SIMPIC 2020##RABIES AND OTHER RHABDOVIRUS INFECTIONS#HARRISON’S##BY : RAJA

PARDOMUAN HARAHAP

Rabies virus is classified in which viral genus?

1
Lyssavirus

Name 5 proteins encoded by rabies virus.

2
Nucleocapsid protein
Phosphoprotein
Large polymerase protein
Glycoprotein
Matrix protein

Vesicular stomatitis virus is classified in which viral genus?

3
Vesiculovirus

Mention four transmission route of rabies virus infection.

4
Bitten by infected animals : dog, skunks, foxes, bats, raccoon
Inhalation of aerosolized infectious particles from bats
Corneal and solid organ transplantation
Human-to-human transmission (rare)

Rabies virus attach to what receptor on muscle cells?

5
Nicotinic acetylcholine receptor

Rabies virus spreads centripetally along peripheral nerves toward the CNS via which
transport?
6
Retrograde axonal transport
Retrograde fast axonal transport to the spinal cord or brainstem

Rabies virus replicates in what type of cell in salivary glands?

7
Acinar cells

Babes nodule is associated with pathologic change caused by rabies virus to what
type of cell?
8
Microglia

What is eosinophilic cytoplasmic inclusions in brain neurons that are composed of

rabies virus proteins and viral RNA?
9
Negri bodies

Negri bodies are associated with pathologic changes of what type of cell?
10
Purkinje cells of cerebellum
Pyramidal neurons of hippocampus

Order the phases in rabies virus infection.

11
Incubation period (20-90 d) - Prodromal phase – Acute neurologic phase – Comatose
phase – Progressive to death
What is the late complication of rabies associated with disturbance water balance?
12
SIADH (Syndrome of inappropriate antidiuretic hormone)
Diabetes insipidus

Mention three cardinal features of encephalitic rabies.

13
Hyperexcitability
Hydrophobia
Aerophobia

Name the disease often misdiagnosed with paralytic rabies.

14
Guillain-Barre syndrome
di atas huruf “e” ada semacam garis atau tanda koma kecil ya harusnyaaa

In skin biopsies, rabies virus antigen may be detected in cutaneous nerves in what
anatomic site?
15
At the base of hair follicles

16
What is the postexposure prophylaxis used for rabies?
Rabies immune globulin (RIG) 20 IU/kg

17
What is the differential diagnosis for vesicular stomatitis caused by VSV?
Hand-foot and mouth disease