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Si
Histology department
Medical Faculty of Udayana University
Cartilage :
◦ Type: hyaline, elastis, fibrocartilage
◦ Element : cells and matrix
◦ Growth : interstitial and appositional
Bone :
- Shape : long, short, flat, irregular, sesamoid
- Element: cells and matrix
- Ossification : intramembraneous and
endochondral
- Growth : length and width appositional
Distribution :
1. Hollow but flexible tube
Respiratory passage : larynk, trachea,
bronchus
Auditory tube : external auditory meatus,
eustachian tube, auricle
condroblast condrocytes
in lacuna (e) Isogenous cell group
condroclast (macrophages) only in
endochondral bone formation
2. Cartilage matrix (ground substance) :
Proteoglycan, glycoprotein, glycosaminoglycan
Fiber (collagen and elastic)
- territorial and interteritorial matrix
3. Perichondrium
Outer fibrous layer : collagen, fibroblast, blood
vessel
Inner fibrous layer : chondrogenic cells
Harbor blood vessel for avascular cartilage
matrix
Absent in :
- fibrocartilage
- articular cartilage :
diffusion of nutrient by synovial fluid
TYPE OF CARTILAGE :
1. Hyaline C
2. Elastic C
3. Fibrocartilage
Articular, larger
respiratory passage,
epiphyseal plate
Condrocytes >>
isogenous group
Collagen type II
Matrix : GAG,
proteoglycan,
glycoprotein
(condronectin)
Territorial matrix
- Auricle of the ear, the
epiglottis, eustachian tube
- Chondrocytes
- Elastic fiber (elastin) >>,
collagen type II
- Matrix
Intervertebral disks,
pubic symphysis,
articular disk
Chondrocytes
Collagen type I
Matrix : rich in dermatan
and condroitin sulfate
1. Interstitial growth 2. Appositional growth
- Resulting from the - Resulting from the
(6.6a)
Compact Bone
Area with numerous
interconnecting cavities
Trabecula, lacuna, canaliculi
Endosteum
No haversian systems
Fetal development and bone repair
Anorganic element <<
Abundant osteocytes and irregular bundles of
collagen
secondary bone (except : suture
of calvaria)
Primary / Immature/ Woven bone
Lamellae >>
Canaliculi : osteocytes processes cell
communication; channel (nutrient, hormones,
ions and waste product)
Intramembraneous
Endochondral
Occur in epiphyseal Appositional growth
plate
5 zone : reserve Begin from Periosteum
cartilage, proliferation,
maturation and Continously througout
hypertrophy, the total period of
calsification, bone growth and
ossification development
In length In width
Cartilage VS Bone similarities
Development begin at embryo in 5 week of age
1. Hard tissue
2. Lacuna – matrix systems
3. Same family of cellular components
Chondroblast –chondrocytes
Osteoblast-osteocytes
4. Surrounded by CT membrane
Perichondrium and periosteum
Difference Cartilage Bone
1. Inorganic No High
substance
2. Flexibility Yes No
3. Blood vessel Avascular Vascular
4. Nutrient supply Diffusion Canaliculi
5. Mechanism of Interstitial & Only appositional
growth appositional
6. Remodelling No Constantly
7. Destruction cell No Osteoclast