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UNIVERSIDAD DE ZAMBOANGA

School of Allied Medicine


Department of Respiratory Therapy
Pulmonary Disease Management Laboratory

DRUG STUDY

MECHANISM OF ACTION, SIDE INDICATIONS & RESPIRATORY THERAPIST


DRUG EFFECTS & ADVERSE EFFECTS CONTRAINDICATIONS RESPONSIBILITIES
Generic Name: Ipratropium Ipratropium is an acetylcholine Indications:  Check Physicians order.
Salbutamol antagonist via blockade of muscarinic Ipratropium and albuterol  Follow the 14 rights of medication
cholinergic receptors. Blocking combination is used to help  Position patient on high back rest
Brand Name: Duavent cholinergic receptors decreases the control the symptoms of lung position
production of cyclic guanosine diseases, such as asthma,  Protect solution for inhalation from
Classification: Adrenergics in monophosphate (cGMP). This chronic bronchitis, and light. Store unused vials in foil
combination with Anticholinergics decrease in the lung airways will lead emphysema. It is use to pouch.
to decreased contraction of the smooth manage reversible  Use nebulizer mouthpiece instead of
Route: Inhalation muscles. Salbutamol promotes the bronchospasm. face mask to avoid blurred vision or
production of intracellular cyclic aggravation of narrow-angle
Frequency: Q6H adenosine monophosphate (cAMP), Contraindications: glaucoma.
which enhances the binding of Hypersensitivity to  Can mix albuterol in nebulizer for
Dosage: 500mcg/2.5mg per 2.5ml intracellular calcium to the cell salbutamol, ipratropium or up to 1 hr. Ensure adequate
pulmoneb membrane. This action decreases the fenoterol, atropine or its hydration, control environmental
calcium concentration within cells and derivatives. Hypertrophic temperature to prevent hyperpyrexia.
results in the relaxation of smooth obstructive cardiomyopathy,
 Have patient void before taking
muscle and bronchodilation. tachyarrhythmia, severe
medication to avoid urinary
The combination is used to treat airway obstruction, cystic
retention.
conditions where breathing is a fibrosis, prostatic hyperplasia
 Teach patient proper use of inhaler.
problem, such as COPD, chronic or bladder-neck obstruction,
 Do back tapping after you nebulize
bronchitis and emphysema. They convulsive disorders,
the patient
work by relaxing and opening up the
air passages, making breathing easier hyperthyroidism, diabetes  Do not give food immediately, may
and improving shortness of breath, mellitus. cause vomiting
chest tightness and wheezing.  Report rash, eye pain, difficulty
voiding, palpitations, and vision
SIDE EFFECTS changes.
Headache, dizziness, nausea, dry
mouth, shaking (tremors),
nervousness, or constipations may
occur.

ADVERSE EFFECTS
Edema, Fatigue, Hyprtension,
Upper respiratory infections,
Epistaxis, Pharyngitis, Headache,
Xerostomia, Change of taste, Nausea,
Nasal irritation and Gastro-intestinal
motility disorders.

References:
https://www.scribd.com/document/462100804/ipratropium-salbutamol-DUAVENT

https://www.mayoclinic.org/drugs-supplements/ipratropium-and-albuterol-inhalation-route/description/drg-20062048

https://www.rnpedia.com/nursing-notes/pharmacology-drug-study-notes/ipratropium-bromide/

https://www.mims.com/philippines/drug/info/ipratropium%20bromide%20+%20salbutamol?mtype=generic

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