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by
Whnd
OwndPhorma
Phorm
not
MOT
(ORel 7or
for
Tust
TUst
TUsf
.Ttis
Is
YOUF
#NOTICE - you have any doubt
If

in any structure or definition,

Must Check it on Google.

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PAGE No
201
DATE:

Uut5
qtLALAal AunesthaetiM
AuIaAUAEAALL0au AeLAAatnosA loss
AuteMOA-
0AtgiA meaMA-
teAnm auaeaHAsti o Ak,
Jothcehtuou nseAkibility
itlaouk

LAwaldeaa Jiis Stage bequaa iujH tA AlkaLation

Stage

LmictousAAl
Atage(Oetuuiunm ox bxtitenmtunt)JhýAtage Atasta
wiH Hae s oCoAAeioUsAOsA
wnkouseibuneka d_0halkia o OLloMeL

&tage4 Meduiay laxaliyu)- dlKi &Eage dunuld be

Coadhc 0iuu. doaty
euda uita
mlaalakisAAwakthehies

Lause Oal dtbktaua MOEAARAiOL by Aapidly

Keatlu

Quaesttkeadtl is ALely bAobauhoualo

pohey

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HaiatsaAR
wnllammalesalatunkdudiotnho.
Oun
Hathi
toAEA Aopta dinduhaa autHa
Jutlto a eMrittmtut

-H-a-
B--Ch
taIALn oAth usaEKHstLLa
tausA 0al byUtuug Ow mulhple
tluauAnl& 0debAesuingeude Conductiou,baaadaw
CAscliattoutsartilty
LLAA

Q1AQRAHLAeAL

MetuoxlLuLaLAR

AdtuAg aAkOIAA9eLAAaARLLHAEALG
HC 0-H-

Mouaailmo hoAthimual
9AecuUAEA AMaluttaue bu oletAADAIA 9

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DATE
T201

PApaMaase, AADH olelaydang.eAA

AiuAditiuAty Y3AtAkly
Aolaako Adurh palA
tiiAoQlyuleok u dlxtal, dungiaN, 0
obtetAitoba.cuoa-

44 e20Mctkeont stablei_iAlAalatuna 0AORAHARtu_

wlaut Aakia aduktmud nauaQRAHLALALA debta
Ca be olmae by _itleauteAatiaaa" uaplule o

CH-C- 0-H
C

MRluAaLim -o Akin
Mme dA MHAoryuQne

URA=
QLAORAHABALO
dusuG kudgeA CoLA0uAekhoA
deliulku

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uokAated.
VAdutwA mduakauaug CeuLal oJA024 HaAia

MetlaMA DAtnA
_KMme adA mekaoTy LlikaAL

JokAduutiag mauat.auaUAG g8LuLAal

ADESHAEO wadulh & poediataA akar impatituat
outleahieLak busgeu

tobieanu-AcAis sALatatio aua.kastaei.,

Am Aimaiiraut &ide elet

T 1
Metlkaaim o Atio=
Aame

keakorndurung mliunduaig guexalanoeatat

OUteAA LLAUe eMMikabuy uaduriuq mudele
elaxatiou odutiagboua Aeudiit

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-

AholauiA tae L membrhul

COG-te
MArlaaIaLm oAektouu
SomeA roNAaukan

ndutaiLgRaeAMaeia
Oukhnkak Au.QLLA
a adulta" oriuoteut

Alakt_Actiup bahihiaotkk=
Jy_ARuithdennuAly OdmuuideAel \ossåoducua
Sapd uuaAMAiouALA upual& Kaaal
OuaetaRAA

MeAnlarakikal. xlium
a Bagst -0ctug lLatiaieIADIL OOOAHAetie Adunls
QUAAAHAEALA

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DATS 201

AMHALAIA

CEC-OHg
Bauhynaul.mogueah -Chlcsa-3- peuagiA

ltbgtuhà nuC
-0s

HC C-CH- C

VCFCH C Aly Btrmude

6--nmakkyHtuyA £layl-l-mttalaA
Cutuanatetoto

NH=CCH,OA =t=tH ngaO

NO0-
CH
4
CH
MEtADoital šdum
Metunlkecibal

Mpslkaiiam o AttDA

buadug ot o distaunt buaduug te elateol atae

lppaoae.at talAAAA RAestnr Jtuelokt
pLolaagH
LAAn a HA Ulalamus

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"
AAALA-

aiamylals sokuum
m daugtna
a odlucea tompteke QuaduiteAao

Na S

MlaLAM,DctuL
Aame 0AmttiotalAcihal adium

4i uAtd 4ox bpduuAa LombletA QnaAR&LO D

uAnRALARALdu
uuptio state

Uukal drolum
4 0dlmua tRieok iuntsausLADAAJO udluaRUAg

OundELALAA o &aoAt_dusatima,

HS
0

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PAN
GATE

4 alsn ueslopka.duan amwouii duain0 halanzeo

KadasmatD

atintiae uakskaatus

Amiaku JaeyAaauce his btade by ooctiug RAL

DD CMS
KAhamuA HucdictaLoide-

uaRAHAetit
t
:1
HCH

to OLLKalt
G-thdrobvoide bkonitutlo
Cpoyom
C

HCL
KEOK
OHCA
Au 4ut is
IKekaumul ydocthlord

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aluke 0HAA lheagLatketamiia oeAwnt

uteAaskwit aAaA Aorhokk butk uahetost
ALtANMDA &UtEptokaoiatolAReepto.mozttmueagíc.

diaaaoktit. kuagtal páeesdu

AAhn alao be adoudutuip aLAD AMULAKOL.

AaiapadtuAt Ogeuts
20tahi aa:Aautntuu Hualgtaut
iAalaurd0ttAtt_ HAe CNS
uAteadR þaua
Hunksold Luithauk distuubing ansuicudiuess o
Aelie
oasid. ualgsit an lNADtm tie OiAolgeti
kaliqach

Dpinio
oAalatskO AADhuxally 0CAuuAg
Seraibatatti psebik
lixe .axttow ie. aty pAadu hauxiug nhaplaun
CMS lekessLmkelaked tn dhunidie paa
oëkLLdauc
m
Noxtatie Qualaesicstompase odpLatas
mahua
LAakouAs wuiwdlptost
D
ARmtas. tkuskL

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Mosbla
RDmle bal hisa.o
Qh.Logae Ah
Qwtog.cualst ! T4
Aggait- 0de
iandnaglee saun.
hucluteDLsalouo_
bundiig o C.usbpiake Kuabko
AgaLt Anttaouit -|e9
albuli upkunlaa huroaRuL
OLdulag aboiou pkadue walgtio
hy

Mopauak. Relatad Ouk

dsug L &0iclaect tnbt He pshtohypiral
optaid Mncallyt
Ouoleaucs
k Hhegold stauddkok a-
ed in relikLA Se pau ailAung
2Moplauae &imlos in2oHlaicpioLcL29Latlo
udknvdaaa, ihLtylnndsRKiaALiues
"Moplkue daasaigt poteuhia or a.ddichna
alo deeldp habidb

Moblaiaa 0JAAimueAoLel heLatesd to moAplaina

y mau be Qgoist mskLaaa Cikmaiskuie 0adan

osXinogouist4aalpliai k laudkana anpnuat
altyta

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Adpkaa
ahaiwne
Kele ocoug
AuagHAEALG. Pse-amaea tineko
oHodianuobtula luxK AOUAL by Oua Uuu.
Sa
uunaushyORALRmo._
GaaaothunuaalduApuDo
nbAAAIAMUKAnU-
SAR Moklasae-
dtiay utiagu
AUyeie ALokunta. uAKaR
Akoolu dintyLaup

Pdatucue
lydilgam-

QAHeLiud Oindizekt moed or Aaplate b alneiA

COmpaud htneased
Aedluthan
w o-6 Ketn t u
mokstana quRs NaNthupiune-6
plltotuy
automIAHW_OAtunm o
0Cthtok
Jae tul obo oti dauble hoLad ok
atina mde pottut Mmbcund
BakdhrnokhlamG uudtoco deiu&

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PAGENa
ATE
21

AreAtes deckedke, atituASiuE

Octs Hauee

Atdouag-
-&C-lu HAngl Haylee 1uknge
guaoteat oleALokue:

LAModiicot opl&eylAi
A 0Aamodiel Aunib essatiok or 0ckity
MeOcbiuty
Artaty
Modkealou o Aihngaun
A 4hay arau usually iAPCLALaKy oromol.

orapowAL potQAAML ut 0gcLALAt tkAeLRAAe

QMtag oiktie aAuthy

AopeAydae dMALased H Aized Me kubiutin

hy_35 Couhoa SesuutA uskhgouishe OAtuct
aLyl N-
clo uKul OAu LenddaA to watentio
QutOgomubo Acbekty

4Ekoxide Aioge
RémoJnl o 3u paide baidlge iA muplaututna
AeAuLtA

ALuMaehd phoLe.dune eldia ompuadtu a kauMu

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PAGE
HO- 201
DATE:

taa dlentaa dkoma, latuk MARLosrtiussuk

EAh
ATY
eanrblaRal Buknisplaauno
aaunl ia m
potent QualgeAL HADIAL mbhre

Moplauaa Aublaatk-
àoAuAaia, aukalaisk uik opum pkatgat0
ia duaalgedit mdLotid

HO oH

MeelauauLm oAcugu.

beoun Aocqnlked otuilu o AAsonsubla Hae

Q14algeki
et omothuie

t used ok-itug keluug eA_A

A amorplaua elated, pLoid unalaea itu leM

dsteunt Ouaalguie Achetie
nnild dathe elucts
14 adso SutkueS ougu ay athigAeatal

OH

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MAclaaJAMAM 1]_ Ackra-

Qutidasaa i, Coup ALupxekAaAt

Mepidiuat Hgaodalands

CHHC

-Oha ecestor: t4 aluuty KE AUEhtnX LArÕuclas.

AulRidluaHplaociainide

ttHtH
H
Coots

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RATE

amgOk deLal

QLdw atidiasslaneal dtts uke moilaun

GN

H
Ces

tia p-htor u laLL

useA
diaaalanea
a 0Aadiushue faiaay ia maopuAg

oesamide Hudaatllmid
t a loug-actu uattetir Oatiduoaxiaok
N

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BABE la

MALAALALAA oAttanA
4M wlkn Oial ktuieOugdest Hok AapesAnuole
llerkialyke mnkmiun Halotaw tae bo

Ae
cA oiasglana mlaked
AoLamratry boiR dea.e. Quatneuleu.ti

t oateat u0ktotie 0uAalgetit udw staulka ua

Odaktusa akuseck
EA oL-punid 0Q0Aut

H-CooOH
Ho--CoyH
UH-oOH

AH, Cclth-N Codnsed

PscaaLdhdam
-lBaiyl-aulis Nphidayl) -prmpusni

tujutPhaxttllas

Ctn- - Ho-C-CH

Peutanyb Ctiate

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DATE

Merkuaiaiwm
ol4ctioua
mLOA Adeu

RDIACpaiautsKaag SLRAL pau

MettasadouHdaodalaRudls-
aclaubita Vackunu
Sonulask nmlaua
CCH, CH

igiN
CH,HUH
Auatiat

H CH-CH Ui
Dinleytatstuxtule,

Sodomdte
uon--cl-âmuapnbau 4-QimeHulamuno)-R.
H talotiutlttonuhil
=

Ko-u.uM HydanuyAs
-CEN-MA-6
HU)

WEnaolanLRydkclaloride.

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akhehedpa npindAnloeais
mltiŠimilaa omh t main HaoNdpeautu
olkcaliootuna
dunt oddikiaa m0uatzzn

A A uAeck pr tueodug daytougaaukdsug

atAdAnluak Aypaline ohid dkuo olebeadeuACe

opoChlauasi Hdialonde
A CombaALs

0ccHs
OH3),CH= - CA H

MeclanAim octuu= q
t ausOk0q.oi t 04 0,OP3 ohiate Auntastui

makti taukiLOA La la- þAnteu shit

Qthte oktoA kne ly mainly atg HA

et oP2 ecdphoks Coupledwi apxdteuAofebte.

At uLAed. or elueng mild tnimodesnt patuA

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DATE 4

atazntitae
At omteokogaAt-aLatagnuLsk Ouokataat aat
HH=CUUHS)
DH
H

MElaaim oho euLdtAce Manua Haak

AkarROCuAe Comhe

ukagouius aofioiuk, ellkt.

A
4tikJLked p_elteuuAg mcolAat to JRLAA OU

CooH
H

A-- --OH

ooH
MUlhAuinohou
uke cHuu0ALstpucd
tlhaunl arta at
maHs iun Hao bxau akaal &okd, "akun

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MONMnti
AakngouIst_
MOlnTauuak
HdactAlaaide
9h isaMuredOpiad agcuLAt uAtagouALAt_udela
k un CoLod Aeeltoaa N 0c

H= CH HC

MerlaaaiArm o ina
pAeduL
m.0Aplisk ntlaodne nneaisdu leuoaunL
oLLeLE
it de, nni hoe auy OAkag odLltio dct
Ogiias loguBtuk.akeA o guALAL HAasadaetie"dahrakian

mAKDALAL

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DATE:

allolkan Tokduka-
opinis stogauilt: JaAAg bhantLAA Limilas
oAOloeouseo kokkesauag
Sonë basaut pidhttie
-CoOH

-OH GH-

Had
atottiue 4A ARrestor alg

dekeAkd kulka Rptakotuy deuALRd by opunidl.

OocaAe. Hycdantdrudo

M-CH CH= H

RA mitlAaiLAdn_0toA
AAnt wadustoook
but Ha
Kane aARptor Aites
hgnaiais Ha
Cni. olt Keksitlyt aaahee uga9stesk. Haat

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DATE
4"

AaA lauad. toal 3 thuDtd okabioKA but aiu

UAGAL

At edr Aomblalëli or 0xhally 4LLAAIAq Ttapuaatg

Clebkeshina obniclh
uARdor diagacaig aLut aioid otLdoka
AAAAed n Odiwt. nuAtALaAiAg nlond
AMK

AOAAAahA Auaigesu 0r AutinlLamoratnzy Q9ta

AMAAiAnisdal. Auhiiulamorakuny dugaE0-0dbu
hkina Aoloomiaoru nlanxtia aobmea
Sosliu AtIALbunznus uliacdouc.04tamalan
LA huhik Qutiykahis uAnlgezu atiiutLamomtnn
hheAkioJAA k higCu ut tlhaatal
hustuHaus A0ie LeAEoAAek otina
duLato o t mttahalikm A Oackiehàn
Su oaaim.atu. aitiA brral dloieA oAanutuik
OalgekiAHa 0A be Ad Ar Keliliq modliak to

oruimakulato,

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kotunjait o
Aaltyale ocAaktAduceA
uAammahha aa byakibtluag paktaglakekz
-AHAABsiLtAsouga taJALeAaikto Aethlcokuou o
Cox-1 ox-3 4LAKLeA
Is=
Sisusad as_aw Oualgeuc QutRetic

0AAkiaueiptDktR

AuARA
Sh psoduroa by iHae aAstlatan olRauatie acd.
lullt atetic Buulackde

uplaneyqAaAe,CD)_aan Phol aeasrotin

4 KodurRA pauM , JRiuAg_bu blatkhag ALLt

0AuLeltiAg uA

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PATEla
DAFE 20

Meluamis Aut-
OuAtihsekic bAnperkieA wdkihitN itueltmeunee
LoeM-

dndauaiA

A CH-H
Htt
CooH

CHa

Mgrlaikmn Acmi
OtkoA o oAtoqLoAoliu dyuatinekaxe by
bundiAg ho Haephottnglaudua ataetazekehioks
Lox 4 Cox-9

duybmenokAlaRa milobomodeuake. (awá_uAllanamtina ke leLe

Meckoluaamate.-
iupluhika hnAkaqlavndin bLndpathesk
4h aNEAID uAiss
ustiauketa. utL-QAQLAlotzos Othuthiks
AAhts

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ALomtalAauilm LActuou, isiunt kiuotoA mal

TLdA haieiAnuO HAat meLenamicAMO ulaihiun
-SAOkhglauda oreptox te

mkIAhual blonck lo6s o selëLLLAg nilok a mgleth,

Alaeurmtnd outilikh. DAtbostaitis.
Sadmeiaakiu
AiK auaA HOAnidal,Quti-wa|lammatoky ageut
AMclaxhutig OuibyAetis aIualgesir Otuty

Co
MaluaAm o4daA
AOstagloAdia
CoX - COx-2AytLoneyolLAOAe,
0OkalARA
OAacluicloLALC
Ocd dpLosknqlaudias
alammatiua 50telzt adokggodioa a

Aute QoLuy OiALtia 0ukute_haialul ÄAouldta

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PAGEHo
OATE
291
QuAkuloAg pousdyuhi
SuuiAclar
At aAndgAdAIRA, d deuedinm
AuAdere.
Ati uNAid Agmpouad

A-S
1

MAlaaLLim Acio
dCOx- &lox -9 Jeoda An tla Lalalbitoa O
HA
uati -illAmradnm et o uluaoldo

HAR Auak umetomsal osteroutaubblaemakad

CAHANkaaklokuag- aiitiOtuke00Lty 0iAutak_
OAuke aiul Aulda
JalmetM

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DATE
2.
MNhauiko
oAuoua=

ualadaitin taglaudia AuLutlaekae.

iAdin
LLAMA

Alaeuskatnid
ataiihi
Zomesisat

MAlAaui o4ctmia,
Atuueiohmuor Hiat a 5-3a.cng due omdMA

DO

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MSAIDita Qutikykefie aalneAis OiMA

H-N

MecaaiLm taA
U Cnx-& lox2|
aaalkiitiaa otkoty tearaiin.
A dpoHAOlamusaLAiAg pukaanl dilotioa
MALLRak LAeoi diaaihatina.

UAes=
0AteXUttauti sumatni.d duitsuhi

ketoxolo
daKAalikua kasbantylit-
tAurtLAalty Aenked io AciDmiAaia

ddolm o Ketnralht.ssmpt HÄaniue

lietitiejlar Kétaola

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PGE R
DATE 20 20

UAlaubutanx-4 Cox- wAwlw Auunas ululhiy

AOLHnglaadia Apattani

ADA=
Jdaemndu,ately LeAL OLuaaia wlaita, AaAitos

Ab'in optaitatd
A8ALD lhnig Aalg
dountiue a pctoyato
utiluLetit opeltPA

IAALA-
3
HCo)g O
CH CHCH
D-CotHa
JAdoustil-eAraA

CH HCN

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Cnoydt

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DATE:1 201

MAlaaAm n 4chDLA:

AAVA: Beleekiuely kLaikitkLrlo49on0 A

duzum
JAAdULd, a pAbktaglodu AuHaLA Dia H dkacluidorue
id oatanui At &_ laaumctologutal Qttue.aA it
alaubiuta CoxL

UARd UAed lo Lumhtoorutio hoatmlusto AneLumathd.

atAA,ei htumatnd atuti otera.tutis

4 koduue poul e, AkLohmm.aiinank

petakcdii,

Aauutüuin lammatouy agetaauiAg OLnlgeaic

Ontubykeht pope
CH
, DH

COX=1-
uuta Ayei0 MYqexale athuit_uAlALlhtADA
wtwile Cox- ulahdim giuEAauti-iomt
Qctu

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DATET 0

ea
oadyltu,
uA Ahtumatod Qttaidis,okte00tlaitkQNkuo
Atuko qout
dAod _Aeliunamld to rnglodatu auA.
0AtuA htiaAyomlIADAMAOO,

yuloruguADE AlAhutingMSAIQ-slilus- ued

THE
N

MaALilmoACou
LELALle Jualaubutto ALyluogELAGLA& sludaA
uhRALAtOuses pRAipGLGXbti oboktaglaolin
XuatAt is saskpouLiklaor ttae auti. -uammabku
topiauoncicom otltog lavedud 0.
\pnoduicad y- Lox-

4t ued o ALo.ttug OAteooHAuti &Alatunaatoud

Peuattiua

SLLALOA LOA
hoduL ualgeti oleet
N

MHCDCH

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DATE 201

MRclaiuin ohou
Ocuee ualgztik tt by otbiAg DA tl LALCL
Qutuburito

UAEA
poduly LALd OLA QL OJAlgeuc

Acekamuluaaxatct.aml
eetubt OalgAu 0ustiudkctud rtHLuAaputolly
itu Latk butaas
d d Sumilakto Atuplatlet Ootai uleesatue elt
LTLULanmubu

MeAa 4 ualaubitaCox-4,Oox-Cox-3
t 0cts HkL ks

uclpba4Quio LA peLIALAl tusuA

dokuctlubib
4ALA s ectie ACAS ad.odeuàl.cell

sau

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At as ALAalgui buctilkyketie 9.eA

ollyC
CH

0ets A CN& uuteokek Ha OLLA HARALADLA

QA i JualaubutsCox-, Cox- Cox-3

ARALLoutaual
elabit QutiiLamennbou uctib atac d ana lgekie
Ottuute

MgelAauAmDAtoA
St buagL wtltA poktaalauAckun
&utaake
pkostotuuti uiddAake actuwaterAam bu
uOncide meoded deoctuatioa
bAtadaunduaAoluttiou
a
Adueki04
MutAUSAaduucek

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DATE: 201

iused ox othusg bockocla QukuLoLgAduti,

AAeumatoid etA Audknon

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