RAM LAL VALASAI BIOCHEMISTRY BCQS 1

A. Valine
B. Serine
BIOCHEMISTRY BCQS OF C. Homocysteine
D. Methionine
2ND YEAR MBBS LUMHS E. Glutamate

7. Cause of negative nitrogen balance is:

1. Which one of the following amino acids serve as a A. Starvation
carrier of ammonia and carbon skeleton of pyruvate from B. Insulin & GH
skeletal muscle to liver: C. Pregnancy
A. Glutamate D. Growth
B. Aspartate E. Recovery from illness
C. Alanine
D. Arginine 8. What is the importance of citrate in the fatty acid
E. Ornithine metabolism:
A. To add the activated carbon dioxide in the formation of
2. Regarding DNA replication: malonyl CoA
A. Doesn’t require RNA primer B. Activation of carnitine acyl transferase
B. DNA polymerase synthesize new DNA strand in 3’ to 5’ C. Activation of acetyl CoA carboxylase
direction D. To act as a precursor of one carbon units
C. DNA polymerase can only bind onto 3’end of existing E. Activation of fatty acid synthetase
DNA strand
D. Chief enzyme involved in DNA replication is RNA 9. Positive nitrogen balance is seen in all of the following
polymerase E. DNA is synthesized as Okazaki fragments on conditions, except:
forward strand A. Convalescence
B. High level of androgens
3. Which of the following compounds is formed from C. Growth
hydroxylation requiring vitamin C and subsequent D. Fever
methylation: E. Pregnancy
A. Tyrosine
B. Melanin 10. A 03-months old is being evaluated for vomiting and
C. Cysteine an episode of convulsion. Laboratory workup shows
D. Dopamine hyperammonia and orotic aciduria. Which enzyme
E. Epinephrine deficiency is suspected in this case:
A. Arginase
4. Lovastatin lowers the cholesterol level by: B. Carbomyl phosphate synthase-II
A. Activating HMG CoA synthetase C. Glutaminase
B. Inhibiting HMG CoA synthetase D. Ornithine transcarbamoylase
C. Activating HMG CoA reductase E. Arginosuccinate synthase
D. Inhibiting acetyl CoA carboxylase
E. Inhibiting HMG CoA reductase 11. In a patient with phenylketonuria, synthesis of which
of the following compound is unaffected:
5. A 22-years old female with poorly controlled gestational A. Thyroid hormone
diabetes delivers a large for gestational age infant at 24 B. Catecholamine
weeks. Within 06 hours of birth the baby experiences C. Melanin
respiratory difficulty associated with rapid breathing rate D. Melatonin
and cyanosis. Which of the following is likely to be E. Dopamine
deficient in this baby:
A. Ceramide 12. Which of the following is required as a coenzyme for
B. Dipalmitoyl phosphatidylcholine the transamination reaction:
C. Sphingomyelin A. Pyridoxal phosphate
D. Cardiolipin B. Thiamine pyrophosphate
E. Ganglioside C. Coenzyme A
D. Folic acid
6. In a newborn presenting with refusal to feeds and E. Biotin
irritability, a deficiency of Cystathione-β-synthase has
been diagnosed. Which of the following compounds is
expected to be elevated in the blood:
 RAM LAL VALASAI BIOCHEMISTRY BCQS 2

13. Before a fatty acid can undergo β-oxidation, it must be C. Pyruvate

activated and then shuttled across the inner mitochondrial D. Acetoacetate
membrane. The activating agent and shuttle molecule are E. Citrate
respectively:
A. Acetyl CoA & citrate 20. When excess acetyl CoA produced by the liver cannot
B. Carnitine & CoA be utilized by the TCA cycle, it accumulates in the form
C. CoA & citrate of:
D. Acetyl CoA & carnitine A. Glycogen
E. CoA & carnitine B. Triglycerides
C. Glucose
14. The first line of defense of brain in conditions of D. Acetyl CoA
hyperammonia: E. Beta-hydroxybutarate
A. Urea formation
B. Asparagine formation 21. During starvation, ketone bodies are synthesized in one
C. Glutamate synthesis of the following organs:
D. Glutamine synthesis A. Intestine
E. Tyrosine synthesis B. Brain
C. Skeletal muscle
15. Under expanded program on immunization, against D. Kidney
which of the following infections a vaccination is given at E. Liver
nine months of age:
A. Measles & mumps 22. In tissues that do not carry out active de novo
B. Poliomyelitis only synthesis, maintenance of an adequate supply of
C. Diphtheria & tuberculosis adenosine:
D. Tuberculosis only A. Depends upon action of nucleoside phosphorylase
E. Measles B. Occurs primarily by adenine salvage by APRT
C. Requires uptake of ATP from blood
16. In parenchymal liver diseases, which of the following D. Involves hypoxanthine salvage using HGPRT
liver function tests will show a decrease from normal E. Is accomplished by action of adenylate kinase
value:
A. Alanine transaminase 23. The test of choice for assessment of fatty liver is:
B. INR A. LDH
C. Alkaline phosphatase B. Gamma GT
D. Prothrombin time C. ALP
E. Albumin D. AST
E. ALT
17. A mutation in a codon that leads to the substitution of
one amino acid with another is: 24. DNA glycosylase is an enzyme involved in base excision
A. Promotor mutation repair. The function is:
B. Nonsense mutation A. Addition of correct nucleotide
C. Frameshift mutation B. Replacement with another base
D. Operator mutation C. Addition of correct base
E. Missense mutation D. Removal of incorrect base
E. Removal of phosphodiester bond
18. A 07-years old child suffers from mental retardation
and self-mutilation. His uric acid level are found to be 25. Which of the following conditions the plasma activities
elevated. He is diagnosed to have Lesch Nyhan syndrome, of both ALP and GGT are likely to be increased:
which is due to defective: A. In trimester of normal pregnancy
A. Salvage pathway for pyrimidine biosynthesis B. Alcoholic cirrhosis
B. Hypoxanthine guanine phosphoribosyl transferase C. Osteomalacia
C. De novo synthesis of pyrimidine biosynthesis D. Carcinoma of prostate
D. Xanthine oxidase E. Infectious hepatitis
E. Formyl transferase
26. Incubation period of staphylococcal food poisoning is:
19. The starting material for the process of ketogenesis is: A. 18-24 hours
A. Acetyl CoA B. 24-48 hours
B. Lactate C. 12-18 hours
 RAM LAL VALASAI BIOCHEMISTRY BCQS 3

D. 6-12 hours D. Influenza

E. 1-6 hours E. Malaria

27. Which of the following contributes nitrogen atoms to 34. In a 55-years old male, who has been diagnosed with
both purine and pyrimidine ring: cirrhosis of liver, ammonia is not being detoxified and can
A. Aspartate cause brain damage. Which of the following amino acids
B. Tetrahydrofolate can covalently bind ammonia, transport and store it in a
C. Glutamate nontoxic form:
D. Carbomyl phosphate A. Serine
E. Carbon dioxide B. Cysteine
C. Aspartate
28. Density dependent separation of plasma lipoproteins is D. Glutamate
achieved by the technique known as: E. Lysine
A. Centrifugation
B. Electrophoresis 35. Dopamine is synthesized from which of the amino acid:
C. Ultracentrifugation A. Histidine
D. HPLC B. Tyrosine
E. Atomic absorption C. Tryptophan
D. Glutamate
29. Which of the following organelles, which is defective in E. Methionine
Gaucher’s disease contains enzymes that degrade complex
carbohydrates, lipids and proteins: 36. Relationship between GFR and serum creatinine
A. Lysosome concentration is:
B. Mitochondria A. Indirect
C. Peroxisome B. Haphazard
D. Golgi bodies C. Inverse
E. Endoplasmic reticulum D. Direct
E. Non-existent
30. In the liver, a substantial proportion of the activity of
the following enzymes is membrane bound: 37. A 55-years old man despite having strict dietary
A. Ornithine transcarbamoylase control had elevated serum cholesterol level. He was
B. Lactate dehydrogenase suggested to take simvastatin and after 03 months his
C. Aspartate aminotransferase cholesterol level was normal. Which enzyme is inhibited
D. Alkaline phosphatase by the simvastatin:
E. Alanine aminotransferase A. Cyclase
B. HMG CoA reductase
31. Which of the following is a degradation product of C. HMG CoA synthase
pyrimidine: D. Squalene synthetase
A. Xanthine E. Thiolase
B. Allantoin
C. Beta-alanine 38. The stored triacylglycerol in adipose tissues are
D. Uric acid hydrolyzed by:
E. Glycine A. Co-lipase
B. Hepatic lipase
32. Methotrexate, an antimetabolite drug, inhibits which C. Hormone sensitive lipase
of the following enzyme: D. Lipoprotein lipase
A. Thymidylate synthase E. Pancreatic lipase
B. PRPP amidotransferase
C. Dihydrofolate reductase 39. The net ATPs produced by complete oxidation of one
D. PRPP synthase mole of palmitic acid are:
E. Ribonucleotide reductase A. 05
B. 28
33. Which of the following infection is most likely to C. 106
spread among residents of an overcrowded house: D. 108
A. Enteric fever E. 131
B. Poliomyelitis
C. Amoebiasis
 RAM LAL VALASAI BIOCHEMISTRY BCQS 4

40. The main source of reducing equivalents (NADPH) for B. It is synthesized from methionine & lysine
lipogenesis is: C. It is required for transport of all types of fatty acids into
A. Aerobic glycolysis mitochondria
B. Anaerobic glycolysis D. Its deficiency can occur due to hemodialysis
C. Citric acid cycle E. It is synthesized in the liver
D. Glycogenolysis
E. Pentose phosphate pathway 48. Richner-Hanhart syndrome is due to defect in:
A. Tyrosinase
41. In de novo synthesis of fatty acids which of the B. Phenylalanine hydroxylase
following is rate limiting enzyme: C. Hepatic tyrosine transaminase
A. Acetyl CoA carboxylase D. Fumaryl acetoacetate hydrolase
B. Acetyl transacylase E. β-hydroxy phenyl pyruvate hydroxylase
C. Acyl CoA synthetase
D. Pyruvate carboxylase 49. Parents bring in their 02 week old child fearful that he
E. Malonyl CoA synthetase has ingested a poison. They had delayed disposing one of
the child’s diapers and noted a black discoloration where
42. Which of the following shows the most marked the urine had collected. Later they realized that all of the
increased in plasma concentration during starvation: child’s diapers would turn black if stored as waste for a
A. Cholesterol day or so. Which of the following amino acid pathways are
B. Chylomicrons implicated in this phenomenon:
C. Free fatty acids A. The phenylalanine, tyrosine & homogentisate pathways
D. Triacylglycerol B. The histidine pathway
E. All of the above C. The leucine, isoleucine & valine pathway
D. The methionine & homocysteine pathway
43. In de novo synthesis of fatty acids, end product is: E. The arginine & citrulline pathway
A. Acyl CoA
B. Acyl enzyme 50. Serotonin:
C. Free palmitate A. Acts as a vasodilator
B. Is stored in macrophages
D. Palmitoyl CoA
C. Deficiency in brain tissues produces depression
E. Triacylglycerol
D. Produces relaxation of smooth muscles
44. Apo A1 acts as: E. Excess in brain tissues produces depression of cerebral
activity
A. Cofactor for LCAT
B. Cofactor for lipoprotein lipase
51. Which of the following amino acids are required for
C. Inhibitor for LCAT
synthesis of creatine:
D. Inhibitor for lipoprotein lipase
A. Arginine, Aspartate, S-adenosyl methionine
E. Ligand for LDL receptor related protein (LRP)
B. Arginine, Glycine, S-adenosyl methionine
C. Arginine, Lysine, Methionine
45. The primary substrate for lipogenesis in most
D. Glycine, Aspartate, Ornithine
mammals is:
E. Arginine, Glutamate, S-adenosyl methionine
A. Acetate
B. Acetyl CoA
52. A 60-years old patient is admitted in hospital in coma,
C. Amino acids
his serum ammonia level is increased. This suppression of
D. Glucose
CNS activity because of hyperammonia is due to:
E. Malonyl CoA A. Lack of α-ketoglutarate in cells of CNS
B. Excess of glutamine
46. β-hydroxy β-methyl glutaryl-CoA reductase (HMG C. Inability effect of neurotransmitter glutamate
CoA reductase) is activated by:
D. Excitatory effect of GABA (neurotransmitter)
A. Bile acids
E. Lack of acetylcholi
B. Glucocorticoids
C. Insulin
53. Which one of the following amino acids give rise to
D. Lovastatin
alpha keto acids that are excreted in the urine in maple
E. Movilonate
syrup urine disease:
A. Lysine
47. All the following statements about carnitine are true,
B. Methionine
except:
C. Phenylalanine
A. It can be synthesized in the human body
D. Tyrosine
 RAM LAL VALASAI BIOCHEMISTRY BCQS 5

E. Valine
61. Virus mediated transfer of cellular genetic material
54. Epinephrine is formed from norepinephrine by: from one bacterial cell to another by means of virus
A. Decarboxylation particles is called:
B. Hydroxylation A. Transposition
C. N-methylation B. Transduction
D. O-methylation C. Induction
E. Oxidative deamination D. Transection
E. Transformation
55. The two nitrogen atoms in urea arise from:
A. Alanine & glutamine 62. An enhancer:
B. Ammonia & aspartic acid A. Is a consensus sequence in DNA located where RNA
C. Ammonia & glutamine polymerase first binds
D. Aspartic acid & glutamine B. May be located in various places in different genes
E. Glutamine & glutamic acid C. May be located on a separate chromosome from the gene to
which it regulates
56. Histidine is converted into histamine by: D. Functions by binding RNA polymerase
A. Carboxylation E. Stimulates transcription in both prokaryotes & eukaryotes
B. Decarboxylation
C. Methylation 63. Mammalian RNA polymerase-I synthesizes:
D. Hydroxylation A. mRNA
E. Transamination B. rRNA
57. Carbamoyl phosphate required for urea synthesis is C. tRNA
formed in: D. nRNA
A. Cytosol E. hnRNA
B. Mitochondria
C. Cytosol & mitochondrion 64. Which of the following descriptions of DNA replication
D. Ribosome is not common to the synthesis of both leading and lagging
E. Inter membranous space strands:
A. RNA primer is synthesized
58. Sickle cell anemia is the clinical manifestation of B. DNA polymerase-III synthesizes DNA
homozygous genes for an abnormal hemoglobin molecule. C. Helicase continuously unwinds duplex DNA at the
The mutational event causing mutation in the β-chain is: replication fork during synthesis
A. Deletion D. DNA ligase repeatedly joins the ends of DNA along with
B. Insertion the growing strand
C. Missense mutation E. None of the above
D. Nonsense mutation
E. Point mutation 65. Bacterial ribosomes do not have the following:
A. Two subunits
59. All the enzymes required for de novo synthesis of B. 5S RNA
pyrimidine nucleotides are cytosolic, except: C. 16S RNA
A. Carbamoyl phosphate synthetase D. 18S RNA
B. Succinyl CoA E. Sensitivity to streptomycin
C. Dihydro-orotase
D. Dihydro-orotate dehydrogenase 66. Elongation of peptide chain involves all the following,
E. None of the above except:
A. mRNA
60. Regarding nitrogen bases metabolism: B. GTP
A. Xanthine oxidase deficiency induces hyperuricemia C. Formyl-Mot-tRNA
B. Purine overproduction & over excretion are clinical D. Tu, Ts & G-factor
characteristic of Lesch Nyhan syndrome E. None of the above
C. The principle catabolic product of pyrimidine is aspartic
acid 67. In obstructive jaundice which of the following enzymes
D. End product of purine catabolism is urea is diagnostically important:
E. Increases in gout A. Alkaline phosphatase
C. Creatinine phosphokinase C.Creatinine phosphokinase
B. Acid phosphatase D. Lactate dehydrogenas
 RAM LAL VALASAI BIOCHEMISTRY BCQS 6

68. Creatinine clearance is decreased in:

A. Acute tubular necrosis 75. In de novo synthesis of fatty acid, which of the
B. Acute glomerulonephritis following enzyme is required for formation of malonyl
C. Hypertension CoA:
D. Myopathies A. Acetyl CoA carboxylase
E. Nephritic syndrome B. Acetyl transacylase
C. Acyl CoA synthetase
69. Polymerase chain reaction (PCR) involves three basic D. Malonyl CoA synthetase
steps in which of the following orders: E. Pyruvate carboxylase
A. Annealing, denaturation, extension
B. Annealing, extension, denaturation 76. Ketonemia occurs due to:
C. Denaturation, annealing, extension A. Decreased excretion
D. Denaturation, extension, annealing B. Decreased utilization by extrahepatic tissues
E. Extension, annealing, denaturation C. Increased production & decreased excretion
D. Increased production by the liver & decreased utilization
70. Against which one of the following infection, an oral by extrahepatic tissues
vaccine is administered: E. Increased production of ketone bodies by the liver
A. Whooping cough
B. Poliomyelitis 77. A patient with anemia is admitted in hospital. His
C. Tuberculosis vitamin B12 level is very low. If he takes the fatty diet rich
D. Tetanus in odd chain carbon containing fatty acids. Which of the
E. None of the above following metabolite will be excreted in urine:
A. Formic acid
71. Food poisoning is an acute gastroenteritis caused by B. Methyl malonic acid
ingestion of: C. Octanoic acid
A. Tobacco D. Propionic acid
B. Skimmed milk E. Cyanocobalamin
C. Oral polio vaccine
D. Contaminated milk 78. In de novo synthesis of fatty acids, end product is:
E. None of the above A. Acyl CoA
B. Acyl enzyme
72. A 07-years old boy has a digestive problem. He often C. Free palmitate
feels severe abdominal cramps after eating a high fat diet. D. Palmitoyl CoA
On laboratory investigation he is diagnosed as having E. Triacylglycerol
lipoprotein lipase deficiency. Which of the following
substances would most likely be elevated in the patient’s 79. LDL receptor related protein is identified as:
plasma after fatty meal: A. HDL receptor
A. Chylomicrons B. LDL receptor
B. HDL C. Receptor for chylomicrons
C. LDL D. Reminant receptor
D. Triacylglycerol E. VLDL receptor
E. VLDL
80. The enzyme glycerol kinase has low activity in:
73. The stored triacylglycerol in adipose tissues are A. Liver
hydrolyzed by: B. Kidney
F. Co-lipase C. Intestine
G. Hepatic lipase D. Adipose tissue
H. Hormone sensitive lipase E. All of the above
I. Lipoprotein lipase
J. Pancreatic lipase 81. Neimann-Pick disease is due to the deficiency of
74. When one mole of palmitic acid is completely oxidized, enzyme:
it gives rise: A. Ceramidase
A. 05 ATPs B. Ceramide lactosidase
B. 28 ATPs C. Hexosaminidase A
C. 106 ATPs D. Hexosaminidase B
D. 108 ATPs E. Sphingomyelinase
E. 131 ATPs
 RAM LAL VALASAI BIOCHEMISTRY BCQS 7

82. A male infant was admitted to the hospital. The D. Microcephaly

examination reveals the presence of Gaucher’s disease. E. Mental retardation
Which of the following enzyme deficiency leads to
Gaucher’s disease: 89. The level of which compound will be increased after
A. Sphingomyelinase taking protein rich meal:
B. Ceramidase A. Ammonia
C. β-glucosidase B. Glutamate
D. β-galactosidase C. Nitrogen
E. Hexosaminidase D. N-acetyl glutamate
E. Uric acid
83. Which one of the following is unmatched:
A. Alkaptonuria ----- Homogentisate oxidase 90. Mother of 06-months boy comes with complaints of
B. Branched chain amino acid ----- Hartnup disease dark staining of diapers of his boy and pigmentation
C. Glycine ----- Biosynthesis of heme & creatine around ears. Which enzyme is defective in this clinical
D. Phenylketonuria ----- Phenylalanine hydroxylase condition:
E. Tryptophan ----- Kynurenine anthranilate pathway A. Alpha keto acid decarboxylase
B. Beta synthase
84. Deficiency of which enzyme will cause the C. Hydroxylase
Citrullinemia: D. Homogentisic acid oxidase
A. Arginase E. Tyrosinase
B. Arginosuccinate lyase 91. Transamination reaction:
C. Arginosuccinate synthase A. Best operates in the presence of vitamin B6
D. Carbamoyl phosphate synthase B. Is irreversible
E. Ornithine transferase C. Is inhibited by thyroxine
D. Involves cytochrome p450 system
85. Carbamoyl phosphate required for urea synthesis is E. Requires coenzyme Q
formed in:
A. Cytosol 92. Which one of the following amino acids gives rise to
B. Cytosol & mitochondrion alpha keto acids that are excreted in the urine in maple
C. Mitochondria syrup urine disease:
D. Rough endoplasmic reticulum A. Lysine
E. Ribosome B. Methionine
C. Phenylalanine
86. In the urea cycle the enzyme ornithine D. Tyrosine
transcarbomylase is concerned with: E. Valine
A. Hydrolysis of ornithine
B. Synthesis of citrulline from ornithine 93. A gene is a section of DNA that codes for protein. This
C. Synthesis of ornithine to citrulline unique sequence that codes for a protein is called:
D. Synthesis of urea to arginine A. Enhancer
E. Transamination of ornithine B. Exon
C. Intron
87. A 20-years old patient presents with complaints of D. Promoter
body ache from few days. On clinical examination his E. Regulatory protein
limbs are long and thin, lens of eye also dislocated.
Laboratory investigation shows increased plasma level of 94. Mutations that arise in the absence of known mutagens
methionine. This clinical picture is in favor of: are called:
A. Alkaptonuria A. Induced mutation
B. Homocysteinuria B. Fusion mutation
C. Maple syrup disease C. Nonsense mutation
D. Phenylketonuria D. Silent mutation
E. Tyrosinosis E. Spontaneous mutation
88. All of the following are related with maternal 95. Which of the following enzymes is used for synthesis of
phenylketonuria, except: polynucleotide strands during polymerase chain reaction:
A. Congenital heart disease A. Primase
B. Hypoactivity B. Restriction endonuclease
C. Low birth weight C. Taq polymerase
 RAM LAL VALASAI BIOCHEMISTRY BCQS 8

D. Topoisomerase stop codon in mRNA. Which type of mutation the affected

E. All of the above can be used individual carries in his DNA:
A. Deletion
96. A patient is suffering from obstructive jaundice, which B. Insertion
of the following enzymes is diagnostically important in this C. Missense mutation
patient: D. Nonsense mutation
A. Alkaline phosphatase E. Silent mutation
B. Acid phosphatase
C. Creatinine phosphokinase 103. Creatinine clearance is decreased in:
D. Lactate dehydrogenase A. Acute tubular necrosis
E. All of the above B. Acute glomerulonephritis
C. Hypertension
97. The bond/linkage present between adjacent nucleotides D. Myopathies
in DNA molecule is: E. Nephritic syndrome
A. Covalent bond
B. Hydrogen bond 104. The recognition sequence to which RNA polymerase
C. Ester linkage binds at the initiation of transcription is found:
D. Peptide linkage A. Downstream of the promoter target sequence
E. Phosphodiester linkage B. Upstream of the gene to be transcribed
C. Within the first intron
98. Amino acid that have single codon: D. Downstream of the transcription bubble
A. Arginine E. Within the cap structure
B. Cysteine
C. Lysine 105. EPI stands for:
D. Serine A. Extensive planning of immunization
E. Tryptophan B. Expanded program on immunization
C. Extended program for immunization
99. Which of the following best describes a promoter: D. Expanded program for immunization
A. An element that promotes termination of transcription E. Eradication plan for infections
B. A regulatory protein that accelerates mRNA turnover
C. A specific target sequence to which RNA polymerase binds 106. Communicable diseases are:
D. An extracellular environmental inducer that controls gene A. Transmitted genetically
expression B. Noninfectious in origin
E. Binding site of DNA polymerase C. Transmitted from human to human
D. Chronic illness
100. Which one of the following enzymes is used to join the E. Associated with malnutrition
bits of DNA:
A. Primase 107. The metabolic pathway considered as “amphibolic”
B. DNA polymerase in nature is:
C. DNA ligase A. Glycogenesis
D. RNA polymerase B. Krebs cycle
E. Restriction endonuclease C. Glycolysis
D. Lipolysis
101. Regarding RNA synthesis (transcription): E. Glycogenolysis
A. RNA polymerase needs a primer to initiate transcription 108. Regarding enzyme repression, the enzyme of
B. RNA synthesis is always in the 5’-3’ direction gluconeogenesis are inhibited by:
C. New nucleotides are added onto the 2’OH of the ribose A. Leucine
sugar B. Adrenaline
D. In transcription U is inserted opposite T C. Glucagon
E. Poly-A tail is added to 5’-end D. Tryptophan
E. Insulin
102. On sequencing the DNA of an individual affected with
an autosomal recessive disorder, it was found that at a 109. Considering a person who has undergone 03-days of
particular point in DNA, cytosine (C) has been substituted starvation what is in --- of blood glucose:
with uracil (U), which resulted in the synthesis of A. Gluconeogenesis from lactate
nonfunctioning protein due to appearance of a premature B. Gluconeogenesis from glycerol
C. Liver glycogenolysis
 RAM LAL VALASAI BIOCHEMISTRY BCQS 9

D. Both liver & muscle glycogenolysis C. Enterokinase

E. Gluconeogenesis from glucogenic amino acids D. Enterogastrone
E. Pepsin
110. Regarding IMNCI all are correct, except:
A. Malnutrition is common factor in more than 50% of cases 117. The major glycolytic product formed under normal
B. It is an integrated approach to child health that focuses on circumstances by erythrocytes for unloading of oxygen to
the wellbeing the whole child the peripheral tissues is:
C. It has three components A. 2,3 Bisphosphoglycerate
D. It includes age group from 02 months to 05 years B. 1,3 Bisphosphoglycerate
E. Yellow color triage system indicates simple advice to home C. Pyruvate
management to mothers D. Lactate
E. Acetyl CoA
111. Hormones that have galactobolic effect is:
A. Calcitonin 118. One Kcal is equal to:
B. Leptin A. 4.184 J
C. Calcitriol B. 10 food calorie
D. Gastrin C. 4.184 J
E. Oxytocin D. 1 KJ
E. 100 cal
112. A liver biopsy from an infant with hepatomegaly,
stunted growth, hypoglycemia, lactic acidosis, 119. Following hormones transmit signals through cGMP
hyperlipidemia, revealed accumulation of glycogen having as second messenger:
normal structure. A possible diagnosis would be: A. Nitric acid
A. Branching enzyme deficiency B. Glucagon
B. Acid maltase deficiency C. Insulin
C. Liver phosphorylase deficiency D. Somatostatin
D. Debranching enzyme deficiency E. Prolactin
E. Glucose-6-phosphatase deficiency
120. FMN linked dehydrogenase involved in E.T.C is:
113. Following functions are performed by growth A. NADH dehydrogenase
hormone: B. Isocitrate dehydrogenase
A. Decrease DNA & RNA synthesis C. Lactate dehydrogenase
B. It has diabetogenic action D. Malate dehydrogenase
C. Increase circulating free fatty acids E. Succinate dehydrogenase
D. Stimulate protein synthesis
E. Stimulates the growth & enlargement of mammary glands 121. The only mobile electron carriers amongst the
following are:
114. Epinephrine which of the following hormones act A. Coenzyme Q & Cytochrome C
through adenylyl cyclase pathway using cAMP as second B. Coenzyme Q
messenger: C. NADH dehydrogenase
A. Prolactin D. Cytochrome C
B. Calcitonin E. Succinate dehydrogenase
C. Gastrin
D. Calcitriol 122. In complex-II of E.T.C, electrons are transferred
E. Leptin from succinate to ubiquinone via:
A. NAD+
115. Which salivary gland is most affected by mumps: B. Cu++
A. Parotid gland C. FAD+
B. Submandibular gland D. FMN
C. Sublingual gland E. Fe++
D. Von Ebners gland
E. Submaxillary gland 123. Which of the following is not a surface water:
A. River
116. The zymogen from trypsinogen is converted into B. Spring
active form trypsin by: C. Pond
A. Rennin D. Stream
B. Soyabeans E. Lake
 RAM LAL VALASAI BIOCHEMISTRY BCQS 10

124. Which one of the following is not an intermediate of C. Lingual & pancreatic lipase
the citric acid cycle: D. Gastric & intestinal lipase
A. Oxalosuccinate E. Lingual & intestinal lipase
B. Acetoacetate
C. Citrate 132. Which of these is responsible for contractility of
D. Malate gallbladder:
E. Succinyl CoA 125. It is very important to feed the baby A. Secretin
very soon after the birth because during the first few B. Cholecystokinin
hours after the birth the enzyme phosphoenolpyruvate C. Gastrin
carboxylase is present in very low amount, and this fact D. Bile
compromises: E. Histamine
A. Gluconeogenesis
B. Glucose phosphorylation 133. The potential for disorder in a system is termed as:
C. Glycogenesis A. Enthalpy
D. Glycogenolysis B. Reduction potential
E. Glycolysis C. Free energy change
D. Entropy
126. Hypothyroid patient has which of the following: E. Kinetics
A. Insomnia
B. Moist hand & feet 134. A 43-years old man presents with symptoms of
C. Increased blood cholesterol level weakness, fatigue, shortness of breath and dizziness. His
D. Rapid heart rate Hb level is 5.7 gm/dl. RBCs isolated from the patients
E. Increased BMR showed abnormal low levels of lactate production. Most
likely cause of this patient’s anemia is due to deficiency of:
127. Which is correct regarding the role of fat in stomach: A. Phosphofructokinase
A. Increases the gastric motility B. Hexokinase
B. Delays the rate of gastric emptying C. Pyruvate kinase
C. Possess low satiety value D. Phosphoglucoisomerase
D. Enhances the rate of gastric emptying E. Lactate dehydrogenase
E. Major digestion fat occurs in stomach
135. Which of the following coenzymes is responsible for
128. Carboxypeptidase is secreted in: transfer of H+ in the chemical reactions:
A. Intestinal juice A. Coenzyme A
B. Pancreatic juice B. Biotin
C. Salivary juice C. Thiamine pyrophosphate
D. Bile juice D. Coenzyme Q
E. Gastric juice E. Pyridoxal phosphate

129. Which of the following substrates derived from 136. The oxidation of one FADH2 molecule through
adipose tissues contributes to gluconeogenesis in the electron transport chain results in pumping out of:
mammalian liver: A. 8 H+
A. Pyruvate B. 4 H+
B. Alanine C. 10 H+
C. Glycerol D. 6 H+
D. Lactate E. 2 H+137. When iodine supplies are sufficient the T4:T3
E. Glutamate rate is:
A. 7:1
130. Hormone that has receptor in nucleus is: B. 3:1
A. Nerve growth factor C. 5:1
B. Thyroid hormone (T3) D. 2:1
C. Erythropoietin E. 4:1
D. Antidiuretic hormone
E. Acetylcholine 138. One of the following parameters predicts that
whether a reaction is favorable:
131. Hydrolysis of triacylglycerol is initiated by: A. Change in enthalpy
A. Lingual & gastric lipase B. Change in entropy
B. Gastric & pancreatic lipase C. Change in free energy
 RAM LAL VALASAI BIOCHEMISTRY BCQS 11

D. Enthalpy
E. Entropy 146. The complex of electron transport chain and
oxidative phosphorylation name as ATP synthase is:
139. The chemical energy required for synthetic processes A. Complex 1
is provided by: B. Complex 2
A. Dephosphorylation of ADP C. Complex 3
B. Hydrolysis of GTP D. Complex 4
C. Hydrolysis of ATP E. Complex 5
D. Hydrolysis of phosphocreatine
E. Phosphorylation of ADP 147. A medical student developed hemolytic anemia after
taking the antimalarial drug primaquine. This is most
140. Accumulation of which of the following sugar and its likely due to:
derivatives in blood causes liver damage, mental A. Glucose-6-phosphatase dehydrogenase deficiency
retardation and cataracts: B. Concomitant scurvy
A. Fructose C. Diabetes
B. Ribose D. Glycogen phosphorylase deficiency
C. Galactose E. None of the above
D. Xylulose
E. Mannose 148. The oxidative phosphorylation in intact membrane is
blocked by:
141. Calcium facilitates the action of lipase by: A. Aspirin
A. Formation of tiny droplets B. Penicillin
B. Soap formation C. Septran
C. Emulsification D. Streptomycin
D. Micelle formation E. Oligomycin
E. Inhibition of emulsification
149. Gastric lipase is destroyed by:
142. Glucose cannot be aerobically oxidized by the: A. Chymotrypsin
A. Kidney B. Rennin
B. Skeletal muscle C. Pepsin
C. Liver D. Trypsin
D. Erythrocytes E. Lipoxin
E. Brain
150. Which of the following biochemical processes is
143. Which of the following hormones do not bind with inhibited by insulin:
intracellular receptors: A. Glycolysis
A. Retinoic acid B. Lipogenesis
B. Estrogen C. Protein synthesis
C. Mineralocorticoids D. Gluconeogenesis
D. Calcitriol E. Entry of K+ ion cells
E. Erythropoietin
151. Which of the following is not an action of PTH:
144. The only non-protein electron carrier of the electron A. Activation of vitamin D in kidney
transport chain is: B. Increased excretion of phosphate from kidneys
A. Cytochrome oxidase C. Increased reabsorption of Ca+2 by renal tubular cells
B. ATP synthase (complex-V) D. Resorption of bone
C. Ubiquinone E. Decreased activity of osteoclasts
D. NADH dehydrogenase
E. Cytochrome C 152. Action of oxytocin is enhanced during labor mainly
by:
145. The collection and removal of all refuse except human A. Local release of oxytocin
excreta is known as: B. Increased secretion of oxytocin
A. Scavenging C. Increased number of receptors for oxytocin
B. Decomposition D. Release of prostaglandins by oxytocin
C. Water carriage system E. Increased blood levels of oxytocin
D. Conservancy
E. Sewage carriage system
 RAM LAL VALASAI BIOCHEMISTRY BCQS 12

153. Which of the following is not an action of A. Starch

testosterone: B. Glycogen
A. Growth of scalp hair C. Lactose
B. Protein synthesis D. Sucrose
C. Descent of testis E. Fructose
D. Formation of male genital ducts
E. Stimulation of spermatogenesis 161. Which is the inhibitor of salivary amylase:
A. Chloride ion
154. Action of estrogens include all, except: B. Calcium ion
A. Makes cervical mucus thin & watery C. Alkaline pH of intestine
B. Development of secondary sexual characteristics in D. Acidic pH of stomach
females E. All of the above
C. Development of alveoli & lobules in breast
D. Cause pigmentation of areola 162. The breakdown of sucrose into fructose and glucose
E. Cause deposition of fats in breast in stomach. The reaction is catalyzed by:
A. Enzyme
155. All of the following increase prolactin secretion, B. Coenzyme
except: C. Cofactor
A. Stress D. Acid
B. Sucking E. Bacterial flora
C. Pregnancy
D. Dopamine 163. The secondary lactose intolerance is commonly due
E. Leutrine to:
A. Genetic disorder
156. Oral contraceptives act by inhibiting: B. Bacterial infection
A. Release of estrogen C. Congenital birth defects
B. Ovulation D. Viral infection of GIT
C. Release of progesterone E. Chemotherapy
D. Union of sperm & ovum
E. Implantation of ovum 164. Which hormone has negligible effect in absorption of
monosaccharide:
157. Which of the following does not cause secretion of A. Aldosterone
growth hormone (GH): B. TSH
A. Sleep C. Growth hormone
B. Starvation D. Insulin hormone
C. Hyperglycemia E. None of the above
D. Stress
E. Arginine infusion 165. Which glucose transporter used for reabsorption of
glucose:
158. Hypothalamic pituitary axis controls the secretions of A. SGLT-1
all of the following glands, except: B. SGLT-2
A. Thyroid gland C. GLUT-1
B. Adrenal gland D. GLUT-2
C. Testes E. GLUT-5
D. Parathyroid gland
E. Ovaries 166. L-amino acids absorbed in small intestine by:
A. Simple diffusion
159. Hormones can produce their effects by all of the B. Facilitated diffusion
following mechanisms, except: C. Osmosis
A. By changing membrane protein conformation D. Active transport
B. By activating same enzymes in the cell E. None of the above
C. By inactivating same enzymes in the cell
D. By forming complex lipids in the cell 167. Which enzyme is responsible for the breakdown of
E. By forming new proteins in the cell triglycerides into fatty acids and monoglyceride in small
intestine:
160. Which carbohydrates can easily absorb at small A. Pancreatic lipase
intestine: B. Lipoprotein lipase
 RAM LAL VALASAI BIOCHEMISTRY BCQS 13

C. Hormone sensitive lipase

D. Phospholipase 175. Which class of the enzyme is involved in the digestion
E. All of the above of food:
A. Oxidoreductase
168. Which fatty acids directly absorbed from small B. Hydrolyases
intestine: C. Isomerases
A. Short chain FA D. Ligases
B. Medium chain FA E. Lyases
C. Long chain FA
D. Very long chain FA 176. Saliva does not contain:
E. Cholesterol A. Water
B. Amylase
169. What is precursor of bile salt synthesis: C. Peptidase
A. Cholesterol D. Lysozyme
B. Glycerol E. Lactoferrin
C. Ketone bodies
D. Lecithin 177. Regarding digestion and absorption:
E. Palmitic acid A. Hartnup’s disease is related to defective monosaccharide
absorption
170. In the stomach sucrose splits into fructose and B. Fetus & neonates absorb intact protein
glucose, this reaches in catalyzed by: C. Portal vein transport absorbed dietary lipids as TAG ‘
A. Amino acids D. Amino acids are absorbed from intestinal lumen via
facilitated diffusion
B. Chymotrypsin
E. Gallstones are formed when cholesterol to lecithin ratio is
C. Disaccharide
disturbed
D. HCL
E. Sucrose
178. The terminal electron acceptors of ETC (electron
transport chain) is:
171. A carbohydrate splitting enzyme ptylin is present at:
A. Hydrogen
A. Gastric juice
B. Oxygen
B. Bile
C. Water
C. Intestinal juice
D. Fe3+
D. Pancreatic juice E. Complex
E. Saliva
179. Proton channel is:
172. Which immunoglobulin act as antibacterial effect in
A. CI, III & IV
succas entericus:
B. CIV, V
A. IgA
C. FI fraction & complex V
B. IgG D. For function of complex
C. IgM E. CIV
D. IgE
E. IgA & IgE 180. Respiratory chain:
A. Is present in outer mitochondrial membrane
173. Main function of secretin hormone in pancreatic juice B. Inner mitochondrial membrane is highly permeable
is: C. Electron shuttle from cytochrome C to O2 to form H2O
A. Decrease pepsin secretion
D. FADH2 can reduce second complex
B. Increase activity of pyloric antrum E. All substrate can link to respiratory chain through NAD &
C. Decrease bicarbonate secretion in bile P dehydrogenase
D. Relaxation of lower esophageal sphincter
E. Decrease secretion of duodenal gland 181. Electron from pyruvate enter the electron transport
chain at:
174. Which one is the inhibitory factor of gastric juice A. Coenzyme Q
secretion: B. Cytochrome C oxidase
A. Parasympathetic drugs C. NADH – Coenzyme Q oxidoreductase
B. Protein D. Coenzyme Q – Cyto oxidoreductase
C. Coffee E. Succinate – Coenzyme Q reductase
D. Nicotine
E. Insulin
 RAM LAL VALASAI BIOCHEMISTRY BCQS 14

182. Cyanide acts by blocking: A. A hexokinase isoenzyme

A. Complex-I B. Induced in the fasting state
B. Complex-II C. Specific for D-glucose only
C. Complex-III D. Inhibited by fructose-6-phosphate
D. Complex-IV E. Not inhibited by glucose-6-phosphate
E. Proton pump
190. The enzyme not specific to gluconeogenesis is:
183. The major glycolytic product formed under normal A. Pyruvate kinase
circumstances by erythrocytes for unloading of oxygen to B. Pyruvate carboxylase
the peripheral tissue is: C. Phosphoenol pyruvate carboxykinase
A. 2, 3 bisphosphoglycerate D. Fructose 1, 6- biphosphatase
B. 1, 3 bisphosphoglycerate E. Glucose-6-phosphatase
C. Pyruvate
D. Lactate 191. Which of the following intermediates of the citric acid
E. Acetyl CoA cycle is used in the biosynthesis of heme:
A. Citrate
184. Hemolytic anemia occurs due to deficiency of which B. Isocitrate
of the following enzymes of glycolysis: C. Malate
A. Hexokinase D. Succinate
B. Phosphofructokinase E. Succinyl CoA
C. Glucokinase
D. Pyruvate kinase 192. The highest group transfer potential is present
E. Lactate dehydrogenase amongst the following in:
A. 1, 3 biphosphoglycerate
185. Citric acid cycle occurs in: B. Creatine phosphate
A. Inner mitochondrial membrane C. Carbamoyl phosphate
B. Mitochondrial matrix D. Phosphoenol pyruvate
C. Outer mitochondrial membrane E. Glucose-6-phosphate
D. Cytosol
E. Nucleus 193. Hormone mainly control:
A. Exchange of respiratory gases
186. Glycogen storage disease I (Von Gierke’s disease) is B. Rate of chemical reactions
diagnosed by: C. Secretions of the human body
A. Hypoglycemia D. Transport in the human body
B. Low insulin level E. Growth of the human body
C. Injection of glucagon
D. Deficiency of α-1-4 glucosidase 194. The most biologically active androgen is:
E. Deficiency of muscle phosphorylase A. Androsterone
B. Progesterone
187. Which of the following compound is inhibitor of C. Testosterone
pyruvate dehydrogenase and activator of pyruvate D. Androstendione
carboxylase: E. Dihydroepiandrosterone
A. NADH
B. FADHP 195. Addison’s disease is characterized by:
C. ATP A. Acidosis
D. AMP B. Dehydration
E. Acetyl CoA C. Hyperkalemia
D. Hypernatremia
188. In between meals blood glucose level is maintained by E. Hyperpigmentation
release of glucose from:
A. Adipose tissue 196. Steroid hormones produce their effects by:
B. Brain A. Formation of cAMP
C. Skeletal muscle B. Formation of diacylglycerol & inositol triphosphate
D. Liver C. Gene activation
E. Pancreas D. Tyrosine kinase activity
E. Altering ion channels
189. Glucokinase is:
 RAM LAL VALASAI BIOCHEMISTRY BCQS 15

197. In hypothyroidism: C. Growth hormone

A. T4 is elevated D. Insulin
B. Serum cholesterol & triglyceride are raised E. Thyroid hormone
C. Serum sodium is increased
D. Serum TSH is decreased 205. The center for secretion of saliva due to conditional
E. Patient shows intolerance to heat reflexes is located at:
A. Spinal cord
198. Glucagon: B. Medulla oblongata
A. Promote glycogenesis C. Cerebellum
B. Is composed of two polypeptide chains D. Hypothalamus
C. Suppress cyclic AMP formation in liver E. Cerebral cortex
D. Decrease fatty acids in blood
E. Is secreted in response to hypoglycemia 206. An 18-years old boy admitted in emergency with
history of sudden blindness. On examination his optic
199. The parathyroid hormone regulates the metabolism nerve degeneration was observed and diagnosed as leber’s
of: hereditary optic neuropathy. Which one of the following is
A. Calcium & magnesium most probable cause:
B. Calcium & phosphate A. Mutation in nuclear DNA
C. Calcium & potassium B. Mutation in mitochondrial DNA
D. Phosphate & sodium C. Somatic mutations
E. Potassium & phosphate D. Suppressor mutations
E. Mutation in anticodons of tRNA
200. Biphosphoglycerate mutase is present in:
A. Liver 207. The conversion of pepsinogen into pepsin is the:
B. Muscles A. Intracellular rearrangement
C. Brain B. Covalent modification
D. Erythrocytes C. Breaking of hydrogen bond
E. Heart D. Polymerization
E. Addition of sulfur group
201. The first pentose formed in HMP shunt is:
A. Ribose-5 phosphate 208. Which enzyme of pancreatic juice help in milk
B. Ribulose-5 phosphate clotting:
C. Xylose-5 phosphate A. Pancreatic lipase
D. Xylulose-5 phosphate B. Phospholipase A2
E. PRPP C. Enterokinase
D. Trypsin
202. The waste water coming out of a house which does E. Chymotrypsin
not contain faecal matter is known as:
A. Garbage 209. The coupling of energy reduced from substrate
B. Sludge ______ by respiration chain is known as oxidative
C. Sewage phosphorylation:
D. Sullage A. Oxidation
E. Silt B. Reduction
C. .
203. For which of the following disease of childhood there D. .
is no problem of treatment under integrated management E. .
of neonatal and childhood illness:
A. Diarrhea 210. The reduce coenzymes donate a pair of electrons to
B. Influenza specialized set of electron carriers, except:
C. Malaria A. FMN
D. Otitis media B. Coenzyme Q
E. Meningitis C. FO or proton channel
D. Iron sulfur center
204. Which endocrinological hormone increase the rate of E. Cytochrome
secretion of succas entericus:
A. Follicular stimulating hormone 211. High energy phosphates are designated by:
B. Glucagon A. PPi
 RAM LAL VALASAI BIOCHEMISTRY BCQS 16

B. ҄ P 219. What movement of GLUT-4 to the cell membrane

C. -P surface in response to insulin:
D. Pi A. Dephosphorylation of GKB3
E. P B. Dephosphorylation of PKB
C. Dephosphorylation of GSB3
212. Which prostaglandin decrease the secretion of gastric D. Phosphorylation of PKB
juice: E. Phosphorylation of SOS
A. PGE-1
B. PGE-2 220. Which of the following molecules function as switch
C. PGF-1 in insulin mediated gene expression:
D. PGF-2 A. EIK-1
E. PGH-2 B. GSK-3
C. PBK
213. Pancreatic juice does not contain: D. SOS
A. Bile salts E. RAS
B. Phospholipase A2
C. Colipase 221. A 35-years old lady present with amenorrhea and
D. Lipoprotein lipase weight loss. The history and physical examination reveals
E. Pancreatic lipase exophthalmos, fine resting tremors and tachycardia. All
are following laboratory abnormalities are excepted,
214. Rotenone: except:
A. Rapidly absorbed from human GIT A. Increased TSH
B. Its chronic exposure in humans may cause cancers B. Increased T3
C. Fish poison inhibit C1 (complex 1) C. Increased T4
D. Uncouples oxidative phosphorylation D. Increased T3 renin uptake
E. Derived from insects E. Increased radioactive iodine uptake

215. Redox potential is measured in: 222. Glucocorticoid have:

A. Ohm A. Increased insulin activity
B. m/c2 B. Hypoglycemia
C. Volts C. Decrease glycolysis
D. K/cal D. Anti-inflammatory effect
E. Ampere E. Positive nitrogen balance

216. The JAK-STAT transduction mechanism: 223. Alpha-OH-Pregnenolone converted to DHEA in Δ4

A. Stimulates somatostatin activity pathway by cleave the side chain by:
B. Activates the MAP by X-SH2 domain A. 17-β-OH hydroxylase
C. Dephosphorylation of tyrosine kinase B. 3-β-OH-Steroid dehydrogenase
D. Suppress the X-SH2 domain C. Lyase
E. STAT protein activated by PKB D. Isomerase
E. Reductase
217. An aldosterone is overproduced, renin angiotensin
system is ______ and plasma renin is ______: 224. All are the effects of angiotensin-II, except:
A. Amplified & decreased A. Bind with zona glomerulosa & release aldosterone
B. Amplified & increased B. Raised blood pressure
C. Suppressed decreased C. Increased vasopressin release
D. Suppressed increased D. Antidiuretic effect
E. Suppressed & amplified E. Inhibit PGE2

218. Thyroid hormone stimulates _____ cells in the 225. Which of the following substances derived from
pancreas and sensitive muscle to _____: adipose tissues contributes to gluconeogenesis in the
A. Alpha, Epinephrine mammalian liver:
B. Alpha, Glucagon A. Alanine
C. Alpha, Somatostatin B. Glutamate
D. Beta, Epinephrine C. Glycerol
E. Beta, Somatostatin D. Pyruvate
E. Lactate
 RAM LAL VALASAI BIOCHEMISTRY BCQS 17

233. Which of the following enzymes produces ATP by

226. Which one of the following is not an intermediate of substrate level phosphorylases in TCA cycle:
the citric acid cycle: A. Aconitase
A. Acetoacetate B. Fumarase
B. Citrate C. Isocitrate dehydrogenase
C. Oxalosuccinate D. Succinate dehydrogenase
D. Succinyl CoA E. Succinate thiokinase
E. Malate
234. Which of the following enzyme is not involved in
227. In conversion of lactic acid to glucose, three reactions HMP shunt:
of glycolytic pathway are circumvented. Which of the A. Glyceraldehyde-3-P-dehydrogenase
following enzymes do not participate: B. Glucose-6-P dehydrogenase
A. Pyruvate carboxylase C. Transketolase
B. Phosphoenolpyruvate carboxykinase D. Phosphogluconate dehydrogenase
C. Pyruvate kinase E. Transaldolase
D. Glucose-6-phosphatase
E. Fructose-1, 1-biphosphatase 235. Hartnup’s disease absorption of which amino acid is
highly affected:
228. Von Gierke’s disease is characterized by deficiency of A. Tyrosine
which enzyme: B. Phenylalanine
A. Glucokinase C. Methionine
B. Glucose-6-phosphatase D. Proline
C. A-1,6 glucosidase E. Tryptophan
D. Glycogen synthase
E. Debranching enzyme 236. The normal ratio of bile salts with cholesterol in bile
is:
229. Which of the following is substrate for aldolase A. 1:30
activity in glycolytic pathway: B. 1:13
A. Glyceraldehyde-3-P C. 1:20
B. Glucose-6-P D. 10:1
C. Fructose-6-P E. 20:1
D. 1,6-bi-P
E. 1,3-diphosphoglycerate 237. The absorption of D-amino acids is mediated by:
A. Simple diffusion
230. UDP-glucose is converted to UDP-glucuronic acid by: B. Osmosis
A. ATP C. Active transport
B. GTP D. Facilitated diffusion
C. NADP E. None of the above
D. NAD+
E. FAD 238. During neurological surgical process, neurosurgeon
accidently cut off the fibers of sympathetic nerves, due to
231. A 24-years old student presents with severe muscle this complication there is continuous secretion of succus
cramps and weakness even on mild exercise. Muscle entericus. This clinical condition is known as:
biopsy shows glycogen accumulation. Your diagnosis is: A. Dumping syndrome
A. Hartnup’s disease B. Horn disease
B. Krabbe’s disease C. Paralytic entericus
C. Mc Ardle’s disease D. Upper motor neuron lesion
D. Neimann-Pick disease E. Paralytic secretion
E. Von Gierke’s disease
239. Which GI juice contain good amount of solids in their
232. Which of the following pathway is stimulated by composition:
glucagon: A. Saliva
A. Citric acid cycle B. Gastric juice
B. Glycogenesis C. Pancreatic juice
C. Glycogenolysis D. Succus entericus
D. Glycolysis E. Bile
E. Pentose phosphate pathway
 RAM LAL VALASAI BIOCHEMISTRY BCQS 18

240. In pancreatic juice the pH of pancreatic lipase 247. In oxidative phosphorylation, one molecule of
maintain up to 8.0 due to presence of: reduced flavoprotein produce ATP:
A. Amino acid A. 1-5
B. Fatty acids B. 2-5
C. Bicarbonate ions C. 3-5
D. Calcium ions D. 4-6
E. Bile salts E. 5-6

241. A person of 35-years age attends the physician clinic 248. Which one of the following is terminal with acceptor:
with complaints of oligospermia, the physician said might A. Water
be the problem of carbohydrate absorption and B. Coenzyme Q
metabolism. In this clinical condition which glucose C. H2
transporter may be not functioning properly: D. O2
A. GLUT 1 E. Proton
B. GLUT 2
C. GLUT 3 249. Which of the following speed up the metabolic rate
D. GLUT 4 and used in slimming pills before WW:
E. GLUT 5 A. Dinitrophenol
B. Atractyloside
242. Which one is the inhibitory hormone of HCL C. Rotenone
secretion: D. Oligomycin
A. Somatostatin E. Antimycin A
B. Acetylcholine
C. Gastrin 250. Exergonic reaction is denoted as:
D. Histamine A. +ΔG
E. Insulin B. ΔG=0
C. -ΔG
243. The function of Haptocorrin in saliva is: D. ΔH
A. Act as antimicrobial agent E. ΔG
B. Pain killer action
C. Prevent the vitamin B12 from degradation 251. Which of the following decreases production of
D. Act as lubricant reactive oxygen species (ROS):
E. All of the above A. Oligomycin
B. Dinitrophenol
244. Trypsin is the antagonist of: C. UCP
A. Lingual lipase D. Astractyloside
B. Pancreatic lipase E. Dimercaprol
C. Salivary amylase
D. Pancreatic amylase 252. Redox potential:
E. Gastric lipase A. Ampere
B. Ohm
245. Chronic exposure of potential in human may cause: C. Reducing equivalents
A. Parkinson’s disease D. Volts
B. Addison’s disease E. Joules
C. Cushing syndrome
D. ---- syndrome 253. Regarding ATP:
E. Nephritic syndrome A. Prime energy currency of all cells
B. Acts as a donor of phosphate group
246. Oxidative phosphorylation: C. Transfer energy from substances of lower energy potential
A. Uncoupling of energy by respiratory chain to higher energy potential
B. Synthesis of ATP D. On hydrolysis minimum energy is dissipated as heat
C. Formation of 1,3 bisphosphoglycerate E. Heat is continuously being regenerate & consumed
D. Transfer of reducing equivalents
E. Required protein & enzyme are present in outer 254. Which one of the following block electron transport
mitochondrial membrane between NADPH and ubiquinone:
A. Atractylosides
B. Rotenone
 RAM LAL VALASAI BIOCHEMISTRY BCQS 19

C. Malonate E. Uterus
D. Actinomycin A
E. Carbon monoxide 262. It has receptors in the nucleus:
A. FSH
255. Free energy released during oxidation of substrate is B. TSH
used for: C. Calcitonin
A. Uncoupling D. Thyroxin
B. Oxidation E. A & B both
C. Translocation
D. Phosphorylation 263. All are the necessary for the formation of thyroid
E. Generation of heat hormones, except:
A. Iodide trapping
256. The affinity for Mg++S about ______ times more than B. Coupling of iodotyrosines
that of ADP: C. Iodination of tyrosine
A. 5 D. Reduction of iodide
B. 7 E. Thyroperoxidase
C. 8
D. 10 264. ADH:
E. 100 A. Acts on collecting duct to reabsorb water
B. Increases blood volume
257. Elements in E.T.C alternately bear _____ and _____ C. Relaxes smooth muscles
as it is transported to the next member of the chain: D. Released from posterior pituitary
A. Oxidized & reduced E. Increases intracellular Ca++ concentration
B. Oxidized & phosphorylated
C. Phosphorylated & oxidized 265. Aquaporin attached on the collected tubule by ADH
D. Reduced & phosphorylated which stimulated ______ coupled protein:
E. Reduced & oxidized A. Gs
B. Gq
258. At the end of E.T.C H+ are donated to: C. G1
A. H+ D. IP3
B. O2 E. Phospholipase C
C. V complex
D. Mitochondrial matrix 266. Cortisol:
E. ADP A. Decreases permeability of capillary membrane
B. Decreases lipolysis
259. All of the following statements are correct, except: C. Decreases inflammation
A. Total energy of a system including its surrounding remain D. Decreases extrahepatic protein synthesis
constant E. Decreases stability of lysosomal membrane
B. High energy phosphate play a control role in energy
capture & transfer 267. Testosterone is converted into:
C. Oxidase use oxygen as hydrogen acceptor A. Androstenedione
D. Dehydrogenase use O2 as hydrogen acceptor B. Dihydrotestosterone in target cells
E. Component of respiratory chain are arranged in order C. Androgens
increasing redox potential D. Progesterone
E. Estrogen
260. Function of somatostatin is:
A. Release of TSH & growth hormone 268. Glucagon increases:
B. Release of growth hormone A. Glycogenesis
C. Release of prolactin B. TG synthesis
D. Release of TSH & prolactin C. Excretion of glucose
E. Inhibits growth hormone & TSH release D. Protein synthesis
E. Force of contraction
261. Oxytocin is secreted by:
A. Supra optic nuclei 269. Tyrosine kinase phosphorylated and stimulated all,
B. Para optic nuclei except:
C. Paraventricular nuclei A. IRS complex
D. Posterior pituitary B. PIP3
 RAM LAL VALASAI BIOCHEMISTRY BCQS 20

C. PDK1 E. All of the above

D. PKA
E. Activated akt 277. Which of the following transporter is involved in
fructose metabolism:
270. Growth hormone: A. GLUT-1
A. It stimulates erythropoiesis B. GLUT-2
B. Decrease excretion of Na+ & K+ from kidneys C. GLUT-3
C. Decrease fat contents in body D. GLUT-4
D. Increases phosphate levels E. GLUT-5
E. Synergized with androgens & increase size of reproductive
organ 278. Steroidal hormones act via:
A. IP3
271. Intermediary in the metabolism of cortisol and B. GMP
androgen is: C. mRNA
A. Cholesterol D. Ca+2
B. Pregnenolone E. Tyrosine kinase
C. Progesterone
D. Aldosterone 279. An infant develops diarrhea, abdominal
E. Corticosterone cramps/discomfort after breastfeeding. This is due to
deficiency of:
272. Growth hormone increases: A. Disaccharide
A. Glucose uptake in adipocytes B. Isomaltase
B. Glucose uptake in muscles C. Lactase
C. Lipolysis D. Maltase
D. Protein synthesis E. Sucrase
E. DNA & RNA
280. Which one of the following factor decrease the rate of
273. Adrenaline differ from nor-adrenaline in all of the gastric juice secretion:
following, except: A. Parasympathetic activated drugs
A. Is a more potent dilator of bronchi B. Amino acids in diet
B. Causes vasodilation C. Coffee
C. Both are secreted by adrenal medulla D. Nicotine
D. Cause tachycardia when injected intravenously E. Insulin
E. Increase myocardial contraction
281. Which of the following constituents of food does not
274. Which of the following bile salt is lethal for human require digestion before it is absorbed:
health: A. Albumin
A. Cholate B. Triacylglycerol
B. Deoxycholate C. Maltotriose
C. Glycocholate D. Sucrose
D. Lithocholate E. Water
E. Taurocholate
282. The bile salts are reabsorbed from:
275. Which of the following hormone is involved in A. Ascending colon
reabsorption of water from renal tubular epithelium: B. Descending colon
A. Epinephrine C. Transverse colon
B. Cortisol D. Duodenum
C. Vasopressin E. Ileum
D. Oxytocin
E. Aldosterone 283. ACTH promotes the production of cortisol by
stimulating which one of the following reactions:
276. In which of the following conditions, level of A. 11-dioxycortisol to cortisol
androgens is increased: B. 17-OH progesterone to 11-dioxycortisol
A. Intraovarian adrenals C. Cholesterol to progesterone
B. Hydatiform mole D. Pregnenolone to progesterone
C. Turner’s syndrome E. Progesterone to 17-OH progesterone
D. Polycystic ovarian syndrome
 RAM LAL VALASAI BIOCHEMISTRY BCQS 21

284. A young woman has puffy eyes and hoarse voice and
her plasma TSH concentration is low but increases 291. All energy released from oxidation of carbohydrates,
markedly, when she is given TRH. She probably has: lipids and proteins is made available in mitochondria as:
A. Hyperthyroidism due to thyroid tumor A. Reducing equivalents
B. Hypothyroidism due to primary abnormality in thyroid B. Redox carriers
gland C. Water
C. Hyperthyroidism due to primary abnormality in pituitary D. Oxygen
gland E. ATP
D. Hyperthyroidism due to primary abnormality in thalamus
E. Hyperthyroidism due to primary abnormality in thyroid 292. Which of the following enzyme produces ATP by
gland substrate level phosphorylation in TCA cycle:
A. Aconitase
285. All of the following are actions of epinephrine, except: B. Fumarase
A. Increases cAMP level by binding to β-receptors C. Isocitrate dehydrogenase
B. Increases gluconeogenesis in liver D. Succinate dehydrogenase
C. Lipolysis E. Succinate thiokinase
D. Promotes glycogenolysis in skeletal muscle
E. Stimulates the synthesis of fatty acids 293. Parathyroid hormone acts via:
A. Adenylyl cyclase
286. Aldosterone increases:
B. Guanylyl cyclase
A. Reabsorption of Na+
C. Phospholipase C
B. Excretion of Na+
D. Tyrosine kinase
C. Reabsorption of K+
E. Diacylglycerol
D. Excretion of water
E. All of the above 294. Which of the following reactions of glycolysis is
catalyzed by enzyme aldolase:
287. Which of the following hormone transmits the signals A. Fructose 1,6-bisphosphate Glyceraldehyde-3-phosphate
in the target cell through tyrosine kinase pathway: & dihydroxyacetone phosphatase
A. Adrenocorticotropic hormone B. Phosphoenol pyruvate Enol pyruvate
B. Antidiuretic hormone C. 1,3-bisphosphoglycerate 3-phosphoglycerate
C. Thyroid hormones D. 2-phosphoglycerate Phosphoenol pyruvate
D. Insulin E. 3-phosphoglycerate Phosphoenol pyruvate
E. Adrenaline
295. Which of the following two compounds are the
288. In pancreatic juice, trypsin is formed from primary products of the pentose phosphate pathway:
trypsinogen by the action of: A. NAD+ & ribose
A. Exopeptidase B. NADH & ribose
B. Endopeptidase C. NADP+ & ribose
C. Enteropeptidase D. NADPH & ribose
D. ------peptidase A E. NADPH & ribulose
E. ------peptidase B
296. Which of the following intermediate of
289. The powerful and active thyroid hormone is: gluconeogenesis is found inside the mitochondria:
A. T3 A. Fructose 1,6-bisphosphate
B. T4 B. Glyceraldehyde-3-phosphate
C. Reverse T3 C. Glucose-6-phosphate
D. . D. Oxaloacetate
E. . E. Phosphoenol pyruvate

290. An African develops hemolytic anemia. He has given 297. Von-Gierke’s disease is characterized due to
history of ingestion of poorly ------ Feva beans. The deficiency of:
hemolytic anemia is due to the reduced activity of: A. Branching enzyme
A. Glucokinase B. Debranching enzyme
B. Glucose-6-phosphatase C. Glycogen synthase
C. Glucose-6-phosphate dehydrogenase D. Glucose-6-phosphatase
D. Hexokinase E. Glucose-6-phosphate dehydrogenase
E. Pyruvate kinase
 RAM LAL VALASAI BIOCHEMISTRY BCQS 22

298. Which one of the following glycogen storage disease

results from a defect in muscle phosphorylase: 305. The major metabolic end product produced under
A. Andersen’s (Type IV) normal circumstances by erythrocytes and by muscle cells
B. Cori’s (Type III) during intensive exercise is:
C. Mc Ardle’s (Type V) A. Oxaloacetate
D. Pompe’s (Type II) B. Glycerol
E. Von-Gierke’s (Type I) C. Alanine
D. Pyruvate
299. Complex-II of the electron transport chain is E. Lactate
inhibited by: 306. The principal organs involved in gluconeogenesis are:
A. Carbon monoxide A. Liver & GIT
B. Cyanide B. Brain & kidney
C. Antimycin A C. Muscle & adipose tissue
D. Amobarbital D. Liver & kidney
E. Carboxin E. Heart & muscle
300. Energy produced by oxidation in the body which is 307. Concerning the case management of integrated
not conserved as ATP is used for: management of neonatal and childhood illness, the color
A. Biosynthesis coding for danger sign in child is:
B. Ion exchange A. Black
C. Thermogenesis B. Blue
D. Contraction C. Pink
E. Catabolism D. Green
E. White
301. Glucagon stimulates:
A. Citric acid cycle 308. Concerning disposal waste, the waste water that is
B. Gluconeogenesis collected from kitchen of house is called:
C. Glycolysis A. Sewage
D. Pentose phosphate pathway B. Scub
E. Glycogenesis C. Scum
D. Sullage
302. Since the inner mitochondrial membrane is E. Scavage
impermeable to ions in general particularly to protons,
that accumulate in inter membrane space create which 309. The most biologically active androgen is:
one of the following force predicted by chemiosmotic A. Androsterone
therapy:
B. Progesterone
A. Progressive motive force
C. Testosterone
B. Permissive motive force
D. Androsendione
C. Predictive motive force E. Dehydroepiandrosterone
D. Prognosis motive force
E. Proton motive force 310. Hormone mainly control:
A. Exchange of respiratory gases
303. Which one of the following is competitive inhibitor of
B. Rate of chemical reactions
succinate dehydrogenase:
C. Secretions of the human body
A. Carboxin
D. Transport in the human body
B. Malonate
E. Growth of the human body
C. Malate
D. Dimercaprol 311. Which glucose transporter is only under the influence
E. Amobarbital of insulin:
A. GLUT-1
304. Transketolase activity in the HMP shunt is affected
B. GLUT-4
by the deficiency of:
C. GLUT-5
A. Ascorbic acid
D. GLUT-7
B. Biotin
E. GLUT-9
C. Niacin
D. Pyridoxine 312. All energy released from oxidation of CHO, lipids and
E. Thiamine protein is made available in mitochondria as:
 RAM LAL VALASAI BIOCHEMISTRY BCQS 23

A. Redox carriers C. H2S

B. Reducing equivalents D. Cyanide
C. Oxygen E. Oligomycin
D. H2O
E. ATP 320. The enzyme not specific to gluconeogenesis is:
A. Pyruvate kinase
313. The terminal electron acceptors of electron transport B. Pyruvate carboxylase
chain is: C. Phosphoenol pyruvate carboxykinase
A. Hydrogen D. Fructose 1,6-bisphosphatase
B. Oxygen E. Glucose-6-phosphatase
C. Water
D. Fe2+ 321. A patient with PTH deficiency after thyroidectomy
E. Complex show:
A. Decrease plasma PO4 & Ca++ levels & tetanus
314. Addison’s disease is characterized by: B. Decrease plasma Ca2+, increase muscular excitability
A. Acidosis C. Increase plasma PO4 & Ca2+, bone demineralization
B. Dehydration D. Increase plasma Ca2+, muscular excitability & bone
C. Hyperkalemia demineralization
D. Hypernatremia E. Increase plasma PO4 & muscular excitability & bone
E. Hyperpigmentation demineralization

315. Which of the following is a source of surface water: 322. Which one are stimulatory factors of gastric juice
A. Rain secretion:
B. River A. Antihistamine drugs
C. Superficial well B. Secretin hormone
D. Deep well C. Glucocorticoids
E. Spring D. Fatty acids
E. Prostaglandins
316. Insulin is required for entry of glucose into:
A. All tissues 323. A carbohydrate splitting enzyme ptylin is present in:
B. Adipose tissues A. Gastric juice
C. Renal tubular cells B. Bile
D. Most neurons in the cerebral cortex C. Intestinal juice
E. The mucosa of the small intestine D. Pancreatic juice
E. Saliva
317. Human excreta is the source of orofecal infections in
human being, which of the following is the least possible 324. In anaerobic glycolysis, significance of conversion of
channel of transmission of disease agent: pyruvate to lactate is to:
A. Water A. Block the entry of pyruvate to citric acid cycle
B. Finger B. Oxidize NADH for continuation of glycolysis & to produce
C. Food ATPs
D. Clothing C. Produce lactate for Cori’s lactic acid cycle
E. Flies D. Produce less ATPs
E. Produce more 2,3-bisphosphoglycerate for unloading of
318. Which of the following hormones can cause more oxygen in hypoxic conditions
hyperglycemia without known effect in glycogen or
gluconeogenesis: 325. In the pancreatic juice, trypsinogen is converted into
A. Thyroxine trypsin by the help of:
B. Epinephrine A. Enteropeptidase
C. Glucocorticoids B. Endopeptidase
D. Epidermal growth factor C. Exopeptidase
E. Glucagon D. Carboxypeptidase A
E. Carboxypeptidase B
319. A 55-years old man went into shock during traffic.
Which one of the following will be cause of shock: 326. The synthesis of adenylyl kinase enzyme is increased
A. Amobarbital by:
B. Carbon monoxide A. Epinephrine
 RAM LAL VALASAI BIOCHEMISTRY BCQS 24

B. Parathyroid hormone E. All of the above

C. ACTH
D. Thyroid hormone 334. The bile salts are reabsorbed from:
E. Glucagon A. Ileum
B. Ascending colon
327. Regarding gastric juice: C. Descending colon
A. Chief cells secrete HCL D. Transverse colon
B. Parietal cells secrete pepsinogen E. Duodenum
C. Pepsinogen is activated by enterokinase
D. pH is highly acidic due to week acid like HCL 335. The most powerful and active thyroid hormone is :
E. Main organic constituent is enzymes & intrinsic factor A. T3
B. T4
328. Regarding disposable of waste, which of the following C. TSH
method of manual collection of household and street D. Reverse T3
garbage: E. Calcitonin
A. Scavenging
B. Screening 336. In the pancreatic juice, Trypsin jo formed from
C. Sewage forming trypsinogen by the action of:
D. Land disposable A. Enteropeptidase
E. Filtration B. Exopeptidase
C. Endopeptidase
329. Concerning Integrated Management of Neonatal and D. Carboxypeptidase A
Childhood illness IMNCI the term neonate means a child
E. Carboxypeptidase B
of age:
A. Between 0-28 days 337. Which of the following hormone transmits the signals
B. Between 1-2 years in the target cell through tyrosine kinase pathway:
C. More than 01 year A. Insulin
D. Between 3-6 months B. Adrenocorticotropic hormone
E. Between 6-12 months C. Antidiuretic hormone
330. Which of the following hormone is involved in D. Thyroid hormone
reabsorption of water from renal tubular epithelium: E. Adrenaline
A. Vasopressin
B. Epinephrine 338. Which of the following enzyme produces ATP by
C. Cortisol substrate level phosphorylation in TCA cycle:
D. Oxytocin A. Succinate thiokinase
E. Aldosterone B. Succinate dehydrogenase
C. Aconitase
331. Steroidal hormones act via: D. Fumarase
A. IP3 E. Isocitrate dehydrogenase
B. mRNA
C. Tyrosine kinase 339. Which one of the following glycogen storage disease
D. GMP results from a defect in muscle phosphorylase:
E. Ca2+ A. Mc Ardle's (Type V)
B. Andersen’s disease (Type IV)
332. Which one of the following factor will decrease the C. Cori’s disease (Type III)
rate of gastric juice secretion: D. Pompe’s disease (Type II)
A. Parasympathetic activated drugs
E. Von Gierke’s disease (Type I)
B. Coffee
C. Amino acids in diet 340. Of energy observed from extraction of carbohydrates,
D. Nicotine lipids and proteins is mostly available in mitochondria as:
E. Insulin A. Water
B. Oxygen
333. Aldosterone increases:
C. ADP
A. Reabsorption of Na+ D. Redox c
B. Excretion of Na+ E. Reducing equivalents
C. Reabsorption of K+
D. Excretion of water
 RAM LAL VALASAI BIOCHEMISTRY BCQS 25

341. Which of the following compounds are the primary B. ACTH

products of the pentose phosphate pathway: C. Glucagon
A. NAD & ribose D. Insulin
B. NADH & ribose E. Norepinephrine
C. NADP & ribose
D. NADPH & ribose 349. Addison's disease is characterized by:
E. NADPH & ribulose A. Acidosis
B. Hyperkalemią
342. Von Gierke's disease is characterized due to C. Hyperpigmentation
deficiency of: D. Dehydration
A. Glucose-6-phosphatase E. Hypernatremia
B. Branching enzyme
C. Debranching enzyme 350. Which endocrinological hormone increase rate of
D. Glycogen synthase secretion of succus entericus:
E. Glucose-6-phosphate dehydrogenase A. Glucagon
B. Follicular stimulating hormone
343. Glucagon stimulates: C. Growth hormone
A. Gluconeogenesis D. Insulin
B. Citric acid cycle E. Thyroid hormone
C. Glycolysis
D. Pentose phosphate pathway 351. Which glucose transporter is only influence of insulin:
E. Glycogenolysis A. GLUT-4
B. GLUT-1
344. Transketolase activity in the HMP shunt is affected C. GLUT-5
by the deficiency of:
D. GLUT-7
A. Thiamine E. GLUT-9
B. Ascorbic acid
C. Biotin 352. In the stomach sucrose splits into fructose and
D. Niacin glucose, this reaches in catalyzed by:
E. Pyridoxine A. Amino acids
B. Disaccharide
345. Hemolytic anemia occurs due to deficiency of which C. Sucrose
of the following enzymes of glycolysis: D. Chymotrypsin
A. Pyruvate kinase E. HCL
B. Hexokinase
C. Phosphofructokinase 353. A carbohydrate splitting enzyme is present at:
D. Glucokinase A. Saliva
E. Lactate dehydrogenase B. Gastric juice
C. Bile
346. Fructose is transported in human body by: D. Intestinal juice
A. Facilitated diffusion E. Pancreatic juice
B. Active transport
C. Passive transport 354. Insulin is required for entry:
D. Osmosis A. Adipose tissue
E. Simple diffusion B. All tissues
C. Renal tubular cells
347. Hormone mainly control: D. Most neurons in the ce-----
A. Growth of the human body E. The mucosa of the small -----
B. Exchange of respiratory gases
C. Rate of chemical reactions 355. Which of the following hormone has longest duration
D. Secretion of the human body of action:
E. Transport in the human body A. Thyroxine
B. Thyroid stimulating hormone (TSH)
348. Which of the following hormone initiates biological C. Insulin
actions by crossing the plasma membrane and then D. Glucagon
binding to a receptor: E. Adrenocorticotropic hormone (ACTH)
A. Estradiol
 RAM LAL VALASAI BIOCHEMISTRY BCQS 26

A. Acetylcholine
356. In hypothyroidism: B. Gastrin
A. Serum cholesterol & triglyceride are raised C. Somatostatin
B. T4 is elevated D. Magnesium sulphate
C. Serum sodium is increased E. Gastrin
D. Serum TSH is decreased
E. Patient shows intolerance to heat 364. The pancreatic enzyme which activated by
endopeptidase also responsible for milk clotting:
357. Electron from pyruvate enter the electron transport A. Chymotrypsin
chain at: B. Trypsin
A. Coenzyme Q C. Pancreatic lipase
B. NADH coenzyme Q oxidoreductase D. Pancreatic amylase
C. Cytochrome C oxidase E. Exopeptidase
D. Coenzyme Q cyto-oxido-reductase
E. Succinate coenzyme Q reductase 365. The secretion of Succus Entericus is inhibited by:
A. Vagus nerve stimulation
358. The mitochondrial membrane contain a transporter B. Pilocarpine
for: C. Sympathetic stimulation
A. NADH D. Parasympathetic stimulation
B. GTP E. Glucagon hormone
C. Cyclic AMP
D. Acetyl COA 366. Following are the choleretics of bile, except:
E. ATP A. Hepatocrininic
B. CCK
359. Respirator chain: C. Gastrin
A. Is present in outer mitochondrial membrane D. Insulin
B. Inner mitochondrial membrane is highly permeable E. Bile salts
C. Electron shuttle from cytochrome C to O2 to form H2O
D. FADH2 can reduce second complex 367. The ratio of cholesterol bile salts which is the
E. All substrate can link to respiratory chain through NAD & indicator of cholelithiasis is:
P dehydrogenase A. 1:10
B. 1:1
360. Which of the following hormone has no role in growth C. 13:1
and development: D. 1:13
A. Glucagon E. 16:2
B. Growth hormone
C. Sex steroids 368. Which glucose transporter help in the transport of
D. Insulin fructose:
E. Somatomedins & insulin like growth factor (IGFs) A. GLUT 1
B. GLUT 2
361. Amylase present in saliva is: C. GLUT 3
A. α-amylase D. GLUT 4
B. β-amylase E. GLUT 5
C. δ-amylase
369. Regarding absorption of proteins which statement is
D. Ф-amylase
correct:
E. q-amylase
A. Transport of peptides are chloride dependent
B. Absorption of amino acres increases more distally in small
362. Anabolic hormone is:
intestine
A. Testosterone
C. Amino acids are absorbed by active transport
B. Cortisol D. Lithium greatly increases absorption
C. Thyroxine E. All of the above
D. Glucagon
E. Adrenaline 370. The commonest cause of temporary lactose
intolerance:
363. The HCI secretion in stomach is inhibited by the A. Cirrhosis of liver
receptors of: B. Gastroenteritis
 RAM LAL VALASAI BIOCHEMISTRY BCQS 27

C. TB Abdomen 377. A medical student developed hemolytic anemia after

D. Respiratory acidosis taking the antimalarial drug primaquine. This is most
E. All of the above likely due to:
F. Glucose-6-phosphatase dehydrogenase deficiency
371. Proteins are converted to the peptones by the action G. Concomitant scurvy
of which enzyme: H. Diabetes
A. Di-peptidase I. Glycogen phosphorylase deficiency
B. Elastase J. None of the above
C. Pepsin
D. Trypsin 378. The major glycolytic product formed under normal
E. Carboxypeptidase circumstances by erythrocytes for unloading of oxygen to
the peripheral tissues is:
372. In intestinal lumen after the absorption of dietary F. 2,3 Bisphosphoglycerate
triacylglycerol are hydrolysis as: G. 1,3 Bisphosphoglycerate
A. Fatty acids & glycerol H. Pyruvate
B. Fatty acids & two monoacylglycerol I. Lactate
C. Glycolipid J. Acetyl CoA
D. Acyl CoA
E. All of the above 379. The terminal electron acceptor of E.T.C is:
A. Hydrogen
373. Which of the following substrates derived from B. Oxygen
adipose tissues contributes to gluconeogenesis in the C. Water
mammalian liver: D. Fes protein
A. Alanine E. Complex v
B. Glutamate
C. Glycerol 380. Mark the incorrect statement regarding cytochrome
D. Pyruvate oxidase:
E. Lactate A. It is the enzyme which finally derives the reducing
equivalent to molecular oxygen in ETC
374. Which of the following is not an intermediate of the B. It is heme containing enzyme
citric acid cycle: C. it is especially found in last complexes of ETC
A. Acetoacetate D. it is regulatory enzyme of ETIC
B. Citrate E. It is the degradative enzyme present in lysosomes
C. Oxalosuccinate
D. Succinyl COA 381. Following are the inhibitors of E.T.C exception:
E. Malate A. Carbon monoxide
B. Antimycin A
375. A liver biopsy from an infant with hepatomegaly, C. Cyanide
stunted growth, hypoglycemia, lactic acidosis, D. Oligomycin
hyperlipidemia, revealed accumulation of glycogen having E. Amytal
normal structure. A possible diagnosis would be:
F. Branching enzyme deficiency 382. A 55-years old man went into shock during traffic
G. Acid maltase deficiency block. Which one of the following will be the cause of
H. Liver phosphorylase deficiency shock:
I. Debranching enzyme deficiency A. Amobarbital
J. Glucose-6-phosphatase deficiency B. Carbon monoxide
C. Hydrogen sulphide
376. It is very important to feed the baby very soon after D. Cyanide
the birth because during the first few hours after the birth E. Oligomycin
the enzyme phosphoenolpyruvate is present in very low
amount, and this fact compromises: 383. Aldosterone increases:
F. Gluconeogenesis A. Excretion of Na+ of
G. Glucose phosphorylation B. Reabsorption of Na+
H. Glycogenesis C. Reabsorption of K+
I. Glycogenolysis D. Excretion of H2O
J. Glycolysis E. All of the above
 RAM LAL VALASAI BIOCHEMISTRY BCQS 28

384. Insulin: B. ↑ Plasma RA 11 level

A. Increase lipolysis C. ↓ plasma RA 11 level
B. Increase FFA level D. ↑ Na+ & ↓ K+ alkalosis
C. Is metabolized mainly in the kidney E. Alkalosis
D. Is a catabolic hormone
E. Depresses the glucourogenic enzymes 392. Release of which one of the following hormone
inhibited by Somatostatin:
385. Incorrect statement regarding Cushing syndrome is: A. TRH
A. Results from aldosteronism B. GH
B. Is caused by ACTH producing tumors C. T3 & T4
C. Usually results from prolonged cortisol therapy D. PRL
D. Is characterized by increased plasma epinephrine E. TSH
E. Results from hypercortisonism
393. Which of the following carbohydrate is absorbed
386. A patient with PTH deficiency after thyroidectomy more rapidly from intestine:
show: A. Fructose
A. ↓ Plasma PO4 & Ca2++ levels & Tetanus B. Galactose
B. ↓ Plasma Ca2++ & ↑ muscular excitability C. Glucose
C. ↑ Plasma PO4 & Ca2++, bone demineralization D. Mannose
D. ↑ Plasma Ca2++, muscular excitability & bone E. Sucrose
demineralization
E. ↑ Plasma PO4, muscular excitability & bone 394. Which of the following is responsible for curdling of
demineralization milk in babies:
A. Pepsinogen
387. Testosterone is activated to DHT by which one of the B. HCL
following: C. Lactase
A. Oxidation of 17 position of ketosteroids D. Gastric Lipase
B. Hydroxylation of androgens E. Renin
C. Reduction of A ring of cholesterol
D. Oxidation of D ring of cholesterol 395. Free amino acids are absorbed by:
E. Removal of side chain on 17 C of D ring of cholesterol A. Active transport
B. Sodium dependent active transport
388. Cortisol increases blood glucose level by: C. Passive diffusion
A. ↑ lipolysis D. Facilitated diffusion
B. ↑ protein synthesis in muscles E. Osmosis
C. ↑ gluconeogenesis
D. ↑ GH secretion 396. Normal cholesterol in bile salt ratio, in bile is:
E. ↑ glycolysis A. 01:30
B. 02:30
389. It is known as love hormone: C. 30:01
A. Estrogen D. 30:02
B. Testosterone E. 01:10
C. Prolactin
D. Oxytocin 397. Hartnup’s disease results from defect in:
E. Lactogen A. Absorption of tyrosine
B. Proteolytic enzymes
390. Inappropriate ADH secretion is expressed with all, C. Hydrolysis of small peptides
except: D. Hydroxylation of tryptophan
A. Normal or increased ADH production E. Membrane transport system specific for tryptophan
B. Hypo-osmolality
C. Persistent & progressive dilutional hyponatremia 398. The most powerful lipolytic enzyme is:
D. Excretion of hypotonic urine A. Cholinesterase
E. Ectopic production by a variety of tumors B. Lecithinase
C. Phospholipase
391. Which one of the following is not characteristic of D. Salivary lipase
Conn’s syndrome: E. Steapsin
A. HTN
 RAM LAL VALASAI BIOCHEMISTRY BCQS 29

399. Gastric lipase is destroyed by: 407. Which of the following hormone does not act through
A. Amylopsin cyclic AMP as second messenger:
B. Chymotrypsin A. Adrenaline
C. Pepsin B. Adrenocorticotropic hormone (ACTH)
D. Steapsin C. Antidiuretic hormone (ADH)
E. Trypsin D. Follicle stimulating hormone (FSH)
E. Mineralocorticoid hormone
400. Growth hormones exert its growth promoting effects
primarily through the action of: 408. Steroid hormones act through:
A. Insulin A. Altering ion channels
B. Cortisol B. Formation of cAMP
C. Testosterone C. Formation of DAG+IP3
D. Insulin like growth factor-I (IGF) D. Gene activation
E. Prolactin E. Tyrosine kinase activity

401. Acromegaly results from over production of: 409. Addison's disease is characterized by:
A. ACTH A. Acidosis
B. TSH during adult life B. Dehydration
C. Growth hormone during childhood C. Hyperkalemia
D. Growth hormone during adult life D. Hypernatremia
E. TSH during childhood E. Hyperpigmentation

402. Steroid hormones are synthesized from: 410. Superoxide radicals can be detoxified by:
A. Cholesterol A. Cytochrome a
B. Calcitriol B. Cytochrome b
C. 7-dehydrocholesterol C. Cytochrome c
D. 7-hydroxycholesterol D. Cytochrome a3
E. Sitosterol E. cytochrome b1

403. Insulin receptor is made up of: 411. The compound having highest redox potential is:
A. 1-alpha & 1-beta subunit A. Cytochrome a
B. 2-alpha & 2-beta subunits B. Cytochrome b
C. 2-alpha & 2-delta subunits C. Cytochrome c
D. 2-alpha & 2-beta & 2-delta subunits D. Coenzyme Q
E. 1-alpha & 1-beta & 1-delta subunit E. NAD

404. The most powerful thyroid hormone isi do e 412. Low energy phosphate compound includes:
A. MIT A. ATP
B. DIT B. ADP
C. T3 C. HTP
D. Reverse T3 D. ТР
E. T4 E. AMP

405. Diabetes Insipidus is caused by deficient secretion of: 413. Which of the following is the inhibitor of cytochrome
A. Insulin oxidase:
B. Glucagon A. Antimycin A
C. Vasopressin B. Carbon monoxide
D. Oxytocin C. lodoacetic acid
E. Glucocorticoids D. Dintrophenol acid
E. Malonyle CoA
406. Cortisol:
A. Decrease the blood glucose 414. Electron from pyruvate enter the electron transport
B. Gives rise to positive nitrogen balance chain at:
C. Increases the activity of the insulin A. Coenzyme Q
D. Mobilizes fatty acids from adipose tissues B. Cytochrome C oxidase
E. Stimulates glycolysis C. NADH-Q-oxidoreductase
D. Q-cyto-oxidoreductase
 RAM LAL VALASAI BIOCHEMISTRY BCQS 30

E. Succinate Q-reductase C. Glycogenolysis

D. Glycolysis
415. lodoacetate inhibits: E. Pentose phosphate pathway
A. Aldolase
B. Endolase 423. Glucokinase is:
C. Gluco-6-phosphate phosphatase A. A Hexokinase isoenzyme
D. Glyceraldehyde-3-phosphate dehydrogenase B. Induced in the fasting state
E. Phosphoglycerate mutase C. Specific for D-glucose only
D. Inhibited by fructose-6-phosphate
416. Hexose monophosphate shunt provides: E. Not inhibited by glucose-6-phosphate
A. ATP for synthesis of cholesterol
B. Glucose-1 phosphate for glycogen synthesis 424. IMNCI stands for:
C. Glucuronic acid for mucopolysaccharides synthesis A. Integrated management of neonatal & childhood illness
D. Glycerol-3-phosphate for triacylglycerol Synthesis
E. NADPH for fatty acids synthesis 425. Which of the following source is other than the
surface water origin:
417. Mac Ardle's disease is due to deficiency of: A. River
A. Liver phosphorylase B. Lake
B. Glucose-6-phosphorylase C. Tanks
C. Muscle phosphorylase D. Reservoir
D. Phosphofructokinase E. Spring
E. Gluco-kinase
426. Glycolysis:
418. Gluconeogenesis is decreased by: A. ATP synthesis at pyruvate kinase is reversible
A. Insulin B. Phosphofructokinase (PFK-2)
B. Glucagon C. Muscle cells depend on malate
C. Glucocorticoids D. Pyruvate kinase is activated by addition of phosphate via
D. Epinephrine insulin
E. Norepinephrine E. Citrate is an activated by PFK-1

419. In citric acid cycle GDP is phosphorylated by: 427. Glycolysis, significance of conversion of pyruvate to
A. Succinate thiokinase lactate is to:
B. Succinate dehydrogenase A. Block the entry of Pyruvate to citric acid cycle
B. Oxidize NADH for continuation of glycolysis and to
C. Aconitase
produce ATPs
D. Fumarase
C. Produce lactase for Cori's lactate acid cycle
E. Isomerase
D. Produce less ATPs
E. Produce more 2, 3-biphosphoglycerate for including of
420. Which of the following enzyme by glycolytic pathway
more oxygen in hypoxia condition
is inhibited by fluoride ions:
A. Aldolase
B. Enolase
C. Glucokinase
For more such helpful
D. Hexokinase
E. Phosphoglycerokinase
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421. In which of the following type of glycogen storage
medicoengineer.com
diseases severe fasting hypoglycemia occurs:
A. Andersen disease
B. Forbe's disease
C. McArdle's disease
D. Pompe's disease
E. Von Gierke's disease

422. Which of the following pathway is inhibited by

insulin:
A. Citric acid cycle
B. Glycogenesis