Analgesic Drugs

A
B303099036


(MorphineCodeineSulpyrin)
()

1. (Narcotic analgesic)

(1)Morphine
Opioid HCl
morphine
C17H19NO3
285.34 Morphine

Morpheus
Morphine

Morphine
Morphine

3672

NALOXONE 400ug
kg 510ug
(2)Codeine
Morphine
Morphine 1/4 1/6

Codeine C18H21NO3
opioid

Codeine 0.7-2.5%
Morphine
2


Codeine
10% Morphine
Codeine Morphine Codeine Morphine

3~4 12 15~30 5~12 7.5~15

1~5 3
orthostatic hypotension
Codeine
(3)Morphine Codeine
opioid
receptor agonist GI
(1)
(2)
(3)Anal Sphincter
Anal Sphincter
90 30~45
Morphine
Codeine Codeine Morphine 1/4~1/6
2. (antipyretic anagesics)

(1)Sulpyrin
Dipyrone Sulpyrin
MetamizoleAnalginNovalgin
Melubrin
non-steroidal anti-inflammatory drug
(NSAID)
( Cyclooxygenase )
Sulpyrin PGE2 and PGF2
diarrhea Sulpyrin

(2)Aspirin

3. (Saline)
Saline


1.
2.
(1)
(2)
(3)
(4)
(5)
(6)Tail flick analgesia meter
3.
(1)MorphineHCl (5mg/kg)
(2)Codeinephosphate (20mg/kg)
(3)Sulpyrin (100mg/kg)
(4)Saline 0.9% NaCl
Control

1.
2. pain threshold,PT

PT 205sec 2010sec
3.
A. B. C. D. E.

4. subcutaneously,SC 0.01ml/g bodyweight

0.02ml/g 2hr 1hr

1sec
5. 5min 0min 5min

0min PT 10~15
1min
60sec PT 60

6. 1~4
4


1.

NO 1

NO 2

NO3

NO 4

M(g)

40

40

42

40

PT(s)

10

8.33

7.67

10.67

16

11

6 2/

12

10

16

15

20

25

24

11

44

26

12

10

17

11

18

15

30

10

12

20

15

16

11

10)

30

)
25

38

51

30

1 1

34

35

24

29

40

33

34

45

49

50

60

()
(1)NO.1

(2)NO.2

NO 2 Saline

40
20
0

30
20
10
0

0
5
10
15
20
25
30
35
40
45
50

PT()

60

0
5
10
15
20
25
30
35
40
45
50

PT()

NO 1 Codeine

()

()

(3)NO.3

(4)NO.4

NO 4 Morphine

20
10
0

80
60
40
20
0

0
5
10
15
20
25
30
35
40
45
50

PT()

30

0
5
10
15
20
25
30
35
40
45
50

PT()

NO 3 Sulpyrin

()

()

2.
animal

NO 1

NO 2

NO3

NO 4

62

Codeine

Saline

Sulpyrin

Morphine

++++

++++

++++

++++

++++

++++

++++

++++

++++

+++

++

++

++

++

++++

53


1.
(1)
(2)

(3)

(4)NO.1
Codeine
2.
(1)NO.1
Codeine
NO.4 NO.4
(2)NO.2
Saline
60
(3)NO.3
Sulpyrin

(4)NO.4
Morphine
60

1.
http://drug.doh.gov.tw/
2.
http://www.fda.gov/