Ospe Psu

OSPE 2555 Rx 28-29
OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29
3
10
12
14
15
17
20
24
27
22
28
29
37
//
/
41
47
53
75
85
89

101
108
111
114

..2510
116
..2518
..2522
125
131
..2537
137

..2538
139
143

/

1-2
5

Bulk powders

Mucilln (Isphagula husk)
Agiolax (Isphagula husk+Senna)

GRANULES

Divided powders

Mucilln (Isphagula husk)
ORS

Dusting powders
( )

Granules

0.24 mm
Agiolax (Isphagulahusk+Senna)
Fluimucil (Carbocysteine)

ENO
Effervescent granules

Hard gelatin capsules

capsule gelatin
cap
body

(pellets)
Soft gelatin capsules
capsule gelatin
Vitamin E
Isotretinoin

Plain compressed tablets

Filmcoated tablets
Multiple compressed tablets

Magesto
Decolgen
Effervescent tablets

CDR

Sugar-coated tablets

Film-coated tablets

Lozenges, Troches

Pastilles, Jujubes

Pills


Rectal suppositories

Vaginal suppositories,
Pessaries

Solutions

Syrups

Elixirs

alcohol

Spirits ()

alcohol
alcohol
Spirit

Mixtures

colloid

Suspensions
()

Emulsions

Scott's emulsion (Cod liver oil)

Lotions

Suspensions Solutions
Emulsions
Liniments

emulsions
Creams

emulsion
Ointments ( )

Pastes

Gels

Emulsion gels, Emulgels

Paints ()

Transdermal patches
( )
(eye, ear, nose and throat preparations)

(parenteral products)
(controlled released products)
(drug delivery systems)

1.
tight container

(desiccant)
salicylic acid aspirin

Hard Gelatin Capsules Soft Gelatin Capsules

Uncoated Tablets

(
mottling)
Coated Tablets

Dry Powders and Granules

Effervescent Tablets, Granules, and Powders

10

dead mixture
Rectal suppositories
(2-8 C)
Vaginal suppositories

2.

Solutions, Elixirs, Syrups

Emulsions (cracking)

Suspensions (caking)

Tinctures Fluidextracts

Sterile Liquids

3.
Creams (crystal growth)

Ointments
(bleeding)
11
1.
(expiration date)
5 2-3
/

2. (beyond-use date)

-
1 (dispensed)

-

(tight, light-resistant containers stored at controlled room temperature)
1) (non-aqueous)
25%
6 diazepam tablet 1
3 (25% 1 )
6 Diazepam USP powder
2)
14
Diazepam oral suspension Diazepam tablet Diazepam USP powder
14 60
14
3) (duration of therapy)
30
12
30 Diazepam suppositories Diazepam tablet ( 1 )

Diazepam USP powder 3 (25% 1 Diazepam tablet)
6 ( 6 Diazepam USP powder) 30

4)

13

1.
- (freezer) -25 C -10 C
- (cold) 8 C
-
(refrigerator) 2-8 C
(cool) 8-15 C (in a cool place)
(room temperature)
(controlled room temperature, CRT) 20-25 C
(warm) 30-40 C
(excessive heat) 40 C
(protection from freezing) 0 C
(dry place) CRT (20-25 C) (relative humunity, RH)
40%

CRT
15 C

2-8 ( 10) C

2.
/

3.

4.
Salicylic Acid Lotion BP

14

/
closure immediate
container
(strength) (quality) (purity)

- (child resistant packaging)

- (tamper resistant packaging, tamper evident packaging, tamper proof
packaging)

- (light-resistant container)

light-resistant container
protect from light ( )
- (well-closed container)

- (tight container)

(efflorescence) (deliquescence)

(hermetic container) single dose
- (hermetic container)

- (single-unit container)
(single dose) immediate container
/ tamper-resistant packaging single-unit container
/ (lot number)

15
- (single-dose container) single-unit

container pre-filled
syringes, cartridges, fusion-sealed containers closure-sealed containers
- (unit-dose container) single-unit container

- (multiple-unit container)

- (multiple-dose container) multiple-unit container
16

Certificate 1
2

Certificate
Certificate of analysis
Product Name
: CALTAB-1250
Registered No.
: 1A 251/45
Batch Size
: 400,000 tablets
Lot & Control No.
: CUT1204
Mfg. Date
: 11-01-12
Analytical No.
: 1201/135
Exp. Date
: 11-01-16
Active Ingredients
: Each tablet contains :
Calcium carbonate
1250.0 mg
Equivalent to calcium
500.0 mg
Description
White ,oblong ,biconvex, with engraved CALTAB on one side and 1250 on the other
TESTS
Identification
Range of mean weight
Uniformity of dosage units
REQUIREMENT
RESULTS
Positive
Positive
293.0-332.6 mg/tab
1406.64 mg/tab
Acceptance value is not more than L1
1.9%
(Weight variation)
(L1 = 15.0)
Disintegration time
Not more than 10 mins
6 mins 54 seconds
Not less than 75% (Q)of LA of Calcium carbonate
Min. 87.2%, Max 98.0%
is dissolved in 30 minutes
Av. 93.3%
Not less than 5 mEq of acid is consumed by the
23.2 mEq/tab
Dissolution
Acid neutralizing capacity
minimum single dose recommended in the

labeling and not less than 22.5 mEq/tab
Assay
Reference
92.5-107.5 %LA of Calcium carbonate

: USP 30
Raw material : Calcium Carbonate Light Batch No. 12610
99.7%
17

1.
2.

3.
:
Active ingredient
Metabolite
Description
Identification
- Chemical test
- Chromatographic method
HPLC, IR
Uniformity of dosage unit

2
- Weight variation ( )
- Content uniformity ( )
Type
25 mg 25%
< 25 mg < 25%
Uncoated
WV
CU
Film coated
WV
CU
Other coated
CU
CU
Thickness
punch-die
- Teclock micrometer caliper
- 1 3 mm
Hardness
- Stoke-Monsanto hardness tester
- 1 kg
18
Friability
% = ( ) 100

USP 30
1.
2. % target value (<1.0%)
3. % target value
2 1.0 %
Disintegration time
Dissolution /
- Apparatus 1 basket
- Apparatus 2 paddle capsule
-
2 Unit sample Pooled sample ( monograph Unit sample)
Acid neutralizing capacity
pH -
Particulate matter
Sterility
Loss on drying
Bacterial endotoxins test

Assay
Degradation product
Average weight (Range of mean weight)
Heavy metal
T MAX
T 1/2
19

station 2 station station
station
( )

1.
- :
- : (
)

810 cm
- 1
-
( volumetric flask)
2. :
(Petrolatum/Vaseline) (Iodine) /
(NaOH, KOH)
3. :
4. :
** White bee wax, Stearyl alcohol, Cetyl alcohol ------
** Wool fat, White petrolatum
------

1 :
2 :
3 :
20
(top loading balance)

1.
2.
3. (
)
4. Tare
5. 1 ( )
6. 2 ( )
7.
8.
9.
10. Tare
11.
12. 3 ( )

------
------

(calibrate)

spatula 2 spatula
------
------
21

Station

1.
20%
(mL)
(mL)
10
25
50
10
100
20
500
100
2.
3. 1 ( )
4.
5.
6. 2 ( )
7.
lower meniscus

8.
9. 3 ( )
22
:
- (, ) ------ lower miniscus
- (Mineral oil, Glycerin, Syrup) ------ lower miniscus
- ( /Potassium permanganate, Iodine soluton) ------
upper meniscus

(calibration
dropper)
A 0.8 mL
1.
2. 20%
3.
A
mL
0.8
mL
4.
23

station station

(Communication)
(Trituration)
>>
Activated charcoal, >>
Calamine Sulfur
(Levigation)
( levigating agent)
glycerine, mineral
oil slab & spatula
(Pulverization by
interventon)
Camphor, Menthol

geometric dilution
1.
2.
3.
24
(trituration)
1)
2)
3)

4) geometric dilution
5) spatula
spatula

6)
slab spatula (spatulation)
1) slab slab slab
2) slab spatula spatula
spatula
3) levigating agent solvent
smooth paste
4) slab spatula geometric
dilution
(Incorporation)
1)
levigating agent smooth paste

geometric dilution
levigating agent levigating agent (base)
25
Water in oil cream base
Oil in water cream base
(Levigating agent = Mineral oil*)
(Levigating agent = Glycerin, Propylene glycol)
- Water in oil cream base

- White ointment USP
- Wool alcohols ointment USP
- Simple ointment USP
- Oil in water cream base

- Water soluble ointment base
- Hydrophilic ointment USP
- Macrogol ointment BP (PEG ointment USP)
- Emulsifying ointment BP
- Paraffin ointment
- Hydrophobic petrolatum USP
- Petrolatum**
- Cold cream
- PEG base
- Vanishing cream
* Mineral oil Liqid petrolatum, Liquid paraffin

** Petrolatum Vaseline, Yellow soft paraffin, Soft paraffin
levigating agent
levigating agent
levigating agent
, glycerin, mineral oil
2) ( )
( base)
3)
26

station Solution

1.
0.5-1 cm
(Plain Filter) 60

(Plaited Filter)
32

2 4 ( )
2. separatory funnel
3. flask
flask
4.
-water (Perpermint water) ------
-sprit ------
5. 45

6.

27

1.
1) (direct heat)
(burner) (hot plate)

collar
(air intake) nonluminous flame

(tripod) wire gauze
wire gauze
wire gauze beaker, casserole

2) (water bath)
100 C wax, fat

water bath
wire guaze

( )
2.
100 C

casserole beaker
( order of melting point)

( )

28

1-3 suspension, syrup
( + ) station 6
- Mucilages ; Magmas ; Gels : bentonite, carbopol, MC, suspension, syrup Etc.
- ( )

aa,
mEq
ad
mg
div
ml., mL.
d.t.d, DTD
mmol
DW
mOsm, mOsmol
et
No., #
ft.,Ft.
oz.
ounce = 30 g
fl.oz.
fluid ounce = 30 ml
q.s. ad
g.
Rx
gr.
= 65 ml
Sig
gutt.
tbsp.
= 15 ml
M.
Tsp.
= 5 ml
29
OSPE Rx 2829 PSU OSPE 2555 Dutch 099 Rx 29

1 kg
= 2.2 lb (pound)
1 pint
2 pint
4 quart
1 gallon
1 grain
1 oz.
1 fl.oz.
=
=
=
=
=
16 fl.oz. = 400 mL
1 quart
1 gallon
3840 mL
65 mg
= 30 g
= 30 mL

1 Metronodazole oral suspension Metronidazole tablet 200 mg
Rx
Metronidazole
Syrup
Purified water q.s. to
100 mg/tsp
15 ml
2 fl.oz.
1. metronidazole 200 mg
Metronidazole
200 mg
=
=
=
=
(100 mg/5 ml) 60 ml

1200 mg
1200 mg/ 200 mg
6
6
2.
1) 6 syrup
smooth paste
2) syrup ( 2 ) (
draining time )
3)
60 ml
4)
30
2 Tetracycline solution 2.5 % w/v Tetracycline capsule 250 mg

Rx
Tetracycline HCl
M.Ft. Solution
2.5 % w/v
1 fl.oz.(1*30 = 30 ml)
1. tetracycline 250 mg
Tetracycline HCl
= (2.5g/100 ml) 30 ml
= 0.75 g
= 750 mg ( !!!!)
250 mg = 750 mg/ 250 mg
= 3
3
2.
1)
3
2) (3/4 30 ml = 22 ml)
3) 30 ml
4) additive
(32 )

Clindamycin gel 1 % w/w Clindamycin injection 300 mg/2 ml
Rx
Clindamycin Phosphate
Carbopol 940
Purified water q.s. ad
1 % w/v
2 % w/v
1 fl.oz.
1. Clindamycin Carbopol
Clindamycin Phosphate
= (1 g/100 mL) 30 mL
= 0.3 g
= 300 mg
Clindamycin injection
= 2 ml = 1 ampule
31
Carbopol
Carbopol
= (2 g/100 mL) 30 mL
= 0.6 g
= 0.6 g
2.
1) gel base 30 Carbopol 0.6 g ( Carbopol
2 )
2) Carbopol

= 30 g - Carbopol 0.6 g
29.4
= 29.4 g
= 22 ml
Carbopol
22 ml 30 ml
2 22 ml Carbopol
30 ml
3) Clindamycin (2 ml)
4) Carbopol Triethanolamine pH

Sodium citrate 2 % w/v

Rx
Sodium citrate
2 % w/v
Purified Water q.s. ad 50 ml

1. Sodium citrate = (2 g / 100 ml) 50 ml = 1.00 g
2. sodium citrate 1
3.
= 50 1 g < >

= 50 ml - 0.5 ml
= 49.5 ml
32
4.
= 49.5 ml = 37 ml
5. 37 ml 50 ml

6.
50
ml
7.

alcohol,
stock solution
benzakonium chloride 1:2500
Rx
benzakonium chloride 1:2500
M.Ft. Solution
50 ml
Benzakonium chloride 1% w/v

1. stock solution
1 : 2500 = (1 g/ 2500 ml) 100 = 0.04 %
N 1V 1 = N 2V 2
(0.04% 50 ml) = (1% V 2 ml)
V 2 = 2 ml
2. Benzakonium chloride 1% w/v
10 ml
3.
= 50
= 50 ml 2 ml = 48 ml

= 48 ml = 36 ml
4. 36 ml ( )

5. 50 ml

33

(Mucilages) ,Magmas, Gels polymer

2

- Acacia
- (dispersing agent) glycerin , alcohol

- Bentonite, Sodiumcarboxymethylcellulose,
Carbopol
- Bentonite,Veegum
- Methylcellulose
1 Acacia mucilage
Rx
Acacia
10 g (10% w/v) ()
Purified water to make 100 ml

1. acacia acacia
2.
= 100 -
= 100 ml - 5 ml = 95 ml

= 95 ml = 71.25 ml 72 ml
3. 72 ml acacia acacia
4. acacia mucilage ( )
acacia mucilage 100 ml

34
2 Bentonite magma
Rx
Bentonite
5 % w/w ( )
Purified water to make 100 g

1.

2.
= 100
= 100 ml 5 ml = 95 ml

= 95 ml = 71.25 72 ml
3. 72 ml
4. Bentonite
24 .
5. 100
3 Methylcellulose solution
Rx
Methylcellulose 1500 1 % w/w
Purified water to make 100 ml

Methylcellulose
1. 1/3 30 ml

2. methylcellulose methylcellulose
3. 2/3 60 ml
4.

Allegation method
Allegation method :
%
35

1. ( A)
2. ( B)
3.
( C)
4. 3

Allegation method
0.1%
0.01 ( 0.01% - 0.0%)

0.01%
0.0%
0.09 ( 0.1% - 0.01%)
(column A)
(column B)
(column C)
Iso-alcoholic elixir alcohol

alcohol
Iso-alcoholic elixir alcohol 40 %v/v 100 ml alcohol 9 % 75 %v/v
9
35
40
75
+
31
66
66 ml alcohol 9 % 35 ml
100 ml alcohol 9 % (35/66)100 = 53 ml

-
66 ml alcohol 75 % 31 ml
100 ml alcohol 75 % (31/66)100 = 47 ml

Iso-alcoholic elixir alcohol 40 % v/v alcohol 9 % 75 %
53 ml 47 ml
36

/

1-4 ( 2-3 )
1.
2.

( VS VS )
technical term
technical term

37

( )
( )

1.

(wheeze)

3 -4
2.

3.

38
39

4.

phenytoin, antihistamin drug/ anticholinergic
5.

6.

cancer drug/ wafarin/ pyrazinamide/ rifam
//

7.

/
isoniazid/ alcoholism
8.

9.
10.
40

//

review 2545 2555 station
1-2 Station
1. ( )

2.

station

- , HN, ,
/

/ / / ,

30

- ,
, ( ) , , ,
41

regimen 2

------ / / /,
------
/
Cloxacillin /

14 ac
Dicloxacillin 500 mg
Amoxycillin 500 mg
-
- - 1
2
14 pc 22 pc
Amoxycillin+Clavulanate 650
mg, 1000 mg
q 8 hrs
Azithromycin 250 mg
Roxitromycin 150 mg
12 ac
-
- - 1
2
Erythromycin 250 mg
14 ac
-
-
- - 1
2
Norfloxacin 400 mg
12 ac
-
-
-

42
Doxycycline 500 mg

12 pc
-
-
-

Tetracycline 500 mg
12 pc
-
-
-
Ketoconazole 200 mg, 400 mg
11 pc
-
-
-
Metronidazole (trichromoniasis)
1000 mg SD
-
Metronidazole ( )
400 mg 13 pc 5 -
200 mg 14 pc 5
NSAIDs
11 pc, 13pc
( )
Sulfa
-

-

( SABA )
1 2 puff prn

( steroid )
1 2 puff OD
- (
)
Simvastatin 10, 20 mg
Metformin 500 , 850 mg
Furosemide 5 mg
HCTZ
11 hs
max dose 2550 mg/day -

11 12
-
-
11
-
-
43
Drug interaction
Substrate
Inhibitor
Itraconazole,
Ketoconazole
Simvastatin,
Protease
Lovastatin
inhibitor
(CYP 3A4)
Amitriptyline
Fluoxetine/
Sertraline
Inducer
Phynytoin
(CYP 3A4)

metabolism
Itraconazole,
Ketoconazole
Rifampicin
(CYP 3A4)
Rifampicin

Fluconazole
Simvastatin

rhabdomyolysis
Atorvastatin,
Pravastatin

Amitriptyline
Amitriptyline

2-4 weeks

Amitriptyline
fluvoxamine
(CYP 2D6)
Theophylline
Cimetidine
(CYP 1A2)

Theophylline

Ranitidine
Norfloxacin/
Ciprofloxacin
(CYP 1A2)

Theophylline

Levofloxacin
Ofloxacin
Erythromycin
(CYP 1A2)
Erythromycin Amoxycillin
Roxithromycin

Theophylline
all make theophylline inc dose//
44
Substrate
Inhibitor
Wafarin
Cimetidine
Inducer
(CYP 1A2)
Wafarin
bleeding
Norfloxacin/
Ciprofloxacin
(CYP 1A2)
Fluoxetine
(CYP 1A2)
Phenytoin
Cimetidine
(CYP 2C9/19)
Omeprazole

Phenytoin

Ranitidine, Lansoprazole
warfarin

PT INR

(CYP 2C9/19)
S-warfarin
Cabamazepine
(CYP 2C19)
Phenobarbital
(CYP 2C9/19)
Phenytoin
(CYP 2C9)
Rifampicin
(CYP 2C9)
G6PD

Acetanilide
Aceophenetidine (phenaceti)
Amindopyrine (amiopyrine)
Antipyrine
Chloroquine
Hydroxychloroquine
Mepacrine (quinacrine)
Pamaquine
Aspirin
Phenacetin
Probenicid
Pyramidone
Pentaquine
Primaquine
Quinine
Quinocide
45

Dapsone
Sulfacetamide
Sulfamethoxazole (Bactrim)
Sulfamethoxypyrimidine
Sulfanilamide
Sulfapyridine
Sulfasalazine
Sulfisoxazole

Procainamide
Quinidine
Alpha-methyldopa
Ascobic acid
Dimercapol (BAL)
Hydrazine
Mestranol
Methylene blue
Nalidixic acid
Naphthalene
Niridazole
Phenylhydrazine
Toluidine blue
Trinitrotoluene
Urate oxidase
Vitamin K (water soluble)
Pyridium
46

/

1 3 pc 7

5

( )

( )
-
( )

47
-
-
-
-
-
-
-
-
-
- (mixtures)
- 1-2
........................
-
- 1
- Antihistamine: Brompheniramine,
- Chlorpheniramine, Dimenhydrinate,Diphenhydramine,
Hydroxyzine, Triprolidine
- Sedative: Alprazolam, Bromazepam,
- Chlordiazepoxide, Clonazepam, Diazepam, Haloperidol,
Lorazepam, Midazolam, Zolpidem
- Antidepressants: Amitriptyline, Nortriptyline,
- Doxepin, Imipramine,
- Anticonvulsants: Carbamazepine, Phenobaebital,
- Primidone
- Analgesic: Methadone, Morphine, Pentazocine
- Atc: Cinnaricine, Disulfuram, Methyldopa,
- Orphenadrine. Pizotifen
48
- Disulfuram, Chlorpropamide, Glibenclamide,

- Metronidazole, Tinidazole
- Tetracyclines: Chlortetracycline, Demeclocyclin,

- Oxytetracycline, tetracycline Doxycycline, Minocyclin
-
- 2-4 :
Azithromycin, Cefpodoxime, Gabapentin, Itraconazole,
Ketoconazole, Sucralfate
- Enteric coat: Bisacodyl, Diclofenac, Lansoprazole,
- Omeprazole, Sodium valproate, Sulfasalazine,
- Ciprofloxacin, Norfloxacin, Ofloxacin, Doxycycline,

- Minocycline, Penicillamine Cefdinir
- /
-
-
- Glucocorticosteroids: cortisone, Dexamethasone,
- Prednisolone
- : Allopurinol, Dapsone
- Amiodarone, Demeclocycline, Doxycycline,

- Griseofulvin, Minocycline, Ofloxacin, Chlorpromazine
49
- Metamucil,
- Ascorbic acid effervescent, Calcium effervescent tablet,

Cholestyramine powder
- : Levodopa
- : Nitrofurantoin
- : Rifampicin, Rifabutin
- : Phenolphthalein
- : Triamterene
- : Ferrous fumarate, Ferrous
Gluconate, Ferrous Sulfate
- : Activated Charcoal
- Steroid: Dexamethasone, Prednisolone

- NSAIDs: Aspirin, Diclofenac, Ibuprofen, Ketoprofen,
- Indomethacin, Mefenamic acid, Naproxen, Piroxicam,
Sulindac, Tenoxicam
- Xanthine der.: Aminophyline, Theophyline
- Atc: Allopurinol, Bezafibrate, Bromocriptine,
- Clofibrate, Cyprosterone, Fenofibrate, Ferrous salt,
Gancyclovir, Griseofulvin, Itraconazole, Ketoconazole,
Levodopa, Lithium carbonate, Metformin, Metronidazole,
Nicotinic acid, Nifendipine, Nitrofurantoin, Pantazocin
Potassium chloride, Thiabendazole, Tinidazole
- ,
- Mebendazole, Niclosamide
- Penicillin: Ampicillin, Cloxacillin, Dicloxacillin,

- Cephalexin, Cefaclor
- Macrolide: Azithromycin, Erythromycin,
- Tetracycline: Doxycycline, tetracycline
- Atc: Penicillamine, Sucralfate, Domperidone,
- Metoclopramide
50

2 1

Paracetamol
8
24 5
6 24
10 1
Ergotamine tartrate
Corticosteroid
Isordil
- Allopurinol, Chloral hydrate, Cyclophosphamide,

- Ferrous sulfate, Iodine solution, Metronidazole, Phenytoin,
Potassium chloride
- Furosemide, HCTZ,
- Enteric coat: Bisacodyl,Diclofenac, Lansoprazole,

- Omeprazole, Sodium valproate, Sulfasalazine
- Sustain release
(protect from light)

Acetaminophen(Paracetamol)
Alprazolam
Atenolol
Acyclovir
Amiodarone
Azathiopine
Benzocaine
Betamethasone
Buspirone
Calcitriol
Chlortetracycline HCl
Cisplatin
Clonidine
Benzyl benzoate
Bromocriptine
Calcifediol
Carbamazepine
Cimetidine
Clarithromycin
Colchicine
Allopurinol
Ascorbic acid (Vitamin C)
Azidothymidine
(AZT, Zidovudine)
Betacarotene
Brompheniramine maleate
Calciferol, cholecalciferol
Carbidopa
Ciprofloxacin
Clomiphene
Co-trimoxazole
51
Cromolyn sodium
Diphenhydramine
Ephedrine
Estradiol
Felodipine
Floctafenine
Fluvastatin
Furazolidone
Glyceryl trinitrate
Isoniazid(INH)
Itraconazole
Levodopa
Losartan
Methotrexate(MTX)
Metoprolol
Morphine
Neostigmine
Nifedipine
Nitrofurantoin
Norfloxacin
Orphenadrine citrate
Para-aminosalicylic acid(PAS)
Phenylephrine
Piperazine
Propanolol
Ranitidine
Salbutamol
Tetracycline
Timolol
Vitamin A

Dexamethasone
Disulfiram
Ergotamine
Estrone
Ferrous salts
Fluocinolone acatonide
Folic acid
Furosemide(Frusemide)
Griseofulvin
Isotretinoin
Kanamycin
Leflunomide
Melphalan
Methydopa
Metronidazole
Naphazoline nitrate
Neomycin sulphate
Nimodipine
Nitrofurazone
Nortriptyline
Omeprazole
Pentoxifylline
Phenytoin
Prednisolone
Pyrimethamine
Riboflavine
Sulphonamides
Theophylline
Triamcinolone acetonide
Warfarin
Digitoxin/Digoxin
Doxycycline
Erythromycin
Ethinylestradiol
Finasteride
Fluoxymesterone
Folinic acid(Leucovorin)
Glipizide
Indomethacin
Isosorbide dinitrate
Ketoconazole
Levothyroxine
Methimazole
Metoclopramide
Miconazole nitrate
Naproxen
Nicardipine
Nitrazepam
Norethisterone
Nystatin
Oxyetracycline
Perphenazine
Pilocarpine
Provastatin
Pyridoxine
Rifampicin
Tamoxifen
Thyroxine
Verapamil
52

1-4 ( 2-3 )

(Eye drops)

1 50 (
).

1.
2. Chloramphenicol eye drop
2 4
3.
4.

5.
6.
7. 1

8. ( 30 )

- 1 1
1 1 5
- 2 5 -10
10

-
53
-
-

-
-

-
- 1
-

-

-
(Eye ointment)

1.
2. Terramycin eye ointment
1
3.
4.
5.
6.
7.

8.
9.
10.
54

- 2 10
10
-
-

-
-
(Nasal spray)
1.
2.
- Rhinocort 1 puff ( 1 )

- Otrivin 1 puffs
3. ()
4.
( )
5.
6.
7.

8. 2-3
9. ( 2 )
10. 2 1 2
2
11.

-
55
2
-
-
-

(Nasal drops)

1.
2. Oxymetazoline 2
3.
4.
5.
6.
7.
()

8. 5
9. ( )
10.

- 3-
5
-
-
(Nasal wash, Nasal douche) (0.9% normal saline)

1.
2. 0.9% Normal saline nasal wash
3. 0.9% Normal saline

4.
56
5 -10 cc

0.5-1 cc
5.
6.
(Metered Dose Inhaler MDI)

1.
2.
- Seretide Evohaler 1 puff ( 1 )

- Ventolin Evohaler 2 puffs
3.
3-4 (

)
4.
5.
(
)
3-4 1-2
(

)
6. 1
7. 10
57
8.
9. 1-2
10.

11.

2
2

5

-
-

-
-
2
-
1-4

-
Accuhaler

1.
2. Seretide accuhaler
1 2 -
3.
4. accuhaler

5.
6.
58

7.
( MDI)
8.
9.

10. 10
11.

12.

-
- accuhaler
- accuhaler
- 0
Turbuhaler

1.
2. Budesonide 1
2
3.
4.
5. ( )
( )
6.
( MDI)
7.
8.
59
9. 10
10. 1
11.

12.

-
-
2
-
-
1-4

- 20
(dose)

(Ear drops)

1.
2. Neomycin ear drop
3.
4.
5.
6.
4 4

3-5
7.
8.
2-3
60
(Sublingual tablets)

1.
2. Isosorbide dinitrate 5 mg

3.
4. 1

5. 5
2 3
6.

7. 5-10
(Rectal suppositories)

1.
2. Glycerol suppository 2250 mg

3.
4.

5.
6.

7.

61
8. ( 15 ) 15-20

(Rectal enema)

1.
2. Sodium Chloride enema 250 ml

3.
4.

5.

6.
( )
7.
8. 2-3
9. 15-30

(Vaginal suppositories)

1.
2. Clotrimazole 500 mg

3.
4. ( 1-2 )
62
5.
6.
7. 15
(Vaginal suppositories)

1.
2. Clotrimazole 500 mg

3.
4.
5.
-
-
6.
7.
-

-

-
8. 15
63
(Insulin injection)

1.
2.
regular insulin 60
15-30
3.
4.

5. ()
6. (syringe)( syringe
insulin )

7.
8.

9.

1.
2.
() ( )
3.
4.

5. ()
64
65
6. (syringe)

7. (syringe)

8.
9. (syringe)

1.
2.

45-90

3.
4.

-
- 1
-

(Insulin pen)

1.
2. Mixtard 30 HM Penfill
15 unit 30
3.
4.
5.
6. 10
7.
8.
9.

10.

66
(Pregnancy test)

1.
2. Human Chorionic Gonadotropin (HCG)
1
3. ( )

-
:
30? 10-15
30 (
) 1-5
:
3
1-5
- : 1 5
4.
- 1 C
- 2 C T
- 1 T
(Nicotine gum)

1.
2. 2 mg
3.
4. ( )
67
5. ( 1
)
6. 30
7.

- 15
- (heart burn)
-
< 25 / 2 mg 30 /
> 25 / 4 mg 15 /
(Nicotine patch)

1.
2.
3.
4.

5.
6.
7. 10

8. 24
16
9.
10.
11.
12.
< 20 / 20 cm 2 1 6-8
10 cm 2 1 3-4
68
> 20 / 30 cm 2 1 3-4
20 cm 2 1 3-4 10 cm 2 1 3-4
Nitroglycerin

1.
2. Nitroglycerin
3.

4.
5.
6. 10
7. 12-14
Nitrate free interval time 12
8.
9.
10.
(Powder for reconstitution)
(Dry syrup)
1

1.
2. Amoxicillin
2.5 ml 3
3.
4.
5.
6.
7.
69
8. 7 2
9. 2
Sodium thaiosulfate for solution

1.
2. Sodium thaiosulfate for solution

3. 1/2 4.
5.
6.
7.
2/3

2
7

8.
(Oral rehydration salt)

1.
2. ORS

-
3. 250, 750 ml 1

4. 24
70
Cholestylamine

1.
2. Cholestylamine 3

3. 1 60-90 ml
4.
5.
6. 3
(Syringe)

1.
2. (household measurement)

3.
4.
5.
(Oral contraceptive tablets)

21
1 21 1
( 1) 5

( ) 7 2 -4
7
71
28
1 21 7

combined pills
1.
2. ethinylestradiol 30-35 g 1 2 ( 1
2 ) ethinylestradiol 20 g ( 1 )
1

2 ( ethinylestradiol 30-35 g)

-

-

- 2

3. ethinylestradiol 30-35 g 3 ( 3
) ethinylestradiol 20 g 2 ( 2 )

72

7
- 1 ( 1-7)

- 3 ( 15-21)
7 ( )
( 28 )

1.
1
2. tetracyclines, penicillins, quinolones, cephalosporins

metronidazole

progestin
3. rifampicin enzyme inducer

4
rifampicin enzyme inducer

1. 2-3

2.

3.

73
4.

5.
2 -3

: Levonorgestrel 750 mcg/tablets (Madonna, Postinor)

Levonorgestrel 750 mcg 2 12
72
1 12 4 (2
)
Levonorgestrel 750 mcg
72-120

( 2
1 )

74

0-2 ( 1 )
1.
2.

Digoxin

digoxin ... / ...(
)

digoxin ..... g ..... ..... (
)

( 12 )
12
2

( )

digoxin 2
digoxin
75
Phenytoin (Dilantin )

phenytoin .....
.....( )

phenytoin .....mg ..... ..... (
)

phenytoin

phenytoin

phenytoin
phenytoin
76

phenytoin
Theophylline

Theophylline ..... .....(
)

theophylline .....mg ..... ..... (
)

2 (shortness of breath)

theophylline

( )

theophylline
77
Warfarin

warfarin .....
( )

warfarin .....mg ..... .....
( )
12
2

Warfarin

Warfarin
Warfarin

Warfarin

78

Methotrexate

Methotrexate .....
..... ( )

Methotrexate ..... / ..... (
)

1
( 12 ) 12 .

1
2
:

:
-
:
-
( ) (
HIV) Methotrexate
79
Methotrexate

Cyclophosphamide

Cyclophosphamide

Cyclophosphamide ..... ..... (
)

12 12

2

/

Cyclophosphamide

80

10

Cyclophosphamide
Cyclophosphamide

Isoniazid

Isoniazid

Isoniazid ..... .. ( )
2 (
)

6

81

Isoniazid 1
Isoniazid

Rifampin

Rifampin ..... .....( )

Rifampin ..... .. ( )
1 2 (
)

( )
Rifampin
Rifampin

82

Rifampin

Rifampin
Rifampin
Rifampin
Rifampin

Pyrazinamide

Pyrazinamide

Pyrazinamide ..... ..... ( )

Pyrazinamide
83

Pyrazinamide
Ethambutol

Ethambutol

Ethambutol .. .. (
)

12 12

2

Ethambutol

2
ethambutol

Ethambutol
84

Maculopapular rash, Urticaria ( )
Steven-Johnson syndrome 3
1.
( )

2.

Maculopapular rash

Urticaria ( )

85
Fixed drug eruption

Eczematous drug eruption

MP
rash

Erythema multiforme (EM)

3

1

Steven - Johnson syndrome (SJS)

EM
3

10
1
86
Toxic Epidermal Necrolysis (TEN)

MP rash

SJS
WHO criteria
1. Certain ( )
(1)
(2)
(3)
(4)
2. Probable ()
(1)
(2)
(3)
(4)
3. Possible ()
(1)
(2)
(3)
4. Unlikely ( )
(1)
(2)
: 4 certain
Certain 4
Probable 3
Possible 2
Unlikely
87
Naranjos algorithm
1.
+1
2.

+2
-1
3.
( specific
antagonist)
+1
4.

+2
-1
5.
( )
-1
+2
6.
-1
+1
7. (
)

+1
8.

+1
9.

+1
10.
+1
9
5-8
1-4
0
Definite
Probable
Possible
Doubtful
()
88

1 2
1. lab +
2. ( ) + lab+

Lipid profile

- LDL, lab ( goal )
- LDL; mg/dL, mg% ( TG < 400 mg/dL)

Lab
NCEP ATP III

Lab
Goal
Total cholesterol (TC)
< 200
Triglyceride (TG)
< 150
VLDL (VLDL TG/5 )
< 50
HDL
40-59
LDL CHD
Risk
LDL goal
CHD/ CHD risk equivalent
< 100
Risk factor 2
< 130
Risk factor = 0-1
< 160
89
CHD and CHD risk equivalent

1. Coronary heart disease (CHD) = CHD
-
Acute miocardial infarction
Silent miocardial infarction or miocardia ischemia =
Unstable angina pectoris or stable angina pectoris =
Coronary procedure (coronary angioplasty, coronary surgey) =

2. CHD risk equivalent = CHD

Other clinical atherosclerotic diseases =
-
Peripheral arterial disease =
Abdominal aortic aneurysm =
Carotid artery disease on angiography or ultrasound =

50%
Renal artery disease =
Risk factors
Risk factor
55
45
+1

CHD
( (
) CHD
) CHD
55 65
+1
+1
+1
HDL
< 40mg/dL
+1
60mg/dL
-1
90

( )

(aerobic exercise) 30 3

- -

- (
stage )
- HCTZ Enalapril

SBP
Optimal
<120
Prehypertension
120-139
Stage 1 Hypertension
140-159
Stage 2 Hypertension
160
DBP
and
<80
80-89
or
+20
90-99
100 +10
91

Goal (mmHg)
Pt.
<140/90
Pt. Chronic kidney disease / Diabetes mellitus
<130/80
Pt. Protienuria
<125/75

/

(
)


92

- FBS Hb A1C

lab
FBS 8
Hb A1C Hemoglobin ( ) 3

FBS Hb A1C
diagnosis DM
Goal
Fasting blood sugar (FBS)
126
70-130
Hb A1C
6.5%
< 7%
93
-

-
-


Thyroid function

- lab

Thyroid disorders
TT 4 & TT 3
TSH
Hyperthyrodism
Hypothyrodism
1. Hyperthyrodism
Hypermetabolism & Sympathetic

( )

94
Graves disease ( )

(
)
Amiodarone (
)

Atrail fibrillation, Hypothyrodism, (Congestive heart failure), ,

2. Hypothyrodism
Hypometabolism

( )
( )
Hasimotos thyroid

Lithium (Lithium Thyroid hormone ),
Amiodarone

*** Amiodarone Hyperthyrodism Hypothyrodism ***
95
Hematorogy

- lab

Lab

96
Liver function test

- lab ( lab ) + lab ( review
AST, ALT Alkaline phosphatase) +
+

lab
AST ALT

Alkaline phosphatase (ALP)

Billirubin by product heme heme bilirubin
conjugation Conjugated bilirubin
urobilirubin
Billirubin 2 Direct Bilirubin (Conjugated)
Indirected Bilirubin (Unconjugated) Total Bilirubin

- Total Bilirubin (TB)/ Bilirubin =

(Juandice)
- Direct Bilirubin (DB) = (Conjugated) (
)
- Indirect Bilirubin ( TB- DB)
(Unconjugated Bilirubin)
97
Lab
AST(Aspatate transaminase, SGOT)
0-35
ALT(Alanine transaminase, SGPT)
0-35
Alkaline phosphatase (ALP)
30-120
Total bilirubin (TB)
0-1.4
Direct bilirubin (DB)
0-0.30

( )
- (Pyrazinamide, Isoniazid, Rifampin)

- Statins (Atorvastin, Simvastatin, Lovastatin, Pravastatin,
Rosuvastatin) Fibric acid derivatives (Gemfibrozil, Clofibrate, Benzafibrate)
- Methotrexate
- Paracetamol

98
(Hepatitis B virus)

-

Lab
AST ALT

HBsAg ( + )
AntiHBs Ag (+)
HBeAg ( + ) ( / )
AntiHBe Ag (+) /
HBV DNA ( + )
HBsAg ( + ) + AntiHBs Ag (+) = +
HBsAg ( - ) + AntiHBs Ag (+) =
AntiHBe Ag (+) + AntiHBs Ag (+) =
Acute ( 6 )
-
- ALT (ALT > 2.5 upper limit )
Chronic ( 6 )
- 6
- AST > ALT
- HBeAg ( + ) = Active ( / )
HBeAg ( - ) = Persistance
Carrier
-
- normal AST & ALT
****
99
- HBeAg ( + ) = Asymtomatic ( )
HBeAg ( - ) = Active ( )

( ) (
)

Paracetamol, Isoniazid, Erythromycin
100

1 3 station
Key word
Drug information handbook ,
MIMs , Drug interaction facts

AHFS Drug Information
/
index
Availability & Indentification USA
Drug information

-
MIMS Annual
Use
Dosage & administration
Caution
Pregnancy & lactation
Pharmacology
Mechanism of action
Pharmacokinetic
Chemistry & stability
Generic & brand name index

- Trade name, Generic name
- Dosage & Administration
- Description
-
Indication
Storage
Presentation
Action
- Pharmacology
- Pharmacokinetic
101
Drug information handbook
International brand names index International

trade names index
A- Z

- Generic name /U.S. Brand name/Canadian Brand name
- Pharmacology categories - Additional appendix information
-
Uses/Unlabeled use
Pregnancy
Medical safety issues
Warning/precaution
Restrictions
Lactation
Contraindication
Adverse reaction
Overdose/Toxicity
Stability
Pharmacokinetic
Administration
Reference range
Drug interaction
Mechanism of action
Dosage
Dosage form
Monitoring parameter
- Test interaction
- Extemporaneous prep.
Drug fact & comparison
- Additional information
- Appendix table of contents
index

- Information
- Indications
-
Administration & Dosage

Actions
Contraindications
Warnings & Precautions
Drug Interactions
- Adverse reactions
- Overdosage
- Patient information
102
Handbook on
index
Injectable Drug

- Products (size, strength, volume, form)
- Administration
- Stability
- Compatibility & additional Information ( )
(Solution, Additive, Drug in syringe, Y-site)
-
Drug interaction facts
index , , trade name

significant rate

- Drugs or drug classes
-
Significance 1-5
Onset ,Severity, Documentation
Effects
Mechanism
- Management
- Discussion
Drug in pregnancy &
lactation
index

- Fatal risk summary & recommendation
- Breast feeding summary & recommendation
103

MIMS Thailand
/
index trade names & generic name

- manufacturer
- Content (C)
- Dosage (D)
- Contraindication (CI)
- Adverse reaction (AR)
- Presentation/price (P/P)
- Poison classification

Distributor
Indication (I)
Administration of oral drugs (A)
Special precaution (SP)
- Drug interaction (DI)

- Pregnancy category
- P2 = 2
- P3&P4 = 3&4
- N3 = 3
- S =
- D =
- NDD =
- E D = exteranal

a pathophysiologic approach index

Pharmacotherapy :
-
-
Remington
index

- -
-
-
-
104

Merck index
/
index 2 name index formula index
index A-Z 0-9

-
-
-
-
-
-
- therapeutic category, antidote
Martindale
index

-
-
-
-
-
-
-
- Interaction Pharmacokinetic
-
-
-
105

British pharmacopoeia (BP)
/
(BP 1993, 1998, 2001) 2 Volume
- Appendix Vol.2
- Content of appendix A3 Vol.2
BP 2011 6 Volume
- Vol.1& 2 --> Medicinal substance -->
- Vol.3 --> tablets, suspensions
- Vol. 4 --> Blood Product, Immune, Radiopharmacy
etc.
- Vol.5 --> Appendix and index
- Vol.6 -->
Appendices BP General Chapter
USP
monograph Appendix IIIA
2.2.27
Appendix
- 2.2.27 European Pharmacopoiea Appendix
BP
- monograph 2.2.27
Appendices 2.2.27 App. IIIA
App.IIIA A122 Thin-Layer
Chromatography
106
U.S. Pharmacopeia National
USP(30) 2007 USP(34) 2011 2 3
Formulary (USP)
Volume
- Volume 1 --> General Chapter (
<xxx>) <621> Chromatography
Page 29 Vol.1 <621>

Vol.1 monograph
Excipients, Dietary Supplements **
Vol.1
- Volume 2 -->Monograph A-L (USP 30/2007)
A-I (USP 34/2011)
- Volume 3 -->Monograph M-Z(USP 30/2007)
J-Z (USP 34/2011)

-
Microbial limit test
Dissolution -->Tolerance --> Q
107

1 2
1. mL + + ( Paracetamol
drop 60 mg/0.6 ml 15 ml Paracetamol syrup 125 mg/5 ml 60 ml) +
2. mL + +
review regimen regimen
Paracetamol (10-15 mg/kg/dose)

10 kg Amoxicillin 125
mg/5ml 60 ml
Rx
Amoxicillin 80 mg/kg/day devided 2 dose for 14 days

Paracetamol
10-15 mg/kg/dose
CPM
0.35 mg/kg/day in divided dose q 4-6 hr
Ibuprofen
Analgesic
: 4-10 mg/kg/dose q 6-8 hr
Antipyretic
: 5-10 mg/kg/dose q 6-8 hr
Otitis media
GAS pharyngitis
: 80-90 mg/kg/day divided 2-3 dose 10 days

: 40-50 mg divided 2-3 dose 10-14 days
Amoxicillin
Sinusitis;
High risk
( ATB 1-3 / nursery)
108

Body Mass Index (BMI)
( : kg/m 2)

BMI (kg/m 2)
18.5-22.9
23
25
Body Surface Area (BSA)

2
1.
( : m 2)
2. Nomogram
( : m 2)
109
Ideal Body Weight (IBW)

( : kg)
( : kg)
Creatinine clearance (CrCl)

( : mL/min, L/hr)
0.85
( : mL/min, L/hr)
110

1. Osmol:
Osmol = molar x ion
2. drip, drop
1 ml = 60 microdrop
3. % Labeled amout
% Labeled amout = ( / ) x 100
4. Molarity, Normality
Eq. wt = MW / Valency
Mole = g/MW
Molarity = (g/MW) /L
Number of Eq. = g/Eq.wt

Normality = (g/Eq.wt) /L
N = M x valency
1

Rx
Boric acid
1.24
Sodium borate
0.02
Sodium chloride
0.29
Water qs.
100
NaCl mOsmol/L ( NaCl MW = 58)
100 ml
1000 ml
g
g
g
ml
NaCl = 0.29 g
NaCl = 2.9 g
= 2.9/58 = 0.05 mol
= 50 mmol
mOsmol
NaCl 100 mOsmol/L
= mmol x ion
= 50 x 2 = 100 mOsmol
111
2
Dopamine (1:1) 5 mcg/kg/min 60 kg microdrop / min
Dopamine 5 mcg/kg/min
60 kg ;
5 x 60 = 300 mcg/min
= 300/1000 mg/min ----------------- > mcg mg
= 0.3 mg/min
= 0.3 ml/min ------------------------ > Dopamine 1 mg : 1 ml
= 0.3 x 60 microdrop / min --------> 1 ml = 60 microdrop
= 18 microdrop / min
3
Dopamine (2:1) rate 5 microdrop/min 50 kg dopamine
mcg/kg/min
Dopamine 5 microdrop/min =
ml/min -------------------------- > 1 ml = 60 microdrop
mg/min --------------------- > Dopamine 2 mg : 1 ml
mg/kg/mi -------------- > 50 kg
mcg/kg/min --- > mg mcg
= 3.33 mcg/kg/min
4
% label amount 5 95.68, 97.42, 99.16, 105.42
101.68 mg 100 mg active ingredient/tab
% label amount 95.0-105.0 %
% Labeled amout
% Label amount
= ( / ) x 100
= (95.68 + 97.42 + 99.16 + 105.42 + 101.68)/5
( 5 )
= 99.87 mg

112
5
1
Sodium chloride
Trisodium citrate dehydrate
Potassium chloride
Glucose anhydrous
1 L
2.9 g
2.9 g
1.5 g
13.5 g
sodium mEq/L (MW Sodium chloride = 58, Trisodium citrate dehydrate =

290, Potassium chloride = 74)
Sodium 2 Sodium chloride Trisodium citrate dehydrate

Sodium chloride
Trisodium citrate dehydrate
2.9 g
2.9 g
=
=
=
=
=
2900 mg
2900/58
50 x 1
2900 mg
2900/290
= 10 x 3
sodium 50 + 30 = 80 mEq/L
= 50 mmol
= 50 mEq
= 10 mmol
N = M x valency
Eq = mol x valency
= 30 mEq

113

1.
Displacement Value = g Theobroma oil 1 g
2. (Tonicity adjustment)
E = g NaCl 1 g
3. Required HLB
1
10
Rx
Aspirin
300 mg
PEG base
q.s.
displacement value aspirin = 1.5
1 = 2.2 g
Aspirin
Aspirin
PEG base
PEG base
1.5 g
0.3 x 10 g
1
10
1 g
(1 x 0.3 x 10)/1.5 = 2 g
2.2 g
2.2 x 10 = 22 g
22 2 = 20 g
2
sodium chloride gentamicin 1
mg/mL 50 mL isotonic
E gentamicin 0.3 E NaCl 1
114
gentamicin 1 mg/mL 50 mL 50 mg = 0.05 g

E gentamicin 0.3 ;
1 g
= NaCl 0.3 g
0.05g
NaCl 9%
NaCl 0.9% 50 mL NaCl
= NaCl 0.015 g
= ( 0.9/100) x 50 = 0.45 g
NaCl= 0.45 0.015 = 0.435 g

3
required HLB emulsifier
Mineral oil
30 g (HLB = 12)
Wool fat
2g
(HLB=10)
Stearyl alcohol 1.5 g (HLB = 14)
Emulsifier
10 g
Water
56.5 g
Span 80 Tween 80 HLB = 4.3 15.0

HLB
Mineral oil
Wool fat
Stearyl alcohol
Tween 80
30%
2%
1.5%
33.5%
12
10
14
15.0
30/33.5 = 0.896
2/33.5 = 0.060
1.5/33.5 = 0.045
HLB
0.896 x 12 = 10.75
0.060 x 10 = 0.597
0.045 x 14 = 0.627
required HLB = 11.974
7.7
12
Span 80
4.3
3.0
10.7 10
Tween 80 (7.7/10.7) x 10 = 7.2 g

Span 80 10 7.2
= 2.8 g
115

..2510

Station 3
1. (
) Station
1
2. 5 1 -5

3. Station
Station

55 Pseudoephedrine Codeine

.. 2510

.
4

(1)
(2)

(3)
(4)

116
1

2
12

13 12
(1)

(2)

(3)

(4)
(5)

(1) (5)
14

(8)

(9) 38 39 40 40 41 42 43
44
(9)

15
117
( 31
.. )

3
19
(1)

/ ...

4

38 20

(1) 79..........(
)
(5) 25(6).........( )
39 21

(1) 26 (2) (3)
(2)
(3)
(4)
(5)
26 (5)
( )
26 (4)

(6)

(7) ()
(8)
118
45

*** ...

***
5
6
7
5 - 7 2 - 4
8
72
(1)
(2)
(3)
(4)
(5)

.... Kamagra (Sidenafil )

...
Sibutamine
(6)
(4)

73
(1)
(2)
(3)
(4)
(5)
79
119
74
(1)
79
73(5)
(2)
79
86
75
(1)
(2) ()
74
75

9
76
10
79

79 79
(1)
(2)
(3)

(4)

120
80 79
11
88
(1)

(2)
(3)

(4)
(5)
(6)
(7)
(8)
7
(5) (6) (1) (4) (5)
(6) (7) (8)

88

(1)
(2)
12
91
(1)

(2)
13
95

121

14
109 38 39 40 40
41 42 43 44
110 45
117 72 (1)

73 (2) (3) (4) 72 (1)

119 72
(1)

122
72 (4)
122 75

124 88 88 89 90

Aluminium Hydroxide 200-600 mg. 4 10

Magnesium Hydroxide 200-400 mg.
Asafetida 20 %w/v
15, 30 60 ml
ORS
1 250 ml
122

Glycerin suppository 91%
1.5 g
2.55 g
Sennosides
Sennoside B 7.5 mg
4 10
NaCl enema 15 %w/v
10 20 ml
Mebendazole 100 mg
Paracetamol 500 mg
4 10
Paracetamol 325 mg
4 10
Paracetamol 325 mg/5 ml
30 60 ml
Chlorpheniramine maleate 2 mg
4 10
60 ml
Dimenhydrinate 50 mg
Gentian Violet 1 %w/v
15 30 ml
15 30 ml
15 30 ml
Isopropyl Alcohol Solution 70%v/v
30 ml
Ethyl Alcohol Solution 70%v/v
30 ml
Sodium Chloride 0.9 %w/v
500 ml
Benzyl Benzoate 25 %w/v
30 60 ml
Coal Tar 1 %w/w
5 g 15 g
Calamide 8-15 %w/v
60, 120, 180 ml
Zinc Oxide 3-12 %w/v

(B 1 5 mg + B 2 2 mg +
B 6 2 mg + Nicotinamide 20 mg)
Vitamin C (Ascorbic Acid) 100 mg
Ferrous Sulfate
Equivalent to Iron 60 mg

4 10
4 10
4 10
4 10 Cap
A D
123
Paracetamol 500 mg + CPM 2 mg NSAIDs

10
Antituberculosis
Anti-neoplastic
HCTZ 50 mg 4 10
Antimalarial
NSAIDs
Antihelmintic :
CPM 2 mg 4 20
- Albendazole 200 mg
General Anesthetic
Aminophylene 100 4
Fluoxetine
Corticosteroid
Penicillin V Potassium equivalent

to Penicillin V 200,000 unit
60 ml
Manoxidil
Clofibrate
Amitriptyline

Chlorampinical

Mebendazole 100 mg 6
Mebendazole 500 mg 1

Steroid
Dextromethophan HBr 15 mg
Erythropoietin
Dimenhydrinate 50 mg
Cafergot
Gancyclovir
4 10
Ambroxal HCl 30 mg
Barbiturate
Steroid
Valproic acid
mucolic ???
Retinoids
Anti HIV (AIDs)
Tramadol
Clozapine
Amoxycillin
Sidenafil
Phenylephene 10 mg +
Paracetamol 325 mg + CPM
Azethromycin
Cisapride
Norfloxacin
Misoprostol
Bromphenniramine 4 mg
Finesteride
Lamivudine Hepatitis B
Phenylephene 10 mg + CPM Sumatriptan

Bromphenniramine 4 mg
Cinnarizine
Oseltamivir
Chloramphenicol eye drop
Aspirin 81 mg
Antipsychotic drugts
Haloperidol
Nimesulide ( NSAIDs)
124

..2518

4

1

2
13 1

125
13 2
2
6 (4 )

15 13
(1) 2

(2) 2

(3) 2

(4) 2

14
16 3 4

17 16
(1) 3 4

(2) 3 4

(3) 3 4

(4) 3 4

126
(5) 3 4

16
3

3 4
/

4
33 3 4
(1)
(5)
34 3 4
(1) 28 (2)
(3)
(5)

(7)
(8) (5)

(9)
5
36
(1)
127
(2)
(3)
(4)
(5)
37, 38, 39
6
40 3 4

41 40
7
48
(1)

(2)
8
49

9
53

128

4

1. 1 :
1
Cathinone
Mescaline analog
4-methylaminorex
DET
Escaline
Parahexyl
DMHP
Isoproscaline
Proscaline
PCE
DMT
Etryptamine
GHB (Gamma-hydroxybutyrate)
Methcathinone
Mescaline
Mescaline derivatives
PHP(PCPY)
4-Thiomescaline 4-TM
4-Thioescaline 4-TE
4-Thioproscaline 4-TP
3-Thiomescaline 3-TM
Psilocine
Psilocybine
TCP
Tetrahydrocannabinol
3-Thioescaline 3-TE
3-Thiometaescaline 3-TME

2. 2 :

2
Amfepramone
Flunitrazepam
Nimetazepam
Secobarbital
(diethylpropion)
Flurazepam
* Nitrazepam
Temazepam
Amineptine
Haloxazolam
Pemoline
Triazolam
Aminorex
* Ketamine ()
Phenylpropanolamine
Zaleplon
Butorphanol
Loprazolam
* Phencyclidine
Zipeprol
Brotizolam
Lormetazepam
Phendimetrazine
Zolpidem
Cathine
Mazindol
Phenmetrazine
Zopiclone
* Ephedrine
Methylphenidate
* Phentermine
Buprenorphine
Estazolam
Mesocarb
Pipradrol
Fencamfamin
* Midazolam
Pseudoephedrine
Fenethylline
N-Ethylamphetamine
Quazepam
129
3. 3 :

3
Amobarbital
Glutethimide
Meprobamate
Butalbital
Pentazocine
Cyclobarbital
Pentobarbital
4. 4 :

4
Inorganic bromide (
Clorazepate
Allobarbital
2 ?
Lithium bromide

Potassium bromide
Technical grade sodium

(Clorazepic acid)
bromide technical grade
)
Pinazepam
* Alprazolam
Clortermine
Ketazolam
Prazepam
Barbital
Clotiazepam
Lorazepam
Propylhexedrine
Benzphetamine
Cloxazolam
Medazepam
Pyrovalerone
Bromazepam
Diazepam
Mefenorex
Secbutabarbital
Butobarbital
Delorazepam
Methyprylon
SPA
Camazepam
Ethchlorvynol
Methylphenobarbital
Tetrazepam
Ethinamate
Nordazepam
Tofisopam
Chlordiazepoxide
Ethyl loflazepate
Oxazepam
Vinylbital
Chlorphentermine
Fenproporex
Oxazolam
Clobazam
Fludiazepam
Perlapine
Clonazepam
Halazepam
Phenobarbital
Chloral hydrate and its

adducts
130

..2522

4

1

2
15
1
16 2

17 2

20
3

(1) 3

(2) 3

131
26
4 5

3

/ ...

4
36 3
(1)
(2)
(3)
(4)

3 29 (3)

3 31
(5)
37 3

(1) 3 31 (2)
(2) 31 (3)
(3)
(4)
5 3
3 9 3

(1)
(2)
(3)
(4)
40
41
42
43
(5) 46
40, 41, 42 3

132
6 3
43 3

7
48
(1) 2 3

(2) 2 3 4
2 3 4

8
49
(1)

(2)

(3)

(4)
(5)

133
9
52

10
57 1 5
58 2

17
11
12
70 3 20

71
3 20 20

3 20

82 3
19 (1)
83 3 39 (1)

84 3
3 39 (2) (3)

85 3
3 39 (2) (3)

134
5
1. 1
1
*MDMA (
*Amphetamine
*Methamphetamine
Ectasy Adam)
( )
()
*MDA ( )
*Heroin
Etorphine
PMA
Thiofentanyl
Desomorphine
Dexamphetamine
Dihydroetophine
*LSD (d-lysergic acid)
2. 2
2
*Opium
*Medicinal Opium
( )
*Cocaine
*Fentanyl
*Dextropropoxyphene
*Morphine
*Pethidine
ROPECT
*Coca bush
*Codeine
*Methadone
*Diphenoxylate
Trimepridine
8 (1)
(Medicinal Opium)

3. 3 2

3
1. codeine
60
2. codeine phosphate
3. dextropropoxyphene
4. dihydrocodeine tartrate
5. diphenoxylate
lomotil
6. 60
135
4. 4 1 2 ( ergot alkaloid
cafergot
)
acid acid
4
*Acetic Anhydride
*Acetyl Chloride
*Lysergic Acid
Safrole
Piperonal
Phenylacetic Acid
*Ergotamine

*Ergometrine

Ethylidine Diacetate
Chlorpseudoephedrine
5. 5 1 4
3
1. (Cannabis) ( Cannabis sativa L. Cannabis
indica Auth)
2. (Mitragyna speciosa Korth)

3.
Papaver somiferum Linn Papaver bracteatum

4. Psilocybe cubensis
Psilocybin

1, 2, 4 5
1.
2. 1 2
3. 1 2
136

..2537
5
28

(1)
(2)

(3)

(4)

29

30

137
31

33

44 28

45
44 50

46

138

..2538
2 3(4) () ..253 7

1

1
2
3
4
5
6
7
8
9
139
10

11
12

13

14

3

15

(1)
(2)
(3)

16

(1)

(2)

(3)
(4)
17

16
140
18

17
19

4

20
21
22
5

23
24
25
6

26

27

28

141

29

30

31

142
1.
2.
3.
4.
Rx 27
Rx 28
Rx 28
Rx 28
Pharmaceutical Sciences
Pharmaceutical Care
Pharmaceutical Care
077
131
2002
2020
5.
6.
7.
8.
Rx 28
Rx 29
Rx 29
Rx 29
Pharmaceutical Care
2031
008
009
011
9.
10.
11.
12.
Rx 29
Rx 29
Rx 29
Rx 29
019
024
026
055
13.
14.
15.
16.
17.
Rx 29
Rx 29
Rx 29
Rx 29
Rx 29
070
073
075
081
090
18.
19.
20.
21.
Rx 29
Rx 29
Rx 29
Rx 29
098
099
109
117
22.
23.
24.
Rx 29
Rx 29
Rx 29
Pharmaceutical Sciences 119

143
144

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OSPE 2555 Rx 28-29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

Agiolax (Isphagula husk+Senna)

Mucilln (Isphagula husk)

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

Hard gelatin capsules

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

Scott's emulsion (Cod liver oil)

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

Emulsion gels, Emulgels

(eye, ear, nose and throat preparations)

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

30 Diazepam suppositories Diazepam tablet ( 1 )

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

- (single-dose container) single-unit

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

Lot & Control No.

: Each tablet contains :

Acceptance value is not more than L1

Not more than 10 mins

Not less than 75% (Q)of LA of Calcium carbonate

Min. 87.2%, Max 98.0%

Not less than 5 mEq of acid is consumed by the

minimum single dose recommended in the

92.5-107.5 %LA of Calcium carbonate

Raw material : Calcium Carbonate Light Batch No. 12610

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

Uniformity of dosage unit

< 25 mg < 25%

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

2 Unit sample Pooled sample ( monograph Unit sample)

Acid neutralizing capacity

Bacterial endotoxins test

Average weight (Range of mean weight)

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

(top loading balance)

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

Activated charcoal, >>

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

levigating agent smooth paste

levigating agent levigating agent (base)

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29

Water in oil cream base

Oil in water cream base

(Levigating agent = Mineral oil*)

(Levigating agent = Glycerin, Propylene glycol)

- Water in oil cream base

- Oil in water cream base

* Mineral oil Liqid petrolatum, Liquid paraffin

OSPE 2555 Rx 2829 PSU Dutch 099 Rx 29