Doxinciples odru discevery

fssigoment-

Kode otronsgenic Animo in foxgel Uaholalkiom

Submited by:
CShaheen)
Sk. Sham Surnis
a

.No, oiSISO60.
.phaym yeay
n
.Som r . mid

Submitled fo
P.S.PsokPrishron Sir
M.p haym, ph D
Pepovlnens o hasymaoo

TNTUR, Schto o phaymorukicol Seience Anal Technot

lotonsqenic Pnimals
0t Onimol hol haue Qoleon genl
0nenit onimal

inled toy) delaled ouom ne o e

delitonlek
gerolicoluy engin eeyed
om deuelppnersl
dsuo diseoteuy
ndsutlod,
30 model 0y
mce ard gerlicala engireesyed

Stoiasd echn AS osaoiign 0

ordo inisuoruchor -gene Conkqer)

u

syerkseoseo isvodkate cKootk 9u7) gen

ansgenic 0sials05e Conutled itiu

. Micve topelion Co) Suvemut gee deliues

2mêsuonit Jem Cell.

3 atssyis0 Uecloy meha,

u s discouu ocessI
ereolt R
ru needs te desciheg
te
tn deroi i 0shy 0enic techo
Con olee Drimo.
Campasaliye ouon
esomics. TU

ead eog elinuto clinicol

Tuoiec ose npmant

o lec h gyto
enhonee du9 discoy@m
laxe oCelbslos ord ay Stácuyeinvotved in
ushith ose sposile R dteose

hey .Roceilo
202ye
3. Nusluit D o

tyosone.
o n chonpel

lougt dentfiesio Gme o deriyi tR

divec moferuoy - 9 0 i.e Doslein nurlair orid, Jolo ~t yme

oee o be mapiBualed
mpBuaed o pyenthe dereopmen o disoose
disense
l) ollariafe dympfaTms
Psugg usuol, rl gm t Celay C1) gereieoso 0ye
beliener-n oosialed t t dise0

Siesk use o
asiyoHerhniouts Cidenl bnd sofate o
oge p eNs
cune toms ho Thece tn und
dise95e
*COmppd Dye Th ideniten tRt
hoe tious otoyakions th
d'v9os.9 telppa in veo?men Spers dsebse
Geromic

oo ovo
Solern icolion

io in 8tmolt c
.Tospel Ualidaleon
ooo Uolidotonm o oras b hit h The 6syerreted msler
0 osugo7 eTOmie bofeun oY) urleit ud o
Sm mofecle 0ed
Tob00 oidbltonm Con ibeludle koock dousn (oy) oey eP0312PSrom
Bsyesumeo oo7
Selex Hosolt mos kely Co 6 uelul t tre dureloAmer
u veotmerl dis0de, jeseoychasys Droly Comfosy e
tP.
r e on hes9 0KAoIolto
Hosoe u Speul
dtseose nd etr - jogula 6oboiro Compeuusdc t
Bo
exds sye tTrurled C T tis cejoilians crugaso
oSAoRiotled uth derive home i be
hotreus 0 dis ended
eoded
Cells

toledotm.
ieSente
oi9dourleelicler
3 Lead ideriifuslign;

leod eomut co1)Sub/onee t gne

thabeteued to aye
o o o vea: diseate
lokosolu dciesie COTpoo Ssbons
Comghusd Cdelymire as tkel:ber o Suecs
 0e Soelime deve lpped 0 6asyr'es 0 Paryricuo
molles oSes eeded tn
he m impoa oee lead yoyiej
M
o madeuse,

Nol osy suour ryav'es

eplide G6avies
Casshupho lh tihsynyes
Urtuobvostes
cOn 6e CYcoec b utro Combino 0Mt'o
chemit
T9 (ead

cderico0n
SCreept' rNQ
Seveepr

4. leod Opiimigaltion
Oo oplimyo7ton compos the
ouopate o ead
Uooieus ead
Com Dusn rd s0ride tn09ymalon eler com Dtu CoCo)
Comp9an t syede eo -Co be detyelapes e
a lesiye medicinQ

h e coordo e keif'er o ole

OrsoRe t'n o Dcco un rho dush os

e0ke eylthesis o mulalton.

ter th ty Dye
0ye
u9eved a onnueytgoltonal new drue
 Sabmtlen .lintaeru9

.ye-clinio phase
ti yeclin
r rtye ompous, Teslino
oplimigin
Am
Dnimofeslio SCASed Co Iy ,ohether
cal pase (ob

0inci0.y suite
humon hmie
16 eosymine his
hus Ses00 hey Pame ne Dmaro giher thing!

ike ADOe o olee 0Mans.

o addition they
they emire oheTher on tn uho Corcen/vo//on

mstox t0xiC eec Om 9enelic moeup.

6. clinislials:
tAre
e 0liye COTnpound Oouer Autas ul a

legny9pusyens, e n oreci, letroo

oltO dtal
Ths foleasio clinitol phoses.
Duman banos

D ose. uman posmo.co boy Commahhte in hoo/Thy tes Subjecl-

mse o.Deli epold'o7o uos. -PDeTesymina hon o
opttmol olose
rose- 3 synpelie
orluene2s
prose-q Csmoskelirq Susrni lonu Sucies
lotmen oer oensb/a
Rode of transqenie onimals t
Rrle oxge yalidalion
Uaidalion
Ualidolio icominudo Cyiico xbcts ang, en

tn discoaS phasse Pfexenl ualielolon me hos hoe o be

ufed dsi dillour toges this sou%

ho o be moole 6
Seleclions
tthe e phokes en

cOA
oos om utusyed Ce lt
o 0s9e o o o r eioindlo/ic

Comsidesyabte e o y e bai made idesit aid, oyeliobte

om genesnltot n-vavo alidalton b 66 p,Onl

amgenic ntma eyelkoty ae Jos9e o T a u a i s

enl ualkdalion as-0 d dienlal dr9 ombirolkon

Dar
arbieved Cun
nlethe Deu ortiol dug leke t chnual

COTmOT S1e0
pstmen t The Yas-ge Ualidalton phose i The
Ooorlur lio genelieolly moified Dnmalta7 elher
orey expYers
(Qene 9odrtion) (o) ongey ess The to9e Cgen krerk oul
hese onio ouéde Cn-Ueva onal daro on enl'al

he mas Sopid! tuont9eoic ntmo.ls hish con bo oura'

isthe ore tho OwCY he
exa91@ tvasgen iher uitous
) issu Sperilit ManneyY
 (nsuge 0 issutpeii omoly hove Deu beep useg

-o yed t honsgene erpjosisn b diso ce ype,

P:esan Sysdom 0ye 0valable o Janulá he egoyestam

tsonsend usi nOn-ohuygio boro thoasys, Surb 0S

mefallahionetn oomoier
phxspho em Byyova coxboxy kinoge omofer
leyoce lioe dyçlem.

Cnene knbe -ou ni'mals ack gioen 9epe'eunchon

otrcepron
ard teugheil thotr eve tbis yreld 9vea thtioht toto
he co-u cutons de
torlb
mofacule int/ove Sioco Dnsd'utleon
Cnenerh-8u dyram

Cve-ox alom
eCve-Ste Sporijtombirate enyme, hucb 0Gnize o pSite
hith
whith i fTAhCTTC TATfAG, CATACATTA
TRCG fAAGT7

Csene

Cre

Cye exeisiom.
 emolre

enex

kodce-uil al.

Cve Meot
Cox P Mb te.
fo 9n90/eon
Cye Bveed

Cre lox p lboe reroltom

noc-Bui7 nema..

sense moculs t
10 minimize 1 ittom ol n eliracolaial, len6/ ohuge
t most dhseau need o b eded tn eefayimerilal dyilemt

ypsemkle hussas phuyeu sgy ond oo 0s Closoly as

sibla.,
Asangenic erhas mi
erultes in he
deuelepmen ad.o
diseose models d ome These oue alleuad ttA tectiroter
hrealman posodhgm.s.
 lsheimey dêsea 1 tye0uodegeneya/iue diseate
vessitre
No on' mal mode eeited c his oiseose befote-fou0nsqpnie

erhosmy empyed.

ontmomovelhoye bee etoklic hed,

odoy, Aevevo yoAsqenie
human ond
lhdlmyond cuopon
yo u0pon
Jjesomble muth
hese
these model

noue FOsaltc Comeuushs

tl used

ilosuq edersTelicoon
Tha
JdesTiy the ditease a Stuoy
othalogy.

onya thi aesease moal eno

heimer's diseoe.
Stou plosfotin useo -o t'urs -amylad

sein hippEramfpoc.

Tosgetdlerel iea by genomier sb/e0mice

Ouer exoAsion O tmyoid atusyst psuole.i

CAPP) Sjeponciba
i) tagel Ualtdolion

traleda ta 3ypal fPPyesponeible

figheimer direace

to
mulan fPP gens
eliver

mulan fPP n
ho/to
plgerusis

Tos42e Ualrda7as,

tte esh Doleun fAB41

mmunizalt on suenltoy
esulted
e sufed tn
ta diteoce
dtteace
direase berame eiabished
bolu
bolhu iohibeted oieoke os09yestro
ay) Lcler Ancmale
Ototme

S:oeslo
tuontgenteom Rndc -edonimak
Lo Oncol09y
umeyomiro
tkun k on g ODCO9nds
hove been uke tn

Fumb Jupyerso 9es,

tumo ores tom ad melactotis.

iMechonsm
maltoronl disease 10ften 9yela ed b

melovas tmOsuy tuum0

 6
behin me7odosit Cua

BoBlr'de Ua/tob Tneopenlc ppounihes

odhesron Dofecales ms ben udred ( oongtnc

hAhe
e ole o
ontmal mo wwth uovuy dlafi
uevu mu etaoe tumb p0 sin

eCoolherin gen on RRip.1ag2hsontopsic e hoj

chbused the esenltolole - Codhsin

ond me7altal ts

he essenlta ofo anthey Cell adheston malo

o Nchg

tn meastasis was demanthoTad Rip 1 Taq 2 mol.

rgioopnetts
tR o mlton new boo Uessel
c09Lntr

exsiuleng Vesselr a Sugpy

tumoy ul.

hibidon S t6ipo
oppoiuny
ubasut festad to Kip.1 a9
ors oor nile
Shbused dthel dieventumoy
Stogerested,suggoilinq that oi lesanangoeneji tnhiatoys
should be use o spelic diseo STopes,
 eevences

. the use aont9nic Sydoont n

phoymattu ural yeieasych'
Miehael R. Sraith and Jan Toinet (ootio )
ne-Rote o aso tdesleleotion an asgl
. INtN.Selde Shave,
Ualtdale om in ovuo dttcbeyty OULS