20/6/2020 Drug Interactions results - MICROMEDEX

Drug Interaction Results

Fármacos seleccionados: Amoxacillin/Clavulanate Potassium , Depakene , Metronidazole , Naproxen
, Prednisone
Gravedad: Todo
Documentación: Todo
Interaction Type: Todo

Drug-Drug Inte raccione s (1)

Fármacos: Grav e dad: Docume ntación: Re sume n:

NAPROXEN -- PREDNISONE Fair Concurrent us e of

Major CORTICOSTEROIDS
and NSAIDS m ay res ult
in increas ed ris k of
gas trointes tinal ulcer or
bleeding.

Duplicación de ingrediente (Sin coincidencias)

Drug-ALERGIA Interacciones (Sin coincidencias)

Drug-COMIDA Interacciones (Sin coincidencias)

Drug-ETANOL Inte raccione s (1)

Fármacos: Grav e dad: Docume ntación: Re sume n:

METRONIDAZOLE Good Concurrent us e of

METRONIDAZOLE and
Contraindicated ETHANOL m ay res ult in a
dis ulfiram -like reaction
(abdom inal cram ps ,
naus ea, vom iting,
headaches and flus hing)
or s udden death.

Drug-LABORATORIO Inte raccione s (12)

Fármacos: Grav e dad: Docume ntación: Re sume n:

NAPROXEN Fair NAPROXEN m ay res ult in

increas ed urinary 17-
Moderate ketogenic s teroid as s ay
res ults due to interaction
with the m -
dinitrobenzene reagent.

NAPROXEN Fair NAPROXEN m ay res ult in

interference in s om e
Moderate urinary s creening tes ts
for 5-hydroxyindoleacetic
acid due to m echanis m
unknown.

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AMOXICILLIN/ CLAVULANATE POTASSIUM Fair AMOXICILLIN m ay res ult
Minor in a fals e pos itive for
glucos e in the urine due
to exces s ive am ounts of
urinary am oxicillin.

AMOXICILLIN/ CLAVULANATE POTASSIUM Fair TICARCILLIN/

Minor CLAVULANIC ACID m ay
res ult in a fals e-pos itive
Coom bs ' tes t due to
nons pecific binding of
IgG and album in by red
cell m em branes .

METRONIDAZOLE Good METRONIDAZOLE m ay

Minor res ult in interference in
s erum hexokinas e
m eas urem ent due to
abs orbance peak
s im ilarities .

METRONIDAZOLE Good METRONIDAZOLE m ay

Minor res ult in interference in
s erum alanine
am inotrans feras e
m eas urem ent due to
abs orbance peak
s im ilarities .

METRONIDAZOLE Good METRONIDAZOLE m ay

Minor res ult in interference in
s erum triglycerides
m eas urem ent due to
abs orbance peak
s im ilarities .

METRONIDAZOLE Good METRONIDAZOLE m ay

Minor res ult in interference in
s erum as partate
am inotrans feras e
m eas urem ent due to
abs orbance peak
s im ilarities .

METRONIDAZOLE Good METRONIDAZOLE m ay

Minor res ult in interference in
s erum lactate
dehydrogenas e
m eas urem ent due to
abs orbance peak
s im ilarities .

NAPROXEN Good NONSTEROIDAL

Minor ANTIINFLAMMATORY
AGENTS m ay res ult in
fals ely pos itive fecal
hem occult tes ts due to
NSAID-induced
gas trointes tinal bleeding.

PREDNISONE Fair PREDNISONE m ay

Minor res ult in fals e increas es
in digoxin levels due to
digoxin as s ay
interference.

VALPROIC ACID Fair VALPROIC ACID m ay

Minor res ult in a fals e-pos itive
urine ketone tes t due to
valproic acid being

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partially elim inated in the
urine as a keto-
m etabolite.

Drug-TABACO Inte raccione s (1)

Fármacos: Grav e dad: Docume ntación: Re sume n:

NAPROXEN Fair Concurrent us e of

Major CYP1A2 SUBSTRATES
and TOBACCO m ay
res ult in decreas ed
expos ure of CYP1A2
s ubs trates .

Drug-EM BARAZO Inte raccione s (5)

Fármacos: Grav e dad: Docume ntación: Re sume n:

AMOXICILLIN/ CLAVULANATE POTASSIUM Unknown Am oxicillin is rated as US

FDA Category B. Anim al
Moderate s tudies have revealed no
evidence of harm to the
fetus , however, there are
no adequate and well-
controlled s tudies in
pregnant wom en. (OR)
Anim al s tudies have
s hown an advers e effect,
but adequate and well-
controlled s tudies in
pregnant wom en have
failed to dem ons trate a
ris k to the fetus .

METRONIDAZOLE Unknown No US FDA rating is

available for
Moderate Metronidazole.

NAPROXEN Unknown No US FDA rating is

available for Naproxen.
Moderate

PREDNISONE Unknown No US FDA rating is

available for Prednis one.
Moderate

VALPROIC ACID Unknown No US FDA rating is

available for Valproic
Moderate Acid.

Drug-LACTANCIA Inte raccione s (5)

Fármacos: Grav e dad: Docume ntación: Re sume n:

AMOXICILLIN/ CLAVULANATE POTASSIUM Unknown Infant ris k cannot be

Major ruled out: Available
evidence and/ or expert
cons ens us is
inconclus ive or is
inadequate for
determ ining infant ris k
when Am oxicillin is us ed

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during breas t-feeding.
Weigh the potential
benefits of treatm ent
agains t potential ris ks
before pres cribing
Am oxicillin during breas t-
feeding.

METRONIDAZOLE Unknown According to the

Major Am erican Academ y of
Pediatrics , Metronidazole
has unknown effects and
m ay be of concern during
breas t-feeding.

NAPROXEN Unknown Infant ris k cannot be

Major ruled out: Available
evidence and/ or expert
cons ens us is
inconclus ive or is
inadequate for
determ ining infant ris k
when Naproxen is us ed
during breas t-feeding.
Weigh the potential
benefits of treatm ent
agains t potential ris ks
before pres cribing
Naproxen during breas t-
feeding.

PREDNISONE Unknown Infant ris k cannot be

Major ruled out: Available
evidence and/ or expert
cons ens us is
inconclus ive or is
inadequate for
determ ining infant ris k
when Prednis one is
us ed during breas t-
feeding. Weigh the
potential benefits of
treatm ent agains t
potential ris ks before
pres cribing Prednis one
during breas t-feeding.

VALPROIC ACID Unknown Infant ris k cannot be

Major ruled out: Available
evidence and/ or expert
cons ens us is
inconclus ive or is
inadequate for
determ ining infant ris k
when Valproic Acid is
us ed during breas t-
feeding. Weigh the
potential benefits of
treatm ent agains t
potential ris ks before
pres cribing Valproic Acid
during breas t-feeding.

Definiciones
Gravedad:

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20/6/2020 Drug Interactions results - MICROMEDEX
Los fármacos están contraindicados para su uso simultáneo

Contraindicado

Importante La interacción puede causar la muerte y/o requerir intervención médica

para minimizar o evitar efectos adversos graves.

Moderada La interacción puede agravar la condición del paciente

y/o requerir una alteración de la terapia.

Secundario La interacción puede tener efectos clínicos limitados. Los síntomas

pueden incluir un aumento de la frecuencia o la gravedad de los efectos
adversos pero, en general, no requerirán una alteración importante de la
terapia.

Desconocida Desconocida.

Documentación:

Excelente Los estudios controlados han establecido claramente la existencia de

interacción.
Buena La documentación sugiere plenamente que existe interacción,
pero faltan estudios bien controlados.
Suficiente La documentación disponible es escasa pero las consideraciones
farmacológicas han llevado a los médicos a sospechar de la existencia de
interacción; o la documentación es buena para un fármaco similar
farmacológicamente.
Desconocida Desconocida.

© Copyright IBM Corporation 2020

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