WONG, Lecery Sophia C.

OBWard

BSN 2-I1

III. Drug Study

1. Naproxen Sodium

Generic Name: Naproxen Sodium

Brand Name: Aleve, Anaprox DS, Apo-Naproxen, EC-Naprosyn, Naprelan, Naprosyn

Dose and Route: 500mg 1 tab OD, Oral

Indication:Treatment of acute or long-term mild to moderate pain, primary dysmenorrhea,

Classification: Analgesic, anti-inflammatory.

Mechanism of Action: Reversibly inhibits COX-1 and COX-2 enzymes, resulting in decreased formation of
prostaglandin precursors.

Therapeutic Effect: Reduces inflammatory response, intensity of pain.

Side effect: Nausea, constipation, abdominal cramps/pain, heartburn, dizziness, headache, drowsiness.

Adverse Effect: Rare reactions with long-term use include peptic ulcer, GI bleeding, gastritis, severe hepatic reactions
(cholestasis, jaundice), nephrotoxicity (dysuria, hematuria, proteinuria, nephrotic syndrome), and severe hypersensitivity
reaction (fever, chills, bronchospasm).

Nursing responsibilities/considerations:

Baseline assessment: Assess onset, type, location, duration of pain/inflammation. Inspect appearance of affected joints for
immobility, deformities, skin condition. Question history of GI bleeding, gastric or duodenal ulcers, hypertension.

Intervention/evaluation: Assist with ambulation if dizziness occurs. Periodically monitor renal function test during
chronic use. Monitor daily pattern of bowel activity, stool consistency. Evaluate for therapeutic response: relief of pain,
stiffness, swelling; increased joint mobility, reduced joint tenderness, improved grip strength.

2.Ampicillin

Generic Name:Apo-Ampi Novo-Ampicillin Nu-Ampi

Brand Name: Ampicillin

Dose and Route: 500 mg, IV

Indication: Treatment of susceptible infections due to streptococci, S. pneumoniae, staphylococci

(non–penicillinase-producing), meningococci, Listeria, some Klebsiella, E. coli, H. influenzae, Salmonella, Shigella,
including GI, GU, respiratory infections, meningitis, endocarditis prophylaxis.

Classification: Antibiotic

Mechanism of Action: Inhibits cell wall synthesis in susceptible microorganisms.

Therapeutic Effect: Bactericidal in susceptible microorganisms.

Side effect: Pain at IM injection site, GI disturbances (mild diarrhea, nausea, vomiting), oral or vaginal candidiasis.
Adverse Effect: Antibiotic-associated colitis, other superinfections (abdominal cramps, severe watery diarrhea, fever)
may result from altered bacterial balance in GI tract. Severe hypersensitivity reactions, including anaphylaxis, acute
interstitial nephritis, occur rarely.

Nursing responsibilities/considerations:

Baseline assessment: Question for history of allergies, esp. penicillins, cephalosporins; renal impairment.

Intervention/evaluation: Promptly report rash (although common with ampicillin, may indicate hypersensitivity) or
diarrhea (fever, abdominal pain, mucus and blood in stool may indicate antibiotic-associated colitis). Evaluate IV site for
phlebitis. Check IM injection site for pain, induration. Monitor I&O, urinalysis, renal function tests. Be alert for
superinfection: fever, vomiting, diarrhea, anal/genital pruritus, oral mucosal changes (ulceration, pain, erythema).

3.MultiVitamins with Iron

Generic Name: MultiVitamins with Iron

Brand Name: Fero-Folic 500, Theragran, Hematinic

Dose and Route:1 tablet, Oral

Indication: used to provide vitamins and iron that are not taken in through diet,Used to treat Iron and Vitamins
deficiency caused by illness, poor nutrition,diegestive disorders.

Classification: Vitamins and/or minerals

Mechanism of Action: Replaces lost iron and minerals

Side effect: Constipation, Diarrhea, Vomiting,Headache

Adverse Effect: Heartburn, Bright red stools, unpleasant taste in mouth

Nursing responsibilities/considerations:

Baseline assessment: Tell the patient to avoid taking any other multi-vitamins product within 2 hours before or after the
patient take multivitamins with iron.

4.Tranxamic Acid

Generic Name: Tranxamic Acid

Brand Name: Transamin, Tren

Dose and Route: 5oomg, IV

Indication: Used to treat heavy bleeding

Classification: Haemostatics

Mechanism of Action: Inhibits fibronolysis by blocking gthe binding ofplasminogen and plasmin to fibrin, thus
preventing dissolution of the hamostatic plug.

Side effect: Pale Skin, Trouble breathing, Bruising

Adverse Effect: Unusual bleeding, Anxiety, Confusion

Nursing responsibilities/considerations:

Baseline assessment: Question for history of allergies.

REFERENCES:

Hodgson,B.B., & Kizior, R. (2019) Saunders Nursing Drug Handbook. Philadelphia: Saunders

MIMS Australia. (2018). Panadol. In MIMS online. Retrieved from, https://www.mimsonline.com.au