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45 year ol d pati ent f asti ng bl ood gl ucose l evel 135 i ncrease appeti te? D i abetes type 2
A D H acts on whi ch part of ki dney? D i stal convul ated tubul e and col l ecti ng duct
Physio
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A speech di sorder devel ops af ter head i nj ury pati ent started f eel i ng di f f i cul ty i n
utteri ng words. H i s speech became l i mi ted to a f ew words. T here i s most l i kel y Broca's area
damage to?
Adrenal medul l a secretes M ore epi nephri ne and l ess N orepi nephri ne
Adrenocorti cal secreti on of al dosterone i s greatl y i ncreased wi th I ncrease potassi um concentrati on i n extracel l ul ar f l ui d
Af ter head i nj ury pati ent devel ops speech def ect there he can understand words
but f eel s di f f i cul ty i n a utteri ng the words speech i s l i mi ted to a f ew words the Broca's area
pati ent i s havi ng damage to
Al dosterone secreti on i s greatl y sti mul ated by? I ncreased potassi um i on concentrati on i n extracel l ul ar f l ui d
Physio
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An i ncrease i n the permeabi l i ty of cel l s of col l ecti ng tubul e to water i s due to? I ncrease i n producti on of AD H
Brai n can suppress i nput of pai n si gnal s to nervous system by acti vati ng a pai n
Anal gesi a system?
control system cal l ed the anal gesi a system
Physio
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Anti i nf l ammatory acti on of corti sol i s mai nl y due to Stabi l i z ati on of cel l ul ar l ysosomal membrane
Anti di ureti c hormone secreti on i s sti mul ated by? I ncrease osmol ari ty of body f l ui ds
Physio
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Resul ts f rom wi despread destructi on of that porti on of the substanti a ni gra the
Cause of Parki nson's di sease (pars compacta) that sends dopami ne secreti ng nerve f i bres to the caudate nucl eus
and putamen
Cause of dwarf i sm I nsuf f i ci ent growth hormone produced by the anteri or pi tui tary
1. Autoi mmuni ty > Long Acti ng T hyroi d Sti mul ator LAT S, an anti body >bi nds at the
Causes of H yperthyroi di sm? same receptors on thyroi d cel l membrane as T SH > i nc sec of T 3 and T 4.
2. Local i z ed adenoma i n thyroi d gl and > i nc sec of T 3 and T 4.
D escendi ng l i mb of l oop of henl e contai ns? F l ui d that becones more concentrated as i t moves down i nto medul l a
D etermi nati on of the di recti on f rom whi ch the sound comes i s the f uncti on of Audi tory cortex
Physio
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D i f f erence between gl omerul us and other capi l l ari es of body? I ts drai ned by an ef f erent arteri ol e
-l evodopa/carbi dopa
-L-D eprenyl
D rugs used to treat Parki nson's?
-transpl anted f etal dopami ne cel l s
-by destroyi ng part of the f eedback ci rcui tary
D uri ng devel opment of a hi gh grade f ever wi th chi l l s and ri gors there i s Shi veri ng
Physio
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D uri ng f etal l i f e the devel opment of brai n i s promoted mai nl y by T hyroi d hormones
-depressi on
E f f ect of H yperthyroi di sm on Brai n? -dec concentrati on
-general l ack of i nterest
-consti pati on
E f f ect of H yperthyroi di sm on I ntesti nes?
-dec GI acti vi ty
-i nc LD L
E f f ect of H yperthyroi di sm on Li ver? -i nc chol estrol
-el evated tri gl yceri des
Physio
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-dec f uncti on
E f f ect of H yperthyroi di sm on ki dneys?
-f l ui d retenti on and edema
-dec f erti l i ty
E f f ect of H yperthyroi di sm on reproducti ve system -menstrual abnormal i ti es
-may harm devel opment of i nf ant
E f f ect of al dosterone on sodi um reabsorpti on I ncreases sodi um reabsorpti on f rom di stal part of renal tubul es
Au t o no mi c c o nt ro l : i nc GI T acti vi ty
-crani al porti on by vagus nerve
-sacral porti on by 2nd, 3rd and 4th pel vi c spl anchni c nerve
-postgangl i oni c neurons are l ocated i n myenteri c and submucosal pl exus.
E f f ect of parasympatheti c sti mul ati on on GI T ?
F u nc t i o ns :
>i nc peri stal si s and tone
>rel axes sphi ncters
>i nc di gesti ve secreti ons
-I nhi bi ts GI T acti vi ty
-f i bres ori gi nate i n spi nal cord between segments t5 to L2
-some f i bres enter sympatheti c chai ns and then pass to cel i ac gangl i on a myenteri c
gangl i on
M ost of the post gangl i oni c neurones are i n thi s gangl i on
E f f ect of sympatheti c sti mul ati on on gi t - i nnervates al l the GI T securi ty.
-secrete epi nephri ne and norepi nephri ne
F u nc t i o ns
> decrease peri stal si s and tone
> contracts sphi ncters
>decrease di gesti ve secreti on
Physio
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Prol acti n
Oxytoci n
E numerate hormones that take part i n l actati on
estrogen
progesterone
Physio
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E xcreti on of di l ute uri ne requi res? I mpermeabi l i ty of col l ecti ng tubul e to water
-buf f al o torso
-moon f ace
-mascul i ni z i ng ef f ects
- i nc bl ood gl ucose l evel
-i nc bl ood corti sol l evel
-i nc uri nary sec of 17 hydroxysteroi ds
-verti go
-acne
F eatures of Cushi ngs Syndrome?
-bl urry vi si on
-f emal e bal di ng
-water retenti on
-menstrual abnormal i ti es
-purpl e stri ae
-thi n ski n and brui si ng
-poor wound heal i ng
-hi rsuti sm
-severe depressi on
-cogni ti ve di f f i cul ti es
Physio
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F etal Ki dneys don't have to work very hard because? Pl acenta al l ows the mothers uri nary system to cl ear the waste f rom f etal bl ood
F i l trati on f racti on? Rati on of gl omerul ar f i l trate rate GF R to renal pl asma f l ow RPF
1. Gl omerul ar endothel i um
F i l trati on membrane i ncl udes? 2. Podocytes
3. Basement membrane
Physio
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F i nd touch and two poi nt di scri mi nati on i s transmi tted by D cml system
E R and gol gi apparatus of thyroi d f ol l i cul ar cel l s f orm and secrete a gl ycoprotei n
F ormati on and secreti on of thyrogl obul i n on synthesi s of thyroi d hormones? cal l ed thyrogl obul i n i nto f ol l i cl es, contai ni ng 70 tyrosi ne ami no aci d resi dues.
T 3 and T 4 are f ormed as parr of thyrogl obul i n
- mai ntai ns h o me o s t a s i s by control l ong tj e composi ti on, vol ume and pressure of
bl ood
F uncti on of Uri nary Sysyem -regul ates b l o o d g l u c o s e l e ve l s
-produces h o rmo ne s
-mai ntai ns bl ood o s mo l a ri t y
Physio
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F uncti on of attenuati on ref l ex? Protects the i nner ear f rom the damage by very l oud sounds
F uncti on of j uxtagl omerul ar apparatus? Regul ate BP and rate of bl ood f i l trati on by ki dneys
F uncti on of l oop of henl e? F orms l arge vol ume of very di l ute uri ne a smal l vol ume of very concentrated uri ne
M ai ntai ns uteri ne l i ni ng
F uncti on of the pl acental estrogen
Sti mul ates mammary gl ands
T hey of f er
1.nutri ti on
2.support
3.spermatogenesi s
F uncti ons of sertol i cel l s
4.spermi ogenesi s
5.mul l eri an i nhi bi tory f actor
6.estradi ol
7.i nhi bi n
T ri l ayered:
M ucosa
H i stol ogy of ureters?
M uscul ari s
Adventi ti a
H ormone produci ng growth of al veol i l obul es and secretory changes i n the breast
Progesterone
is
- dopami ne
- epi nephri ne
H ormones deri ved f rom tyrosi ne
- norepi nephri ne
- thyroxi n and T 3
1.testosterone
2.F SH
H ormones whi ch control sperm f ormati on? 3.LH
4.GH
5.estradi ol
I ncreased H + I on concentrati on i n metabol i c aci dosi s > sti mul ates respi ratory
H ow i s metabol i c aci dosi s compensated centre i n medul l a > i ncrease rate of Pul monary venti l ati on > excess CO2bl own of f
>H + i on conc dec to normal
Physio
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I f T m f or a parti cul ar ami no aci d i s 120 mi l l i gram per 100ml and the
concentrati on of that ami no aci d i n the bl ood i s 230 mi l l i gram per hundred ml ,the Wi l l appear i n uri ne
ami no aci d?
I f ovum i s not f erti l i z ed, menstruati on occurs. Why? Reducti on i n estrogens and progesterone
I f the cl earance val ue of gl ucose i s z ero what does i t mean? N ormal l y al l gl ucose i s reabsorbed
Physio
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D oes not i nvol ve awareness and i ts retenti on does not usual l y i nvol ve processi ng i n
the hi ppocampus
I mpl i ci t or non decl arati ve memory? >such as al l the ski l l s devel oped f or hi tti ng a tenni s bal l i ncl udi ng automati c
memory to si ght the bal l and cal cul ate the rel ati onshi p and speed of the bal l to
the racket
I mportant hormone regul ator's of el ectrol yte reabsorpti on and secreti on? Angi otensi n l l and Al dosterone
Physio
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I n a pati ent havi ng ri ght si ded hemi secti on of spi nal cord on the contral ateral
Pai n
si de bel ow the hemi secti on there i s l oss of ?
I n ascendi ng Li mb of l oop of henl e? T he thi ck segment moves i ons out i nto i ntersti ti al spaces f or reabsorpti on
I n body F l ui ds phosphate buf f er i s qual i tati vel y more powerf ul than bi carbonate
pKa val ue 6.8
buf f er because i t has
Physio
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I n chi l dren when eyes are f ocused on an obj ect the ref racti ve power of l ens i s
14 di opters
i ncreased by
I n conducti ve deaf ness ef f ect on the af f ected ear Webberz test i s l ateral i z ed
I n pati ents of thyrotoxi cosi s or Graves di sease there i s decrease pl asma l evel of ? T SH
I nf arct of i nternal capsul e resul ts i n Contral ateral spasti c chroni c paral ysi s
Acti ve transport of i odi de f rom E CF i nto thyroi d f ol l i cul ar cel l s and then i nto
I odi ne trappi ng i n synthesi s of thyroi d hormones?
f ol l i cl es
Ketone bodi es are f ormed i n excess when there i s def i ci ency of I nsul i n
T he pri mary motor cortex l i es i n the f i rst conversati on of the f rontal l obes i nteri or
to the central sul cus. i t begi ns l i teral l y i n the syl vi an f i ssure, spreads repeatedl y
Locati on of pri mary motor cortex
to the upper most porti on of brai n, and then takes deep i nto the l ongi tudi nal
f i ssure
Physio
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M acul a densa cel l s respond to? Changes i n sol ute content of f i l trate
M i ni mum separabl e di stance f or two poi nts tacti l e di scri mi nati on i s on? T i ps of f i ngers
M ost el ectrol yte re absorpti on by renal tubul es i s? H ormonal l y control l ed i n di stal tubul e segments
Physio
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N ot a method by whi ch the cel l s of renal tubul es can rai se bl ood PH ? By secreti ng sodi um i ons
Physio
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Li ver
I ntesti nes
Reproducti ve
Organs af f ected by hyperthyroi di sm?
Brai n
H eart
Ki dneys
Parki nson's di sease i s due to i mbal ance of neurotransmi tters i n basal gangl i a
Acetyl chol i ne and dopami ne
these neurotransmi tters are
Physio
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- granul ar cel l s
Parts of j uxtagl omerul ar apparatus? - macul a densa
- mesangi al cel l s
-H ypertensi on causes general i z ed edema due to sal t and water retenti on.
-D ec i n f uncti on of neurons >I nc i n urea and other protei n ni trogens such as
creati ni ne whi ch are the end products of protei n metabol i sm must be remi ved f rom
body, causes uremi a > symptoms of uremi a: nausea, vomi ti ng, mental deteri orati on,
Pathophysi ol ogy of chroni c renal f ai l ure? conf usi on
-Aci d accumul ati on i n body f l ui ds> budf eri ng power used up > bl ood pH f al l s
and pati ent wi l l comatose> death i f pH f al l s bel ow 6.8
(body f l ui ds can normal l y buf f er 500 to 1000 mi l l i mol es of aci d and phosphate
compounds can buf f er addi ti onal f ew thousand mi l l omol es of aci d)
Physio
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Pati ent wi th ri ght homonymous hemi anopi a i s l i kel y to have a l esi on i n? Lef t opti c tract
Percentage of f i l tered sodi um reabsorbed i n the proxi mal tubul e i s about? 65percent
Physio
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Pi tch percepti on of sound havi ng f requency l ess than 2000 words i n the organ of
Vol l eys theory
corti i s due to
Post gangl i oni c sympatheti c chol i nergi c nerve f i bres suppl y Sweat gl ands
Prol acti n f rom the anteri or pi tui tary causes? M i l k secreti on i n breast
- beta waves i n E E G
- acti ve dreami ng
RE M sl eep i s characteri z ed by
- D el ta waves i n E E G
- rapi d eye movement
Reabsorpti on of sodi um and chl ori de i n di stal tubul es and col l ecti ng duct i s
Al dosterone
i ncreased by
A) CRF a pepti de sec by post medi al basal hypothal amus > ACT H a pepti de sec
by ant pi tui tary gl and > corti sol sec by adrenal cortex.
B) D i f f erent stresses eg trauma i nf ecti on operati on > corti sol sec by adrenal
Regul ati on of Corti sol ? cortex.
C) Corti sol > negati ve f eedback i nhi bi ton of ACT H CRF .
D ) Ci rcadi an rhythm sec rates of CRF ACT H and corti sol : hi gh i n earl y morni ng,
l ow i n l ate eveni ng
Rel ease of human chori oni c gonadotropi n f rom pl acenta sti mul ates Leydi g cel l s of mal e testes
Bowman's capsul e
Renal corpuscl e i s made up of ?
Gl omerul us
Physio
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Reti nal cel l s i nvol ved i n l ateral i nhi bi ti on are H ori z ontal cel l s
Rol e of f atty ti ssue surroundi ng the ki dney? Stabi l i z es the posi ti on of ki dneys by hol di ng them i n normal posi ti on
Semi ci rcul ar canal s can detect? Vel oci ty of angul ar accel erati on
Physio
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- crude touch
- pi n
Sensati ons carri ed by spi nothal ami c tract
- temperature
- ti ckl e
Sensory Associ ati on area l esi on ef f ect I nabi l i ty to recogni se opposi te si de of body
Sensory receptors whi ch respond to rotati on of head are present i n Cri sta ampul l ari s
Sensory receptors whi ch undergoes sl ow adaptati on? F ree nerve endi ngs
Physio
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Sequence f rom f ormati on of uri ne drop to i ts el i mi nati on f rom the body? N ephron > col l ecti ng duct > mi nor cal yx >maj or cal yx > ureter > urethra
Sodi um bal ance i s regul ated mai nl y by the control of amounts of sodi um E xcreted i n uri ne
Sodi um i s reabsorbed f rom the baso l ateral surf ace of Renal tubul ar epi thel i al
Sodi um hydrogen exchange
cel l s by
T he chi ef source pushi ng water and sol utes out of bl ood across f i l trati on
Gl omerul ar hydrostati c pressure(gl omerul ar bl ood pressure)
membrane i s?
T he greatest amount of H + secreted by proxi mal tubul e i s associ ated wi th E xcreti on of potassi um i on
T he growth hormone acti on on f atty aci ds I ncreases uti l i sati on of f atty aci ds f or energy
T he hormone acti ng on the target cel l s through the acti vati on of phosphol i pase C
Gonadotropi n rel easi ng hormone
i s?
Physio
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T he ki dneys are sti mul ated to produce Reni n by? A dec i n bl ood pressure
T he l i ght rays comi ng f rom di stant obj ects are f ocused i n f ront of the Reti na i n? M yopi a
T he mechani sm that establ i shes the medul l ary osmoti c gradi ent depends mostl y
Loop of henl e
on permeabi l i ty properti es of ?
Physio
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T he reti nal cel l s whi ch generate acti on potenti al al ong the opti c nerve f i bres are? Gangl i on
T otal body water can be measured by usi ng Radi oacti ve? Water (tri ti um)
T ubul ar reabsorpti on by acti ve mechani sm usual l y i nvol ves? M ovement agai nst an el ectri cal and or chemi cal gradi ent
Physio
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T wo poi nt di scri mi nati on i s del i vered by whi ch tract? D orsal col umn
T ype of pai n transmi tted by dorsal col umn tract F ast pai n
Physio
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1. E xcretory
2. Regul atory
T ypea of f uncti ons of ki dney?
3. Syntheti c
4. E ndocri ne
Uri nary excreti on of vanl l yl mandel i c aci d i ncreases when there i s i ncrease
Catechol ami nes
secreti on of
Pel vi s of ki dney
To
Ureter
Uri ne passes through? To
Bl adder
To
Urethra
Water f i l ter i nto renal tubul es i s maxi mal l y reabsorbed i n Proxi mal tubul e
Physio
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1. I nc proteol ysi s of thyrogl obul i n that has al ready been stored i n the f ol l i cl es,
resul tong i n rel eaae of thyroi d hormones i n ci rcul ati ng bl ood and di mi ni shment of
the f ol l i cul ar substance i tsel f .
2. I nc acti vi ty of i odi de pump whi ch onc rate of i odi ne trappi ng i n gl andul ar
cel l s,sometomes i nc the rati o of i ntracel l ul ar to extracel l ul ar I conc i n gl andul ar
Wf f ect of T SH thyroi d gl and? substance to as much aa 8x normal .
3. I nc i odi nati on of tyrosi ne to f orm thyroi d hormones.
4. I nc si z e and sec acti vi ty of thyroi d cel l s.
5. I nc i n no of thyroi d cel l s and change f rom cuboi dal to col i mnar cel l s and much
i nf ol di ngs of thyroi d epi thel i em i nto f ol l i cl es.
H ence T SH i nc al l known sec f uncti ons of thyroi d gl andul ar cel l s
What acts as a tri gger f or i ni ti ati on of M i cturi ti on? Stretchi ng of bl adder wal l
Physio
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What does pari etal cel l s secrete H CL and i ntri nsi c f actor
Physio
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T he short term memory, i f acti vated repeatedl y, wi l l i ni ti ate chemi cal physi cal
and Anatomi cal changes i n the synapses that are responsi bl e f or the l ong term type
of memory.
What i s consol i dati on of memory
>thi s process requi res 5 to 10 mi ns f or mi ni mal consol i dati on and 1 hr or more f or
stri ng consol i dati on.
> rehearsal enhances the transf erence of short term memory i nto l ong term memory
What i s the sal t l evel moni tori ng part of nephron? M acul a densa
What woul d happen i f capsul ar hydrostati c pressure were i ncreased was normal ? N et f i l trati on woul d decrease
When a baby cycl es mothers breast the hormone i nvol ved i n mi l k ej ecti on i s Oxytoci n
Physio
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Podocyte
Whi ch **** i s associ ated wi th the Renal Corpuscl e? F enestrated capi l l ary
E f f erent arteri ol e
Whi ch artery l i es on the boundary between cortex and medul l a of ki dney? Arcuate artery
>Posteri or spi nocerebel l ar f i bres recei ve muscl e j oi nt i nf ormati on f rom the muscl e
spi ndl es, tendon organs and j oi nt receptors of the trunk and l ower l i mbs.
-T hi s i nf ormati on regardi ng tensi on of muscl es and j oi nts i s used by the
cerebel l um i n the mai ntenance of posture
Why does a person wi th cerebel l ar di sease has di f f i cul ty i n mai ntai ni ng bal ance? >anteri or spi nocerebel l ar tract provi ded the same i nf ormati on f rom upper and l ower
Li mbs
>Cuneocerebel l ar tract provi de i nf ormati on of muscl e j oi nt
>i n cerebel l ar l esi on, the cerebel l um cannot comprehend thi s i nf ormati on and
resul ts i n l oss of bal ance