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Predict Question
1 Predict Question: Predict what will happen to the resting membrane potential if the
extracellular K+ concentration is increased.
Your answer: The resting membrane potential will become less negative.
2 What does it mean that the voltage just inside the membrane is negative?
You correctly answered: There are more negative charges than positive charges just inside
the membrane.
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3 The membrane of most cells, including neurons, contains passive, open, K+ leak channels.
Given the normal K+ concentrations and the resultant concentration gradient, which
direction would K+ be expected to move (diffuse) through these leak channels?
4 What effect does increasing extracellular K+ have on the net diffusion of K+ out of the cell?
5 Which way would Na+ move across the membrane if there were open Na+ channels?
6 The membrane has open K+ channels, and changing extracellular K+ concentration results in
a change in membrane potential. Changing the extracellular Na+ concentration does not
significantly change the membrane potential. What do your results suggest about the
number or state (open or closed) of Na+ channels in the resting membrane of a neuron?
Experiment Data
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1 A negative membrane potential was recorded when the tip of the microelectrode was
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You correctly answered: both inside the cell body and inside the axon.
2 Which of the following caused a change in membrane potential from -70 to -40 in the cell
body?
You correctly answered: between the inside of the axon and the outside of the axon with
control K+ ECF.
Your answer:
2 Explain why increasing extracellular K+ causes the membrane potential to change to a less
negative value. How well did the results compare with your prediction?
Your answer:
3 Explain why a change in extracellular Na+ did not significantly alter the membrane potential
in the resting neuron?
Your answer:
4 Discuss the relative permeability of the membrane to Na+ and K+ in a resting neuron.
Your answer:
5 Discuss how a change in Na+ or K+ conductance would affect the resting membrane
potential.
Your answer:
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