MCN Form 005

Lyceum of the Philippines University

College of Nursing

Name Patient J.G Age 71 years old

Diagnosis Rectal adenocarcinoma Hospital No.
Ward/RM Medical Ward

PATHOPHYSIOLOGY

Rectal adenocarcinoma

Predisposing factors: Modifiable factors:

 Age  Diet(high fat, low fiber)
 Family history of
rectal cancer

Affects normal cell

Proto-oncogenes transform to oncogenes Inactivation of the adenomatous polyposis coli gene

Allows unchecked cellular replication

Tumor suppressor genes is turned off

Increased cell division

Cell grown and divide very quickly

Increases survival and proliferation of cancer cells causes

Mutation inactivates DNA repair gene
further mutations

Springs out from the colon

Activation of K-ras oncogene

P53 mutations

Prevent apoptosis

Prolong lifespan of affected cells

Continuous replication of affected cells

 MCN Form 005

Increases number of malignant cells

Mass formation

Neoplasm

Cancer