Rivastigmine with Aurobindo API

Batch Weighed Checked

; Ingredient Item Code % w/w quantity (g) Overages Liquid % Mfger/Supplier Lot No. By By

1 Rivastigmine Base USP 15.00 7.560 NA 15.10 Hetero drugs

2 Pressen 1471 35.00 17.50 34.96 BeardoAdams
3 Plastoid B 4.00 2.00 4.00 Evonik
4 EVA 1062 37.80 18.90 37.75 Glue Machinery
5 DL-Alpha tocopherol USP 0.20 0.10 0.20 Piramal
6 White mineral oil 8.00 4.00 7.99 Sonneborn
7 Release Liner Silicone coated liner, PET, 75 mic Garware
8 Backing membrane Alu, Tan colour 1109, 34 micron 3M
Total solid blend to make 50
Total liquid blend to make 50.06
Total % W/W 100.00
Total Liquid % 100.00
Assay Rivastigmine (AOA) 99.3 Assay & water
content included in
Water content of Rivastigmine 0.09 calculation
833 patches

Patch Size: Calculations:

Wet coating thickness:
Temprature
Target amount of drug per patch:
Target weight of matrix
Weight of Release liner + Backing:
Target Patch weight
Stirring time:
Stabilization time:
Lamination Pressure:
Actual patch weight:
Actual matrix weight:
Actual amount of drug per patch:

Rivastigmine with Aurobindo API

Batch Weighed Checked

Sr No. Ingredient Item Code % w/w quantity (g) Overages Liquid % Mfger/Supplier Lot No. By By

1 Rivastigmine Base USP 15.00 3.780 NA 15.10 Aurobindo

2 Pressen 1471 33.00 8.25 32.96 BeardoAdams
3 Plastoid B 4.00 1.00 4.00 Evonik
4 EVA 1062 46.80 11.70 46.74 Glue Machinery
5 DL-Alpha tocopherol USP 0.20 0.05 0.20 Piramal
6 White mineral oil 1.00 0.25 1.00 Sonneborn
7 Release Liner Silicone coated liner, PET, 75 mic Garware
8 Backing membrane Alu, Tan colour 1109, 34 micron 3M
Total solid blend to make 25
Total liquid blend to make 25.03
Total % W/W 100.00
Total Liquid % 100.00
Assay Rivastigmine (AOA) 99.3 Assay & water
content included in
Water content of Rivastigmine 0.09 calculation
417 patches

Patch Size: Calculations:

Wet coating thickness:
Temprature
Target amount of drug per patch:
Target weight of matrix
Weight of Release liner + Backing:
Target Patch weight
Stirring time:
Stabilization time:
Lamination Pressure:
Actual patch weight:
Actual matrix weight:
Actual amount of drug per patch:

Rivastigmine with Aurobindo API

Batch Weighed Checked

Sr No. Ingredient Item Code % w/w quantity (g) Overages Liquid % Mfger/Supplier Lot No. By By

1 Rivastigmine Base USP 15.00 7.560 NA 15.10 Aurobindo

2 Pressen 1471 33.00 16.50 32.96 BeardoAdams
3 Plastoid B 4.00 2.00 4.00 Evonik
4 EVA 1062 43.80 21.90 43.75 Glue Machinery
5 DL-Alpha tocopherol USP 0.20 0.10 0.20 Piramal
6 IPM 4.00 2.00 4.00 Sonneborn
7 Release Liner Silicone coated liner, PET, 75 mic Garware
8 Backing membrane Alu, Tan colour 1109, 34 micron 3M
Total solid blend to make 50
Total liquid blend to make 50.06
Total % W/W 100.00
Total Liquid % 100.00
Assay Rivastigmine (AOA) 99.3 Assay & water
content included in
Water content of Rivastigmine 0.09 calculation
833 patches

Patch Size: Calculations:

Wet coating thickness:
Temprature
Target amount of drug per patch:
Target weight of matrix
Weight of Release liner + Backing:
Target Patch weight
Stirring time:
Stabilization time:
Lamination Pressure:
Actual patch weight:
Actual matrix weight:
Actual amount of drug per patch: