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Asthma

Mainly in young Age


Later in life it causes degeneration of the lung parenchyma.

Patho: Bronchoconstriction
Inflammation
Obstruction lung disease (OLD)
IgE-Mast.

Pt: Wheezing (consider OLD other than asthma), shortness of breath, cough.
Atopy, Asthma, Allergy
Response to allergens

Late asthma diagnoses:


- Lung sound (disappeared wheezing; bas sign it means patient cannot move any air)
Ominous
- Hyper-resonance
(Loud, lower pitched sound over areas that normally produce a resonant sound).
Hyper-inflated lung (Emphysema)

Dx: PFTs (Pulmonary/lung function test) = OLD = FEV1/FVC 

Asthma Day Reversible: Beta Agonist


Night FEV1 Treatment
I Intermittent
Normal
<2/weekOLD <2/mo 80% Producable:
(normal) AchSABA
Agonist
II mild PFTs <1/day <1/week 80% SABA + ICS
III moderate 1 day 1 week 60-80% SABA + ICS +
LABA
IV severe
Methylcholine 1 day Frequent 60% SABA + ICS +
Albuterol
(Induce asthma) LABA
(Bronchodilator)
V Refractory
(Bronchoconstriction)
Oral
- + + - corticosteroids

Asthma

Asthma Athletic Asthma COPD

18y 65y

TX:
Bronchodilators
- SABA short acting beta agonist
- LABA Long acting beta agonist

Anti-histamines
- ICS Inhaled corticosteroids
- LTs leukotriene antagonists
Severe
From the wrap-up session
Anti-IgE

ICS+SABA+SAA

LABA/LAA

SABA/SAA
Mild
Smoking cessation

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