Drug Study

Pauline Marie N. Ebanos BSN3-C

Name of Drug Dosage, Route Mechanism of Action Indication Contraindication Adverse Effect Nursing Responsibility
and Frequency

Generic Name: Dosage: Blocks the Alone or with Hypersensitivity; CNS: dizziness, ● Assess BP and pulse
vasoconstrictor and other agents in Concurrent use fatigue, frequently during initial
VALSARTAN 40 mg
aldosterone-secreting the management with aliskiren in headache dosage adjustment and
effects of angiotensin of hypertension. patients with periodically throughout
CV: edema,
II at various receptor Treatment of diabetes or therapy. Notify health
Brand Name: Frequency: hypotension
sites, including heart failure moderate-to- care professional of
DIOVAN Q12hrs vascular smooth (New York Heart severe renal EENT: significant changes.
muscle and the Association class impairment pharyngitis,
● Monitor frequency of
adrenal glands. II-IV). Reduction (CCr 60 rhinitis,
Classification: Route: prescription refills to
Therapeutic Effects: of risk of death mL/min); sinusitis.
determine compliance.
Antihypertensive PO Lowering of BP in from
OB: Can cause F and E:
s patients with cardiovascular ● Assess patients for signs
injury or death hyperkalemia.
hypertension. causes in patients of angioedema (dyspnea,
Angiotensin II of fetus – if
Decreased risk of with left GI: abdominal facial swelling).
receptor pregnancy
heart-failure-related ventricular pain, diarrhea,
antagonists occurs, ● HF: Monitor daily
hospitalizations in systolic nausea.
discontinue weight and assess patient
patients with heart dysfunction GU: impaired
immediately routinely for resolution of
failure. Decreased following renal function. fluid overload (peripheral
risk of death from myocardial Lactation:
edema, rales/crackles,
cardiovascular causes infarction Discontinue MS: arthralgia,
dyspnea, weight gain,
in patients with left drug or use back pain.
jugular venous
ventricular systolic formula Misc: distention).
dysfunction following ANGIOEDEM
myocardial infarction ● Lab Test
A
Considerations: Monitor
renal function. May cause
 increase in BUN and
serum creatinine.

Name of Drug Dosage, Mechanism of Indication Contraindication Adverse Effect Nursing Responsibility
Route and Action
Frequency

Generic Name: Dosage: Direct-acting Moderate to Hypersensitivity; CNS: dizziness, ● Monitor BP and pulse
peripheral severe Some products drowsiness, headache. frequently during initial dose
Hydrazaline 25 mg
arteriolar hypertension contain tartrazine adjustment and periodically
CV: tachycardia,
Brand Name: Frequency: vasodilator. (with a diuretic). and should be during therapy.
angina, arrhythmias,
Therapeutic Unlabeled Use: avoided in
Apresolin Q8hrs edema, orthostatic ● Monitor frequency of
Effects: HF unresponsive patients with
hypotension prescription refills to
Classification: Route: Lowering of BP to conventional known
determine adherence.
in hypertensive therapy with intolerance. GI: diarrhea, nausea,
Antihypertensives PO
patients and digoxin and Cardiovascular vomiting. ● Lab Test Considerations:
Vasodilators decreased diuretics. or Monitor CBC, electrolytes,
Derm: rash
afterload in cerebrovascular LE cell prep, and ANA titer
patients with HF disease F and E: sodium prior to and periodically
retention during prolonged therapy.
Severe renal and
hepatic disease MS: arthralgias, ● May cause a positive direct
(dose arthritis Coombs’ test result.
modification may Neuro: peripheral
be necessary) neuropathy
OB, Lactation: Misc: drug-induced
Has beenused lupus syndrome
safely during
pregnancy.
 Name of Drug Dosage, Route Mechanism of Action Indication Contraindication Adverse Effect Nursing Responsibility
and Frequency

Generic Name: Dosage: Inhibits the Edema due to Hypersensitivity CNS: blurred ● Assess fluid status.
reabsorption of heart failure, vision, dizziness, Monitor daily weight,
Furosemide 20 mg Cross-sensitivity
sodium and chloride hepatic headache, intake and output ratios,
with thiazides
Brand Name: Frequency: from the loop of impairment or vertigo amount and location of
and sulfonamides
Henle and distal renal renal disease. edema, lung sounds, skin
Lasix BID may occur EENT: hearing
tubule. Increases renal Hypertension. turgor, and mucous
loss, tinnitus
Classification: Route: excretion of water, Hepatic coma or membranes. Notify health
sodium, chloride, anuria CV: hypotension care professional if thirst,
Loop Diuretics PO
magnesium, dry mouth, lethargy,
Some liquid GI: anorexia,
potassium, and weakness, hypotension, or
products may constipation,
calcium. oliguria occurs.
contain alcohol, diarrhea, dry
Effectiveness persists
avoid in patients mouth, ● Monitor BP and pulse
in impaired renal
with alcohol dyspepsia, liver before and during
function. Therapeutic
intolerance enzymes, nausea, administration. Monitor
Effects: Diuresis and
pancreatitis, frequency of prescription
subsequent Severe liver
vomiting. refills to determine
mobilization of excess disease (may
compliance in patients
fluid (edema, pleural precipitate GU: BUN,
treated for hypertension.
effusions). Decreased hepatic coma excessive
BP urination, ● Geri: Diuretic use is
concurrent use
with potassium- nephrocalcinosis
associated with increased
sparing diuretics risk for falls in older
Derm:
may be adults. Assess falls risk
ERYTHEMA
necessary) and implement fall
MULTIFORME,
prevention strategies.
Electrolyte STEVENS-
depletion JOHNSON
SYNDROME,
Diabetes
TOXIC
mellitus;
EPIDERMAL
Hypoproteinemia NECROLYSIS,
(risk of photosensitivity,
ototoxicity) pruritis, rash,
urticaria. E
Severe renal
impairment (risk
of ototoxicity)