Polyenes Antibiotics :(mode of action, uses, ADR, Brand name, dose & half-life ).

Polyene M . O. A Uses A. D. R Dose & Half life

antibiotics Brand name

1.nystatin Nystatin acts a)candidiasis 1)mouth » Brand (130 min -

by inhibiting of skin, irritation name - 155 min )
ergosterol mouth, and (Nyaderm,
synthesis of intestine. 2)stomach nystop,
fungal cell upset nyamyc,
membrane b)vaginal viaderm etc.)
which leads candidiasis 3)diarrhoea,
to cell nausea, »Dose -
content leak c)fungal vomiting. 1)Mycostatin
out and cell infection of tab (500,000
death of blood. units)
fungi. 2)Nadastatin
sus
(100,000unit/
ml)

2.Amphoteri Same as a)histoplasm 1)GI upset »Brand »plasma half

cin B nystatin osis name - life ≈24 hour
2)nephrotoxi (Abelcet,
b)cryptococc city ambisome, »eliminate
osis amphotec, half life ≈15
3)renal fungizone.) days
c)blastomyc failure
osis »Dose-
4)bone 1)amphoteric
d)local and marrow in-b(50-200
systemic suppression mg) tab
candidiasis 2)amphoteric
5)cardiac in-b(250
e)meningitis. arrest mcg/kg/day)
(›5gm/kg) Iv infusion.

3.natamycin Same as a)candidiasis 1)nausea »Brand (10-30 min)

nystatin name -
b)fungal 2)vomiting (Natacyn)
keratitis
3)diarrhoea »Dose -
c)aspergillosi 1)natacyn
s (50mg)tab/s
us

4.hamycin Same as a)candidiasis 1)GI upset »Brand (3-6 hours )

nystatin name -
b)tinea 2)nausea (Hamycin by
blastomycosi Hindustan
s 3)vomiting antibiotics
Ltd.)
c)vaginal »Dose-
candidiasis Hamycin(10
0,000
unit)sus