2 $&rusa$an 2ati
a$ut 5ang 'iin'u$si ol&2 DDl
4
'an as&ta,ino3&n
*a'a ,&n6it+ S&lain itu 8uga t&la2 'i$&ta2ui &3&$
2&*ato*rot&$ti3 'ari &$stra$ t&,u *uti2 (Curcuma
zedoaria Cos6) a$i)at *&,)&rian as&ta,ino3&n *a'a
ti$us *uti2 8antan (Nurro62,a' 'an !ur:anti,
2000)+ 7&ngan a'an5a $an'ungan s&n5a:a
kurkumin 'ala, $un5it, 5ang 8uga t&r'a*at *a'a
t&,ula:a$ 'an t&,u *uti2, ,a$a 'i2ara*$an )a2:a
&$stra$ ri,*ang $un5it 'a*at ,&,)&ri$an &3&$
s&ru*a+
Ci,*ang $un5it ,&ngan'ung s&n5a:a 5ang
)&r$2asiat o)at 5aitu kurkuminoid, 5ang t&r'iri atas
Kelmpk
kadar SGOT darah
tikus putih (+41)
kadar SGPT darah
tikus putih (+41)
kurkumin, desmetoksikurkumin, 'an
S* S*
1 (N J 5) 152,00 G 21,40
a
41,00 G 6,29
a
2 (N J 5) 1091,20 G 110,99
)
311,00 G 17,71
)
3 (N J 5) 262,20 G 30,61
a
202,60 G 16,11
6
4 (N J 5) 214,40 G 41,07
a
143,00 G 91,40
'
%&t&rangan: 2uru3 5ang sa,a *a'a satu $olo,
,&nun8u$$an ti'a$ )&'a n5ata *a'a u8i $nova 'ilan8ut$an
'&ngan #ost 'oc "est '&ngan J 0,05+
B3&$ 2&*ato*rot&$tor 'ari ri,*ang $un5it
'itun8u$$an 'ari *&r)&'aan $a'ar rata-rata S<=-A
S<"- antara $&lo,*o$ 2 'an $&lo,*o$ 3, antara
$&lo,*o$ 2 'an $&lo,*o$ 4, s&rta antara $&lo,*o$
3 'an $&lo,*o$ 4+ %a'ar rata-rata S<=- $&lo,*o$
3 s&)&sar 262 #AE 8au2 l&)i2 r&n'a2 'i)an'ing
$a'ar rata-rata S<=- $&lo,*o$ 2 5aitu 1091 #AE+
7&,i$ian 8uga $a'ar S<"- rata-rata $&lo,*o$ 3
s&)&sar 202 #AE ,asi2 l&)i2 r&n'a2 'ari $a'ar rata-
rata $&lo,*o$ 2 5aitu 311 #AE+ @asil analisis
statisti$ '&ngan u8i Ano(a 'i*&rol&2 2asil t&r'a*at
*&r)&'aan rata-rata $a'ar S<=- 'an S<"- 5ang
bisdesmetoksikurkumin+ S&n5a:a kurkumin ini 5ang
'i'uga ,a,*u ,&lin'ungi s&l-s&l 2ati 'ari )a2an
to$si$ (%2anna, 1999)+ Kurkumin ,&,)&ri$an
$ara$t&risti$ :arna $uning t&rang 'an rasa 5ang
$uat *a'a $un5it (Anoni,, 2004)+ Kurkumin larut
'ala, al$o2ol 'an asa, as&tat glasial, ti'a$ larut
'ala, air 'an &t&r (Bu'a(ari et al+, 1996)+ S&t&la2
*&,)&rian *&roral a$an 'ia)sor*si ol&2 usus 'an
&$s$r&sin5a s&)agian )&sar l&:at 3&s&s+ %ons&ntrasi
'ala, s&ru, a$an ,&n6a*ai *un6a$ s&t&la2 satu
8a,, $&,u'ian turun sa,*ai nol s&t&la2 li,a 8a,
(Anoni,, 2000)+ S&lain ,&,*un5ai &3&$
anti2&*atoto$si$, $un5it 8uga ,&,*un5ai &3&$
antiin3la,asi, anti)a$t&ri, anti*&ro$si'asi,
s*as,oliti$, ,&ning$at$an s&$r&si &,*&'u,
,&nurun$an $a'ar $ol&st&rol 'ara2, s&rta 'a*at
,&n6&ga2 *&rl&,a$an 2ati (Su8atno, 1997)+
Kurkumin 5ang a'a 'ala, &$stra$ $un5it )&r3ungsi
s&)agai anti2&*atoto$si$ 5ang ,&lin'ungi s&l-s&l
2ati 'ari $&rusa$an+ Kurkumin ini t&la2 t&r)u$ti
,a,*u ,&ning$at$an ,uatan glutathion 2ati
s&2ingga $&)utu2ann5a untu$ )&r$on8ugasi '&ngan
60
Biofarmasi 3 (2): 57-60, Agustus 2005
NA"KI a$an t&r*&nu2i 'an ti'a$ t&r8a'i i$atan
NA"KI '&ngan ,a$ro,ol&$ul 2&*atosit (Ston&r 'an
!u$2tar, 1995)+
KES)3P+1A&
B&r'asar$an 2asil *&n&litian ini 'a*at 'isi,*ul-
$an )a2:a *&,)&rian &$stra$ ri,*ang $un5it *a'a
s&,ua 'osis *&rla$uan ,a,*u ,&,)&ri$an &3&$
2&*ato*rot&$tor t&r2a'a* $&rusa$an 2&*ar 2&:an
u8i a$i)at *&,)&rian as&ta,ino3&n 5ang 'itan'ai
'&ngan $&nai$an $a'ar S<=- 'an S<"-+
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