1

1. -
?
2.
:
) _____________________________________________________
) _______________________________________________________
3. . Hendersson-Hasellbach-
,
.
4.
6.4
5.
3.7
6. 1=2.4 2=6.8
7.
,
8.
,
9.
. .
10. = 4.5 , = 6.5 . .
11. = 2.8 , = 3.8 . .

12. .
.
3.5, ,
. 1.9,
( ).
13. = 6.2 , = 5.3 .
.
,
.
14. :

.
.
15. 1 2
16. .
?
.
17.
2 . :
) 100
) 1000
) 2
)
18. :
) /

) /

) /
19.
20. :
) /
) /

) /
21.
22. ( = 7.4)
( = 7.4)
23. :

, , .
.

1. log P log D.
2. log P = 2.3 , log P = 4.3.
?
3. log D
, .
4. log D
, .
5. (log P = 3.1,
= 7.6). log P = log D.
6. (log P = 2.7, = 3.8).
.
7. (log P = 2.8, = 6.7). log P = log D.
8.
9.
10. , .
?
11. : ( = 10.5), ( = 28)
( = 0.7), .
12. . 3

13. . 3

14.
15. D
16. log P

17. ( )

18. ( )

19.

20.

. (+) ,

21.

log P :

Cl
O2NO( )
( -)
S

,
-, ,

NO2 ()
NO2 ()

+ 0.5
+2.0
+0.5
+0.2
+0.65
0.0
-0.7
-0.7
-1.0
-1.0
-0.85
-0.85

22.

- (1=9.36, 2=7.42,
logP=1.48)

23. .
(
), ( )

:
1.
2. - (=6.8,
logS 0 =2.4)
3. - (=3.9,
S 0 =3.3gml-1)
4.
, ( ) .

5.
,

6. ,
:
) ____________________________________________
) ____________________________________________

7. ( )

8.

9. /
.
.