pharMaCokinetiCs

pharMaCokinetiCs
GG: Chapter 2-4
Enzyme kinetics (FA12 p258) (FA13 p226) (SU13 p22)
Pharmacokinetics (FA12 p259) (FA13 p227) (SU13 p25) (GG p28)
Dosage calculations (FA12 p259) (FA13 p227) (SU13 p328) (GG p28)

Pharmacodynamics (FA12 p261) (FA13 p229) (SU13 p26)

Physiologic antagonism (GG p41, 46)
Therapeutic index (FA12 p261) (FA13 p229) (SU13 p26) (GG p73)

3 QUESTION WARM-UP
1. What is the classic clinical presentation of a thyroglossal duct cyst? (FA12 p138)
asymptomatic mass in the midline of the neck
moves with swallowing

2. What conditions are associated with an elevated ESR (erythrocyte sedimentation rate)?

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(FA12 p248) (FA13 p349)

3. What is the clinical use for tiotropium? (FA13 p234)

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4. Label the following graphs of enzyme kinetics:

1= Vmax

2nd order velocity

2= .5 vmax
1st order velocity

6
Km

1/Vmax

1/-km

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5. Label the following plots as either competitive or noncompetitive inhibition:

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competitive inhib

non comp inhib

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6
3= noncomp inhib
4= comp. inhib.

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 6. What 4 pharmacokinetics equations are most important to know for Step 1?

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6 7. Partial vs. Full Agonists

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END OF SESSION QUIZ
A 60 kg man with status asthmaticus is being given an IV infusion of drug X at 60 mg/hr.
The clearance of drug X is 2L/h, and the volume of distribution is approximately 0.5 L/
kg. 48 hours after administration has begun, the asthma attack is under control. At this
time, the concentration of drug X in his plasma is 20 mg/L.

8. What is the half-life of drug X in this patient?

9. What loading dose could have been used to reach the target concentration of 20
mg/L?

PHARM BASICS
6
10. If the patient begins to show signs of toxicity, and the target dose is decreased to
10 mg/L, what would you do to get to this level?

stop the infusion for one half-life

11. Assuming 100% bioavailability, what oral dose of drug X would be necessary to
maintain the new target level?

12. If the patient has a kidney disease, and the clearance is reduced to 1 L/h, but Vd is
unchanged, what effect will this have on loading dose and maintenance dose?
decrease maintenance dose and dont change loading dose

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